{"id":7964,"date":"2018-01-18T08:40:25","date_gmt":"2018-01-18T01:40:25","guid":{"rendered":"http:\/\/ttud.com.vn\/?p=7964"},"modified":"2018-01-18T08:40:25","modified_gmt":"2018-01-18T01:40:25","slug":"mieng-dan-khong-dau-giup-benh-nhan-tieu-duong-khong-phai-chich-mau-va-tiem-thuoc","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/mieng-dan-khong-dau-giup-benh-nhan-tieu-duong-khong-phai-chich-mau-va-tiem-thuoc\/","title":{"rendered":"Mi\u1ebfng d\u00e1n kh\u00f4ng \u0111au gi\u00fap b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng kh\u00f4ng ph\u1ea3i ch\u00edch m\u00e1u v\u00e0 ti\u00eam thu\u1ed1c"},"content":{"rendered":"

C\u00e1c nh\u00e0 khoa h\u1ecdc mong \u0111\u1ee3i mi\u1ebfng d\u00e1n 1 l\u1ea7n c\u1ee7a h\u1ecd s\u1ebd ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft cho b\u1ec7nh nh\u00e2n trong c\u1ea3 tu\u1ea7n.<\/p>\n

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Theo m\u1ed9t nghi\u00ean c\u1ee9u tr\u00ean t\u1ea1p ch\u00ed\u00a0Nature Communications, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111ang ph\u00e1t tri\u1ec3n m\u1ed9t mi\u1ebfng d\u00e1n tr\u00ean da cho ng\u01b0\u1eddi b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng type 2. Mi\u1ebfng d\u00e1n n\u00e0y c\u00f3 th\u1ec3 theo d\u00f5i n\u1ed3ng \u0111\u1ed9 \u0111\u01b0\u1eddng trong m\u00e1u b\u1ec7nh nh\u00e2n v\u00e0 gi\u1ea3i ph\u00f3ng thu\u1ed1c khi c\u1ea7n thi\u1ebft.<\/p>\n

Trong th\u1eed nghi\u1ec7m tr\u00ean chu\u1ed9t, mi\u1ebfng d\u00e1n \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng m\u1ed9t l\u1ea7n c\u00f3 th\u1ec3 ch\u1ee9a \u0111\u1ee7 thu\u1ed1c cho c\u1ea3 1 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb. C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111ang t\u00ecm c\u00e1ch ch\u1ebf t\u1ea1o ra \u0111\u01b0\u1ee3c m\u1ed9t phi\u00ean b\u1ea3n d\u00e0nh cho con ng\u01b0\u1eddi.<\/p>\n

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B\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng c\u00f3 th\u1ec3 n\u00f3i l\u1eddi t\u1ea1m bi\u1ec7t v\u1edbi b\u1ed9 d\u1ee5ng c\u1ee5 ch\u0103m s\u00f3c n\u00e0y, n\u1ebfu mi\u1ebfng d\u00e1n tr\u00ean da qu\u1ea3n l\u00fd ti\u1ec3u \u0111\u01b0\u1eddng ra \u0111\u1eddi<\/p>\n<\/div>\n<\/div>\n

Mi\u1ebfng d\u00e1n m\u1edbi n\u00e0y th\u1ef1c ch\u1ea5t l\u00e0 b\u1ec1 m\u1eb7t ch\u1ee9a m\u1ed9t ma tr\u1eadn nh\u1eefng chi\u1ebfc kim r\u1ea5t nh\u1ecf. M\u1eb7c d\u00f9 nghe \u0111\u00e1ng s\u1ee3, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u h\u1ee9a r\u1eb1ng ch\u00fang kh\u00f4ng g\u00e2y \u0111au cho ng\u01b0\u1eddi s\u1eed d\u1ee5ng.<\/p>\n

Mi\u1ebfng d\u00e1n c\u00f3 2 t\u00e1c d\u1ee5ng, m\u1ed9t l\u00e0 \u0111o n\u1ed3ng \u0111\u1ed9 \u0111\u01b0\u1eddng trong m\u00e1u, hai l\u00e0 gi\u1ea3i ph\u00f3ng thu\u1ed1c \u0111\u1ec3 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft n\u1ebfu n\u00f3 t\u0103ng qu\u00e1 cao.<\/p>\n

\u0110i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a l\u00e0 mi\u1ebfng d\u00e1n v\u1eeba gi\u00fap ng\u01b0\u1eddi b\u1ec7nh kh\u00f4ng ph\u1ea3i s\u1eed d\u1ee5ng kim ch\u00edch m\u00e1u \u0111\u1ea7u ng\u00f3n tay \u0111\u1ec3 \u0111o \u0111\u01b0\u1eddng huy\u1ebft, v\u1eeba gi\u00fap h\u1ecd n\u00f3i t\u1ea1m bi\u1ec7t v\u1edbi vi\u1ec7c ti\u00eam insulin ho\u1eb7c c\u00e1c lo\u1ea1i thu\u1ed1c ti\u1ec3u \u0111\u01b0\u1eddng kh\u00e1c v\u00e0o b\u1eafp.<\/p>\n

Ch\u1ec9 b\u1eb1ng vi\u1ec7c d\u00e1n m\u1ed9t mi\u1ebfng d\u00e1n kh\u00f4ng \u0111au l\u00ean da, b\u1ec7nh nh\u00e2n\u00a0ti\u1ec3u \u0111\u01b0\u1eddng\u00a0s\u1ebd ti\u1ebft ki\u1ec7m \u0111\u01b0\u1ee3c hai l\u1ea7n \u0111\u00e2m kim v\u00e0o c\u01a1 th\u1ec3 m\u00ecnh.<\/p>\n

\u201cMi\u1ebfng d\u00e1n d\u00f9ng m\u1ed9t l\u1ea7n n\u00e0y \u0111\u01b0\u1ee3c mong \u0111\u1ee3i s\u1ebd ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft cho b\u1ec7nh nh\u00e2n trong su\u1ed1t m\u1ed9t tu\u1ea7n<\/i>\u201d, t\u00e1c gi\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u, Xiaoyuan (Shawn) Chen t\u1eeb Vi\u1ec7n nghi\u00ean c\u1ee9u H\u00ecnh \u1ea3nh y sinh v\u00e0 C\u00f4ng ngh\u1ec7 Sinh h\u1ecdc Qu\u1ed1c gia Hoa K\u1ef3, cho bi\u1ebft.<\/p>\n

“N\u00f3 s\u1ebd kh\u00f4ng ph\u1ee9c t\u1ea1p h\u00f3a th\u00f3i quen sinh ho\u1ea1t h\u00e0ng ng\u00e0y c\u1ee7a b\u1ec7nh nh\u00e2n [so s\u00e1nh v\u1edbi vi\u1ec7c h\u1ecd ph\u1ea3i d\u00f9ng kim ch\u00edch m\u00e1u v\u00e0 ti\u00eam insulin sau b\u1eefa \u0103n]<\/i>“.<\/p>\n

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M\u1eb7c d\u00f9 ch\u1ee9a r\u1ea5t nhi\u1ec1u \u0111\u1ea7u kim c\u00f3 th\u1ec3 xuy\u00ean qua da, mi\u1ebfng d\u00e1n \u0111\u01b0\u1ee3c h\u1ee9a l\u00e0 kh\u00f4ng g\u00e2y \u0111au cho ng\u01b0\u1eddi s\u1eed d\u1ee5ng<\/p>\n<\/div>\n<\/div>\n

Mi\u1ebfng d\u00e1n ch\u1ee9a m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 exendin-4. Khi l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u t\u0103ng cao, exendin-4 s\u1ebd \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng \u0111\u1ec3 k\u00edch ho\u1ea1t c\u01a1 th\u1ec3 s\u1ea3n xu\u1ea5t insulin cho \u0111\u1ebfn khi \u0111\u01b0\u1eddng huy\u1ebft c\u1ee7a b\u1ec7nh nh\u00e2n b\u1eaft \u0111\u1ea7u gi\u1ea3m xu\u1ed1ng.<\/p>\n

Exendin-4 l\u00e0 m\u1ed9t trong s\u1ed1 nh\u1eefng lo\u1ea1i thu\u1ed1c thu\u1ed9c nh\u00f3m \u0111\u1ed3ng v\u1eadn th\u1ee5 th\u1ec3 GLP-1. Tr\u00ean th\u1ecb tr\u01b0\u1eddng hi\u1ec7n \u0111\u00e3 c\u00f3 nhi\u1ec1u lo\u1ea1i thu\u1ed1c n\u00e0y d\u00e0nh cho ng\u01b0\u1eddi b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng, nh\u01b0ng h\u1ecd s\u1ebd ph\u1ea3i ti\u00eam m\u1ed7i tu\u1ea7n m\u1ed9t l\u1ea7n ho\u1eb7c th\u1eadm ch\u00ed \u0111\u1ebfn 2 l\u1ea7n\/ng\u00e0y, t\u00f9y lo\u1ea1i.<\/p>\n

\u0110\u1ed1i v\u1edbi mi\u1ebfng d\u00e1n m\u1edbi, exendin-4 \u0111\u01b0\u1ee3c tr\u1ed9n v\u1edbi alginate, m\u1ed9t v\u1eadt li\u1ec7u gi\u1ed1ng nh\u01b0 k\u1eb9o cao su chi\u1ebft xu\u1ea5t t\u1eeb t\u1ea3o n\u00e2u. H\u1ed7n h\u1ee3p n\u00e0y sau \u0111\u00f3 \u0111\u01b0\u1ee3c ch\u1ebf t\u1ea1o th\u00e0nh d\u1ea1ng microneedle, l\u00e0 nh\u1eefng h\u00ecnh kim c\u1ef1c nh\u1ecf v\u00e0 \u0111\u01b0\u1ee3c \u0111\u1ed5 l\u00ean mi\u1ebfng d\u00e1n.<\/p>\n

Khi d\u00e1n l\u00ean da, c\u00e1c kim s\u1ebd \u0111\u00e2m \u0111\u01b0\u1ee3c t\u1edbi mao m\u1ea1ch, kh\u00f4ng g\u00e2y \u0111au, nh\u01b0ng n\u00f3 hi\u1ec7n m\u1edbi ch\u1ec9 \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m tr\u00ean da chu\u1ed9t. C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 d\u00e1n mi\u1ebfng d\u00e1n c\u00f3 k\u00edch th\u01b0\u1edbc kho\u1ea3ng h\u01a1n 3cm2<\/sup>\u00a0v\u00e0o nh\u1eefng con chu\u1ed9t b\u1ecb ti\u1ec3u \u0111\u01b0\u1eddng type 2.<\/p>\n

V\u1edbi k\u00edch th\u01b0\u1edbc n\u00e0y \u1edf chu\u1ed9t, mi\u1ebfng d\u00e1n ch\u1ee9a \u0111\u1ee7 thu\u1ed1c cho c\u1ea3 m\u1ed9t tu\u1ea7n. “Ch\u00fang t\u00f4i \u0111\u00e3 t\u00ecm ra c\u00e1ch ph\u00e1t h\u00e0nh exendin-4 th\u00f4ng minh, ho\u1ea1t \u0111\u1ed9ng l\u00e2u d\u00e0i v\u00e0 \u0111\u00e1p \u1ee9ng glucose<\/i>“, Chen n\u00f3i.<\/p>\n

Nh\u01b0ng \u00f4ng c\u0169ng l\u01b0u \u00fd r\u1eb1ng m\u1ed9t s\u1ed1 con chu\u1ed9t \u0111\u00e3 b\u1ecb vi\u00eam \u1edf v\u1ecb tr\u00ed c\u1ee7a mi\u1ebfng v\u00e1. \u1ede ng\u01b0\u1eddi, exendin-4 th\u01b0\u1eddng g\u00e2y bu\u1ed3n n\u00f4n cho ng\u01b0\u1eddi b\u1ec7nh, nh\u01b0ng c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u tin r\u1eb1ng mi\u1ebfng d\u00e1n gi\u1ea3i ph\u00f3ng exendin-4 ch\u1eadm n\u00ean kh\u00f4ng g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0y.<\/p>\n

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C\u00e1c m\u0169i kim si\u00eau nh\u1ecf gi\u1ea3i ph\u00f3ng thu\u1ed1c v\u00e0o mao m\u1ea1ch b\u1ec7nh nh\u00e2n<\/p>\n<\/div>\n<\/div>\n

B\u01b0\u1edbc ti\u1ebfp theo c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y l\u00e0 ch\u1ebf t\u1ea1o \u0111\u01b0\u1ee3c m\u1ed9t mi\u1ebfng d\u00e1n l\u1edbn h\u01a1n, v\u1edbi nhi\u1ec1u kim h\u01a1n, Chen gi\u1ea3i th\u00edch. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u0169ng s\u1ebd c\u1ea7n ph\u1ea3i t\u1ea1o ra \u0111\u01b0\u1ee3c nh\u1eefng m\u0169i kim d\u00e0i h\u01a1n \u0111\u1ec3 \u0111\u00e2m xuy\u00ean \u0111\u01b0\u1ee3c qua da ng\u01b0\u1eddi, \u0111\u1ed3ng th\u1eddi v\u1eabn \u0111\u1ea3m b\u1ea3o ch\u00fang kh\u00f4ng g\u00e2y \u0111au.<\/p>\n

Ti\u1ebfn s\u0129 Joel Zonszein, gi\u00e1m \u0111\u1ed1c Trung t\u00e2m B\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng l\u00e2m s\u00e0ng t\u1ea1i Trung t\u00e2m Y t\u1ebf Montefiore New York, cho bi\u1ebft: C\u00f3 v\u1ebb nh\u01b0 nh\u01b0 mi\u1ebfng d\u00e1n trong nghi\u00ean c\u1ee9u \u0111\u00e3 l\u00e0m vi\u1ec7c hi\u1ec7u qu\u1ea3. Nh\u01b0ng \u00f4ng nh\u1ea5n m\u1ea1nh r\u1eb1ng \u0111\u00f3 m\u1edbi ch\u1ec9 l\u00e0 th\u1eed nghi\u1ec7m tr\u00ean chu\u1ed9t.<\/p>\n

“C\u00f3 m\u1ed9t kho\u1ea3ng c\u00e1ch d\u00e0i t\u1eeb th\u1eed nghi\u1ec7m tr\u00ean chu\u1ed9t, th\u1eadm ch\u00ed th\u1eed nghi\u1ec7m t\u01b0\u01a1ng t\u1ef1 tr\u00ean ng\u01b0\u1eddi, cho \u0111\u1ebfn khi [mi\u1ebfng d\u00e1n] \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn b\u1edfi [C\u01a1 quan Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA)]<\/i>“, ti\u1ebfn s\u0129 Zonszein n\u00f3i.<\/p>\n

Tuy nhi\u00ean, \u00f4ng nh\u1eefng nh\u1eadn \u0111\u1ecbnh b\u1ea3n th\u00e2n mi\u1ebfng d\u00e1n n\u00e0y l\u00e0 m\u1ed9t \u00fd t\u01b0\u1edfng r\u1ea5t hay, v\u00e0 \u01b0u \u0111i\u1ec3m c\u1ee7a n\u00f3 l\u00e0 kh\u00f4ng l\u00e0m t\u1ed1n th\u1eddi gian cho ng\u01b0\u1eddi m\u1eafc b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng qu\u1ea3n l\u00fd c\u0103n b\u1ec7nh c\u1ee7a h\u1ecd. C\u00f3 \u0111i\u1ec1u ti\u1ebfn s\u0129 Zonszein c\u1ea3nh b\u00e1o t\u01b0\u01a1ng lai kh\u00f4ng xa s\u1ebd c\u00f3 thu\u1ed1c GLP-1 d\u1ea1ng u\u1ed1ng, n\u00ean n\u1ebfu mi\u1ebfng d\u00e1n ra \u0111\u1eddi n\u00f3 s\u1eafp c\u00f3 \u0111\u1ed1i th\u1ee7 c\u1ea1nh tranh.<\/p>\n

Ngo\u00e0i ra, exendin-4 kh\u00f4ng ph\u1ea3i l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb tr\u1ef1c ti\u1ebfp ti\u1ec3u \u0111\u01b0\u1eddng, ti\u1ebfn s\u0129 Zonszein cho bi\u1ebft. N\u1ebfu c\u00e1c t\u00e1c gi\u1ea3 nghi\u00ean c\u1ee9u c\u00f3 th\u1ec3 t\u00ecm ra c\u00e1ch t\u00edch h\u1ee3p insulin v\u00e0o mi\u1ebfng d\u00e1n, \u0111\u00f3 s\u1ebd l\u00e0 l\u1ef1a ch\u1ecdn t\u1ed1t h\u01a1n.<\/p>\n

Tham kh\u1ea3o\u00a0Upi, Nih<\/i><\/p>\n

Ngu\u1ed3n GenK<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

C\u00e1c nh\u00e0 khoa h\u1ecdc mong \u0111\u1ee3i mi\u1ebfng d\u00e1n 1 l\u1ea7n c\u1ee7a h\u1ecd s\u1ebd ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft cho b\u1ec7nh nh\u00e2n trong c\u1ea3 tu\u1ea7n. Theo m\u1ed9t nghi\u00ean c\u1ee9u tr\u00ean t\u1ea1p ch\u00ed\u00a0Nature Communications, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111ang ph\u00e1t tri\u1ec3n m\u1ed9t mi\u1ebfng d\u00e1n tr\u00ean da cho ng\u01b0\u1eddi b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng type 2. Mi\u1ebfng d\u00e1n n\u00e0y c\u00f3 th\u1ec3 […]<\/p>\n","protected":false},"author":18,"featured_media":7965,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-7964","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/7964","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=7964"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/7964\/revisions"}],"predecessor-version":[{"id":8011,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/7964\/revisions\/8011"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/7965"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=7964"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=7964"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=7964"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}