{"id":5930,"date":"2017-06-16T18:53:42","date_gmt":"2017-06-16T11:53:42","guid":{"rendered":"http:\/\/ttud.com.vn\/?p=5930"},"modified":"2017-10-03T11:03:47","modified_gmt":"2017-10-03T04:03:47","slug":"vat-lieu-hydrogel-co-kha-nang-xu-ly-cac-phan-tu-thuoc-kho-tan-trong-co-the","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/vat-lieu-hydrogel-co-kha-nang-xu-ly-cac-phan-tu-thuoc-kho-tan-trong-co-the\/","title":{"rendered":"V\u1eadt li\u1ec7u hydrogel c\u00f3 kh\u1ea3 n\u0103ng x\u1eed l\u00fd c\u00e1c ph\u00e2n t\u1eed thu\u1ed1c kh\u00f3 tan trong c\u01a1 th\u1ec3"},"content":{"rendered":"

M\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u sinh h\u1ecdc t\u1ea1i Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Rice, Hoa K\u1ef3 do Jeffrey Hartgerink d\u1eabn \u0111\u1ea7u \u0111\u00e3 t\u1ea1o ra m\u1ed9t lo\u1ea1i v\u1eadt li\u1ec7u hydrogel \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp d\u1ef1a tr\u00ean c\u00e1c chu\u1ed7i peptide c\u00f3 c\u1ea5u tr\u00fac r\u0103ng c\u01b0a \u0111\u1ec3 t\u1eeb \u0111\u00f3 ph\u00e1t tri\u1ec3n ph\u01b0\u01a1ng ph\u00e1p hi\u1ec7u qu\u1ea3 nh\u1eb1m ph\u00e2n ph\u1ed1i c\u00e1c ph\u00e2n t\u1eed thu\u1ed1c kh\u00f3 tan \u0111\u1ebfn nh\u1eefng v\u1ecb tr\u00ed ch\u00ednh x\u00e1c trong c\u01a1 th\u1ec3 b\u1ec7nh nh\u00e2n.<\/strong><\/p>\n

\"\"<\/p>\n

Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, ph\u00f2ng th\u00ed nghi\u1ec7m c\u1ee7a Hartgerink \u0111\u00e3 cho ra \u0111\u1eddi nhi\u1ec1u lo\u1ea1i v\u1eadt li\u1ec7u hydrogel \u0111\u01b0\u1ee3c t\u1ea1o th\u00e0nh t\u1eeb c\u00e1c chu\u1ed7i peptide t\u00f9y ch\u1ec9nh, \u0111em \u0111\u1ebfn nh\u1eefng thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 trong \u1ee9ng d\u1ee5ng y khoa bao g\u1ed3m: ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb nh\u1eb1m k\u00edch th\u00edch t\u0103ng tr\u01b0\u1edfng c\u00e1c t\u1ebf b\u00e0o, ph\u1ee5c h\u1ed3i m\u00f4 \u1edf ng\u01b0\u1eddi hay li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng huy\u1ebft kh\u1ed1i c\u0169ng nh\u01b0 c\u1ea7m m\u00e1u trong qu\u00e1 tr\u00ecnh ph\u1eabu thu\u1eadt (nh\u1edd s\u1eed d\u1ee5ng lo\u1ea1i hydrogel v\u1edbi th\u00e0nh ph\u1ea7n n\u1ecdc r\u1eafn).<\/p>\n

V\u1eadt li\u1ec7u hydrogel m\u1edbi c\u00f3 d\u1ea1ng s\u1ee3i nano \u0111\u01b0\u1ee3c t\u1ea1o th\u00e0nh d\u1ef1a tr\u00ean c\u00e1c chu\u1ed7i peptide c\u00f3 c\u1ea5u tr\u00fac “r\u0103ng c\u01b0a”. Kho\u1ea3ng c\u00e1ch gi\u1eefa c\u00e1c r\u0103ng c\u01b0a trong s\u1ee3i \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 gi\u1eef ch\u00e2n c\u00e1c ph\u00e2n t\u1eed thu\u1ed1c c\u00f3 \u0111\u1eb7c t\u00ednh k\u1ef5 n\u01b0\u1edbc. Lo\u1ea1i gel c\u00f3 kh\u1ea3 n\u0103ng ph\u00e2n hu\u1ef7 sinh h\u1ecdc \u0111\u01b0\u1ee3c ti\u00eam \u0111\u1ec3 gi\u1ea3i ph\u00f3ng nh\u1eefng ph\u00e2n t\u1eed thu\u1ed1c d\u1ea7n ra kh\u1ecfi c\u01a1 th\u1ec3 theo th\u1eddi gian.<\/p>\n

Trong nghi\u00ean c\u1ee9u m\u1edbi, m\u1ee5c ti\u00eau m\u00e0 Hartgerink c\u00f9ng hai nghi\u00ean c\u1ee9u sinh Tr\u01b0\u1eddng Rice l\u00e0 I-Che Li v\u00e0 Amanda Moore nh\u1eafm t\u1edbi l\u00e0 x\u1eed l\u00fd nh\u1eefng ph\u00e2n t\u1eed thu\u1ed1c c\u00f3 xu h\u01b0\u1edbng k\u1ebft th\u00e0nh c\u1ee5c, kh\u00f3 l\u01b0u th\u00f4ng trong m\u00e1u.<\/p>\n

Hartgerink cho bi\u1ebft: th\u00f4ng th\u01b0\u1eddng, c\u00e1c ph\u00e2n t\u1eed \u01b0a n\u01b0\u1edbc (c\u00f3 kh\u1ea3 n\u0103ng h\u1ea5p thu n\u01b0\u1edbc) c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ti\u00eam v\u00e0o c\u01a1 th\u1ec3 ng\u01b0\u1eddi m\u00e0 kh\u00f4ng c\u1ea7n th\u00f4ng qua c\u01a1 ch\u1ebf ph\u00e2n ph\u1ed1i. C\u00e1c ph\u00e2n t\u1eed thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng h\u00f2a tan trong n\u01b0\u1edbc s\u1ebd di chuy\u1ec3n trong m\u1ea1ch m\u00e1u v\u00e0 tan ra. Trong khi \u0111\u00f3, vi\u1ec7c \u0111\u01b0a c\u00e1c ph\u00e2n t\u1eed thu\u1ed1c k\u1ef5 n\u01b0\u1edbc v\u00e0o trong c\u01a1 th\u1ec3 l\u1ea1i l\u00e0 m\u1ed9t vi\u1ec7c kh\u00f4ng h\u1ec1 \u0111\u01a1n gi\u1ea3n. Ch\u00ednh v\u00ec v\u1eady, ch\u00fang t\u00f4i \u0111\u00e3 \u0111\u01b0a ch\u00fang v\u00e0o v\u1ecb tr\u00ed kho\u1ea3ng tr\u1ed1ng gi\u1eefa c\u00e1c r\u0103ng c\u01b0a tr\u00ean s\u1ee3i nano, t\u1eeb \u0111\u00f3, ph\u00e2n t\u1eed thu\u1ed1c \u0111\u01b0\u1ee3c gi\u1eef l\u00e0 v\u00e0 theo \u0111\u00f3 ph\u00e2n ph\u1ed1i t\u1edbi b\u1ea5t c\u1ee9 v\u1ecb tr\u00ed n\u00e0o \u0111\u01b0\u1ee3c ti\u00eam hydrogel trong c\u01a1 th\u1ec3.<\/p>\n

\u0110i\u1ec3m kh\u00e1c bi\u1ec7t gi\u1eefa nghi\u00ean c\u1ee9u m\u1edbi c\u1ee7a Hartgerink v\u00e0 nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u01b0\u1edbc \u0111\u00f3 – m\u00e0 trong \u0111\u00f3, c\u00e1c protein ho\u1eb7c ph\u00e2n t\u1eed nh\u1ecf th\u01b0\u1eddng b\u1ecb m\u1eafc k\u1eb9t trong gel \u0111\u01b0\u1ee3c t\u1ea1o th\u00e0nh b\u1edfi c\u00e1c s\u1ee3i si\u00eau nh\u1ecf – n\u1eb1m \u1edf s\u1ef1 thay \u0111\u1ed5i c\u1ea5u tr\u00fac b\u00ean trong s\u1ee3i. C\u1ee5 th\u1ec3 h\u01a1n, Hartgerink c\u00f9ng c\u00e1c c\u1ed9ng s\u1ef1 \u0111\u00e3 ti\u1ebfn h\u00e0nh lo\u1ea1i b\u1ecf m\u1ed9t ph\u1ea7n c\u1ea5u tr\u00fac b\u00ean trong c\u1ee7a s\u1ee3i v\u00e0 g\u1ecdi \u0111\u00f3 l\u00e0 c\u1ea5u tr\u00fac r\u0103ng c\u01b0a, \u0111\u1eb7c bi\u1ec7t \u0111\u00e2y l\u00e0 m\u00f4i tr\u01b0\u1eddng k\u1ef5 n\u01b0\u1edbc.
\n\u0110\u1ec3 t\u1ea1o ra s\u1ee3i c\u00f3 c\u1ea5u tr\u00fac \u0111\u1ed9c \u0111\u00e1o, ban \u0111\u1ea7u, nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 thi\u1ebft l\u1eadp c\u00e1c chu\u1ed7i peptide g\u1ed3m c\u00e1c axit amin k\u1ef5 n\u01b0\u1edbc v\u00e0 \u01b0a n\u01b0\u1edbc \u0111\u01b0\u1ee3c s\u1eafp x\u1ebfp theo tr\u00ecnh t\u1ef1 lu\u00e2n phi\u00ean, xen k\u1ebd gi\u1eefa nh\u1eefng kho\u1ea3ng tr\u1ed1ng r\u0103ng c\u01b0a. C\u00e1c lo\u1ea1i thu\u1ed1c c\u00f3 ph\u00e2n t\u1eed nh\u1ecf k\u1ef5 n\u01b0\u1edbc s\u1ebd b\u1ecb h\u00fat v\u00e0 m\u1eafc k\u1eb9t v\u00e0o nh\u1eefng kho\u1ea3ng tr\u1ed1ng trong qu\u00e1 tr\u00ecnh t\u1ef1 l\u1eafp r\u00e1p \u0111\u1ec3 h\u00ecnh th\u00e0nh s\u1ee3i c\u00f3 c\u1ea5u tr\u00fac r\u0103ng c\u01b0a c\u1ee7a c\u00e1c chu\u1ed7i peptide.<\/p>\n

Hydrogel t\u1eeb d\u1ea1ng gel bi\u1ebfn th\u00e0nh d\u1ea1ng l\u1ecfng d\u01b0\u1edbi t\u00e1c d\u1ee5ng c\u1ee7a l\u1ef1c c\u1eaft trong qu\u00e1 tr\u00ecnh n\u00f3 di chuy\u1ec3n xuy\u00ean qua \u0111\u1ea7u kim ti\u00eam – hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 hi\u1ec7n t\u01b0\u1ee3ng thixotropy, sau khi v\u00e0o b\u00ean trong c\u01a1 th\u1ec3, n\u00f3 l\u1eadp t\u1ee9c quay tr\u1edf l\u1ea1i c\u1ea5u tr\u00fac d\u1ea1ng gel ban \u0111\u1ea7u. C\u00e1c ph\u00e2n t\u1eed thu\u1ed1c ph\u00e2n b\u1ed1 \u0111an xen trong nh\u1eefng khe tr\u1ed1ng c\u1ee7a c\u00e1c peptide cho \u0111\u1ebfn khi \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng kh\u1ecfi hydrogel. C\u00e1c chuy\u00ean gia cho bi\u1ebft h\u1ecd \u0111\u00e3 ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m ti\u00eam hydrogel v\u00e0o c\u01a1 th\u1ec3 b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng c\u00e1c lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0, thu\u1ed1c kh\u00e1ng sinh hay thu\u1ed1c ch\u1ed1ng vi\u00eam. B\u00ean c\u1ea1nh \u0111\u00f3, h\u1ecd c\u0169ng \u0111ang nghi\u00ean c\u1ee9u c\u00e1ch th\u1ee9c gi\u1ea3i ph\u00f3ng c\u1ee7a ph\u00e2n t\u1eed thu\u1ed1c ra kh\u1ecfi c\u01a1 th\u1ec3 ng\u01b0\u1eddi b\u1ec7nh theo th\u1eddi gian.<\/p>\n

Hartgerink \u0111\u00e1nh gi\u00e1 cao c\u1ea5u tr\u00fac “r\u0103ng c\u01b0a” c\u1ee7a v\u1eadt li\u1ec7u hydrogel m\u1edbi v\u00ec nh\u1edd n\u00f3, vi\u1ec7c ch\u1eb7n c\u1ea3 c\u00e1c protein \u01b0a n\u01b0\u1edbc trong ma tr\u1eadn hydrogel l\u00e0 ho\u00e0n to\u00e0n kh\u1ea3 thi. \u00d4ng cho bi\u1ebft: m\u1ee5c ti\u00eau m\u00e0 ch\u00fang t\u00f4i mu\u1ed1n nh\u1eafm t\u1edbi trong t\u01b0\u01a1ng lai l\u00e0 s\u1ebd ph\u00e1t tri\u1ec3n lo\u1ea1i v\u1eadt li\u1ec7u c\u00f3 kh\u1ea3 n\u0103ng c\u00f9ng l\u00fac th\u1ef1c hi\u1ec7n c\u1ea3 hai m\u1ee5c ti\u00eau (gi\u1eef ch\u00e2n c\u1ea3 ph\u00e2n t\u1eed k\u1ef5 n\u01b0\u1edbc v\u00e0 \u01b0a n\u01b0\u1edbc).<\/p>\n

(Nasati)<\/em><\/p>\n

Ngu\u1ed3n T\u1ea1p ch\u00ed Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 Vi\u1ec7t Nam<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

M\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u sinh h\u1ecdc t\u1ea1i Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Rice, Hoa K\u1ef3 do Jeffrey Hartgerink d\u1eabn \u0111\u1ea7u \u0111\u00e3 t\u1ea1o ra m\u1ed9t lo\u1ea1i v\u1eadt li\u1ec7u hydrogel \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp d\u1ef1a tr\u00ean c\u00e1c chu\u1ed7i peptide c\u00f3 c\u1ea5u tr\u00fac r\u0103ng c\u01b0a \u0111\u1ec3 t\u1eeb \u0111\u00f3 ph\u00e1t tri\u1ec3n ph\u01b0\u01a1ng ph\u00e1p hi\u1ec7u qu\u1ea3 nh\u1eb1m ph\u00e2n ph\u1ed1i c\u00e1c ph\u00e2n […]<\/p>\n","protected":false},"author":17,"featured_media":6531,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-5930","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/5930","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=5930"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/5930\/revisions"}],"predecessor-version":[{"id":6532,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/5930\/revisions\/6532"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/6531"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=5930"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=5930"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=5930"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}