{"id":9422,"date":"2018-03-29T07:54:06","date_gmt":"2018-03-29T00:54:06","guid":{"rendered":"http:\/\/ttud.com.vn\/?p=9422"},"modified":"2018-04-13T16:07:18","modified_gmt":"2018-04-13T09:07:18","slug":"dot-pha-trong-chua-tri-alzheimer-thu-nghiem-thanh-cong-khang-the-chua-alzheimer-tren-chuot-ket-qua-cuc-ki-kha-quan","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/dot-pha-trong-chua-tri-alzheimer-thu-nghiem-thanh-cong-khang-the-chua-alzheimer-tren-chuot-ket-qua-cuc-ki-kha-quan\/","title":{"rendered":"\u0110\u1ed9t ph\u00e1 trong ch\u1eefa tr\u1ecb Alzheimer: th\u1eed nghi\u1ec7m th\u00e0nh c\u00f4ng kh\u00e1ng th\u1ec3 ch\u1eefa Alzheimer tr\u00ean chu\u1ed9t, k\u1ebft qu\u1ea3 c\u1ef1c k\u00ec kh\u1ea3 quan"},"content":{"rendered":"

Nghi\u00ean c\u1ee9u m\u1edf \u0111\u01b0\u1eddng cho m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p ch\u1eefa tr\u1ecb \u00edt t\u00e1c d\u1ee5ng ph\u1ee5 m\u00e0 c\u1ef1c k\u00ec hi\u1ec7u qu\u1ea3.<\/h3>\n
Nghi\u00ean c\u1ee9u m\u1edbi nh\u1ea5t tr\u00ean chu\u1ed9t cho th\u1ea5y t\u1ed3n t\u1ea1i m\u1ed9t s\u1ed1 lo\u1ea1i kh\u00e1ng th\u1ec3 c\u00f3 th\u1ec3 lo\u1ea1i b\u1ecf \u0111\u01b0\u1ee3c nh\u1eefng m\u1ea3ng b\u00e1m Alzheimer \u1edf trong n\u00e3o. Theo nh\u1eefng g\u00ec ta bi\u1ebft, ph\u1ea3i t\u1edbi 20 n\u0103m tr\u01b0\u1edbc khi nh\u1eefng tri\u1ec7u ch\u1ee9ng Alzheimer xu\u1ea5t hi\u1ec7n, n\u00e3o ng\u01b0\u1eddi \u0111\u00e3 b\u1eaft \u0111\u1ea7u xu\u1ea5t hi\u1ec7n nh\u1eefng m\u1ea3ng b\u00e1m trong n\u00e3o v\u00e0 c\u00e1c nh\u00e0 khoa h\u1ecdc tin r\u1eb1ng, ch\u00ednh ch\u00fang \u1ea3nh h\u01b0\u1edfng t\u1edbi vi\u1ec7c truy\u1ec1n t\u00edn hi\u1ec7u th\u1ea7n kinh c\u1ee7a c\u00e1c neuron, g\u00e2y ra m\u1ea5t tr\u00ed nh\u1edb v\u00e0 nh\u1eadn th\u1ee9c k\u00e9m.<\/div>\n
\n
\n
\"\"<\/div>\n
<\/div>\n<\/div>\n

Trong n\u1ed7 l\u1ef1c ch\u1ed1ng l\u1ea1i c\u0103n b\u1ec7nh n\u00e0y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i Tr\u01b0\u1eddng D\u01b0\u1ee3c \u0110\u1ea1i h\u1ecdc Washington \u0111\u00e3 ph\u00e1t tri\u1ec3n m\u1ed9t lo\u1ea1i kh\u00e1ng th\u1ec3 \u0111\u00e1nh tan \u0111\u01b0\u1ee3c nh\u1eefng protein t\u1ea1o ra c\u00e1c m\u1ea3ng b\u00e1m n\u00e3o n\u00f3i tr\u00ean.<\/p>\n

Tr\u01b0\u1edbc \u0111\u00e2y, nhi\u1ec1u n\u01a1i \u0111\u00e3 ph\u00e1t tri\u1ec3n nhi\u1ec1u lo\u1ea1i kh\u00e1ng th\u1ec3 nh\u1eafm v\u00e0o nh\u1eefng m\u1ea3ng b\u00e1m n\u00e0y nh\u01b0ng ch\u01b0a l\u1ea7n n\u00e0o ch\u00fang qua \u0111\u01b0\u1ee3c kh\u00e2u th\u1eed nghi\u1ec7m. Nhi\u1ec1u lo\u1ea1i thu\u1ed1c ch\u1eefa d\u00f9 th\u00e0nh c\u00f4ng ph\u1ea7n n\u00e0o, nh\u01b0ng v\u1eabn \u0111\u1ec3 l\u1ea1i nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f3 ki\u1ec3m so\u00e1t.<\/p>\n

C\u00e1ch th\u1ee9c ch\u1eefa Alheimer m\u1edbi n\u00e0y s\u1ebd lo\u1ea1i b\u1ecf \u0111\u01b0\u1ee3c c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 c\u00f3, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u mong r\u1eb1ng n\u00f3 c\u00f3 th\u1ec3 ng\u0103n \u0111\u01b0\u1ee3c c\u00e1c m\u1ea3ng b\u00e1m \u2013 ng\u0103n \u0111\u01b0\u1ee3c b\u1ec7nh Alzheimer ph\u00e1t tri\u1ec3n tr\u01b0\u1edbc c\u1ea3 khi nh\u1eefng tri\u1ec7u ch\u1ee9ng b\u1ec7nh b\u1eaft \u0111\u1ea7u xu\u1ea5t hi\u1ec7n.<\/p>\n

\n
\"<\/div>\n
\n

Kh\u00e1ng th\u1ec3 (m\u00e0u \u0111\u1ecf) t\u1ea5n c\u00f4ng nh\u1eefng m\u1ea3ng b\u00e1m (m\u00e0u xanh d\u01b0\u01a1ng).<\/p>\n<\/div>\n<\/div>\n

M\u1ed7i n\u0103m, h\u00e0ng tri\u1ec7u USD \u0111\u1ed5 v\u00e0o vi\u1ec7c t\u00ecm c\u00e1ch ch\u1eefa tr\u1ecb Alzheimer nh\u01b0ng ta v\u1eabn ch\u01b0a c\u00f3 k\u1ebft qu\u1ea3 kh\u1ea3 quan n\u00e0o. Ta bi\u1ebft \u0111\u01b0\u1ee3c nh\u1eefng y\u1ebfu t\u1ed1 v\u1ec1 gen \u0111\u1eb1ng sau c\u0103n b\u1ec7nh n\u00e0y, th\u1eadm ch\u00ed bi\u1ebft c\u1ea3 nh\u1eefng \u0111i\u1ec3m m\u1ea5u ch\u1ed1t v\u1ec1 c\u01a1 ch\u1ebf sinh h\u1ecdc c\u1ee7a n\u00f3 khi l\u00e2y lan trong n\u00e3o, th\u1ebf nh\u01b0ng vi\u1ec7c nghi\u00ean c\u1ee9u v\u1eabn g\u1eb7p kh\u00f3 kh\u0103n.<\/p>\n

Nh\u1eefng m\u1ea3ng b\u00e1m n\u00e0y \u0111\u01b0\u1ee3c t\u1ea1o n\u00ean t\u1eeb nh\u1eefng m\u1ea9u protein t\u1edbi t\u1eeb m\u00e0ng ch\u1ea5t b\u00e9o b\u1ecdc quanh t\u1ebf b\u00e0o neuron. Th\u00f4ng th\u01b0\u1eddng, n\u1ebfu nh\u1eefng m\u1ea3ng n\u00e0y v\u1ee1 ra, m\u1ed9t lo\u1ea1i enzyme t\u1ef1 nhi\u00ean s\u1ebd l\u00e0m ti\u00eau bi\u1ebfn n\u00f3 tr\u01b0\u1edbc khi n\u00f3 c\u00f3 th\u1ec3 b\u00e1m l\u1ea1i th\u00e0nh c\u1ee5m. Th\u1ebf nh\u01b0ng, kh\u00f4ng r\u00f5 v\u00ec l\u00ed do g\u00ec, m\u00e0 c\u01a1 ch\u1ebf lo\u1ea1i b\u1ecf n\u00e0y kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng trong n\u00e3o ng\u01b0\u1eddi b\u1ecb b\u1ec7nh Alzheimer.<\/p>\n

C\u00e1c nh\u00e0 khoa h\u1ecdc nghi ng\u1edd r\u1eb1ng khi nh\u1eefng protein n\u00e0y d\u00ednh v\u1edbi nhau t\u1ea1o th\u00e0nh m\u1ea3ng b\u00e1m, ho\u1eb7c s\u1ebd b\u00e1m v\u00e0o neuron ho\u1eb7c “b\u01a1i” lung tung trong n\u00e3o, s\u1ebd \u0111\u1ec1u ch\u1eb7n t\u00edn hi\u1ec7u \u0111i\u1ec7n tr\u01b0\u1eddng lan ra to\u00e0n n\u00e3o. T\u00edn hi\u1ec7u n\u00e3o kh\u00f4ng r\u00f5 r\u00e0ng s\u1ebd d\u1eabn t\u1edbi vi\u1ec7c n\u00e3o kh\u00f4ng c\u00f2n ho\u1ea1t \u0111\u1ed9ng hi\u1ec7u qu\u1ea3.<\/p>\n

\n
\"<\/div>\n
\n

B\u00ean tr\u00e1i l\u00e0 b\u1ed9 n\u00e3o kh\u1ecfe m\u1ea1nh, b\u00ean ph\u1ea3i l\u00e0 b\u1ed9 n\u00e3o b\u1ecb Alzheimer, v\u1edbi c\u00e1c “plaque” l\u00e0 c\u00e1c m\u1ea3ng b\u00e1m protein.<\/p>\n<\/div>\n<\/div>\n

C\u00e1c kh\u00e1ng th\u1ec3 l\u00e0 \u1ee9ng c\u1eed vi\u00ean s\u00e1ng gi\u00e1 trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb, ch\u1eefa tr\u1ecb Alzheimer b\u1edfi l\u1ebd ch\u00fang ph\u00f9 h\u1ee3p v\u1edbi vi\u1ec7c ch\u1ed1ng l\u1ea1i, ti\u00eau di\u1ec7t nh\u1eefng y\u1ebfu t\u1ed1 g\u00e2y b\u1ec7nh trong m\u00e1u. Nghi\u00ean c\u1ee9u m\u1edbi cho th\u1ea5y th\u1eed nghi\u1ec7m m\u1ed9t lo\u1ea1i kh\u00e1ng th\u1ec3 kh\u00f4ng t\u1ea5n c\u00f4ng tr\u1ef1c ti\u1ebfp v\u00e0o m\u1ea3ng b\u00e1m protein kia, m\u00e0 t\u1eadp trung v\u00e0o m\u1ed9t protein nh\u1ecf h\u01a1n n\u1eb1m trong \u0111\u00f3, c\u00f3 t\u00ean APOE.<\/p>\n

M\u1ee5c ti\u00eau cu\u1ed1i c\u00f9ng c\u1ee7a nghi\u00ean c\u1ee9u Alzheimer n\u00e0y, c\u0169ng nh\u01b0 m\u1ecdi nghi\u00ean c\u1ee9u kh\u00e1c, l\u00e0 ng\u0103n ch\u1eb7n, \u0111\u1ea3o ng\u01b0\u1ee3c t\u00e1c d\u1ee5ng hay th\u1eadm ch\u00ed l\u00e0 ng\u0103n ng\u1eeba ho\u00e0n to\u00e0n vi\u1ec7c c\u00e1c m\u1ea3ng b\u00e1m protein ph\u00e1t tri\u1ec3n, nh\u1eb1m x\u00f3a s\u1ed5 ho\u00e0n to\u00e0n b\u1ec7nh Alzheimer.<\/p>\n

V\u00ec th\u1ebf, h\u1ecd thi\u1ebft k\u1ebf th\u00ed nghi\u1ec7m \u0111\u1ec3 xem c\u00e1c kh\u00e1ng th\u1ec3 c\u00f3 t\u00ean HEA-4 n\u00e0y c\u00f3 th\u1ec3 t\u00ecm t\u1edbi nh\u1eefng APOE v\u00e0 ti\u00eau di\u1ec7t lu\u00f4n ch\u00fang kh\u00f4ng, ch\u1ee9 kh\u00f4ng \u0111\u01a1n gi\u1ea3n l\u00e0 ch\u1ec9 ng\u0103n ch\u1eb7n m\u1ea3ng b\u00e1m ph\u00e1t tri\u1ec3n.<\/p>\n

\n
\"\"<\/div>\n
<\/div>\n<\/div>\n

H\u1ecd \u0111\u00e3 th\u1eed \u0111\u01b0a c\u1ea3 m\u1ea3ng b\u00e1m b\u1ec7nh Alzheimer v\u00e0 kh\u00e1ng th\u1ec3 n\u00e0y v\u00e0o c\u01a1 th\u1ec3 chu\u1ed9t. Khi nh\u1eefng kh\u00e1ng th\u1ec3 tr\u00ean t\u1edbi \u0111\u01b0\u1ee3c nh\u1eefng protein m\u1ee5c ti\u00eau (APOE), ch\u00fang bi\u1ebfn th\u00e0nh nh\u1eefng \u0111i\u1ec3m ph\u00e1t t\u00edn hi\u1ec7u, g\u1ecdi nh\u1eefng t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch kh\u00e1c c\u00f9ng t\u1edbi v\u00e0 t\u1ea5n c\u00f4ng nh\u1eefng protein g\u00e2y b\u1ec7nh n\u00e0y.<\/p>\n

Trong v\u00f2ng 6 tu\u1ea7n, l\u01b0\u1ee3ng protein t\u1ea1o m\u1ea3ng b\u00e1m \u0111\u00e3 gi\u1ea3m t\u1edbi m\u1ed9t n\u1eeda. Kh\u00e1ng th\u1ec3 HEA-4 \u0111\u00e3 c\u00f3 th\u1ec3 t\u00ecm t\u1edbi \u0111\u01b0\u1ee3c protein APOE, v\u00e0 trong qu\u00e1 tr\u00ecnh ph\u00e1t \u0111\u1ed9ng t\u1ea5n c\u00f4ng, n\u00f3 \u0111\u00e3 c\u00f3 th\u1ec3 ti\u00eau di\u1ec7t lu\u00f4n m\u1ea3ng b\u00e1m protein. C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 lo l\u1eafng, r\u1eb1ng APOE v\u1ed1n c\u00f3 t\u00e1c d\u1ee5ng ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ch\u1ea5t b\u00e9o v\u00e0 cholesterol trong m\u00e1u, kh\u00e1ng th\u1ec3 m\u1edbi s\u1ebd c\u00f3 th\u1ec3 t\u1ea5n c\u00f4ng c\u1ea3 c\u00e1c APOE c\u00f3 l\u1ee3i kh\u00e1c.<\/p>\n

Nh\u01b0ng “h\u00f3a ra c\u1ea5u tr\u00fac c\u1ee7a APOE trong c\u00e1c m\u1ea3ng b\u00e1m protein kia l\u1ea1i kh\u00e1c v\u1edbi c\u00e1c APOE trong m\u00e1u<\/i>“, t\u00e1c gi\u1ea3 nghi\u00ean c\u1ee9u, ti\u1ebfn s\u0129 David Holtzman h\u1ed3 h\u1edfi n\u00f3i. “Kh\u00e1ng th\u1ec3 HEA-4 ch\u1ec9 nh\u1eadn d\u1ea1ng v\u00e0 t\u1ea5n c\u00f4ng c\u00e1c APOE trogn m\u1ea3ng b\u00e1m th\u00f4i<\/i>“. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 khi\u1ebfn ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi n\u00e0y s\u1ebd kh\u00f4ng c\u00f3 (ho\u1eb7c \u00edt c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5).<\/p>\n

N\u1ebfu nh\u01b0 c\u00e1ch th\u1ee9c ch\u1eefa tr\u1ecb n\u00e0y c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c m\u1ed9t hi\u1ec7u qu\u1ea3 t\u01b0\u01a1ng t\u1ef1 tr\u00ean ng\u01b0\u1eddi, \u0111\u00e2y s\u1ebd l\u00e0 m\u1ed9t c\u00e1ch hi\u1ec7u qu\u1ea3 \u0111\u1ec3 ch\u1ed1ng l\u1ea1i b\u1ec7nh Alzheimer, th\u1eadm ch\u00ed ng\u0103n n\u00f3 x\u1ea3y ra tr\u01b0\u1edbc khi nh\u1eefng tri\u1ec7u ch\u1ee9ng \u0111\u1ea7u ti\u00ean xu\u1ea5t hi\u1ec7n.<\/p>\n

Ngu\u1ed3n: genk.vn<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Nghi\u00ean c\u1ee9u m\u1edf \u0111\u01b0\u1eddng cho m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p ch\u1eefa tr\u1ecb \u00edt t\u00e1c d\u1ee5ng ph\u1ee5 m\u00e0 c\u1ef1c k\u00ec hi\u1ec7u qu\u1ea3. Nghi\u00ean c\u1ee9u m\u1edbi nh\u1ea5t tr\u00ean chu\u1ed9t cho th\u1ea5y t\u1ed3n t\u1ea1i m\u1ed9t s\u1ed1 lo\u1ea1i kh\u00e1ng th\u1ec3 c\u00f3 th\u1ec3 lo\u1ea1i b\u1ecf \u0111\u01b0\u1ee3c nh\u1eefng m\u1ea3ng b\u00e1m Alzheimer \u1edf trong n\u00e3o. Theo nh\u1eefng g\u00ec ta bi\u1ebft, ph\u1ea3i t\u1edbi 20 n\u0103m […]<\/p>\n","protected":false},"author":18,"featured_media":9423,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-9422","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/9422","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=9422"}],"version-history":[{"count":3,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/9422\/revisions"}],"predecessor-version":[{"id":9725,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/9422\/revisions\/9725"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/9423"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=9422"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=9422"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=9422"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}