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<\/div>\nKh\u00e1ng sinh m\u1ea1nh nh\u1ea5t \u0111ang b\u1ecb si\u00eau vi khu\u1ea9n kh\u00e1ng l\u1ea1i<\/p>\n<\/div>\n<\/div>\n
CRKP, ch\u1ee7ng vi khu\u1ea9n n\u00e0y c\u00f3 t\u00ean \u0111\u1ea7y \u0111\u1ee7 l\u00e0 Klebsiella pneumoniae<\/em> kh\u00e1ng carbapenem. Tr\u01b0\u1edbc \u0111\u00e2y, ch\u00fang ta bi\u1ebft CRKP c\u00f3 kh\u1ea3 n\u0103ng kh\u00e1ng l\u1ea1i h\u1ea7u h\u1ebft c\u00e1c d\u00f2ng kh\u00e1ng sinh, bao g\u1ed3m c\u1ea3 carbapenems, c\u0169ng l\u00e0 m\u1ed9t trong nh\u1eefng kh\u00e1ng sinh m\u1ea1nh nh\u1ea5t cu\u1ed1i c\u00f9ng.<\/p>\n Nh\u01b0ng nghi\u00ean c\u1ee9u m\u1edbi ti\u1ebfp t\u1ee5c c\u1ea3nh b\u00e1o n\u00f3 c\u00f3 th\u1ec3 kh\u00e1ng \u0111\u01b0\u1ee3c c\u1ea3 colistin v\u1edbi m\u1ed9t c\u01a1 ch\u1ebf b\u00ed \u1ea9n v\u00e0 nguy hi\u1ec3m. CRKP \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea v\u00e0o nh\u00f3m m\u1ea7m b\u1ec7nh \u0111a kh\u00e1ng thu\u1ed1c Enterobacteriaceae (CRE). B\u1ec7nh nh\u00e2n nhi\u1ec5m CRE c\u00f3 t\u1ef7 l\u1ec7 t\u1eed vong cao \u0111\u1ebfn 50%. V\u00e0 trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, CRE \u0111\u00e3 lan r\u1ed9ng kh\u1eafp th\u1ebf gi\u1edbi.<\/p>\n B\u00e1o c\u00e1o n\u0103m 2013 c\u1ee7a Trung t\u00e2m Ki\u1ec3m so\u00e1t v\u00e0 Ph\u00f2ng ng\u1eeba d\u1ecbch b\u1ec7nh Hoa K\u1ef3 (CDC) \u01b0\u1edbc t\u00ednh m\u1ed7i n\u0103m c\u00f3 h\u01a1n 9.300 ca nhi\u1ec5m CRE \u1edf M\u1ef9, trong \u0111\u00f3 c\u00f3 600 tr\u01b0\u1eddng h\u1ee3p t\u1eed vong. C\u1ea3 CDC v\u00e0 T\u1ed5 ch\u1ee9c Y t\u1ebf Th\u1ebf gi\u1edbi (WHO) \u0111\u1ec1u li\u1ec7t k\u00ea CRE l\u00e0 m\u1ed9t trong nh\u1eefng m\u1ed1i \u0111e d\u1ecda nghi\u00eam tr\u1ecdng \u0111\u1ed1i v\u1edbi s\u1ee9c kho\u1ebb c\u1ed9ng \u0111\u1ed3ng, v\u00e0 ch\u00fang ta c\u1ea7n c\u00f3\u00a0“h\u00e0nh \u0111\u1ed9ng c\u1ea5p b\u00e1ch v\u00e0 m\u1ea1nh m\u1ebd<\/i>” \u0111\u1ec3 ch\u1ed1ng l\u1ea1i n\u00f3.<\/p>\n Trong nghi\u00ean c\u1ee9u m\u1edbi n\u00e0y, c\u00e1c nh\u00e0 khoa h\u1ecdc t\u1ea1i \u0110\u1ea1i h\u1ecdc Emory \u0111\u00e3 ph\u00e1t hi\u1ec7n ra hai ch\u1ee7ng CRKP-c\u00f4 l\u1eadp t\u1eeb n\u01b0\u1edbc ti\u1ec3u c\u1ee7a b\u1ec7nh nh\u00e2n \u1edf th\u00e0nh ph\u1ed1 Atlanta\u2013 c\u00f3 kh\u1ea3 n\u0103ng kh\u00e1ng l\u1ea1i colistin. CRKP kh\u00e1ng \u0111\u01b0\u1ee3c c\u1ea3 colistin, lo\u1ea1i\u00a0\u201ckh\u00e1ng sinh cu\u1ed1i c\u00f9ng<\/i>\u201d l\u00e0 \u0111i\u1ec1u ch\u01b0a t\u1eebng ghi nh\u1eadn tr\u01b0\u1edbc \u0111\u00e2y.<\/p>\n C\u00e1c nh\u00e0 khoa h\u1ecdc cho bi\u1ebft qu\u00e1 tr\u00ecnh kh\u00e1ng colistin c\u1ee7a CRKP x\u1ea3y ra \u00e2m th\u1ea7m v\u00e0 b\u00ed \u1ea9n, khi\u1ebfn ch\u00fang qua m\u1eaft \u0111\u01b0\u1ee3c ch\u00fang ta.<\/p>\n L\u00fac \u0111\u1ea7u, CRKP d\u01b0\u1eddng nh\u01b0 d\u1ec5 b\u1ecb ti\u00eau di\u1ec7t b\u1edfi kh\u00e1ng sinh m\u1ea1nh trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ti\u00eau chu\u1ea9n. Nh\u01b0ng \u0111\u1ebfn nh\u1eefng th\u1eed nghi\u1ec7m ti\u00ean ti\u1ebfn, khi CRKP \u0111\u01b0\u1ee3c cho ti\u1ebfp x\u00fac v\u1edbi kh\u00e1ng sinh trong m\u1ed9t th\u1eddi gian, ch\u00fang b\u1eb1ng c\u00e1ch n\u00e0o \u0111\u00f3 \u0111\u00e3 ti\u1ebfn h\u00f3a \u0111\u1ec3 kh\u00e1ng l\u1ea1i \u0111\u01b0\u1ee3c colistin.<\/p>\n Th\u1eed nghi\u1ec7m tr\u00ean chu\u1ed9t nhi\u1ec5m nh\u1eefng ch\u1ee7ng CRKP ti\u1ebfn h\u00f3a n\u00e0y cho th\u1ea5y colistin \u0111\u00e3 kh\u00f4ng c\u00f2n hi\u1ec7u l\u1ef1c. Nh\u1eefng con chu\u1ed9t t\u1ea5t y\u1ebfu \u0111\u00e3 ch\u1ebft v\u00ec nhi\u1ec5m khu\u1ea9n. Trong khi \u0111\u00f3, chu\u1ed9t nhi\u1ec5m CRKP ch\u01b0a ti\u1ebfn h\u00f3a v\u1eabn c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c c\u1ee9u s\u1ed1ng khi s\u1eed d\u1ee5ng kh\u00e1ng sinh colistin.<\/p>\n Cho \u0111\u1ebfn th\u1eddi \u0111i\u1ec3m n\u00e0y, ch\u01b0a c\u00f3 ghi nh\u1eadn nhi\u1ec5m tr\u00f9ng CRKP b\u1ea5t ng\u1edd chuy\u1ec3n h\u00f3a \u0111\u1ec3 kh\u00e1ng colistin tr\u00ean ng\u01b0\u1eddi. Nh\u01b0ng c\u00e1c t\u00e1c gi\u1ea3 nghi\u00ean c\u1ee9u, d\u1eabn \u0111\u1ea7u b\u1edfi nh\u00e0 sinh v\u1eadt h\u1ecdc David Weiss, n\u00f3i r\u1eb1ng ch\u00fang ta kh\u00f4ng bi\u1ebft \u0111i\u1ec1u \u0111\u00f3 \u0111\u00e3 x\u1ea3y ra hay ch\u01b0a, b\u1edfi c\u00e1c b\u1eb1ng ch\u1ee9ng r\u1ea5t kh\u00f3 thu th\u1eadp v\u00e0 d\u1eef li\u1ec7u cho \u0111\u1ebfn nay ch\u01b0a \u0111\u1ee7 \u0111\u1ec3 k\u1ebft lu\u1eadn.<\/p>\n B\u1edfi v\u1eady, nghi\u00ean c\u1ee9u m\u1edbi \u0111\u00e3 \u201crung l\u00ean m\u1ed9t h\u1ed3i chu\u00f4ng b\u00e1o \u0111\u1ed9ng v\u1ec1 hi\u1ec7n t\u01b0\u1ee3ng \u0111\u00e1ng lo ng\u1ea1i<\/i>\u201d, v\u1ec1 kh\u1ea3 n\u0103ng kh\u00e1ng thu\u1ed1c c\u1ee7a CRKP m\u00e0 c\u00f3 th\u1ec3 ch\u00fang ta \u0111ang ch\u1ee7 quan v\u1ec1 n\u00f3. Trong t\u01b0\u01a1ng lai, ch\u00fang ta c\u1ea7n ch\u1ea9n \u0111o\u00e1n ch\u00ednh x\u00e1c v\u00e0 theo d\u00f5i ch\u1ee7ng vi khu\u1ea9n n\u00e0y c\u1ea9n th\u1eadn h\u01a1n.<\/p>\n C\u00e1ch x\u00e1c \u0111\u1ecbnh vi khu\u1ea9n kh\u00e1ng kh\u00e1ng sinh<\/strong><\/p>\n Trong m\u1ed9t cu\u1ed9c ph\u1ecfng v\u1ea5n v\u1edbi Ars, ti\u1ebfn s\u0129 Weiss nh\u1ea5n m\u1ea1nh r\u1eb1ng kh\u1ea3 n\u0103ng kh\u00e1ng thu\u1ed1c \u00e2m th\u1ea7m c\u1ee7a CRKP r\u1ea5t \u0111\u00e1ng quan ng\u1ea1i. Nh\u1ea5t l\u00e0 khi ch\u00fang ta ch\u1ec9 c\u00f2n m\u1ed9t v\u00e0i lo\u1ea1i kh\u00e1ng sinh cu\u1ed1i c\u00f9ng \u0111\u1ec3 ch\u1ed1ng l\u1ea1i n\u00f3, v\u00ed d\u1ee5 nh\u01b0 colistin. “B\u1ec7nh nh\u00e2n kh\u00f4ng c\u00f3 nhi\u1ec1u l\u1ef1a ch\u1ecdn v\u00e0o th\u1eddi \u0111i\u1ec3m n\u00e0y<\/i>“, \u00f4ng n\u00f3i.<\/p>\n H\u1ea7u h\u1ebft c\u00e1c b\u1ec7nh nh\u00e2n b\u1ecb nhi\u1ec5m tr\u00f9ng CRKP \u0111\u1ec1u c\u1ea7n \u0111\u1ebfn colistin, t\u00ecnh tr\u1ea1ng c\u1ee7a h\u1ecd th\u01b0\u1eddng r\u1ea5t n\u1eb7ng, ti\u1ebfn s\u0129 Weiss cho bi\u1ebft. Trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p \u0111\u00f3, c\u00e1c b\u00e1c s\u0129 c\u00f3 xu h\u01b0\u1edbng cho b\u1ec7nh nh\u00e2n d\u00f9ng c\u00e0ng nhi\u1ec1u lo\u1ea1i kh\u00e1ng sinh c\u00e0ng t\u1ed1t. \u0110i\u1ec1u n\u00e0y khi\u1ebfn cho vi\u1ec7c ki\u1ec3m tra xem CRKP kh\u00e1ng colistin \u00e2m th\u1ea7m hay kh\u00f4ng tr\u1edf n\u00ean kh\u00f3 kh\u0103n.<\/p>\n “T\u00f4i kh\u00f4ng n\u00f3i n\u1ebfu l\u00e0 t\u00f4i, t\u00f4i s\u1ebd kh\u00f4ng mu\u1ed1n d\u00f9ng c\u1ea3 lo\u1ea1t kh\u00e1ng sinh<\/i>“, ti\u1ebfn s\u0129 Weiss n\u00f3i. Nh\u01b0ng \u0111\u1ec3 th\u1ef1c s\u1ef1 bi\u1ebft c\u01a1 ch\u1ebf kh\u00e1ng colistin n\u00e0y c\u00f3 ph\u1ea3i l\u00e0 m\u1ed9t v\u1ea5n \u0111\u1ec1 hay kh\u00f4ng, b\u1ea1n ch\u1ec9 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1ec7nh nh\u00e2n v\u1edbi colistin. \u0110\u00f3 l\u00e0 \u0111i\u1ec1u ki\u1ec7n kh\u00f4ng th\u1ef1c t\u1ebf, b\u1edfi ch\u1ec9 s\u1eed d\u1ee5ng colistin th\u00ec kh\u00f4ng t\u1ed1i \u0111a h\u00f3a \u0111\u01b0\u1ee3c c\u01a1 h\u1ed9i cho b\u1ec7nh nh\u00e2n.<\/p>\n B\u1edfi v\u1eady, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 thi\u1ebft k\u1ebf c\u00e1c th\u00ed nghi\u1ec7m trong ph\u00f2ng th\u00ed nghi\u1ec7m \u0111\u1ec3 t\u00ecm hi\u1ec3u qu\u00e1 tr\u00ecnh kh\u00e1ng colistin c\u1ee7a CRKP. Trong nhi\u1ec1u n\u0103m, tr\u00ean c\u01b0\u01a1ng v\u1ecb l\u00e0 gi\u00e1m \u0111\u1ed1c Trung t\u00e2m ch\u1ed1ng kh\u00e1ng kh\u00e1ng sinh \u0110\u1ea1i h\u1ecdc Emory, ti\u1ebfn s\u0129 Weiss \u0111\u00e3 nghi\u00ean c\u1ee9u hi\u1ec7n t\u01b0\u1ee3ng d\u1ecb kh\u00e1ng (hetero-resistance<\/i>).<\/p>\n \u0110\u1ea7u ti\u00ean, ph\u1ea3i n\u00f3i v\u1ec1 c\u00e1ch x\u00e1c \u0111\u1ecbnh vi khu\u1ea9n kh\u00e1ng thu\u1ed1c. Theo quy tr\u00ecnh th\u00f4ng th\u01b0\u1eddng, c\u00e1c nh\u00e0 khoa h\u1ecdc s\u1ebd ph\u00e2n l\u1eadp vi khu\u1ea9n t\u1eeb c\u00e1c m\u1eabu b\u1ec7nh ph\u1ea9m c\u1ee7a b\u1ec7nh nh\u00e2n, sau \u0111\u00f3, ph\u00e1t tri\u1ec3n ch\u00fang trong nh\u1eefng m\u00f4i tr\u01b0\u1eddng dinh d\u01b0\u1ee1ng \u0111\u1ea7y \u0111\u1ee7.<\/p>\n K\u1ebft qu\u1ea3 m\u00e0 h\u1ecd thu \u0111\u01b0\u1ee3c l\u00e0 m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng l\u1edbn vi khu\u1ea9n gi\u1ed1ng h\u1ec7t nhau v\u1ec1 m\u1eb7t di truy\u1ec1n. Th\u00f4ng th\u01b0\u1eddng, n\u00f3 ngh\u0129a l\u00e0 c\u00e1c vi khu\u1ea9n s\u1edf h\u1eefu \u0111\u1eb7c \u0111i\u1ec3m \u0111\u1ec1 kh\u00e1ng th\u1ed1ng nh\u1ea5t ho\u1eb7c c\u00f9ng nh\u1ea1y c\u1ea3m \u0111\u1ed1i v\u1edbi nh\u1eefng kh\u00e1ng sinh nh\u1ea5t \u0111\u1ecbnh.<\/p>\n B\u1edfi v\u1eady, n\u1ebfu \u0111\u00e3 ch\u1ecdn \u0111\u00fang lo\u1ea1i kh\u00e1ng sinh, ch\u1ec9 c\u1ea7n m\u1ed9t n\u1ed3ng \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed1i th\u1ea5p c\u1ee7a thu\u1ed1c l\u00e0 \u0111\u00e3 c\u00f3 th\u1ec3 gi\u1ebft s\u1ea1ch m\u1ed9t d\u00e2n s\u1ed1 l\u1edbn vi khu\u1ea9n. N\u1ebfu vi khu\u1ea9n c\u00f3 th\u1ec3 ch\u1ecbu \u0111\u01b0\u1ee3c li\u1ec1u cao h\u01a1n, ch\u00fang s\u1ebd tr\u1edf n\u00ean kh\u00e1ng thu\u1ed1c.<\/p>\n S\u1ef1 kh\u00e1ng thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 x\u1ea3y ra t\u1eeb y\u1ebfu \u0111\u1ebfn m\u1ea1nh, nh\u01b0ng th\u01b0\u1eddng c\u00f3 nh\u1eefng ng\u01b0\u1ee1ng chu\u1ea9n \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh r\u1eb1ng m\u1ed9t d\u00f2ng vi khu\u1ea9n kh\u00e1ng v\u1edbi m\u1ed9t lo\u1ea1i thu\u1ed1c n\u00e0o \u0111\u00f3. N\u00f3i c\u00e1ch kh\u00e1c, n\u1ebfu to\u00e0n b\u1ed9 qu\u1ea7n th\u1ec3 vi khu\u1ea9n v\u1eabn t\u1ed3n t\u1ea1i trong n\u1ed3ng \u0111\u1ed9 “x<\/i>” c\u1ee7a m\u1ed9t kh\u00e1ng sinh, th\u00ec n\u00f3 s\u1ebd \u0111\u01b0\u1ee3c coi l\u00e0 kh\u00e1ng kh\u00e1ng sinh \u0111\u00f3.<\/p>\n Nh\u01b0ng c\u00e1c qu\u1ea7n th\u1ec3 d\u1ecb kh\u00e1ng kh\u00f4ng tu\u00e2n theo quy t\u1eafc n\u00e0y. Trong c\u00e1c th\u1eed nghi\u1ec7m ch\u1ea9n \u0111o\u00e1n chu\u1ea9n nh\u01b0 tr\u00ean, vi khu\u1ea9n c\u00f3 th\u1ec3 r\u1ea5t \u0111\u00e1p \u1ee9ng v\u00e0 ph\u1ea7n l\u1edbn s\u1ebd b\u1ecb ti\u00eau di\u1ec7t. Nh\u01b0ng trong c\u00e1c th\u1eed nghi\u1ec7m ti\u00ean ti\u1ebfn, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u00f3 th\u1ec3 ph\u00e1t hi\u1ec7n c\u00e1c qu\u1ea7n th\u1ec3 ph\u1ee5 kh\u00e1ng.<\/p>\n Th\u00f4ng th\u01b0\u1eddng, \u0111i\u1ec1u n\u00e0y cho th\u1ea5y r\u1eb1ng ch\u1ec9 c\u00f3 m\u1ed9t s\u1ed1 vi khu\u1ea9n n\u00e0o \u0111\u00f3 trong qu\u1ea7n th\u1ec3, c\u00f3 m\u1ed9t y\u1ebfu t\u1ed1 di truy\u1ec1n b\u1ea3o v\u1ec7 ch\u00fang kh\u1ecfi thu\u1ed1c kh\u00e1ng sinh.<\/p>\n Nh\u01b0ng nh\u1eefng vi khu\u1ea9n ph\u1ee5 kh\u00e1ng n\u00e0y c\u00f3 v\u1ebb nh\u01b0 gi\u1ed1ng h\u1ec7t v\u1edbi c\u00e1c vi khu\u1ea9n nh\u1ea1y c\u1ea3m v\u1edbi thu\u1ed1c. Ch\u00fang v\u1eabn \u0111\u00fang l\u00e0 nh\u1eefng b\u1ea3n sao c\u1ee7a nhau, nh\u01b0ng v\u00ec l\u00fd do n\u00e0o \u0111\u00f3, m\u1ed9t c\u01a1 ch\u1ebf kh\u00e1c bi\u1ec7t ban cho ch\u00fang kh\u1ea3 n\u0103ng kh\u00e1ng kh\u00e1ng sinh.<\/p>\n Hi\u1ec7n t\u01b0\u1ee3ng d\u1ecb kh\u00e1ng c\u1ee7a vi khu\u1ea9n l\u00e0 m\u1ed9t b\u00ed \u1ea9n ch\u01b0a c\u00f3 l\u1eddi gi\u1ea3i<\/p>\n<\/div>\n<\/div>\n C\u00e1i gi\u00e1 c\u1ee7a s\u1ef1 ph\u1ee5 thu\u1ed9c kh\u00e1ng sinh<\/strong><\/p>\n Khi c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u nu\u00f4i ch\u00fang trong m\u00f4i tr\u01b0\u1eddng ch\u1ee9a colistin, nh\u1eefng vi khu\u1ea9n CRKP ph\u1ee5 kh\u00e1ng \u0111\u00e3 c\u1ef1c k\u1ef3 ph\u00e1t tri\u1ec3n. Nh\u01b0ng sau khi chuy\u1ec3n \u0111\u1ed5i qu\u1ea7n th\u1ec3 sang m\u00f4i tr\u01b0\u1eddng n\u01b0\u1edbc c\u1ea5t m\u00e0 kh\u00f4ng c\u00f3 colistin, qu\u1ea7n th\u1ec3 vi khu\u1ea9n CRKP l\u1ea1i tr\u1edf l\u1ea1i tr\u1ea1ng th\u00e1i d\u1ec5 b\u1ecb ti\u00eau di\u1ec7t – ngo\u1ea1i tr\u1eeb t\u1ec9 l\u1ec7 1\/1.000 vi khu\u1ea9n ban \u0111\u1ea7u.<\/p>\n V\u1edbi hi v\u1ecdng t\u00ecm ra \u0111i\u1ec1u g\u00ec \u0111\u00f3 kh\u00e1c bi\u1ec7t gi\u1eefa c\u00e1c vi khu\u1ea9n kh\u00e1ng v\u00e0 kh\u00f4ng kh\u00e1ng, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 s\u1eafp x\u1ebfp b\u1ed9 gen c\u1ee7a ch\u00fang. Nh\u01b0ng th\u1eadt b\u00ed \u1ea9n, ch\u00fang v\u1eabn gi\u1ed1ng h\u1ec7t nhau v\u1ec1 m\u1eb7t di truy\u1ec1n.<\/p>\n M\u1eb7c d\u00f9 c\u00f3 c\u00f9ng b\u1ea3n thi\u1ebft k\u1ebf gen, nh\u1eefng con vi khu\u1ea9n CRKP \u0111ang k\u00edch ho\u1ea1t gen c\u1ee7a ch\u00fang m\u1ed9t c\u00e1ch kh\u00e1c nhau, ti\u1ebfn s\u0129 Weiss d\u1ef1 \u0111o\u00e1n. Kh\u00f4ng r\u00f5 l\u00e0m th\u1ebf n\u00e0o v\u00e0 t\u1ea1i sao \u0111i\u1ec1u n\u00e0y x\u1ea3y ra. Cho \u0111\u1ebfn nay, \u00f4ng v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p c\u1ee7a m\u00ecnh ch\u1ec9 c\u00f3 th\u1ec3 \u0111\u01b0a ra gi\u1ea3 thuy\u1ebft r\u1eb1ng m\u1ed9t h\u1ec7 th\u1ed1ng c\u1ea3m gi\u00e1c \u0111\u1eb7c bi\u1ec7t c\u00f3 th\u1ec3 l\u00e0 ch\u00eca kho\u00e1 khi\u1ebfn CRKP kh\u00e1ng colistin.<\/p>\n H\u1ec7 th\u1ed1ng n\u00e0y l\u00e0 m\u1ed9t d\u1ea1ng c\u1ee7a h\u1ec7 th\u1ed1ng truy\u1ec1n t\u00edn hi\u1ec7u hai th\u00e0nh ph\u1ea7n – li\u00ean quan \u0111\u1ebfn m\u1ed9t protein g\u1eafn v\u00e0o m\u00e0ng c\u1ee7a vi khu\u1ea9n, ph\u1ea3n \u1ee9ng v\u1edbi m\u1ed9t s\u1ed1 d\u1ea5u hi\u1ec7u m\u00f4i tr\u01b0\u1eddng. Protein \u0111\u00f3 c\u00f3 th\u1ec3 truy\u1ec1n t\u00edn hi\u1ec7u n\u00e0y t\u1edbi m\u1ed9t protein kh\u00e1c b\u00ean trong t\u1ebf b\u00e0o, sau \u0111\u00f3 khi\u1ebfn gen bi\u1ec3u hi\u1ec7n ho\u1eb7c kh\u00f4ng.<\/p>\n H\u1ec7 th\u1ed1ng n\u00e0y \u0111\u00e3 \u0111\u1eb7t tr\u1ea1ng th\u00e1i bi\u1ec3u hi\u1ec7n \u1edf m\u1ed9t s\u1ed1 ti\u1ec3u nh\u00f3m vi khu\u1ea9n CRKP khi\u1ebfn ch\u00fang kh\u00e1ng \u0111\u01b0\u1ee3c colistin. N\u1ebfu c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u s\u1eed d\u1ee5ng k\u1ef9 thu\u1eadt di truy\u1ec1n \u0111\u1ec3 ph\u00e1 v\u1ee1 h\u1ec7 th\u1ed1ng trong c\u00e1c vi khu\u1ea9n kh\u00e1ng, qu\u1ea7n th\u1ec3 s\u1ebd m\u1ea5t \u0111i kh\u1ea3 n\u0103ng kh\u00e1ng kh\u00e1ng sinh b\u00ed \u1ea9n c\u1ee7a n\u00f3.<\/p>\n Tr\u00f2 nh\u1ea3y c\u1eebu \u0111ang ti\u1ebfn \u0111\u1ebfn con c\u1eebu cu\u1ed1i c\u00f9ng, khi kh\u00e1ng sinh m\u1ea1nh nh\u1ea5t colistin m\u1ea5t t\u00e1c d\u1ee5ng<\/p>\n<\/div>\n<\/div>\n Nh\u01b0ng c\u00e2u \u0111\u1ed1 \u1edf th\u1eddi \u0111i\u1ec3m hi\u1ec7n t\u1ea1i l\u00e0 kh\u00f4ng r\u00f5 nh\u1eefng gen n\u00e0o h\u1ec7 th\u1ed1ng t\u00edn hi\u1ec7u n\u00e0y \u0111ang ki\u1ec3m so\u00e1t. M\u1ed9t s\u1ed1 b\u1eb1ng ch\u1ee9ng cho th\u1ea5y r\u1eb1ng \u0111\u00f3 l\u00e0 nh\u1eefng gen cho ph\u00e9p t\u1ebf b\u00e0o gi\u1ea3m t\u00edch \u0111i\u1ec7n \u00e2m \u1edf m\u00e0ng ngo\u00e0i \u0111\u1ec3 ch\u1ed1ng l\u1ea1i colistin. Thu\u1ed1c kh\u00e1ng sinh t\u00edch \u0111i\u1ec7n d\u01b0\u01a1ng v\u00e0 c\u00f3 v\u1ebb nh\u01b0 n\u00f3 s\u1ebd ti\u00eau di\u1ec7t vi khu\u1ea9n b\u1eb1ng c\u00e1ch ph\u00e1 v\u1ee1 m\u00e0ng b\u00ean ngo\u00e0i t\u1ebf b\u00e0o vi khu\u1ea9n.<\/p>\n M\u1eb7c d\u00f9 v\u1eady c\u01a1 ch\u1ebf ch\u00ednh x\u00e1c \u0111\u1eb1ng sau v\u00e0\u00a0s\u1ef1 ph\u00f2ng v\u1ec7 c\u1ee7a vi khu\u1ea9n\u00a0v\u1eabn c\u00f2n ch\u01b0a r\u00f5 r\u00e0ng. Ti\u1ebfn s\u0129 Weiss k\u00eau g\u1ecdi th\u00eam nhi\u1ec1u nh\u00e0 khoa h\u1ecdc th\u1ef1c hi\u1ec7n nghi\u00ean c\u1ee9u trong v\u1ea5n \u0111\u1ec1 n\u00e0y. B\u1edfi con ng\u01b0\u1eddi \u0111ang h\u1ebft d\u1ea7n c\u00e1c lo\u1ea1i kh\u00e1ng sinh c\u00f3 hi\u1ec7u l\u1ef1c, colistin hi\u1ec7n nay \u0111ang l\u00e0 l\u1ef1a ch\u1ecdn cu\u1ed1i c\u00f9ng.<\/p>\n “T\u00f4i ngh\u0129 r\u1eb1ng ch\u00fang ta \u0111\u00e3 v\u01b0\u1ee3t qua c\u00e1i th\u1eddi \u0111i\u1ec3m [kh\u00e1ng kh\u00e1ng sinh], \u1edf \u0111\u00f3 [ch\u00fang ta \u0111\u00e3 n\u00f3i] ‘\u1ed2 m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u00e3 m\u1ea5t t\u00e1c d\u1ee5ng \u01b0? Ai quan t\u00e2m? Ch\u00fang ta s\u1ebd s\u1eed d\u1ee5ng lo\u1ea1i kh\u00e1ng sinh ti\u1ebfp theo’<\/i>“, ti\u1ebfn s\u0129 Weiss n\u00f3i. Th\u1eddi \u0111i\u1ec3m \u0111\u00f3, s\u1ebd kh\u00f4ng c\u1ea7n thi\u1ebft \u0111\u1ec3 hi\u1ec3u bi\u1ebft to\u00e0n b\u1ed9 c\u01a1 ch\u1ebf kh\u00e1ng thu\u1ed1c c\u1ee7a vi khu\u1ea9n, b\u1edfi ch\u00fang ta lu\u00f4n c\u00f3 m\u1ed9t lo\u1ea1i kh\u00e1ng sinh d\u1ef1 ph\u00f2ng.<\/p>\n \u201cC\u00f2n b\u00e2y gi\u1edd ch\u00fang ta \u0111ang b\u1ecb m\u1ea5t d\u1ea7n nh\u1eefng kh\u00e1ng sinh d\u1ef1 ph\u00f2ng \u1ea5y, v\u00e0 m\u1ecdi ng\u01b0\u1eddi \u0111ang ph\u1ea3i quan t\u00e2m \u1edf m\u1ee9c \u0111\u1ed9 cao h\u01a1n<\/i>“, ti\u1ebfn s\u0129 Weiss c\u1ea3nh b\u00e1o. C\u0169ng ch\u00ednh v\u00ec s\u1ef1 l\u01b0\u1eddi bi\u1ebfng tr\u01b0\u1edbc \u0111\u00e2y khi ph\u1ee5 thu\u1ed9c v\u00e0o c\u00e1c lo\u1ea1i thu\u1ed1c c\u00f2n t\u00e1c d\u1ee5ng, b\u00e2y gi\u1edd ch\u00fang ta v\u1eabn c\u00f2n m\u1ed9t t\u00e1 nh\u1eefng \u0111i\u1ec1u b\u00ed \u1ea9n ch\u01b0a bi\u1ebft v\u1ec1 vi khu\u1ea9n, v\u00e0 nh\u1eefng con \u0111\u01b0\u1eddng m\u00e0 ch\u00fang kh\u00e1ng \u0111\u01b0\u1ee3c kh\u00e1ng sinh.<\/p>\n Tham kh\u1ea3o\u00a0Arstechnica<\/i><\/p>\n ngu\u1ed3n Genk<\/p>\n","protected":false},"excerpt":{"rendered":" Trong m\u1ed9t b\u00e1o c\u00e1o tr\u00ean t\u1ea1p ch\u00ed vi sinh v\u1eadt mBio, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i \u0110\u1ea1i h\u1ecdc Emory l\u1ea7n \u0111\u1ea7u ti\u00ean ph\u00e1t hi\u1ec7n nh\u1eefng ch\u1ee7ng vi khu\u1ea9n g\u00e2y ch\u1ebft ng\u01b0\u1eddi, \u0111a kh\u00e1ng thu\u1ed1c v\u00e0 c\u00f3 m\u1ed9t c\u01a1 ch\u1ebf b\u00ed \u1ea9n \u0111\u1ec3 kh\u00e1ng c\u1ea3\u00a0colistin, lo\u1ea1i kh\u00e1ng sinh c\u00f2n gi\u1eef \u0111\u01b0\u1ee3c hi\u1ec7u l\u1ef1c m\u1ea1nh nh\u1ea5t hi\u1ec7n […]<\/p>\n","protected":false},"author":18,"featured_media":8855,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-8854","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/8854","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=8854"}],"version-history":[{"count":3,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/8854\/revisions"}],"predecessor-version":[{"id":8902,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/8854\/revisions\/8902"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/8855"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=8854"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=8854"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=8854"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"http:\/\/genknews.genkcdn.vn\/2018\/3\/12\/anh2-1481021882253-15208401838211671185208.jpg\")
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