{"id":6144,"date":"2017-09-15T19:43:19","date_gmt":"2017-09-15T12:43:19","guid":{"rendered":"http:\/\/ttud.com.vn\/?p=6144"},"modified":"2017-10-03T09:06:05","modified_gmt":"2017-10-03T02:06:05","slug":"lan-dau-tien-su-dung-cong-nghe-chinh-sua-gen-de-thay-doi-mau-sac-cua-hoa","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/lan-dau-tien-su-dung-cong-nghe-chinh-sua-gen-de-thay-doi-mau-sac-cua-hoa\/","title":{"rendered":"L\u1ea7n \u0111\u1ea7u ti\u00ean s\u1eed d\u1ee5ng c\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda gen \u0111\u1ec3 thay \u0111\u1ed5i m\u00e0u s\u1eafc c\u1ee7a hoa"},"content":{"rendered":"

\u0110\u1ec3 bi\u1ebfn \u0111\u1ed5i m\u00e0u s\u1eafc c\u1ee7a hoa, b\u00e0 m\u1eb9 thi\u00ean nhi\u00ean ph\u1ea3i m\u1ea5t kho\u1ea3ng 850 n\u0103m m\u1edbi th\u1ef1c hi\u1ec7n \u0111\u01b0\u1ee3c, nh\u01b0ng CRISPR\/Cas9 ch\u1ec9 th\u1ef1c hi\u1ec7n trong v\u00f2ng ch\u01b0a \u0111\u1ea7y m\u1ed9t n\u0103m.<\/strong><\/p>\n

\"\"<\/p>\n

Lo\u00e0i hoa \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i l\u00e0 c\u00e2y b\u00ecm b\u00ecm hoa t\u00eda c\u1ee7a Nh\u1eadt B\u1ea3n. \u0110i\u1ec1u \u0111\u00e1ng ch\u00fa \u00fd l\u00e0 c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ch\u1ec9 bi\u1ebfn \u0111\u1ed5i m\u00e0u s\u1eafc c\u1ee7a hoa m\u00e0 kh\u00f4ng l\u00e0m \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nh\u1eefng ph\u1ea7n c\u00f2n l\u1ea1i c\u1ee7a c\u00e2y. \u0110\u00e2y c\u0169ng l\u00e0 l\u1ea7n \u0111\u1ea7u ti\u00ean c\u00f4ng ngh\u1ec7 CRISPR\/Cas9 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 bi\u1ebfn \u0111\u1ed5i m\u00e0u s\u1eafc c\u1ee7a hoa \u1edf th\u1ef1c v\u1eadt.<\/p>\n

M\u1eb7c d\u00f9 nhi\u1ec1u ng\u01b0\u1eddi lo ng\u1ea1i CRISPR c\u00f3 th\u1ec3 b\u1ecb l\u1ea1m d\u1ee5ng \u0111\u1ec3 ph\u1ee5c v\u1ee5 cho nh\u1eefng m\u1ee5c \u0111\u00edch kh\u00f4ng l\u00e0nh m\u1ea1nh, nh\u01b0ng th\u1ef1c s\u1ef1 n\u00f3 \u0111\u00e3 \u0111em l\u1ea1i nhi\u1ec1u l\u1ee3i \u00edch cho gi\u1edbi khoa h\u1ecdc. Tr\u01b0\u1edbc \u0111\u00e2y, ch\u00fang ta \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng ki\u1ebfn nh\u1eefng t\u00ednh n\u0103ng c\u1ee7a n\u00f3 nh\u01b0 d\u00f9ng \u0111\u1ec3 ch\u1ec9nh s\u1eeda c\u00e1c gen g\u00e2y b\u1ec7nh \u1edf \u0111\u1ed9ng v\u1eadt. Tuy nhi\u00ean, ng\u01b0\u1eddi ta v\u1eabn \u0111ang tranh c\u00e3i kh\u1ea3 n\u0103ng s\u1eed d\u1ee5ng n\u00f3 tr\u00ean ng\u01b0\u1eddi do li\u00ean quan \u0111\u1ebfn v\u1ea5n \u0111\u1ec1 \u0111\u1ea1o \u0111\u1ee9c.<\/p>\n

Hi\u1ec7n, c\u00e1c nh\u00f3m nghi\u00ean c\u1ee9u tr\u00ean kh\u1eafp Nh\u1eadt B\u1ea3n \u0111\u1ec1u cho r\u1eb1ng, k\u1ef9 thu\u1eadt CRISPR\/Cas9 s\u1ebd t\u1ea1o ra s\u1ef1 kh\u00e1c bi\u1ec7t r\u1ea5t l\u1edbn trong nghi\u00ean c\u1ee9u v\u00e0 \u1ee9ng d\u1ee5ng tr\u00ean c\u00e2y tr\u1ed3ng.<\/p>\n

Lo\u00e0i b\u00ecm b\u00ecm hoa t\u00edm l\u00e0 m\u1ed9t trong hai lo\u00e0i th\u1ef1c v\u1eadt \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong D\u1ef1 \u00e1n T\u00e0i nguy\u00ean sinh h\u1ecdc Qu\u1ed1c gia Nh\u1eadt B\u1ea3n n\u00ean c\u00e1c nh\u00e0 khoa h\u1ecdc r\u1ea5t am hi\u1ec3u v\u1ec1 m\u00e3 di truy\u1ec1n c\u1ee7a n\u00f3 c\u0169ng nh\u01b0 \u0111\u00e3 c\u00f3 s\u1eb5n c\u00e1c b\u1ea3n thi\u1ebft k\u1ebf DNA. \u0110\u00e2y c\u0169ng ch\u00ednh l\u00e0 l\u00ed do lo\u00e0i hoa n\u00e0y \u0111\u01b0\u1ee3c ch\u1ecdn \u0111\u1ec3 th\u1ef1c hi\u1ec7n th\u00ed nghi\u1ec7m.<\/p>\n

Nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c gen dihydroflavonol-4-reductase-B (DFR-B) l\u00e0 gen c\u00f3 ch\u1ee9c n\u0103ng t\u1ea1o ra m\u00e0u s\u1eafc cho hoa c\u1ee7a th\u1ef1c v\u1eadt. Tuy nhi\u00ean, b\u00ean c\u1ea1nh DFR-B c\u00f2n c\u00f3 hai gen kh\u00e1c, n\u00ean th\u00e1ch th\u1ee9c \u0111\u1eb7t ra cho c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u l\u00e0 l\u00e0m sao s\u1eed d\u1ee5ng CRISPR\/Cas9 \u0111\u1ec3 lo\u1ea1i b\u1ecf c\u00e1c s\u1ee3i DNA c\u1ee7a DFR-B m\u00e0 kh\u00f4ng l\u00e0m \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ph\u1ea7n c\u00f2n l\u1ea1i c\u1ee7a c\u00e2y.<\/p>\n

Enzym \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi DFR-B c\u00f3 ch\u1ee9c n\u0103ng t\u1ea1o ra c\u00e1c s\u1eafc t\u1ed1 m\u00e0u s\u1eafc anthocyanin (h\u1ee3p ch\u1ea5t m\u00e0u h\u1eefu c\u01a1 t\u1ef1 nhi\u00ean tan trong n\u01b0\u1edbc l\u1edbn nh\u1ea5t trong gi\u1edbi th\u1ef1c v\u1eadt. Ch\u00fang thu\u1ed9c nh\u00f3m flavonoid, c\u00f3 m\u00e0u \u0111\u1ecf, \u0111\u1ecf t\u00eda, t\u00edm v\u00e0 xanh \u0111\u1eadm; th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n trong tr\u00e1i c\u00e2y, rau c\u1ee7, hoa v\u00e0 th\u1ea3o m\u1ed9c). Do \u0111\u00f3, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 v\u00f4 hi\u1ec7u h\u00f3a s\u1eafc t\u1ed1 \u0111\u1ec3 bi\u1ebfn \u0111\u1ed5i m\u00e0u s\u1eafc c\u1ee7a hoa tr\u1eafng.<\/p>\n

Kho\u1ea3ng 75% ph\u00f4i th\u1ef1c v\u1eadt sau khi \u0111\u01b0\u1ee3c x\u1eed l\u00fd \u0111\u00e3 khi\u1ebfn c\u00e2y ra hoa m\u00e0u tr\u1eafng nhi\u1ec1u h\u01a1n so v\u1edbi m\u00e0u t\u00edm. Nh\u1eefng ph\u00e2n t\u00edch s\u00e2u h\u01a1n v\u1ec1 c\u00e1c gen l\u00e2n c\u1eadn cho th\u1ea5y kh\u00f4ng h\u1ec1 c\u00f3 s\u1ef1 \u0111\u1ed9t bi\u1ebfn n\u00e0o x\u1ea3y ra, \u0111\u00e2y l\u00e0 m\u1ed9t minh ch\u1ee9ng cho th\u1ea5y t\u00ednh ch\u00ednh x\u00e1c c\u1ee7a CRISPR\/Cas9.<\/p>\n

Nghi\u00ean c\u1ee9u n\u00e0y c\u00f3 nh\u1eefng h\u1ec7 qu\u1ea3 v\u01b0\u1ee3t xa vi\u1ec7c gi\u00fap b\u1ea1n ch\u1ecdn \u0111\u01b0\u1ee3c nh\u1eefng m\u00e0u hoa y\u00eau th\u00edch \u0111\u1ec3 trang tr\u00ed trong nh\u00e0. B\u1edfi l\u1ebd m\u1ed9t s\u1ed1 th\u1ebf h\u1ec7 ti\u1ebfp theo c\u1ee7a th\u1ef1c v\u1eadt – m\u00e0 ra hoa tr\u1eafng – kh\u00f4ng h\u1ec1 cho th\u1ea5y d\u1ea5u hi\u1ec7u c\u1ee7a vi\u1ec7c b\u1ecb can thi\u1ec7p v\u00e0o DNA.<\/p>\n

\u0110i\u1ec1u n\u00e0y l\u00e0m d\u1ea5y l\u00ean nhi\u1ec1u c\u00e2u h\u1ecfi th\u00fa v\u1ecb v\u1ec1 kh\u1ea3 n\u0103ng ph\u01b0\u01a1ng ph\u00e1p ch\u1ec9nh s\u1eeda gen n\u00e0y c\u00f3 th\u1ec3 l\u00e0m thay \u0111\u1ed5i v\u0129nh vi\u1ec5n b\u1ea3n ch\u1ea5t t\u1ef1 nhi\u00ean c\u1ee7a th\u1ee9 \u0111\u01b0\u1ee3c ch\u1ec9nh s\u1eeda, b\u1ea5t k\u1ec3 \u00fd \u0111\u1ecbnh c\u1ee7a ch\u00fang ta l\u00e0 t\u1ed1t hay x\u1ea5u.
\nM\u1eb7c d\u00f9 v\u1eady, c\u00e1c nh\u00e0 khoa h\u1ecdc v\u1eabn \u0111ang th\u00fac \u0111\u1ea9y nghi\u00ean c\u1ee9u c\u1ee7a h\u1ecd \u0111\u1ec3 ch\u1ee9ng minh cho t\u00ednh ch\u00ednh x\u00e1c v\u00e0 nh\u1eefng l\u1ee3i \u00edch ti\u1ec1m n\u0103ng c\u1ee7a CRISPR\/Cas9.<\/p>\n

C\u00e2y b\u00ecm b\u00ecm hoa t\u00edm \u0111\u01b0\u1ee3c du nh\u1eadp v\u00e0o n\u01b0\u1edbc Nh\u1eadt \u1edf th\u1ebf k\u1ef7 8 tr\u01b0\u1edbc C\u00f4ng nguy\u00ean, nh\u01b0ng \u0111\u1ebfn th\u1ebf k\u1ef7 17 m\u1edbi xu\u1ea5t hi\u1ec7n nh\u1eefng \u201cphi\u00ean b\u1ea3n\u201d hoa c\u00f3 m\u00e0u tr\u1eafng do \u0111\u1ed9t bi\u1ebfn di truy\u1ec1n. \u0110\u1ec3 bi\u1ebfn \u0111\u1ed5i m\u00e0u hoa, b\u00e0 m\u1eb9 thi\u00ean nhi\u00ean \u0111\u00e3 m\u1ea5t kho\u1ea3ng 850 n\u0103m nh\u01b0ng CRISPR\/Cas9 ch\u1ec9 th\u1ef1c hi\u1ec7n trong v\u00f2ng ch\u01b0a \u0111\u1ea7y 12 th\u00e1ng – \u0111i\u1ec1u n\u00e0y v\u1eeba th\u00fa v\u1ecb v\u1eeba khi\u1ebfn ng\u01b0\u1eddi ta lo ng\u1ea1i.<\/p>\n

K\u1ebft qu\u1ea3 th\u00e0nh c\u00f4ng c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y s\u1ebd t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho vi\u1ec7c thay \u0111\u1ed5i m\u00e0u s\u1eafc v\u00e0 h\u00ecnh d\u1ea1ng c\u1ee7a c\u00e1c lo\u1ea1i hoa c\u0169ng nh\u01b0 rau c\u1ee7 d\u00f9ng \u0111\u1ec3 trang tr\u00ed.<\/p>\n

Ngu\u1ed3n T\u1ea1p ch\u00ed Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 Vi\u1ec7t Nam<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

\u0110\u1ec3 bi\u1ebfn \u0111\u1ed5i m\u00e0u s\u1eafc c\u1ee7a hoa, b\u00e0 m\u1eb9 thi\u00ean nhi\u00ean ph\u1ea3i m\u1ea5t kho\u1ea3ng 850 n\u0103m m\u1edbi th\u1ef1c hi\u1ec7n \u0111\u01b0\u1ee3c, nh\u01b0ng CRISPR\/Cas9 ch\u1ec9 th\u1ef1c hi\u1ec7n trong v\u00f2ng ch\u01b0a \u0111\u1ea7y m\u1ed9t n\u0103m. Lo\u00e0i hoa \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i l\u00e0 c\u00e2y b\u00ecm b\u00ecm hoa t\u00eda c\u1ee7a Nh\u1eadt B\u1ea3n. \u0110i\u1ec1u \u0111\u00e1ng ch\u00fa \u00fd l\u00e0 c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ch\u1ec9 […]<\/p>\n","protected":false},"author":17,"featured_media":6265,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-6144","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/6144","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=6144"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/6144\/revisions"}],"predecessor-version":[{"id":6267,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/6144\/revisions\/6267"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/6265"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=6144"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=6144"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=6144"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}