{"id":4771,"date":"2016-02-22T16:27:11","date_gmt":"2016-02-22T09:27:11","guid":{"rendered":"http:\/\/ttud.com.vn\/?p=4771"},"modified":"2017-10-02T11:40:11","modified_gmt":"2017-10-02T04:40:11","slug":"benh-alzheimer-co-the-duoc-phat-hien-20-nam-truoc-khi-bieu-hien-dau-tien-xuat-hien","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/benh-alzheimer-co-the-duoc-phat-hien-20-nam-truoc-khi-bieu-hien-dau-tien-xuat-hien\/","title":{"rendered":"B\u1ec6NH ALZHEIMER C\u00d3 TH\u1ec2 \u0110\u01af\u1ee2C PH\u00c1T HI\u1ec6N 20 N\u0102M TR\u01af\u1edaC KHI BI\u1ec2U HI\u1ec6N \u0110\u1ea6U TI\u00caN XU\u1ea4T HI\u1ec6N"},"content":{"rendered":"

C\u00e1c nh\u00e0 khoa h\u1ecdc tin r\u1eb1ng vi\u1ec7c ph\u00e1t hi\u1ec7n ra c\u00e1c d\u1ea5u hi\u1ec7u s\u1edbm nh\u1ea5t c\u1ee7a c\u0103n b\u1ec7nh Alzheimer c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn nh\u1eefng li\u1ec7u ph\u00e1p m\u1edbi \u0111\u1ec3 ng\u0103n ch\u1eb7n s\u1ef1 kh\u1edfi ph\u00e1t c\u1ee7a ch\u1ee9ng m\u1ea5t tr\u00ed nh\u1edb.<\/strong><\/p>\n

Nh\u1eefng thay \u0111\u1ed5i trong b\u1ed9 n\u00e3o c\u00f3 th\u1ec3 cho th\u1ea5y m\u1ed9t d\u1ea5u hi\u1ec7u ban \u0111\u1ea7u r\u1eb1ng b\u1ec7nh Alzheimer s\u1ebd ph\u00e1t tri\u1ec3n<\/em><\/p>\n

\"\"<\/p>\n

Photo: ALAMY<\/em><\/p>\n

C\u00e1c nh\u00e0 khoa h\u1ecdc t\u00ecm ra r\u1eb1ng b\u1ec7nh Alzheimer tr\u00ean ng\u01b0\u1eddi c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n ra hai m\u01b0\u01a1i n\u0103m tr\u01b0\u1edbc khi tri\u1ec7u ch\u1ee9ng \u0111\u1ea7u ti\u00ean c\u1ee7a c\u0103n b\u1ec7nh xu\u1ea5t hi\u1ec7n.<\/p>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u1edf Vi\u1ec7n Karolinska c\u1ee7a Th\u1ee5y \u0110i\u1ec3n v\u00e0 tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Uppsala \u0111\u00e3 kh\u00e1m ph\u00e1 ra r\u1eb1ng t\u00ecnh tr\u1ea1ng vi\u00eam x\u1ea3y ra trong b\u1ed9 n\u00e3o v\u00e0i ch\u1ee5c n\u0103m tr\u01b0\u1edbc khi b\u1ec7nh tr\u1ea1ng bi\u1ec3u hi\u1ec7n nh\u1eefng d\u1ea5u hi\u1ec7u kh\u00e1c.<\/p>\n

\u0110i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a l\u00e0 trong t\u01b0\u01a1ng lai c\u00e1c b\u00e1c s\u0129 c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n ng\u01b0\u1eddi n\u00e0o s\u1ebd ph\u1ea3i \u0111\u1ed1i m\u1eb7t v\u1edbi c\u0103n b\u1ec7nh Alzheimer khi v\u1eabn c\u00f2n th\u1eddi gian \u0111\u1ec3 thay \u0111\u1ed5i l\u1ed1i s\u1ed1ng ho\u1eb7c d\u00f9ng thu\u1ed1c \u0111\u1ec3 l\u00e0m ch\u1eadm s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a b\u1ec7nh tr\u1ea1ng.<\/p>\n

C\u00e1c ph\u01b0\u01a1ng ph\u00e1p ch\u1eefa tr\u1ecb nh\u1eb1m ki\u1ec1m h\u00e3m ch\u1ee9ng m\u1ea5t tr\u00ed hi\u1ec7n \u0111ang tr\u1ea3i qua giai \u0111o\u1ea1n th\u1eed nghi\u1ec7m v\u00e0 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong v\u00e0i n\u0103m t\u1edbi. Do \u0111\u00f3, c\u00e1c ki\u1ec3m tra \u0111\u1ec3 ph\u00e1t hi\u1ec7n s\u1edbm c\u0103n b\u1ec7nh c\u00f3 th\u1ec3 s\u1ebd r\u1ea5t quan tr\u1ecdng trong ng\u00e0nh ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe \u1edf t\u01b0\u01a1ng lai.<\/p>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 theo d\u00f5i c\u00e1c gia \u0111\u00ecnh \u0111\u01b0\u1ee3c bi\u1ebft r\u00f5 l\u00e0 c\u00f3 mang gen l\u00e0m h\u1ecd d\u1ec5 m\u1eafc b\u1ec7nh Alzheimer h\u01a1n. H\u1ea7u h\u1ebft ng\u01b0\u1eddi trong s\u1ed1 h\u1ecd s\u1ebd ph\u00e1t tri\u1ec3n c\u0103n b\u1ec7nh v\u00e0o gi\u1eefa nh\u1eefng n\u0103m c\u1ee7a \u0111\u1ed9 tu\u1ed5i 50.<\/p>\n

T\u1ea5t c\u1ea3 c\u00e1c ng\u01b0\u1eddi tham gia tr\u1ea3i qua c\u00e1c cu\u1ed9c ki\u1ec3m tra tr\u00ed nh\u1edb v\u00e0 qu\u00e9t n\u00e3o b\u1ed9.<\/p>\n

Nh\u1eefng ng\u01b0\u1eddi mang \u0111\u1ed9t bi\u1ebfn \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n c\u00f3 nh\u1eefng bi\u1ebfn \u0111\u1ed5i vi\u00eam \u2013s\u1ef1 ho\u1ea1t h\u00f3a t\u1ebf b\u00e0o h\u00ecnh sao (astrocyte) \u2013 g\u1ea7n hai m\u01b0\u01a1i n\u0103m tr\u01b0\u1edbc khi c\u00f3 c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 tr\u00ed nh\u1edb. T\u1ebf b\u00e0o h\u00ecnh sao l\u00e0 m\u1ed9t d\u1ea1ng t\u1ebf b\u00e0o n\u00e3o, gia t\u0103ng s\u1ed1 l\u01b0\u1ee3ng sau ch\u1ea5n th\u01b0\u01a1ng \u0111\u1ec3 h\u1ed7 tr\u1ee3 vi\u1ec7c s\u1eeda ch\u1eefa th\u01b0\u01a1ng t\u1ed5n.<\/p>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u0169ng t\u00ecm th\u1ea5y m\u1ed9t \u0111\u1ea7u m\u1ed1i quan tr\u1ecdng, quanh m\u1ed1c th\u1eddi gian m\u01b0\u1eddi b\u1ea3y n\u0103m tr\u01b0\u1edbc khi c\u00e1c tri\u1ec7u ch\u1ee9ng ph\u00e1t tri\u1ec3n, khi m\u00e0 c\u00e1c m\u1ea3ng b\u00e1m amyloid g\u00e2y ch\u1ee9ng m\u1ea5t tr\u00ed b\u1eaft \u0111\u1ea7u gia t\u0103ng.<\/p>\n

\u201cC\u00e1c bi\u1ebfn \u0111\u1ed5i vi\u00eam d\u01b0\u1edbi d\u1ea1ng h\u00ecnh th\u00e0nh t\u1ebf b\u00e0o n\u00e3o h\u00ecnh sao \u1edf m\u1ee9c \u0111\u1ed9 cao \u0111\u01b0\u1ee3c cho l\u00e0 d\u1ea5u hi\u1ec7u r\u1ea5t s\u1edbm c\u1ee7a vi\u1ec7c kh\u1edfi ph\u00e1t b\u1ec7nh\u201d, Nh\u00e0 nghi\u00ean c\u1ee9u ch\u00ednh, Gi\u00e1o s\u01b0 Agneta Nordberg c\u1ee7a Khoa Sinh h\u1ecdc Th\u1ea7n kinh, Khoa h\u1ecdc Ch\u0103m s\u00f3c v\u00e0 C\u1ed9ng \u0111\u1ed3ng, Trung t\u00e2m Nghi\u00ean c\u1ee9u Alzheimer \u1edf Vi\u1ec7n Karolinska gi\u1ea3i th\u00edch.<\/p>\n

\u201cS\u1ef1 ho\u1ea1t h\u00f3a t\u1ebf b\u00e0o h\u00ecnh sao \u0111\u1ea1t \u0111\u1ec9nh \u0111i\u1ec3m kho\u1ea3ng hai m\u01b0\u01a1i n\u0103m tr\u01b0\u1edbc khi c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng v\u00e0 sau \u0111\u00f3 suy gi\u1ea3m; tr\u00e1i ng\u01b0\u1ee3c l\u1ea1i v\u1edbi qu\u00e1 tr\u00ecnh t\u00edch t\u1ee5 c\u00e1c m\u1ea3ng b\u00e1m amyloid, qu\u00e1 tr\u00ecnh n\u00e0y kh\u00f4ng ng\u1eebng t\u0103ng theo th\u1eddi gian cho \u0111\u1ebfn khi c\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng bi\u1ec3u hi\u1ec7n.\u201d<\/p>\n

Hi\u1ec7n nay, c\u00f3 kho\u1ea3ng 850.000 ng\u01b0\u1eddi \u0111ang ph\u1ea3i s\u1ed1ng v\u1edbi ch\u1ee9ng m\u1ea5t tr\u00ed nh\u1edb \u1edf n\u01b0\u1edbc Anh, h\u1ea7u h\u1ebft h\u1ecd m\u1eafc c\u0103n b\u1ec7nh Alzheimer. Con s\u1ed1 \u0111\u00f3 \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f2n t\u0103ng l\u00ean \u0111\u1ebfn m\u1ed9t tri\u1ec7u ng\u01b0\u1eddi v\u00e0o n\u0103m 2020 v\u00e0 hai tri\u1ec7u ng\u01b0\u1eddi v\u00e0o n\u0103m 2050.<\/p>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u n\u00f3i r\u1eb1ng vi\u1ec7c nh\u1eafm m\u1ee5c ti\u00eau v\u00e0o nguy\u00ean nh\u00e2n ban \u0111\u1ea7u c\u1ee7a s\u1ef1 vi\u00eam c\u00f3 th\u1ec3 ng\u0103n c\u00e1c m\u1ea3ng b\u00e1mamyloid h\u00ecnh th\u00e0nh.<\/p>\n

\u201cT\u00ednh \u0111\u1ebfn h\u00f4m nay, kh\u00f4ng c\u00f3 ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb n\u00e0o th\u00e0nh c\u00f4ng trong vi\u1ec7c thay \u0111\u1ed5i ti\u1ebfn tr\u00ecnh c\u1ee7a c\u0103n b\u1ec7nh,\u201d v\u1ecb t\u00e1c gi\u1ea3 \u0111\u1ea7u ti\u00ean Ti\u1ebfn s\u0129 Elena Rodriguez-Vieitez cho bi\u1ebft.<\/p>\n

\u201cC\u00e1c li\u1ec7u ph\u00e1p hi\u1ec7n nay ch\u1ec9 l\u00e0 ch\u1eefa tri\u1ec7u ch\u1ee9ng, ngh\u0129a l\u00e0, ch\u00fang gi\u1ea3m nh\u1eb9 c\u00e1c tri\u1ec7u ch\u1ee9ng ch\u1ee9 kh\u00f4ng thay \u0111\u1ed5i di\u1ec5n ti\u1ebfn c\u1ee7a b\u1ec7nh. V\u00ec th\u1ebf, m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p ch\u1ea9n \u0111o\u00e1n s\u1edbm hi\u1ec7n nay v\u1eabn ch\u01b0a th\u1ec3 ng\u0103n ch\u1eb7n ch\u1ee9ng m\u1ea5t tr\u00ed n\u1ebfu s\u1eed d\u1ee5ng chung v\u1edbi nh\u1eefng lo\u1ea1i thu\u1ed1c hi\u1ec7n c\u00f3.<\/p>\n

Nghi\u00ean c\u1ee9u c\u1ee7a ch\u00fang t\u00f4i nh\u1eb1m m\u1ee5c \u0111\u00edch ch\u00ednh l\u00e0 hi\u1ec3u r\u00f5 l\u00e0 c\u00e1c giai \u0111o\u1ea1n s\u1edbm nh\u1ea5t c\u1ee7a b\u1ec7nh. C\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng nh\u1eb1m lo\u1ea1i b\u1ecf c\u00e1c m\u1ea3ng b\u00e1m amyloid ch\u01b0a th\u00e0nh c\u00f4ng trong ch\u1eefa tr\u1ecb c\u0103n b\u1ec7nh, v\u00e0 v\u00ec th\u1ebf c\u1ea7n t\u00ecm ra m\u1ee5c ti\u00eau tr\u1ecb li\u1ec7u m\u1edbi.\u201d<\/p>\n

Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed Brain.<\/p>\n

\u0110\u00e2y nh\u01b0 l\u00e0 m\u1ed9t nghi\u00ean c\u1ee9u th\u1ee9 hai nh\u1eb1m kh\u1eb3ng \u0111\u1ecbnh kh\u1ea3 n\u0103ng b\u1ec7nh Alzheimer c\u00f3 th\u1ec3 truy\u1ec1n t\u1eeb ng\u01b0\u1eddi sang ng\u01b0\u1eddi.<\/p>\n

V\u00e0o th\u00e1ng 9\/2015, m\u1ed9t nghi\u00ean c\u1ee9u mang t\u00ednh b\u01b0\u1edbc ngo\u1eb7t c\u1ee7a nh\u00f3m c\u00e1c nh\u00e0 khoa h\u1ecdc \u1edf \u0110\u1ea1i h\u1ecdc Lu\u00e2n \u0110\u00f4n (University College London) ph\u00e1t hi\u1ec7n ra r\u1eb1ng b\u1ec7nh Alzheimer c\u00f3 th\u1ec3 l\u00e2y truy\u1ec1n qua truy\u1ec1n m\u00e1u v\u00e0 c\u00e1c tai n\u1ea1n y t\u1ebf gi\u1ed1ng nh\u01b0 c\u00e1ch l\u00e2y truy\u1ec1n c\u1ee7a b\u1ec7nh Creutzfeldt Jakob (CJD).<\/p>\n

M\u1ed9t nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u2013 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean Swiss Medical Weekly \u2013 b\u1edfi c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u1edf Th\u1ee5y \u0110i\u1ec3n v\u00e0 \u00c1o \u0111\u00e3 b\u00e1o c\u00e1o k\u1ebft qu\u1ea3 kh\u00e1m nghi\u1ec7m t\u1eed thi cho th\u1ea5y b\u1ec7nh Alzheimer th\u1ec9nh tho\u1ea3ng c\u00f3 th\u1ec3 l\u00e2y truy\u1ec1n sang ng\u01b0\u1eddi trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb n\u00e0o \u0111\u00f3.<\/p>\n

Nguy\u1ec5n Ng\u1ecdc Thanh (d\u1ecbch)<\/em>
\n The Telegraphhttp: \/\/www.telegraph.co.uk<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

C\u00e1c nh\u00e0 khoa h\u1ecdc tin r\u1eb1ng vi\u1ec7c ph\u00e1t hi\u1ec7n ra c\u00e1c d\u1ea5u hi\u1ec7u s\u1edbm nh\u1ea5t c\u1ee7a c\u0103n b\u1ec7nh Alzheimer c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn nh\u1eefng li\u1ec7u ph\u00e1p m\u1edbi \u0111\u1ec3 ng\u0103n ch\u1eb7n s\u1ef1 kh\u1edfi ph\u00e1t c\u1ee7a ch\u1ee9ng m\u1ea5t tr\u00ed nh\u1edb. Nh\u1eefng thay \u0111\u1ed5i trong b\u1ed9 n\u00e3o c\u00f3 th\u1ec3 cho th\u1ea5y m\u1ed9t d\u1ea5u hi\u1ec7u ban \u0111\u1ea7u r\u1eb1ng b\u1ec7nh […]<\/p>\n","protected":false},"author":17,"featured_media":5300,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-4771","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/4771","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=4771"}],"version-history":[{"count":3,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/4771\/revisions"}],"predecessor-version":[{"id":5301,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/4771\/revisions\/5301"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/5300"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=4771"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=4771"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=4771"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}