{"id":5901,"date":"2016-10-05T18:47:38","date_gmt":"2016-10-05T11:47:38","guid":{"rendered":"http:\/\/ttud.com.vn\/?p=5901"},"modified":"2017-10-03T17:04:07","modified_gmt":"2017-10-03T10:04:07","slug":"nha-khoa-hoc-nhat-ban-doat-giai-nobel-y-hoc-nho-kham-pha-co-che-tu-thuc-bao","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/nha-khoa-hoc-nhat-ban-doat-giai-nobel-y-hoc-nho-kham-pha-co-che-tu-thuc-bao\/","title":{"rendered":"Nh\u00e0 khoa h\u1ecdc Nh\u1eadt B\u1ea3n \u0111o\u1ea1t gi\u1ea3i Nobel Y h\u1ecdc nh\u1edd kh\u00e1m ph\u00e1 c\u01a1 ch\u1ebf t\u1ef1 th\u1ef1c b\u00e0o"},"content":{"rendered":"

Yoshinori Ohsumi – m\u1ed9t nh\u00e0 sinh h\u1ecdc Nh\u1eadt B\u1ea3n v\u1eeba \u0111\u01b0\u1ee3c trao gi\u1ea3i Nobel Sinh l\u00fd h\u1ecdc v\u00e0 Y khoa n\u0103m nay, nh\u1edd c\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u l\u00e0m s\u00e1ng t\u1ecf c\u00e1ch th\u1ee9c c\u00e1c t\u1ebf b\u00e0o c\u1ee7a c\u01a1 th\u1ec3 x\u1eed l\u00fd v\u00e0 t\u00e1i ch\u1ebf ch\u1ea5t th\u1ea3i, m\u1ed9t kh\u00e1m ph\u00e1 c\u00f3 th\u1ec3 s\u1ebd m\u1edf \u0111\u01b0\u1eddng cho nh\u1eefng nghi\u00ean c\u1ee9u kh\u00e1c v\u1ec1 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1ea7n kinh ho\u1eb7c c\u00e1c c\u0103n b\u1ec7nh kh\u00e1c.<\/strong><\/p>\n

\"\"<\/p>\n

Ngo\u00e0i ra, nh\u1eefng hi\u1ec3u bi\u1ebft v\u1ec1 qu\u00e1 tr\u00ecnh n\u00e0y c\u0169ng s\u1ebd \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c t\u00ecm hi\u1ec3u v\u1ec1 nhi\u1ec1u qu\u00e1 tr\u00ecnh sinh l\u00fd kh\u00e1c, ch\u1eb3ng h\u1ea1n nh\u01b0 ph\u1ea3n \u1ee9ng c\u1ee7a c\u01a1 th\u1ec3 tr\u01b0\u1edbc t\u00e1c nh\u00e2n g\u00e2y nhi\u1ec5m tr\u00f9ng. V\u1edbi nh\u1eefng ph\u00e1t hi\u1ec7n quan tr\u1ecdng c\u1ee7a m\u00ecnh v\u1ec1 s\u1ef1 t\u1ef1 th\u1ef1c b\u00e0o \u201cautophagy\u201d, ph\u1ea7n th\u01b0\u1edfng m\u00e0 ti\u1ebfn s\u0129 Ohsumi nh\u1eadn \u0111\u01b0\u1ee3c l\u00e0 s\u1ed1 ti\u1ec1n 8 tri\u1ec7u kronor Th\u1ee5y \u0110i\u1ec3n (t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 933.000 USD).<\/p>\n

Autophagy hay \u201ct\u1ef1 th\u1ef1c\u201d l\u00e0 hi\u1ec7n t\u01b0\u1ee3ng x\u1ea3y ra khi c\u00e1c t\u1ebf b\u00e0o b\u1ecb tho\u00e1i h\u00f3a v\u00e0 t\u1ef1 t\u00e1i ch\u1ebf ch\u00ednh n\u00f3. Nh\u1edd \u201cautophagy”, c\u00e1c t\u1ebf b\u00e0o bi\u1ebfn ch\u1ea5t th\u1ea3i th\u00e0nh nhi\u00ean li\u1ec7u c\u00f3 th\u1ec3 t\u1ea1o ra n\u0103ng l\u01b0\u1ee3ng, \u0111\u1ed3ng th\u1eddi \u0111\u1eb7t l\u00ean nh\u1eefng vi\u00ean g\u1ea1ch nh\u1eb1m l\u00e0m m\u1edbi c\u00e1c th\u00e0nh ph\u1ea7n c\u1ee7a t\u1ebf b\u00e0o. “\u00d4ng \u1ea5y \u0111\u00e3 cho th\u1ea5y c\u00e1c t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c trang b\u1ecb nh\u1eefng nh\u00e0 m\u00e1y t\u00e1i ch\u1ebf tinh vi\u201d, Juleen Zierath, m\u1ed9t th\u00e0nh vi\u00ean c\u1ee7a \u1ee7y ban trao gi\u1ea3i Nobel, cho bi\u1ebft. “\u0110\u00f3 l\u00e0 m\u1ed9t gi\u1ea3i th\u01b0\u1edfng r\u1ea5t \u0111\u1eb9p.”<\/p>\n

Ngo\u00e0i vi\u1ec7c t\u00ecm ra c\u01a1 ch\u1ebf c\u1ee7a \u201ct\u1ef1 th\u1ef1c”, nh\u00e0 sinh v\u1eadt h\u1ecdc \u0111\u01b0\u1ee3c sinh ra \u1edf Nh\u1eadt v\u00e0o n\u0103m 1945 c\u0169ng \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c gen chi ph\u1ed1i qu\u00e1 tr\u00ecnh n\u00e0y, s\u1ebd l\u00e0 ti\u1ec1n \u0111\u1ec1 cho c\u00e1c nh\u00e0 khoa h\u1ecdc nghi\u00ean c\u1ee9u v\u1ec1 nh\u1eefng g\u00ec s\u1ebd x\u1ea3y ra khi autophagy b\u1ecb x\u00e1o tr\u1ed9n. Vi\u1ec7c autophagy gi\u00e1n \u0111o\u1ea1n \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 li\u00ean quan \u0111\u1ebfn b\u1ec7nh Parkinson, ti\u1ec3u \u0111\u01b0\u1eddng lo\u1ea1i 2 v\u00e0 c\u00e1c r\u1ed1i lo\u1ea1n kh\u00e1c, gi\u00e1o s\u01b0 Zierath cho bi\u1ebft.<\/p>\n

\u1ea2nh: thestar\u200b<\/em><\/p>\n

M\u1eb7c d\u00f9 autophagy l\u00e0 kh\u00e1i ni\u1ec7m \u0111\u00e3 \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn t\u1eeb h\u01a1n 50 n\u0103m qua, t\u1ea7m quan tr\u1ecdng c\u1ee7a n\u00f3 \u0111\u00e3 kh\u00f4ng \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn su\u1ed1t m\u1ed9t th\u1eddi gian d\u00e0i, cho \u0111\u1ebfn khi Ti\u1ebfn s\u0129 Ohsumi c\u00f4ng b\u1ed1 nghi\u00ean c\u1ee9u c\u1ee7a m\u00ecnh v\u1ec1 ch\u1ee7 \u0111\u1ec1 n\u00e0y n\u0103m 1990. Ti\u1ebfn s\u0129 Ohsumi cho r\u1eb1ng \u00f4ng \u0111\u00e3 t\u1eadp trung nghi\u00ean c\u1ee9u m\u1ed9t ch\u1ee7 \u0111\u1ec1 kh\u00f4ng thu h\u00fat \u0111\u01b0\u1ee3c s\u1ed1 \u0111\u00f4ng c\u00e1c nh\u00e0 khoa h\u1ecdc \u1edf giai \u0111o\u1ea1n ban \u0111\u1ea7u. “Nguy\u00ean t\u1eafc c\u01a1 b\u1ea3n c\u1ee7a t\u00f4i l\u00e0 t\u00f4i mu\u1ed1n th\u1ef1c hi\u1ec7n nh\u1eefng \u0111i\u1ec1u m\u00e0 ng\u01b0\u1eddi kh\u00e1c kh\u00f4ng l\u00e0m\u201d, Ti\u1ebfn s\u0129 Ohsumi chia s\u1ebb v\u1ec1 quan \u0111i\u1ec3m c\u1ee7a m\u00ecnh sau khi gi\u1ea3i th\u01b0\u1edfng \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1.<\/p>\n

Ti\u1ebfn s\u0129 Ohsumi cho bi\u1ebft \u201cautophagy\u201d t\u1eebng l\u00e0 m\u1ed9t ch\u1ee7 \u0111\u1ec1 “kh\u00f4ng nh\u1eadn \u0111\u01b0\u1ee3c nhi\u1ec1u s\u1ef1 ch\u00fa \u00fd” khi \u00f4ng l\u1ea7n \u0111\u1ea7u ti\u00ean t\u00ecm hi\u1ec3u n\u00f3 nhi\u1ec1u th\u1eadp k\u1ef7 tr\u01b0\u1edbc, c\u00f3 l\u1ebd b\u1edfi v\u00ec ch\u1ee9c n\u0103ng x\u1eed l\u00fd “r\u00e1c th\u1ea3i” c\u00e1c t\u1ebf b\u00e0o kh\u00f4ng ph\u1ea3i l\u00e0 qu\u00e1 tr\u00ecnh h\u1ea5p d\u1eabn nh\u01b0 c\u00e1c v\u1ea5n \u0111\u1ec1 kh\u00e1c trong sinh h\u1ecdc. “T\u00e1i ch\u1ebf ch\u1ea5t dinh d\u01b0\u1ee1ng l\u00e0 ch\u1ee9c n\u0103ng c\u01a1 b\u1ea3n nh\u1ea5t c\u1ee7a autophagy\u201d, \u00f4ng n\u00f3i. “Suy tho\u00e1i lu\u00f4n lu\u00f4n x\u1ea3y ra trong c\u01a1 th\u1ec3 ch\u00fang ta. Cu\u1ed9c s\u1ed1ng kh\u00f4ng t\u1ed3n t\u1ea1i m\u00e0 kh\u00f4ng c\u00f3 m\u1ed1i quan h\u1ec7 song song gi\u1eefa suy tho\u00e1i v\u00e0 t\u1ed5ng h\u1ee3p”.<\/p>\n

Trong qu\u00e1 tr\u00ecnh nghi\u00ean c\u1ee9u, Ti\u1ebfn s\u0129 Ohsumi kh\u00f4ng kh\u00e1m ph\u00e1 qu\u00e1 tr\u00ecnh \u201ct\u1ef1 th\u1ef1c\u201d tr\u00ean c\u00e1c t\u1ebf b\u00e0o c\u1ee7a con ng\u01b0\u1eddi. Thay v\u00e0o \u0111\u00f3, h\u00e0ng ng\u00e0n ch\u1ee7ng n\u1ea5m men \u0111\u00e3 \u0111\u01b0\u1ee3c \u00f4ng ph\u00e2n t\u00edch. Th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 nh\u1eefng \u201c\u0111\u1ea1i di\u1ec7n ti\u00eau bi\u1ec3u\u201d cho t\u1ebf b\u00e0o c\u1ee7a con ng\u01b0\u1eddi trong ph\u00f2ng th\u00ed nghi\u1ec7m, c\u00e1c t\u1ebf b\u00e0o n\u1ea5m men v\u1eabn \u0111\u1eb7t ra nh\u1eefng th\u00e1ch th\u1ee9c nh\u1ea5t \u0111\u1ecbnh cho c\u00e1c nh\u00e0 khoa h\u1ecdc b\u1edfi v\u00ec k\u00edch th\u01b0\u1edbc qu\u00e1 nh\u1ecf c\u1ee7a n\u00f3, gi\u00e1o s\u01b0 Zierath nh\u1eadn \u0111\u1ecbnh.<\/p>\n

Ti\u1ebfn s\u0129 Ohsumi v\u00ec th\u1ebf \u0111\u00e3 ph\u1ea3i nu\u00f4i c\u1ea5y n\u1ea5m men \u0111\u1ed9t bi\u1ebfn, sau \u0111\u00f3 t\u00ecm c\u00e1ch \u0111\u1ec3 k\u00edch ho\u1ea1t qu\u00e1 tr\u00ecnh autophagic khi c\u00e1c t\u1ebf b\u00e0o n\u1eb1m d\u01b0\u1edbi k\u00ednh hi\u1ec3n vi c\u1ee7a m\u00ecnh. “\u00d4ng \u0111\u00e3 t\u1ea1o ra m\u1ed9t gi\u1ea3i ph\u00e1p th\u1ef1c s\u1ef1 kh\u00e9o l\u00e9o \u0111\u1ec3 nghi\u00ean c\u1ee9u c\u00e1c t\u1ebf b\u00e0o\u201d, c\u00f4 n\u00f3i.<\/p>\n

Thomas Perlmann – t\u1ed5ng th\u01b0 k\u00fd \u1ee6y ban trao gi\u1ea3 Nobel cho bi\u1ebft \u00f4ng \u0111\u00e3 c\u00f3 c\u01a1 h\u1ed9i n\u00f3i chuy\u1ec7n v\u1edbi Ti\u1ebfn s\u0129 Ohsumi qua \u0111i\u1ec7n tho\u1ea1i v\u00e0 th\u00f4ng b\u00e1o v\u1ec1 gi\u1ea3i th\u01b0\u1edfng. “\u00d4ng \u1ea5y c\u00f3 v\u1ebb ng\u1ea1c nhi\u00ean\u201d. Gi\u00e1o s\u01b0 Perlmann n\u00f3i. “\u0110i\u1ec1u \u0111\u1ea7u ti\u00ean \u00f4ng ta n\u00f3i l\u00e0 ‘Oh!'”<\/p>\n

N\u0103m ngo\u00e1i, gi\u1ea3i Nobel Y h\u1ecdc \u0111\u00e3 \u0111\u01b0\u1ee3c trao cho nh\u1eefng kh\u00e1m ph\u00e1 li\u00ean quan \u0111\u1ebfn li\u1ec7u ph\u00e1p m\u1edbi nh\u1eb1m ch\u1ed1ng l\u1ea1i b\u1ec7nh m\u00f9 s\u00f4ng, giun ch\u1ec9 b\u1ea1ch huy\u1ebft v\u00e0 b\u1ec7nh s\u1ed1t r\u00e9t, nh\u1eefng c\u0103n b\u1ec7nh \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u00e0ng tr\u0103m tri\u1ec7u ng\u01b0\u1eddi m\u1ed7i n\u0103m.<\/p>\n

Tham kh\u1ea3o: WSJ\u200b<\/em><\/strong><\/p>\n

Ngu\u1ed3n tinhte.vn<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Yoshinori Ohsumi – m\u1ed9t nh\u00e0 sinh h\u1ecdc Nh\u1eadt B\u1ea3n v\u1eeba \u0111\u01b0\u1ee3c trao gi\u1ea3i Nobel Sinh l\u00fd h\u1ecdc v\u00e0 Y khoa n\u0103m nay, nh\u1edd c\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u l\u00e0m s\u00e1ng t\u1ecf c\u00e1ch th\u1ee9c c\u00e1c t\u1ebf b\u00e0o c\u1ee7a c\u01a1 th\u1ec3 x\u1eed l\u00fd v\u00e0 t\u00e1i ch\u1ebf ch\u1ea5t th\u1ea3i, m\u1ed9t kh\u00e1m ph\u00e1 c\u00f3 th\u1ec3 s\u1ebd m\u1edf \u0111\u01b0\u1eddng cho nh\u1eefng […]<\/p>\n","protected":false},"author":17,"featured_media":7167,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-5901","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/5901","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=5901"}],"version-history":[{"count":3,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/5901\/revisions"}],"predecessor-version":[{"id":7169,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/5901\/revisions\/7169"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/7167"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=5901"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=5901"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=5901"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}