{"id":4184,"date":"2015-10-14T12:42:06","date_gmt":"2015-10-14T05:42:06","guid":{"rendered":"http:\/\/ttud.com.vn\/?p=4184"},"modified":"2017-09-28T23:00:26","modified_gmt":"2017-09-28T16:00:26","slug":"vaccine-aids-lan-dau-tien-duoc-chinh-thuc-thu-nghiem-lam-sang-tren-nguoi","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/vaccine-aids-lan-dau-tien-duoc-chinh-thuc-thu-nghiem-lam-sang-tren-nguoi\/","title":{"rendered":"Vaccine AIDS l\u1ea7n \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c ch\u00ednh th\u1ee9c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng tr\u00ean ng\u01b0\u1eddi"},"content":{"rendered":"

H\u1ed3i n\u0103m 1984, nh\u00e0 sinh h\u1ecdc Robert Gallo \u0111\u00e3 ph\u00e1t hi\u1ec7n HIV l\u00e0 nguy\u00ean nh\u00e2n g\u00e2y b\u1ec7nh AIDS v\u00e0 b\u00e2y gi\u1edd, \u00f4ng s\u1ebd ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng tr\u00ean ng\u01b0\u1eddi m\u1ed9t lo\u1ea1i vaccine AIDS m\u00e0 \u00f4ng v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p t\u1ea1i Vi\u1ec7n virus IHV, Hoa K\u1ef3 \u0111\u00e3 ph\u00e1t tri\u1ec3n su\u1ed1t 15 n\u0103m qua.<\/strong><\/p>\n

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Vi\u1ec7c t\u00ecm ki\u1ebfm m\u1ed9t lo\u1ea1i vaccine ch\u1ed1ng l\u1ea1i HIV v\u00e0 b\u1ec7nh AIDS \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n li\u00ean t\u1ee5c trong t\u1eeb nhi\u1ec1u th\u1eadp k\u1ef7 qua. Th\u00f4ng th\u01b0\u1eddng, \u0111\u1eb7c tr\u01b0ng c\u1ee7a vaccine l\u00e0 n\u00f3 c\u00f3 ch\u1ee9a m\u1ed9t d\u1ea1ng y\u1ebfu c\u1ee7a t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh ho\u1eb7c protein tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a n\u00f3 v\u00e0 t\u1eeb tr\u01b0\u1edbc \u0111\u1ebfn nay, \u0111\u00e2y lu\u00f4n l\u00e0 m\u1ed9t lo\u1ea1i v\u0169 kh\u00ed hi\u1ec7u qu\u1ea3 gi\u00fap nh\u00e2n lo\u1ea1i ch\u1ed1ng l\u1ea1i c\u00e1c lo\u1ea1i b\u1ec7nh t\u1eadt do vi khu\u1ea9n, virus g\u00e2y ra.<\/p>\n

C\u00f2n nh\u1edb khi x\u01b0a b\u1ec7nh \u0111\u1eadu m\u00f9a \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00f3a b\u1ecf t\u1eeb m\u1ed9t lo\u1ea1i vaccine ch\u01b0a virus g\u00e2y b\u1ec7nh \u0111\u1eadu b\u00f2, gi\u00fap c\u1ee9u s\u1ed1ng h\u00e0ng tri\u1ec7u m\u1ea1ng s\u1ed1ng tr\u00ean th\u1ebf gi\u1edbi. Kh\u00f4ng l\u00e2u sau \u0111\u00f3 th\u00ec b\u1ea1i li\u1ec7t c\u0169ng b\u1ecb x\u00f3a s\u1ed5 kh\u1ecfi m\u1eb7t \u0111\u1ea5t v\u00e0 s\u1eafp t\u1edbi, b\u1ec7nh s\u1edfi c\u0169ng l\u00e0 m\u1ed9t \u1ee9ng c\u1eed vi\u00ean s\u1eafp b\u1ecb thanh to\u00e1n. Tuy nhi\u00ean, HIV cho t\u1edbi nay v\u1eabn ch\u01b0a c\u00f3 bi\u1ec7n ph\u00e1p ti\u00eau di\u1ec7t b\u1eb1ng ti\u00eam ch\u1ee7ng.<\/p>\n

Gi\u1edd \u0111\u00e2y, ti\u1ebfn s\u0129 Robert Gallo c\u00f9ng nh\u00f3m nghi\u00ean c\u1ee9u t\u1ea1i IHV, Baltimore, Maryland ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng tr\u00ean ng\u01b0\u1eddi lo\u1ea1i vaccine \u0111\u1ea7y h\u1ee9a h\u1eb9n gi\u00fap ch\u1ed1ng l\u1ea1i AIDS. H\u1ec7 mi\u1ec5n d\u1ecbch c\u1ee7a con ng\u01b0\u1eddi c\u00f3 v\u1ebb kh\u00f4ng th\u1ec3 ch\u1ed1ng l\u1ea1i s\u1ef1 l\u00e2y nhi\u1ec5m c\u1ee7a HIV v\u00e0 t\u1eeb \u0111\u00f3 t\u1edbi nay, ngo\u1ea1i tr\u1eeb 1 tr\u01b0\u1eddng h\u1ee3p duy nh\u1ea5t, th\u00ec ch\u01b0a c\u00f3 ai \u0111\u01b0\u1ee3c ch\u1eefa l\u00e0nh.<\/p>\n

HIV c\u00f3 kh\u1ea3 n\u0103ng bi\u1ebfn \u0111\u1ed5i c\u1ef1c k\u1ef3 nhanh nh\u1eb1m tho\u00e1t kh\u1ecfi s\u1ef1 truy qu\u00e9t c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch v\u00e0 \u0111\u00e2y d\u01b0\u1eddng nh\u01b0 l\u00e0 th\u00e1ch th\u1ee9c kh\u00f4ng th\u1ec3 v\u01b0\u1ee3t qua trong qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n vaccine. Khi HIV x\u00e2m nh\u1eadp v\u00e0o c\u01a1 th\u1ec3 ng\u01b0\u1eddi, lo\u1ea1i protein tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a n\u00f3 s\u1ebd li\u00ean k\u1ebft v\u1edbi 1 ph\u00e2n \u0111o\u1ea1n c\u1ee7a m\u1ed9t protein g\u1ecdi l\u00e0 CD4 n\u1eb1m tr\u00ean t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u. T\u1eeb \u0111i\u1ec3m b\u00e1m \u0111\u1ea7u ti\u00ean n\u00e0y, n\u00f3 s\u1ebd ti\u1ebfp t\u1ee5c li\u00ean k\u1ebft v\u1edbi 1 th\u1ee5 th\u1ec3 th\u1ee9 2 n\u1eefa \u0111\u1ec3 \u1ed5n \u0111\u1ecbnh h\u01a1n, cu\u1ed1i c\u00f9ng l\u00e0 chi\u1ebfm \u0111\u00f3ng ho\u00e0n to\u00e0n b\u1ea1ch c\u1ea7u v\u00e0 t\u1ef1 sao ch\u00e9p.<\/p>\n

C\u00e1ch ti\u1ebfp c\u1eadn l\u1ea7n n\u00e0y c\u1ee7a nh\u00f3m nghi\u00ean c\u1ee9u l\u00e0 lo\u1ea1i vaccine \u201cchu\u1ed7i \u0111\u01a1n \u0111\u1ea7y \u0111\u1ee7\u201d – trong \u0111\u00f3 c\u00f3 ch\u1ee9a 1 phi\u00ean b\u1ea3n c\u1ee7a protein tr\u00ean b\u1ec1 m\u1eb7t HIV, \u0111\u00e3 \u0111\u01b0\u1ee3c tinh ch\u1ec9nh sinh h\u1ecdc m\u1ed9t c\u00e1ch \u0111\u1eb7t bi\u1ec7t \u0111\u1ec3 c\u00f3 th\u1ec3 li\u00ean k\u1ebft v\u1edbi 1 v\u00e0i ph\u00e2n \u0111o\u1ea1n ch\u00ednh x\u00e1c tr\u00ean th\u1ee5 th\u1ec3 CD4. B\u1eb1ng c\u00e1ch n\u00e0y, vaccine gi\u00fap h\u1ec7 mi\u1ec5n d\u1ecbch t\u1ea1o ra c\u00e1c kh\u00e1ng th\u1ec3 c\u00f3 kh\u1ea3 n\u0103ng s\u0103n l\u00f9ng v\u00e0 v\u00f4 hi\u1ec7u h\u00f3a t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh m\u00e0 c\u1ee5 th\u1ec3 l\u00e0 virus HIV.<\/p>\n

C\u00e1c kh\u00e1ng th\u1ec3 n\u00e0y s\u1ebd g\u1eafn v\u1edbi protein tr\u00ean b\u1ec1 m\u1eb7t HIV khi n\u00f3 \u0111ang trong tr\u1ea1ng th\u00e1i chuy\u1ec3n ti\u1ebfp \u0111\u1ec3 thi\u1ebft l\u1eadp \u201cch\u1ed7 \u0111\u1ee9ng\u201d tr\u00ean t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u, cu\u1ed1i c\u00f9ng h\u1ee7y b\u1ecf qu\u00e1 tr\u00ecnh l\u00e2y nhi\u1ec5m v\u00e0 ch\u1ea5m d\u1ee9t ho\u00e0n to\u00e0n n\u00f3 tr\u01b0\u1edbc khi HIV c\u00f3 th\u1ec3 l\u00e0m ch\u1ee7 th\u00e0nh c\u00f4ng t\u1ebf b\u00e0o v\u00e0 nh\u00e2n b\u1ea3n ra.<\/p>\n

\u0110\u01b0\u1ee3c bi\u1ebft c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 m\u1ea5t 15 n\u0103m \u0111\u1ec3 c\u00f3 trong tay lo\u1ea1i vaccine mang ra th\u1eed nghi\u1ec7m l\u1ea7n n\u00e0y. Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng l\u00e0 giai \u0111o\u1ea1n 1 trong d\u1ef1 \u00e1n v\u00e0 s\u1ebd \u0111\u01b0\u1ee3c d\u1eabn \u0111\u1ea7u b\u1edfi gi\u00e1o s\u01b0 sinh v\u1eadt h\u1ecdc v\u00e0 mi\u1ec5n d\u1ecbch h\u1ecdc George Lewis t\u1ea1i IHV. Th\u1eed nghi\u1ec7m d\u1ef1 ki\u1ebfn s\u1ebd \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng tr\u00ean 60 ng\u01b0\u1eddi v\u00e0 m\u1ee5c ti\u00eau \u0111\u01a1n gi\u1ea3n ch\u1ec9 l\u00e0 \u0111\u00e1nh gi\u00e1 m\u1ee9c \u0111\u1ed9 an to\u00e0n, theo d\u00f5i ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch c\u1ee7a c\u01a1 th\u1ec3 \u0111\u1ed1i v\u1edbi thu\u1ed1c. D\u00f9 v\u1eady, nh\u00f3m cho bi\u1ebft r\u1eb1ng \u0111\u00e2y m\u1edbi ch\u1ec9 l\u00e0 s\u01a1 kh\u1edfi v\u00e0 c\u00f2n ph\u1ea3i c\u00f3 nhi\u1ec1u th\u1eed nghi\u1ec7m kh\u00e1c \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u01b0\u1edbc khi \u00e1p d\u1ee5ng r\u1ed9ng r\u00e3i tr\u00ean ng\u01b0\u1eddi.<\/p>\n

Tham kh\u1ea3o Science, IFS, HP\u200b<\/p>\n

Ngu\u1ed3n tinhte.vn<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

H\u1ed3i n\u0103m 1984, nh\u00e0 sinh h\u1ecdc Robert Gallo \u0111\u00e3 ph\u00e1t hi\u1ec7n HIV l\u00e0 nguy\u00ean nh\u00e2n g\u00e2y b\u1ec7nh AIDS v\u00e0 b\u00e2y gi\u1edd, \u00f4ng s\u1ebd ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng tr\u00ean ng\u01b0\u1eddi m\u1ed9t lo\u1ea1i vaccine AIDS m\u00e0 \u00f4ng v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p t\u1ea1i Vi\u1ec7n virus IHV, Hoa K\u1ef3 \u0111\u00e3 ph\u00e1t tri\u1ec3n su\u1ed1t 15 n\u0103m qua. Vi\u1ec7c […]<\/p>\n","protected":false},"author":17,"featured_media":4409,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-4184","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/4184","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=4184"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/4184\/revisions"}],"predecessor-version":[{"id":4410,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/4184\/revisions\/4410"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/4409"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=4184"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=4184"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=4184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}