{"id":4567,"date":"2015-11-19T07:00:19","date_gmt":"2015-11-19T00:00:19","guid":{"rendered":"http:\/\/ttud.com.vn\/?p=4567"},"modified":"2017-10-02T08:28:20","modified_gmt":"2017-10-02T01:28:20","slug":"cong-nghe-dendrime-giup-nang-cao-hieu-qua-dieu-tri-ung-thu","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/cong-nghe-dendrime-giup-nang-cao-hieu-qua-dieu-tri-ung-thu\/","title":{"rendered":"C\u00f4ng ngh\u1ec7 dendrime gi\u00fap n\u00e2ng cao hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0"},"content":{"rendered":"

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u thu\u1ed9c tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Purdue (\u1ea4n \u0110\u1ed9) \u0111\u00e3 ph\u00e1t minh ra m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ec3 hi\u1ec3u s\u00e2u h\u01a1n c\u00e1c qu\u00e1 tr\u00ecnh t\u1ebf b\u00e0o ph\u1ee9c t\u1ea1p, b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c h\u1ea1t t\u1ed5ng h\u1ee3p k\u00edch th\u01b0\u1edbc r\u1ea5t nh\u1ecf \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 dendrime. C\u00f4ng ngh\u1ec7 n\u00e0y c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn c\u00e1c ph\u01b0\u01a1ng ph\u00e1p tr\u1ecb li\u1ec7u nh\u1eb1m tr\u00fang \u0111\u00edch h\u01a1n \u0111\u1ed1i v\u1edbi b\u1ec7nh ung th\u01b0.<\/strong><\/p>\n

\"\"<\/p>\n

S\u1ef1 hi\u1ec3u bi\u1ebft ch\u00ednh x\u00e1c v\u1ec1 c\u00e1ch th\u1ee9c c\u00e1c t\u1ebf b\u00e0o c\u00f3 th\u1ec3 thu nh\u1eadn c\u00e1c h\u1ea1t nh\u1ecf \u0111\u01b0a v\u00e0o, m\u1ed9t qu\u00e1 tr\u00ecnh mang t\u00ean n\u1ed9i nh\u1eadp b\u00e0o, c\u00f3 th\u1ec3 gi\u00fap c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn s\u1ef1 v\u1eadn chuy\u1ec3n thu\u1ed1c v\u00e0 kh\u00e1m ph\u00e1 c\u00e1c c\u01a1 ch\u1ebf c\u1ee7a virus. Nh\u01b0ng c\u00e1c h\u1ea1t \u0111\u01b0\u1ee3c c\u00e1c t\u1ebf b\u00e0o thu nh\u1eadn n\u00e0y v\u00e0 c\u00e1c protein \u0111i\u1ec1u khi\u1ec3n con \u0111\u01b0\u1eddng x\u00e2m nh\u1eadp t\u1ebf b\u00e0o l\u1ea1i c\u00f3 qu\u00e1 \u00edt khi\u1ebfn cho c\u00e1c c\u00f4ng ngh\u1ec7 th\u00f4ng th\u01b0\u1eddng kh\u00f3 c\u00f3 th\u1ec3 ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c.<\/p>\n

GS sinh h\u00f3a W. Andy Tao v\u00e0 c\u00e1c c\u1ed9ng s\u1ef1 t\u1ea1i \u0110\u1ea1i h\u1ecdc Purdue \u0111\u00e3 ph\u00e1t tri\u1ec3n m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p c\u00f3 th\u1ec3 \u0111\u01b0a c\u00e1c dendrime n\u1ed9i nh\u1eadp v\u00e0o c\u00e1c t\u1ebf b\u00e0o \u0111\u1ec3 theo d\u00f5i d\u1ea5u v\u1ebft, n\u1eafm b\u1eaft v\u00e0 c\u00f4 l\u1eadp c\u00e1c protein \u0111ang \u0111\u00f3ng vai tr\u00f2 \u0111i\u1ec1u ti\u1ebft qu\u00e1 tr\u00ecnh n\u1ed9i nh\u1eadp t\u1ebf b\u00e0o v\u00e0 h\u1ecd \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c 809 protein tham gia v\u00e0o con \u0111\u01b0\u1eddng x\u00e2m nh\u1eadp t\u1ebf b\u00e0o.<\/p>\n

GS Tao cho bi\u1ebft, c\u00f4ng ngh\u1ec7 theo d\u00f5i quy tr\u00ecnh x\u00e2m nh\u1eadp t\u1ebf b\u00e0o v\u00e0 v\u1eadn chuy\u1ec3n v\u1eadt li\u1ec7u nano (Tracing Internalization and TrAfficking of Nanomaterials – TITAN) c\u00f3 th\u1ec3 gi\u00fap ch\u00fang ta hi\u1ec3u \u0111\u01b0\u1ee3c c\u00e1c t\u1ebf b\u00e0o thu nh\u1eadn c\u00e1c h\u1ea1t ngo\u1ea1i b\u00e0o v\u00e0 c\u00e1ch ch\u00fang di chuy\u1ec3n c\u00e1c h\u1ea1t n\u00e0y ra xung quanh nh\u01b0 th\u1ebf n\u00e0o. C\u00e1c hi\u1ec3u bi\u1ebft \u0111\u1ec1u c\u00f3 gi\u00e1 tr\u1ecb h\u1eefu \u00edch cho c\u00e1c nghi\u00ean c\u1ee9u t\u01b0\u01a1ng lai nh\u1eb1m ph\u00e1 v\u1ee1 nh\u1eefng quy tr\u00ecnh \u0111\u00f3, kh\u00f4ng \u0111\u1ec3 cho c\u00e1c t\u00e1c nh\u00e2n c\u00f3 h\u1ea1i b\u00ean ngo\u00e0i nh\u01b0 virus x\u00e2m nh\u1eadp, v\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c quy tr\u00ecnh cung c\u1ea5p thu\u1ed1c h\u1eefu \u00edch.<\/p>\n

Dendrime l\u00e0 c\u00e1c h\u1ea1t nano ph\u00e2n nh\u00e1nh \u0111\u1ed1i x\u1ee9ng, c\u00f3 k\u00edch th\u01b0\u1edbc t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi c\u00e1c protein xu\u1ea5t hi\u1ec7n t\u1ef1 nhi\u00ean. L\u00e0 c\u00e1c ph\u00e2n t\u1eed c\u00f3 c\u00e1c nh\u00e1nh h\u00ecnh c\u00e2y, c\u1ea5u tr\u00fac v\u00e0 k\u00edch th\u01b0\u1edbc r\u1ea5t nh\u1ecf c\u1ee7a dendrimer l\u00e0m cho ch\u00fang tr\u1edf th\u00e0nh m\u1ed9t v\u1eadt mang l\u00fd t\u01b0\u1edfng \u0111\u1ec3 v\u1eadn chuy\u1ec3n c\u00e1c lo\u1ea1i ph\u00e2n t\u1eed kh\u00e1c nhau th\u00f4ng qua nhi\u1ec1u nh\u00e1nh c\u1ee7a ch\u00fang \u0111\u1ec3 x\u00e2m nh\u1eadp v\u00e0o t\u1ebf b\u00e0o. M\u1ed9t trong nh\u1eefng vai tr\u00f2 c\u00f3 gi\u00e1 tr\u1ecb nh\u1ea5t c\u1ee7a h\u1ea1t dendrimer \u0111\u00f3 l\u00e0 v\u1eadn chuy\u1ec3n thu\u1ed1c nh\u1eb1m m\u1ee5c ti\u00eau trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh ung th\u01b0. C\u00e1c dendrime c\u00f3 th\u1ec3 d\u1eabn n\u1ea1p thu\u1ed1c m\u1ed9t c\u00e1ch c\u00f3 ch\u1ecdn l\u1ecdc \u0111\u1ebfn c\u00e1c t\u1ebf b\u00e0o ung th\u01b0, kh\u00f4ng gi\u1ed1ng nh\u01b0 ph\u01b0\u01a1ng ph\u00e1p h\u00f3a tr\u1ecb g\u00e2y ph\u00e1 h\u1ee7y c\u00e1c t\u1ebf b\u00e0o kh\u1ecfe m\u1ea1nh v\u00e0 ung th\u01b0 nh\u01b0 nhau.<\/p>\n

Tr\u01b0\u1edbc khi \u0111\u01b0a ch\u00fang v\u00e0o c\u00e1c t\u1ebf b\u00e0o, GS Tao v\u00e0 nh\u00f3m nghi\u00ean c\u1ee9u c\u1ee7a \u00f4ng \u0111\u00e3 bi\u1ebfn \u0111\u1ed5i h\u00f3a h\u1ecdc c\u00e1c h\u1ea1t dendrimer b\u1eb1ng c\u00e1ch g\u1eafn th\u1ebb hu\u1ef3nh quang v\u00e0o, \u0111i\u1ec1u n\u00e0y cho ph\u00e9p d\u1ec5 ph\u00e1t hi\u1ec7n ra c\u00e1c h\u1ea1t dendrime h\u01a1n khi ch\u00fang di chuy\u1ec3n b\u00ean trong t\u1ebf b\u00e0o; m\u1ed9t li\u00ean k\u1ebft ch\u00e9o ph\u1ea3n \u1ee9ng quang h\u00f3a (crosslinker photoreactive) s\u1ebd cho ph\u00e9p c\u00e1c dendrime g\u1eafn v\u00e0o c\u00e1c protein d\u01b0\u1edbi b\u1ee9c x\u1ea1 tia c\u1ef1c t\u00edm; v\u00e0 c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u00f3 th\u1ec3 thao t\u00e1c \u0111\u1ec3 t\u00e1ch c\u00e1c dendrime ra kh\u1ecfi ph\u1ea7n v\u1eadt li\u1ec7u t\u1ebf b\u00e0o c\u00f2n l\u1ea1i.<\/p>\n

Khi c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u chi\u1ebfu x\u1ea1 v\u00e0o t\u1ebf b\u00e0o, c\u00e1c dendrime b\u00ean trong b\u00e1m l\u1ea5y t\u1ea5t c\u1ea3 c\u00e1c protein n\u1eb1m \u1edf xung quanh, t\u1ea1o ta m\u1ed9t kho\u1ea3ng d\u1eebng ngay trong th\u1eddi gian th\u1ef1c, khi \u0111\u00f3 c\u00e1c protein ng\u1eebng \u0111i\u1ec1u khi\u1ec3n qu\u00e1 tr\u00ecnh n\u1ed9i nh\u1eadp b\u00e0o (endocytosis). Nh\u00f3m nghi\u00ean c\u1ee9u chi\u1ebfu x\u1ea1 v\u00e0o c\u00e1c t\u1ebf b\u00e0o trong 3 kho\u1ea3ng th\u1eddi gian kh\u00e1c nhau – 30 ph\u00fat, 1 gi\u1edd v\u00e0 2 gi\u1edd.<\/p>\n

\u201cCh\u00fang t\u00f4i \u0111\u00e3 quan s\u00e1t th\u1ea5y c\u00e1c ph\u00e2n t\u1eed kh\u00e1c nhau trong t\u1eebng th\u1eddi \u0111i\u1ec3m, \u0111i\u1ec1u \u0111\u00f3 cho ch\u00fang ta bi\u1ebft n\u01a1i c\u00f3 m\u1eb7t c\u00e1c dendrime v\u00e0 qua \u0111\u00f3 cho bi\u1ebft c\u00e1c c\u01a1 ch\u1ebf ch\u00fang di chuy\u1ec3n v\u00e0o t\u1ebf b\u00e0o\u201d, GS Tao n\u00f3i. \u201cGi\u1ea3 s\u1eed b\u1ea1n l\u00e1i xe \u0111\u1ebfn Wal-Mart, nh\u01b0ng thay v\u00ec n\u00f3i cho t\u00f4i bi\u1ebft b\u1ea1n \u0111i con \u0111\u01b0\u1eddng n\u00e0o, b\u1ea1n c\u00f3 th\u1ec3 ch\u1ee5p \u1ea3nh c\u00e1c t\u00f2a nh\u00e0 v\u00e0 \u0111i\u1ec3m m\u1ed1c \u1edf c\u00e1c th\u1eddi \u0111i\u1ec3m kh\u00e1c nhau d\u1ecdc theo con \u0111\u01b0\u1eddng. Nh\u1eefng h\u00ecnh \u1ea3nh s\u1ebd cho t\u00f4i bi\u1ebft con \u0111\u01b0\u1eddng b\u1ea1n \u0111\u00e3 \u0111i. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u0169ng t\u01b0\u01a1ng t\u1ef1 nh\u01b0 v\u1eady\u201d.<\/p>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 s\u1eed d\u1ee5ng tr\u1eafc kh\u1ed1i ph\u1ed5 \u0111\u1ec3 ph\u00e2n l\u1eadp v\u00e0 x\u00e1c \u0111\u1ecbnh h\u00e0ng tr\u0103m protein tham gia v\u00e0o qu\u00e1 tr\u00ecnh nh\u1eadp b\u00e0o, kh\u1eb3ng \u0111\u1ecbnh c\u00e1c c\u01a1 ch\u1ebf \u0111\u01b0\u1ee3c nhi\u1ec1u nh\u00e0 sinh h\u1ecdc gi\u1ea3 \u0111\u1ecbnh tr\u01b0\u1edbc \u0111\u00e2y.<\/p>\n

Vi\u1ec7c bi\u1ebft \u0111\u01b0\u1ee3c nh\u1eefng protein n\u00e0o d\u1eabn d\u1eaft qu\u00e1 tr\u00ecnh nh\u1eadp b\u00e0o v\u00e0 \u1edf giai \u0111o\u1ea1n n\u00e0o c\u00f3 th\u1ec3 gi\u00fap c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn ph\u01b0\u01a1ng ph\u00e1p v\u1eadn chuy\u1ec3n thu\u1ed1c nano. GS Tao cho bi\u1ebft, ch\u00fang t\u00f4i thu \u0111\u01b0\u1ee3c r\u1ea5t nhi\u1ec1u th\u00f4ng tin quan tr\u1ecdng t\u1eeb c\u00f4ng ngh\u1ec7 TITAN, \u0111\u00e2y l\u00e0 m\u1ed9t c\u00f4ng ngh\u1ec7 n\u1ec1n t\u1ea3ng m\u1edf ra m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p m\u1edbi \u0111\u1ec3 nghi\u00ean c\u1ee9u nhi\u1ec1u qu\u00e1 tr\u00ecnh sinh h\u1ecdc quy m\u00f4 nh\u1ecf b\u00ean trong c\u00e1c t\u1ebf b\u00e0o.<\/p>\n

M\u1ed9t s\u1ed1 \u1ee9ng d\u1ee5ng ti\u1ec1m n\u0103ng c\u1ee7a c\u00f4ng ngh\u1ec7 TITAN bao g\u1ed3m vi\u1ec7c x\u00e1c \u0111\u1ecbnh virus x\u00e2m nh\u1eadp v\u00e0 di chuy\u1ec3n b\u00ean trong t\u1ebf b\u00e0o nh\u01b0 th\u1ebf n\u00e0o, cho bi\u1ebft c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 li\u00ean l\u1ea1c v\u1edbi nhau nh\u01b0 th\u1ebf n\u00e0o v\u00e0 gi\u00fap l\u1ea7n theo d\u1ea5u v\u1ebft n\u01a1i c\u00e1c h\u1ea1t nano k\u1ebft th\u00fac b\u00ean trong t\u1ebf b\u00e0o, m\u1ed9t \u0111\u1eb7c \u0111i\u1ec3m c\u00f2n t\u01b0\u01a1ng \u0111\u1ed1i ch\u01b0a r\u00f5 r\u00e0ng.<\/p>\n

Vi\u1ec7c hi\u1ec3u \u0111\u01b0\u1ee3c c\u00e1c h\u1ea1t nano \u0111i \u0111\u1ebfn \u0111\u00e2u b\u00ean trong c\u00e1c t\u1ebf b\u00e0o v\u00e0 li\u1ec7u ch\u00fang c\u00f3 ph\u00e2n r\u00e3 theo th\u1eddi gian hay kh\u00f4ng l\u00e0 \u0111i\u1ec1u r\u1ea5t quan tr\u1ecdng. C\u00f4ng ngh\u1ec7 TITAN c\u00f3 th\u1ec3 theo d\u00f5i c\u00e1c h\u1ea1t nano di chuy\u1ec3n b\u00ean trong t\u1ebf b\u00e0o v\u00e0 cho bi\u1ebft li\u1ec7u ch\u00fang c\u00f3 k\u1ebft th\u00fac \u1edf trong nh\u00e2n hay kh\u00f4ng, l\u00e0 \u0111i\u1ec1u c\u00f3 th\u1ec3 g\u00e2y ra r\u1eafc r\u1ed1i, hay ch\u00fang ch\u1ea5m d\u1ee9t \u0111\u00fang \u1edf n\u01a1i ch\u1ee9a ch\u1ea5t th\u1ea3i t\u1ebf b\u00e0o.<\/p>\n

Vista<\/em>
\n http:\/\/khoahocvacongnghevietnam.com.vn<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u thu\u1ed9c tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Purdue (\u1ea4n \u0110\u1ed9) \u0111\u00e3 ph\u00e1t minh ra m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ec3 hi\u1ec3u s\u00e2u h\u01a1n c\u00e1c qu\u00e1 tr\u00ecnh t\u1ebf b\u00e0o ph\u1ee9c t\u1ea1p, b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c h\u1ea1t t\u1ed5ng h\u1ee3p k\u00edch th\u01b0\u1edbc r\u1ea5t nh\u1ecf \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 dendrime. C\u00f4ng ngh\u1ec7 n\u00e0y c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn c\u00e1c ph\u01b0\u01a1ng ph\u00e1p […]<\/p>\n","protected":false},"author":17,"featured_media":5040,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-4567","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/4567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=4567"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/4567\/revisions"}],"predecessor-version":[{"id":5041,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/4567\/revisions\/5041"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/5040"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=4567"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=4567"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=4567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}