{"id":3828,"date":"2015-10-01T22:18:10","date_gmt":"2015-10-01T15:18:10","guid":{"rendered":"http:\/\/ttud.com.vn\/?p=3828"},"modified":"2017-09-27T22:19:29","modified_gmt":"2017-09-27T15:19:29","slug":"cac-nha-khoa-hoc-tao-ra-ban-do-protein-lon-nhat-the-gioi-de-tiet-lo-nhung-protein-lam-viec-cung-nhau-trong-mot-te-bao","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/cac-nha-khoa-hoc-tao-ra-ban-do-protein-lon-nhat-the-gioi-de-tiet-lo-nhung-protein-lam-viec-cung-nhau-trong-mot-te-bao\/","title":{"rendered":"C\u00c1C NH\u00c0 KHOA H\u1eccC T\u1ea0O RA B\u1ea2N \u0110\u1ed2 PROTEIN L\u1edaN NH\u1ea4T TH\u1ebe GI\u1edaI \u0110\u1ec2 TI\u1ebeT L\u1ed8 NH\u1eeeNG PROTEIN L\u00c0M VI\u1ec6C C\u00d9NG NHAU TRONG M\u1ed8T T\u1ebe B\u00c0O"},"content":{"rendered":"

M\u1ed9t nh\u00f3m nh\u00e0 khoa h\u1ecdc \u0111a qu\u1ed1c gia \u0111\u00e3 xem x\u00e9t qua c\u00e1c t\u1ebf b\u00e0o c\u1ee7a c\u00e1c sinh v\u1eadt kh\u00e1c nhau, t\u1eeb amip \u0111\u1ebfn con s\u00e2u, chu\u1ed9t r\u1ed3i \u0111\u1ebfn con ng\u01b0\u1eddi, \u0111\u1ec3 kh\u00e1m ph\u00e1 c\u00e1ch protein li\u00ean k\u1ebft v\u1edbi nhau \u0111\u1ec3 t\u1ea1o n\u00ean t\u1ebf b\u00e0o v\u00e0 c\u00e1c c\u01a1 quan kh\u00e1c nhau.<\/strong><\/p>\n

\"\"<\/p>\n

C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 ph\u00e1t hi\u1ec7n ra h\u00e0ng ch\u1ee5c ng\u00e0n c\u00e1c t\u01b0\u01a1ng t\u00e1c protein m\u1edbi, chi\u1ebfm kho\u1ea3ng m\u1ed9t ph\u1ea7n t\u01b0 c\u1ee7a t\u1ea5t c\u1ea3 c\u00e1c k\u1ebft n\u1ed1i protein trong m\u1ed9t t\u1ebf b\u00e0o. Ngu\u1ed3n: Jovana Drinkjakovic<\/p>\n

\u0110\u00e2y l\u00e0 th\u00e0nh t\u1ef1u c\u1ee7a ng\u00e0nh khoa h\u1ecdc protein, l\u00e0 k\u1ebft qu\u1ea3 c\u1ee7a s\u1ef1 c\u00f4ng t\u00e1c gi\u1eefa 7 nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u1ebfn t\u1eeb 3 qu\u1ed1c gia, d\u1eabn \u0111\u1ea7u l\u00e0 Gi\u00e1o s\u01b0 Andrew Emili \u0111\u1ebfn t\u1eeb Trung t\u00e2m Terrence Donnelly c\u1ee7a Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Toronto v\u00e0 Gi\u00e1o s\u01b0 Edward Marcotte t\u1eeb Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Texas t\u1ea1i Austin. K\u1ebft qu\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n h\u00e0ng ch\u1ee5c ngh\u00ecn s\u1ef1 t\u01b0\u01a1ng t\u00e1c protein m\u1edbi, chi\u1ebfm kho\u1ea3ng \u00bc t\u1ea5t c\u1ea3 c\u00e1c t\u01b0\u01a1ng t\u00e1c protein trong m\u1ed9t t\u1ebf b\u00e0o.<\/p>\n

Ngay khi m\u1ed9t li\u00ean k\u1ebft \u0111\u01a1n trong s\u1ed1 \u0111\u00f3 b\u1ecb m\u1ea5t \u0111i, n\u00f3 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn b\u1ec7nh t\u1eadt. B\u1ea3n \u0111\u1ed3 protein \u0111\u00e3 gi\u00fap cho c\u00e1c nh\u00e0 khoa h\u1ecdc ph\u00e1t hi\u1ec7n c\u00e1c protein ri\u00eang l\u1ebb c\u00f3 th\u1ec3 l\u00e0 ngu\u1ed3n g\u1ed1c g\u00e2y n\u00ean nh\u1eefng r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng ph\u1ee9c t\u1ea1p c\u1ee7a con ng\u01b0\u1eddi. C\u00e1c th\u00f4ng tin s\u1ebd \u0111\u01b0\u1ee3c cung c\u1ea5p cho c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u tr\u00ean to\u00e0n th\u1ebf gi\u1edbi th\u00f4ng qua c\u01a1 s\u1edf d\u1eef li\u1ec7u truy c\u1eadp m\u1edf.<\/p>\n

Trong h\u01a1n m\u1ed9t th\u1eadp k\u1ef7 qua, gi\u1ea3i m\u00e3 c\u00e1c tr\u00ecnh t\u1ef1 b\u1ed9 gen c\u1ee7a con ng\u01b0\u1eddi l\u00e0 m\u1ed9t trong nh\u1eefng kh\u00e1m ph\u00e1 v\u0129 \u0111\u1ea1i nh\u1ea5t trong ng\u00e0nh sinh v\u1eadt h\u1ecdc, nh\u01b0ng \u0111\u00f3 m\u1edbi ch\u1ec9 l\u00e0 b\u1eaft \u0111\u1ea7u cho s\u1ef1 hi\u1ec3u bi\u1ebft c\u1ee7a ch\u00fang ta v\u1ec1 c\u00e1ch th\u1ee9c c\u00e1c t\u1ebf b\u00e0o ho\u1ea1t \u0111\u1ed9ng. Gen l\u00e0 b\u1ea3n thi\u1ebft k\u1ebf v\u00e0 protein, s\u1ea3n ph\u1ea9m c\u1ee7a gen, protein th\u1ef1c hi\u1ec7n nhi\u1ec1u ch\u1ee9a n\u0103ng trong t\u1ebf b\u00e0o.
\nC\u00e1c Protein l\u00e0m vi\u1ec7c theo nh\u00f3m b\u1eb1ng c\u00e1ch li\u00ean k\u1ebft v\u1edbi nhau \u0111\u1ec3 th\u1ef1c hi\u1ec7n ch\u1ee9c n\u0103ng c\u1ee7a ch\u00fang. Nhi\u1ec1u protein k\u1ebft h\u1ee3p v\u1edbi nhau \u0111\u1ec3 t\u1ea1o th\u00e0nh c\u00e1i g\u1ecdi b\u1ed9 m\u00e1y ph\u00e2n t\u1eed, \u0111\u00f3ng vai tr\u00f2 quan trong nh\u01b0 t\u1ed5ng h\u1ee3p protein m\u1edbi ho\u1eb7c t\u00e1i s\u1eed d\u1ee5ng c\u00e1c protein h\u1ebft ch\u1ee9c n\u0103ng b\u1eb1ng c\u00e1ch g\u1eafn ch\u00fang v\u00e0o nh\u1eefng ph\u1ea7n t\u00e1i s\u1eed d\u1ee5ng. C\u00f3 h\u00e0ng ch\u1ee5c ng\u00e0n protein trong t\u1ebf b\u00e0o con ng\u01b0\u1eddi nh\u01b0ng \u0111\u1ea1i \u0111a s\u1ed1 ch\u00fang ta v\u1eabn kh\u00f4ng bi\u1ebft ch\u00fang c\u00f3 ch\u1ee9c n\u0103ng g\u00ec.<\/p>\n

Ch\u00ednh v\u00ec l\u00fd do \u0111\u00f3, Emili v\u00e0 Marcotte \u0111\u00e3 ti\u1ebfn h\u00e0nh nghi\u00ean c\u1ee9u b\u1ea3n \u0111\u1ed3. H\u1ecd s\u1eed d\u1ee5ng m\u1ed9t thi\u1ebft b\u1ecb k\u1ef9 thu\u1eadt t \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n b\u1edfi c\u00e1c nh\u00f3m, h\u1ecd c\u00f3 th\u1ec3 l\u1ea5y ra h\u00e0ng ng\u00e0n b\u1ed9 m\u00e1y protein ra kh\u1ecfi t\u1ebf b\u00e0o v\u00e0 \u0111\u1ebfm c\u00e1c protein ri\u00eang l\u1ebb trong b\u1ed9 m\u00e1y. Sau \u0111\u00f3, h\u1ecd \u0111\u00e3 x\u00e2y d\u1ef1ng m\u1ed9t h\u1ec7 th\u1ed1ng, t\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c m\u1ea1ng x\u00e3 h\u1ed9i, cung c\u1ea5p c\u00e1c c\u01a1 s\u1edf d\u1eef li\u1ec7u v\u1ec1 ch\u1ee9c n\u0103ng protein d\u1ef1a v\u00e0o c\u00e1c protein kh\u00e1c m\u00e0 n\u00f3 hay t\u01b0\u01a1ng t\u00e1c. V\u00ed d\u1ee5, m\u1ed9t protein m\u1edbi ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u c\u00f3 kh\u1ea3 n\u0103ng tham gia v\u00e0o s\u1ef1 s\u1eeda ch\u1eefa h\u01b0 h\u1ecfng trong t\u1ebf b\u00e0o n\u1ebfu n\u00f3 g\u1eafn v\u00e0o nh\u1eefng “protein s\u1eeda ch\u1eefa”.<\/p>\n

Nghi\u00ean c\u1ee9u mang t\u00ednh \u0111\u1ed9t ph\u00e1 c\u1ee7a ng\u00e0y \u0111\u00e3 thu th\u1eadp th\u00f4ng tin v\u1ec1 b\u1ed9 m\u00e1y protein t\u1eeb 9 lo\u00e0i \u0111\u1ea1i di\u1ec7n cho c\u00e2y ti\u1ebfn h\u00f3a c\u1ee7a sinh v\u1eadt s\u1ed1ng: n\u1ea5m men, amip, h\u1ea3i qu\u1ef3, ru\u1ed3i, s\u00e2u, nh\u00edm bi\u1ec3n, \u1ebfch, chu\u1ed9t v\u00e0 ng\u01b0\u1eddi. B\u1ea3n \u0111\u1ed3 m\u1edbi m\u1edf r\u1ed9ng s\u1ed1 l\u01b0\u1ee3ng c\u00e1c li\u00ean k\u1ebft protein \u0111\u00e3 bi\u1ebft g\u1ea5p 10 l\u1ea7n v\u00e0 cho c\u00e1i nh\u00ecn s\u00e2u s\u1eafc v\u00e0o c\u00e1ch ch\u00fang \u0111\u00e3 ti\u1ebfn h\u00f3a theo th\u1eddi gian.<\/p>\n

“\u0110\u1ed1i v\u1edbi t\u00f4i \u0111i\u1ec3m n\u1ed5i b\u1eadt c\u1ee7a vi\u1ec7c nghi\u00ean c\u1ee9u l\u00e0 quy m\u00f4 tuy\u1ec7t \u0111\u1ed1i c\u1ee7a n\u00f3. Ch\u00fang t\u00f4i \u0111\u00e3 t\u0103ng g\u1ea5p ba l\u1ea7n s\u1ed1 l\u01b0\u1ee3ng t\u01b0\u01a1ng t\u00e1c protein cho m\u1ed7i lo\u00e0i. V\u00ec v\u1eady, tr\u00ean t\u1ea5t c\u1ea3 c\u00e1c lo\u00e0i \u0111\u1ed9ng v\u1eadt ch\u00fang ta c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n v\u1edbi s\u1ef1 tin c\u1eady cao, h\u01a1n 1 tri\u1ec7u c\u00e1c t\u01b0\u01a1ng t\u00e1c protein – v\u1ec1 c\u01a1 b\u1ea3n \u0111\u00e2y l\u00e0 ‘b\u01b0\u1edbc ti\u1ebfn l\u1edbn’ c\u1ee7a ng\u00e0nh t\u01b0\u01a1ng t\u00e1c protein” Emili, Ch\u1ee7 t\u1ecbch Ontario Research c\u1ee7a Biomarkers trong qu\u1ea3n l\u00fd d\u1ecbch b\u1ec7nh v\u00e0 l\u00e0 gi\u00e1o s\u01b0 t\u1ea1i Khoa Molecular Genetics cho bi\u1ebft.<\/p>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ph\u00e1t hi\u1ec7n ra h\u00e0ng ch\u1ee5c ng\u00e0n li\u00ean k\u1ebft protein v\u1eabn kh\u00f4ng thay \u0111\u1ed5i k\u1ec3 t\u1eeb khi c\u00e1c t\u1ebf b\u00e0o t\u1ed5 ti\u00ean \u0111\u1ea7u ti\u00ean xu\u1ea5t hi\u1ec7n, m\u1ed9t t\u1ef7 n\u0103m tr\u01b0\u1edbc \u0111\u00e2y (!), tr\u01b0\u1edbc s\u1ef1 s\u1ed1ng c\u1ee7a t\u1ea5t c\u1ea3 c\u00e1c lo\u00e0i \u0111\u1ed9ng v\u1eadt tr\u00ean tr\u00e1i \u0111\u1ea5t.<\/p>\n

“T\u1ed5 h\u1ee3p protein \u1edf ng\u01b0\u1eddi th\u01b0\u1eddng gi\u1ed1ng v\u1edbi nh\u1eefng lo\u00e0i kh\u00e1c. \u0110i\u1ec1u n\u00e0y kh\u00f4ng ch\u1ec9 c\u1ee7ng c\u1ed1 nh\u1eefng g\u00ec ch\u00fang ta \u0111\u00e3 bi\u1ebft v\u1ec1 ti\u1ebfn h\u00f3a chung c\u1ee7a t\u1ed5 ti\u00ean ch\u00fang ta, n\u00f3 c\u0169ng c\u00f3 \u00fd ngh\u0129a thi\u1ebft th\u1ef1c, cung c\u1ea5p kh\u1ea3 n\u0103ng \u0111\u1ec3 nghi\u00ean c\u1ee9u c\u00e1c c\u01a1 s\u1edf di truy\u1ec1n cho nhi\u1ec1u lo\u1ea1i b\u1ec7nh v\u00e0 c\u00e1ch n\u00f3 th\u1ec3 hi\u1ec7n \u1edf c\u00e1c lo\u00e0i kh\u00e1c nhau, “Marcotte n\u00f3i.<\/p>\n

B\u1ea3n \u0111\u1ed3 n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh r\u1ea5t c\u00f3 \u00edch trong vi\u1ec7c t\u00ecm ra c\u00e1c nguy\u00ean nh\u00e2n g\u00e2y b\u1ec7nh cho ng\u01b0\u1eddi. V\u00ed d\u1ee5 l\u00e0 \u201cc\u1ed7 m\u00e1y ph\u00e2n t\u1eed\u201d m\u1edbi \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n, \u0111\u01b0\u1ee3c \u0111\u1eb7t t\u00ean l\u00e0 Commander, bao g\u1ed3m kho\u1ea3ng m\u1ed9t ch\u1ee5c c\u00e1c protein ri\u00eang l\u1ebb. Gen m\u00e3 h\u00f3a m\u1ed9t s\u1ed1 th\u00e0nh ph\u1ea7n c\u1ee7a Commander tr\u01b0\u1edbc \u0111\u00e2y \u0111\u00e3 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y nh\u1eefng ng\u01b0\u1eddi b\u1ecb thi\u1ec3u n\u0103ng tr\u00ed tu\u1ec7 nh\u01b0ng kh\u00f4ng l\u00e0m r\u00f5 \u0111\u01b0\u1ee3c c\u00e1ch nh\u1eefng protein n\u00e0y l\u00e0m vi\u1ec7c.<\/p>\n

B\u1edfi v\u00ec Commander hi\u1ec7n di\u1ec7n trong t\u1ea5t c\u1ea3 c\u00e1c t\u1ebf b\u00e0o \u0111\u1ed9ng v\u1eadt, th\u1ef1c t\u1eadp sinh Fan Tu \u0111\u00e3 ph\u00e1 v\u1ee1 c\u00e1c th\u00e0nh ph\u1ea7n c\u1ee7a n\u00f3 trong con n\u00f2ng n\u1ecdc, kh\u00e1m ph\u00e1 nh\u1eefng kh\u00e1c th\u01b0\u1eddng trong t\u1ebf b\u00e0o n\u00e3o \u0111\u01b0\u1ee3c \u0111\u1ecbnh v\u1ecb trong qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n c\u1ee7a ph\u00f4i v\u00e0 cung c\u1ea5p ngu\u1ed3n g\u1ed1c cho c\u1ea5u t\u1ea1o ph\u1ee9c t\u1ea1p c\u1ee7a con ng\u01b0\u1eddi.<\/p>\n

“V\u1edbi h\u00e0ng ch\u1ee5c ng\u00e0n t\u01b0\u01a1ng t\u00e1c protein m\u1edbi kh\u00e1c, b\u1ea3n \u0111\u1ed3 c\u1ee7a ch\u00fang t\u00f4i h\u1ee9a h\u1eb9n s\u1ebd m\u1edf th\u00eam nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p trong vi\u1ec7c nghi\u00ean c\u1ee9u li\u00ean k\u1ebft gi\u1eefa c\u00e1c protein v\u00e0 b\u1ec7nh t\u1eadt, c\u00e1i m\u00e0 ch\u00fang t\u00f4i \u0111ang quan t\u00e2m \u0111\u1ec3 kh\u00e1m ph\u00e1 s\u00e2u h\u01a1n trong nh\u1eefng n\u0103m t\u1edbi,” ti\u1ebfn s\u0129 Emili k\u1ebft lu\u1eadn.<\/p>\n

Theo phys.org<\/em><\/p>\n

Kim T\u01b0\u01a1i<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

M\u1ed9t nh\u00f3m nh\u00e0 khoa h\u1ecdc \u0111a qu\u1ed1c gia \u0111\u00e3 xem x\u00e9t qua c\u00e1c t\u1ebf b\u00e0o c\u1ee7a c\u00e1c sinh v\u1eadt kh\u00e1c nhau, t\u1eeb amip \u0111\u1ebfn con s\u00e2u, chu\u1ed9t r\u1ed3i \u0111\u1ebfn con ng\u01b0\u1eddi, \u0111\u1ec3 kh\u00e1m ph\u00e1 c\u00e1ch protein li\u00ean k\u1ebft v\u1edbi nhau \u0111\u1ec3 t\u1ea1o n\u00ean t\u1ebf b\u00e0o v\u00e0 c\u00e1c c\u01a1 quan kh\u00e1c nhau. C\u00e1c nh\u00e0 khoa h\u1ecdc […]<\/p>\n","protected":false},"author":17,"featured_media":3830,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-3828","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/3828","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=3828"}],"version-history":[{"count":1,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/3828\/revisions"}],"predecessor-version":[{"id":3831,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/3828\/revisions\/3831"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/3830"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=3828"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=3828"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=3828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}