{"id":4789,"date":"2016-03-03T16:40:02","date_gmt":"2016-03-03T09:40:02","guid":{"rendered":"http:\/\/ttud.com.vn\/?p=4789"},"modified":"2017-10-02T11:46:57","modified_gmt":"2017-10-02T04:46:57","slug":"tien-hanh-thu-nghiem-vaccine-dac-tri-sot-ret-o-nguoi","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/tien-hanh-thu-nghiem-vaccine-dac-tri-sot-ret-o-nguoi\/","title":{"rendered":"Ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m vaccine \u0111\u1eb7c tr\u1ecb s\u1ed1t r\u00e9t \u1edf ng\u01b0\u1eddi"},"content":{"rendered":"

K\u1ebft qu\u1ea3 cho th\u1ea5y vaccine kh\u00f4ng th\u1ec3 ng\u0103n ch\u1eb7n qu\u00e1 tr\u00ecnh l\u00e2y nhi\u1ec5m c\u1ee7a Plasmodium vivax nh\u01b0ng c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m th\u1eddi gian ph\u00e1t tri\u1ec3n b\u1ec7nh 1 c\u00e1ch r\u00f5 r\u1ec7t.<\/strong><\/p>\n

\"\"<\/p>\n

L\u1ea7n \u0111\u1ea7u ti\u00ean trong l\u1ecbch s\u1eed, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m vaccine \u0111\u1eb7c ch\u1ee7ng d\u00e0nh cho c\u0103n b\u1ec7nh s\u1ed1t r\u00e9t tr\u00ean ng\u01b0\u1eddi \u0111\u1ec3 b\u1ea3o v\u1ec7 nh\u00e2n lo\u1ea1i kh\u1ecfi m\u1ed9t trong hai lo\u1ea1i k\u00fd sinh tr\u00f9ng s\u1ed1t r\u00e9t nguy hi\u1ec3m nh\u1ea5t hi\u1ec7n nay l\u00e0 Plasmodium vivax. C\u1ee5 th\u1ec3, c\u00e1c b\u00e1c s\u1ef9 t\u1ea1i trung t\u00e2m nghi\u00ean c\u1ee9u Water Reed (tr\u1ef1c thu\u1ed9c B\u1ed9 qu\u1ed1c ph\u00f2ng M\u1ef9) \u0111\u00e3 ti\u1ebfn h\u00e0nh ti\u00eam 3 li\u1ec1u vaccine cho 30 t\u00ecnh nguy\u1ec7n vi\u00ean, sau \u0111\u00f3 14 ng\u00e0y h\u1ecd s\u1ebd \u0111\u01b0\u1ee3c c\u1eafn b\u1edfi mu\u1ed7i mang theo k\u00fd sinh tr\u00f9ng Plasmodium vivax.<\/p>\n

K\u1ebft qu\u1ea3 cho th\u1ea5y vaccine kh\u00f4ng th\u1ec3 ng\u0103n ch\u1eb7n qu\u00e1 tr\u00ecnh l\u00e2y nhi\u1ec5m c\u1ee7a Plasmodium vivax nh\u01b0ng c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m th\u1eddi gian ph\u00e1t tri\u1ec3n b\u1ec7nh 1 c\u00e1ch r\u00f5 r\u1ec7t. B\u00ean c\u1ea1nh \u0111\u00f3, nh\u1eefng ng\u01b0\u1eddi tham gia th\u1eed nghi\u1ec7m kh\u00f4ng c\u00f3 b\u1ea5t k\u1ef3 bi\u1ec3u hi\u1ec7n c\u1ee7a t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0o nguy hi\u1ec3m ngo\u00e0i \u0111au \u0111\u1ea7u v\u00e0 m\u1ec7t m\u1ecfi. Ngo\u00e0i ra, vi\u1ec7c th\u1eed nghi\u1ec7m c\u0169ng ph\u1ea3i \u0111\u1ed1i m\u1eb7t v\u1edbi 1 kh\u00f3 kh\u0103n nh\u1ea5t \u0111\u1ecbnh \u0111\u00f3 l\u00e0 k\u00fd sinh tr\u00f9ng Plasmodium vivax kh\u00f4ng th\u1ec3 t\u1ea1o ra trong ph\u00f2ng th\u00ed nghi\u1ec7m, n\u00ean c\u00e1c b\u00e1c s\u1ef9 \u0111\u00e3 ph\u1ea3i l\u1ea5y mu\u1ed7i th\u01b0\u1eddng h\u00fat m\u00e1u t\u1eeb m\u1ed9t b\u1ec7nh nh\u00e2n \u0111\u00e3 nhi\u1ec5m Plasmodium vivax tr\u01b0\u1edbc \u0111\u00f3.
\nT\u00e1c gi\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u, trung t\u00e1 Jason W. Bennett, cho bi\u1ebft \u0111\u00e2y l\u00e0 b\u01b0\u1edbc ti\u1ebfn \u0111\u1ea7u ti\u00ean c\u1ee7a gi\u1edbi khoa h\u1ecdc v\u1ec1 v\u1ea5n \u0111\u1ec1 \u0111\u01b0a ra 1 vaccine ki\u1ec3m so\u00e1t t\u00ecnh h\u00ecnh s\u1ed1t r\u00e9t hi\u1ec7n nay. Ngo\u00e0i ra, \u00f4ng Bennett c\u0169ng n\u00f3i th\u00eam r\u1eb1ng m\u00ecnh c\u00f9ng c\u00e1c \u0111\u1ed3ng nghi\u1ec7p \u0111\u00e3 ph\u00e1t hi\u1ec7n ra m\u1ed9t 1 b\u1ea5t ng\u1edd v\u1ec1 l\u00fd do v\u00ec sao lo\u1ea1i thu\u1ed1c duy nh\u1ea5t \u0111\u01b0\u1ee3c C\u01a1 quan qu\u1ea3n l\u00fd D\u01b0\u1ee3c ph\u1ea9m v\u00e0 Th\u1ef1c ph\u1ea9m H\u00f2a k\u1ef3 (FDA) c\u00f3 kh\u1ea3 n\u0103ng \u0111i\u1ec1u tr\u1ecb \u0111\u1ed1i v\u1edbi Plasmodium vivax trong giai \u0111o\u1ea1n \u1ee7 b\u1ec7nh l\u00e0 primaquine l\u1ea1i kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1ed1i v\u1edbi nhi\u1ec1u ng\u01b0\u1eddi khi\u1ebfn cho n\u00f3 kh\u00f4ng ph\u1ea3i l\u00e0 d\u01b0\u1ee3c ph\u1ea9m ch\u1ee7 \u0111\u1ea1o trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb s\u1ed1t r\u00e9t.<\/p>\n

C\u1ee5 th\u1ec3, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 kh\u1eb3ng \u0111\u1ecbnh r\u1eb1ng nh\u1eefng ng\u01b0\u1eddi c\u00f3 n\u1ed3ng d\u1ed9 enzyme 2D6 (CYP2D6) trong gan do nh\u1eefng l\u00fd do di truy\u1ec1n s\u1ebd kh\u00f4ng th\u1ec3 chuy\u1ec3n \u0111\u1ed5i primaquine th\u00e0nh nh\u1eefng kh\u00e1ng th\u1ec3 \u0111\u1ec3 ti\u00eau di\u1ec7t k\u00fd sinh tr\u00f9ng b\u00ean trong c\u01a1 th\u1ec3 ng\u01b0\u1eddi. Ch\u00ednh v\u00ec th\u1ebf, trung t\u00e1 Bennett \u0111\u00e3 g\u1ee3i \u00fd v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng k\u1ef9 thu\u1eadt ch\u1ec9nh s\u1eeda gen CRISPR \u0111\u1ec3 h\u1ea1n ch\u1ebf nh\u01b0\u1ee3c \u0111i\u1ec3m n\u00e0y c\u1ee7a thu\u1ed1c primaquine b\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh l\u01b0\u1ee3ng enzyme 2D6 \u1edf trong gan. \u00d4ng hy v\u1ecdng c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng \u0111i\u1ec1u tr\u1ecb c\u1ee7a primaquine s\u1ebd \u0111\u01b0a ra nhi\u1ec1u l\u1ef1a ch\u1ecdn cho b\u1ec7nh nh\u00e2n b\u00ean c\u1ea1nh c\u00e1c ch\u1ee7ng vaccine trong t\u01b0\u01a1ng lai.<\/p>\n

M\u1eb7c d\u00f9 k\u1ebft qu\u1ea3 th\u1eed nghi\u1ec7m l\u1ea7n n\u00e0y ch\u1ec9 m\u1edbi d\u1eebng l\u1ea1i \u1edf vi\u1ec7c h\u1ea1n ch\u1ebf t\u1ed1c \u0111\u1ed9 ph\u00e1t tri\u1ec3n c\u1ee7a b\u1ec7nh, c\u00e1c chuy\u00ean gia y t\u1ebf \u0111\u00e3 l\u00ean ti\u1ebfng ch\u00fac m\u1eebng \u0111\u1ed9i ng\u0169 nghi\u00ean c\u1ee9u c\u1ee7a trung t\u00e1 Bennett v\u00e0 h\u1ecd c\u0169ng nh\u1eadn \u0111\u1ecbnh r\u1eb1ng \u0111\u00e2y s\u1ebd l\u00e0 c\u01a1 s\u1edf \u0111\u1ec3 gi\u1edbi khoa h\u1ecdc ph\u00e1t tri\u1ec3n m\u1ed9t lo\u1ea1i vaccine ho\u00e0n thi\u1ec7n h\u01a1n trong t\u01b0\u01a1ng lai.
\nS\u1ed1t r\u00e9t l\u00e0 m\u1ed9t trong nh\u1eefng b\u1ec7nh truy\u1ec1n nhi\u1ec5m ph\u1ed5 bi\u1ebfn nh\u1ea5t v\u00e0 l\u00e0 v\u1ea5n \u0111\u1ec1 r\u1ea5t nghi\u00eam tr\u1ecdng \u0111\u1ed1i v\u1edbi s\u1ee9c kho\u1ebb c\u1ed9ng \u0111\u1ed3ng. B\u1ec7nh g\u00e2y ra b\u1edfi k\u00fd sinh tr\u00f9ng protozoa thu\u1ed9c chi Plasmodium. Chi n\u00e0y c\u00f3 b\u1ed1n lo\u00e0i l\u00e0m con ng\u01b0\u1eddi nhi\u1ec5m b\u1ec7nh. Nguy hi\u1ec3m h\u01a1n c\u1ea3 l\u00e0 Plasmodium falciparum v\u00e0 Plasmodium vivax. Hai lo\u00e0i c\u00f2n l\u1ea1i (Plasmodium ovale, Plasmodium malariae) c\u0169ng g\u00e2y b\u1ec7nh nh\u01b0ng \u00edt t\u1eed vong h\u01a1n. Nh\u00f3m c\u00e1c lo\u00e0i Plasmodium g\u00e2y b\u1ec7nh \u1edf ng\u01b0\u1eddi th\u01b0\u1eddng \u0111\u01b0\u1ee3c g\u1ecdi chung l\u00e0 k\u00fd sinh tr\u00f9ng s\u1ed1t r\u00e9t. Ri\u00eang lo\u00e0i P. knowlesi, ph\u1ed5 bi\u1ebfn \u1edf \u0110\u00f4ng Nam \u00c1, g\u00e2y b\u1ec7nh s\u1ed1t r\u00e9t \u1edf kh\u1ec9 nh\u01b0ng c\u0169ng c\u00f3 th\u1ec3 g\u00e2y nhi\u1ec5m tr\u00f9ng n\u1eb7ng \u1edf ng\u01b0\u1eddi<\/p>\n

S\u1ed1t r\u00e9t l\u00e2y truy\u1ec1n t\u1eeb ng\u01b0\u1eddi n\u00e0y sang ng\u01b0\u1eddi kh\u00e1c khi nh\u1eefng ng\u01b0\u1eddi n\u00e0y b\u1ecb mu\u1ed7i \u0111\u1ed1t. B\u1ec7nh ph\u1ed5 bi\u1ebfn \u1edf c\u00e1c khu v\u1ef1c nhi\u1ec7t \u0111\u1edbi v\u00e0 c\u1eadn nhi\u1ec7t \u0111\u1edbi c\u1ee7a ch\u00e2u M\u1ef9, ch\u00e2u \u00c1 v\u00e0 ch\u00e2u Phi. M\u1ed7i n\u0103m c\u00f3 kho\u1ea3ng 515 tri\u1ec7u ng\u01b0\u1eddi m\u1eafc b\u1ec7nh, t\u1eeb 1 \u0111\u1ebfn 3 tri\u1ec7u ng\u01b0\u1eddi t\u1eed vong – \u0111a s\u1ed1 l\u00e0 tr\u1ebb em \u1edf khu v\u1ef1c ph\u00eda nam sa m\u1ea1c Sahara, ch\u00e2u Phi. 90% s\u1ed1 ca t\u1eed vong x\u1ea3y ra t\u1ea1i \u0111\u00e2y.S\u1ed1t r\u00e9t th\u01b0\u1eddng \u0111i k\u00e8m v\u1edbi \u0111\u00f3i ngh\u00e8o, l\u1ea1c h\u1eadu v\u00e0 l\u00e0 m\u1ed9t c\u1ea3n tr\u1edf l\u1edbn \u0111\u1ed1i v\u1edbi ph\u00e1t tri\u1ec3n kinh t\u1ebf.<\/p>\n

Tham kh\u1ea3o Iflscience<\/em><\/p>\n

Tham kh\u1ea3o Iflscience<\/em>
\n http:\/\/genk.vn<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

K\u1ebft qu\u1ea3 cho th\u1ea5y vaccine kh\u00f4ng th\u1ec3 ng\u0103n ch\u1eb7n qu\u00e1 tr\u00ecnh l\u00e2y nhi\u1ec5m c\u1ee7a Plasmodium vivax nh\u01b0ng c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m th\u1eddi gian ph\u00e1t tri\u1ec3n b\u1ec7nh 1 c\u00e1ch r\u00f5 r\u1ec7t. L\u1ea7n \u0111\u1ea7u ti\u00ean trong l\u1ecbch s\u1eed, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m vaccine \u0111\u1eb7c ch\u1ee7ng d\u00e0nh cho c\u0103n b\u1ec7nh s\u1ed1t r\u00e9t tr\u00ean […]<\/p>\n","protected":false},"author":17,"featured_media":5323,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-4789","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/4789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=4789"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/4789\/revisions"}],"predecessor-version":[{"id":5324,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/4789\/revisions\/5324"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/5323"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=4789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=4789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=4789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}