{"id":4663,"date":"2015-12-23T14:26:14","date_gmt":"2015-12-23T07:26:14","guid":{"rendered":"http:\/\/ttud.com.vn\/?p=4663"},"modified":"2017-10-02T10:03:21","modified_gmt":"2017-10-02T03:03:21","slug":"phat-hien-ra-4-gen-giup-con-nguoi-song-tho-tren-100-tuoi","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/phat-hien-ra-4-gen-giup-con-nguoi-song-tho-tren-100-tuoi\/","title":{"rendered":"Ph\u00e1t hi\u1ec7n ra 4 gen gi\u00fap con ng\u01b0\u1eddi s\u1ed1ng th\u1ecd tr\u00ean 100 tu\u1ed5i"},"content":{"rendered":"<p><strong>ABO, CDKN2B, APOE v\u00e0 SH2B3 l\u00e0 4 gen m\u00e0 n\u1ebfu \u0111\u01b0\u1ee3c s\u1edf h\u1eefu, b\u1ea1n c\u00f3 th\u1ec3 \u0111\u1ea1t tu\u1ed5i th\u1ecd ngo\u00e0i 100 tu\u1ed5i. \u0110\u00f3 l\u00e0 k\u1ebft lu\u1eadn c\u1ee7a c\u00e1c nh\u00e0 khoa h\u1ecdc theo nghi\u00ean c\u1ee9u m\u1edbi nh\u1ea5t v\u1ec1 m\u1ed1i t\u01b0\u01a1ng quan gi\u1eefa m\u1ed9t s\u1ed1 y\u1ebfu t\u1ed1 di truy\u1ec1n nh\u1ea5t \u0111\u1ecbnh \u0111\u1ed1i v\u1edbi tu\u1ed5i th\u1ecd con ng\u01b0\u1eddi.<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-5137\" src=\"http:\/\/ttud.com.vn\/wp-content\/uploads\/2015\/12\/23122015104155-duytran3576134_cv_keo_dai_tuoi_tho_tinhte.jpg\" alt=\"\" width=\"282\" height=\"187\" \/><\/p>\n<p>B\u1eb1ng c\u00e1ch ti\u1ebfp c\u1eadn ho\u00e0n to\u00e0n m\u1edbi, nh\u00f3m c\u00e1c nh\u00e0 khoa h\u1ecdc d\u1eabn \u0111\u1ea7u b\u1edfi gi\u00e1o s\u01b0 Stuart Kim t\u1ea1i Vi\u1ec7n nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n c\u00f4ng ngh\u1ec7 sinh h\u1ecdc &#8211; di truy\u1ec1n thu\u1ed9c \u0110\u1ea1i h\u1ecdc Standford \u0111\u00e3 ph\u00e1t hi\u1ec7n ra m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa 4 gen quy \u0111\u1ecbnh tu\u1ed5i th\u1ecd r\u1ea5t d\u00e0i. 4 gen \u0111\u00f3 l\u00e0:<\/p>\n<ul>\n<li>ABO: quy \u0111\u1ecbnh nh\u00f3m m\u00e1u<\/li>\n<li>CDKN2B: gi\u00fap \u0111i\u1ec1u ch\u1ec9nh v\u00f2ng \u0111\u1eddi c\u1ee7a m\u1ea1ng t\u1ebf b\u00e0o<\/li>\n<li>SH2B3: gen \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 gi\u00fap k\u00e9o d\u00e0i v\u00f2ng \u0111\u1eddi c\u1ee7a ru\u1ed3i gi\u1ea5m<\/li>\n<li>APOE: m\u1ed9t trong s\u1ed1 HLA gen, c\u00f3 li\u00ean quan t\u1edbi qu\u00e1 tr\u00ecnh h\u1ec7 mi\u1ec5n d\u1ecbch nh\u1eadn bi\u1ebft c\u00e1c t\u1ebf b\u00e0o trong c\u01a1 th\u1ec3<\/li>\n<\/ul>\n<p>Gi\u00e1o s\u01b0 Kim cho bi\u1ebft: <em>&#8220;C\u00f3 nhi\u1ec1u th\u00e0nh ph\u1ea7n di truy\u1ec1n g\u00f3p ph\u1ea7n t\u1ea1o n\u00ean s\u1ef1 s\u1ed1ng l\u00e2u tr\u0103m tu\u1ed5i v\u00e0 ch\u00fang t\u00f4i mu\u1ed1n x\u00e1c \u0111\u1ecbnh r\u00f5 n\u00f3 l\u00e0 g\u00ec. Ch\u00fang t\u00f4i \u0111ang b\u1eaft \u0111\u1ea7u l\u00e0m s\u00e1ng t\u1ecf nh\u1eefng b\u00ed \u1ea9n \u0111\u1eb1ng sau c\u00e1c nh\u00e2n t\u1ed1 di truy\u1ec1n \u0111\u00f3.&#8221;<\/em> C\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y \u0111\u00e3 c\u1ed1 g\u1eafng x\u00e1c \u0111\u1ecbnh nh\u1eefng gen \u0111\u1ed9t bi\u1ebfn xu\u1ea5t hi\u1ec7n \u1edf nh\u1eefng ng\u01b0\u1eddi r\u1ea5t gi\u00e0 so v\u1edbi nh\u1eefng ng\u01b0\u1eddi tr\u1ebb nh\u01b0ng h\u1ecd v\u1eabn ch\u01b0a c\u00f3 nhi\u1ec1u kh\u00e1m ph\u00e1 h\u1eefu d\u1ee5ng. Nguy\u00ean nh\u00e2n l\u00e0 do c\u00e1c nghi\u00ean c\u1ee9u d\u1ea1ng n\u00e0y \u0111\u1ec1u kh\u1ea3o s\u00e1t qua h\u00e0ng tri\u1ec7u bi\u1ebfn th\u1ec3 trong b\u1ed9 gen ng\u01b0\u1eddi nh\u01b0ng c\u00f3 th\u1ec3, h\u1ecd \u0111\u00e3 b\u1ecf qua m\u1ed9t s\u1ed1 gen quan tr\u1ecdng c\u00f3 li\u00ean quan.<\/p>\n<p>Trong nghi\u00ean c\u1ee9u m\u1edbi n\u00e0y, gi\u00e1o s\u01b0 Kim mu\u1ed1n thu h\u1eb9p ph\u1ea1m vi t\u00ecm ki\u1ebfm c\u00e1c gen c\u00f3 li\u00ean quan t\u1edbi k\u00e9o d\u00e0i tu\u1ed5i th\u1ecd b\u1eb1ng c\u00e1ch t\u1eadp trung v\u00e0o nh\u1eefng ng\u01b0\u1eddi c\u00f3 nguy c\u01a1 cao m\u1eafc c\u00e1c b\u1ec7nh do l\u00e3o h\u00f3a nh\u01b0 b\u1ec7nh tim m\u1ea1ch, Alzheimer,&#8230; Theo c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u, ng\u01b0\u1eddi ta th\u01b0\u1eddng ngh\u0129 r\u1eb1ng nh\u1eefng c\u0103n b\u1ec7nh n\u00e0y s\u1ebd t\u0103ng nguy c\u01a1 t\u1eed vong s\u1edbm \u1edf nh\u1eefng ng\u01b0\u1eddi m\u1eafc v\u00e0 do \u0111\u00f3, t\u1ef7 l\u1ec7 xu\u1ea5t hi\u1ec7n c\u1ee7a c\u00e1c \u0111\u1ed9t bi\u1ebfn n\u00e0y s\u1ebd gi\u1ea3m c\u01a1 h\u1ed9i s\u1ed1ng th\u1ecd c\u1ee7a ng\u01b0\u1eddi \u0111\u00f3.<\/p>\n<p>\u0110\u1ea7u ti\u00ean, nh\u00f3m nghi\u00ean c\u1ee9u t\u00ecm ki\u1ebfm nh\u1eefng gen c\u00f3 li\u00ean quan t\u1edbi vi\u1ec7c s\u1ed1ng th\u1ecd trong nh\u00f3m 800 ng\u01b0\u1eddi c\u00f3 \u0111\u1ed9 tu\u1ed5i tr\u00ean 100 v\u00e0 5400 ng\u01b0\u1eddi t\u1eeb 90 tu\u1ed5i tr\u1edf l\u00ean. H\u1ecd ph\u00e1t hi\u1ec7n ra 8 gen c\u00f3 li\u00ean quan t\u1edbi tu\u1ed5i th\u1ecd d\u00e0i v\u00e0 cu\u1ed1i c\u00f9ng, x\u00e1c \u0111\u1ecbnh ra 4 gen \u0111\u1ec3 theo d\u00f5i ph\u00e2n t\u00edch trong s\u1ed1 1000 ng\u01b0\u1eddi. C\u1ee5 th\u1ec3, t\u1ef7 l\u1ec7 xu\u1ea5t hi\u1ec7n \u0111\u1ed9t bi\u1ebfn c\u1ee7a 4 gen l\u00e0 ABO, CDKN2B, APOE v\u00e0 SH2B3 \u1edf nh\u1eefng ng\u01b0\u1eddi tr\u00ean 100 tu\u1ed5i l\u00e0 cao h\u01a1n so v\u1edbi ng\u01b0\u1eddi c\u00f3 tu\u1ed5i th\u1ecd b\u00ecnh th\u01b0\u1eddng (ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh \u1edf M\u1ef9 c\u00f3 tu\u1ed5i th\u1ecd trung b\u00ecnh l\u00e0 kho\u1ea3ng 79 n\u0103m theo s\u1ed1 li\u1ec7u c\u1ee7a Trung t\u00e2m ki\u1ec3m so\u00e1t v\u00e0 ng\u0103n ng\u1eeba d\u1ecbch b\u1ec7nh Hoa K\u1ef3).<\/p>\n<p>Th\u00ed d\u1ee5 nh\u01b0 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n r\u1eb1ng \u0111\u1ed9t bi\u1ebfn c\u1ee7a gen c\u00f3 li\u00ean quan t\u1edbi nh\u00f3m m\u00e1u O xu\u1ea5t hi\u1ec7n ph\u1ed5 bi\u1ebfn \u1edf nh\u1eefng ng\u01b0\u1eddi tr\u00ean 100 tu\u1ed5i trong nghi\u00ean c\u1ee9u v\u00e0 \u0111i\u1ec1u \u0111\u00f3 c\u00f3 ngh\u0129a l\u00e0 ng\u01b0\u1eddi tr\u00ean 100 tu\u1ed5i s\u1ebd c\u00f3 t\u1ef7 l\u1ec7 s\u1edf h\u1eefu nh\u00f3m m\u00e1u O cao h\u01a1n ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng. C\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y c\u0169ng \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng nh\u1eefng ng\u01b0\u1eddi c\u00f3 nh\u00f3m m\u00e1u O s\u1ebd \u00edt c\u00f3 nguy c\u01a1 m\u1eafc b\u1ec7nh tim m\u1ea1ch v\u00e0 ung th\u01b0, c\u00f3 m\u1ee9c cholesterol th\u1ea5p h\u01a1n so v\u1edbi ng\u01b0\u1eddi c\u00f3 nh\u00f3m m\u00e1u kh\u00e1c.<\/p>\n<p>M\u1ed9t d\u1ea1ng bi\u1ebfn th\u1ec3 di truy\u1ec1n kh\u00e1c trong gen CDKN2B v\u1ed1n quy \u0111\u1ecbnh qu\u00e1 tr\u00ecnh t\u1ebf b\u00e0o ph\u00e2n chia ho\u1eb7c ng\u1eebng ph\u00e2n chia c\u0169ng \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong nghi\u00ean c\u1ee9u l\u1ea7n n\u00e0y. Do vi\u1ec7c ng\u1eebng ph\u00e2n b\u00e0o s\u1ebd g\u00f3p ph\u1ea7n t\u1ea1o n\u00ean s\u1ef1 l\u00e3o h\u00f3a v\u00e0 n\u1ebfu nh\u01b0 gen n\u00e0y \u0111\u01b0\u1ee3c \u0111\u1ed9t bi\u1ebfn \u0111\u1ec3 gi\u1ea3m c\u00e1c t\u1ebf b\u00e0o l\u00e3o h\u00f3a, ti\u1ebfp t\u1ee5c ph\u00e2n chia th\u00ec s\u1ef1 l\u00e3o h\u00f3a t\u1ed5ng th\u1ec3 c\u1ee7a ng\u01b0\u1eddi s\u1ebd ch\u1eadm h\u01a1n, t\u1eeb \u0111\u00f3 ng\u01b0\u1eddi ta s\u1ebd s\u1ed1ng th\u1ecd h\u01a1n.<\/p>\n<p>Tuy nhi\u00ean, gi\u00e1o s\u01b0 Kim cho r\u1eb1ng v\u1eabn c\u00f2n nhi\u1ec1u gen n\u1eefa c\u00f3 li\u00ean quan \u0111\u1ebfn k\u1ebft qu\u1ea3 k\u00e9o d\u00e0i tu\u1ed5i th\u1ecd: <em>&#8220;T\u00f4i hy v\u1ecdng r\u1eb1ng b\u00e1o c\u00e1o c\u1ee7a ch\u00fang t\u00f4i s\u1ebd truy\u1ec1n c\u1ea3m h\u1ee9ng cho nh\u1eefng ng\u01b0\u1eddi kh\u00e1c ti\u1ebfp t\u1ee5c vi\u1ec7c \u0111i t\u00ecm nh\u1eefng ng\u01b0\u1eddi k\u00e9o d\u00e0i tu\u1ed5i th\u1ecd trong t\u01b0\u01a1ng lai.&#8221;<\/em><\/p>\n<p style=\"text-align: right;\"><strong><em>Tham kh\u1ea3o <span style=\"text-decoration: underline;\">NS<\/span>\u200b<\/em><\/strong><\/p>\n<p style=\"text-align: right;\"><em>Ngu\u1ed3n tinhte.vn<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>ABO, CDKN2B, APOE v\u00e0 SH2B3 l\u00e0 4 gen m\u00e0 n\u1ebfu \u0111\u01b0\u1ee3c s\u1edf h\u1eefu, b\u1ea1n c\u00f3 th\u1ec3 \u0111\u1ea1t tu\u1ed5i th\u1ecd ngo\u00e0i 100 tu\u1ed5i. \u0110\u00f3 l\u00e0 k\u1ebft lu\u1eadn c\u1ee7a c\u00e1c nh\u00e0 khoa h\u1ecdc theo nghi\u00ean c\u1ee9u m\u1edbi nh\u1ea5t v\u1ec1 m\u1ed1i t\u01b0\u01a1ng quan gi\u1eefa m\u1ed9t s\u1ed1 y\u1ebfu t\u1ed1 di truy\u1ec1n nh\u1ea5t \u0111\u1ecbnh \u0111\u1ed1i v\u1edbi tu\u1ed5i th\u1ecd con ng\u01b0\u1eddi. [&hellip;]<\/p>\n","protected":false},"author":17,"featured_media":5137,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-4663","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/4663","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=4663"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/4663\/revisions"}],"predecessor-version":[{"id":5138,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/4663\/revisions\/5138"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/5137"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=4663"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=4663"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=4663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}