{"id":3585,"date":"2015-08-27T19:18:03","date_gmt":"2015-08-27T12:18:03","guid":{"rendered":"http:\/\/ttud.com.vn\/?p=3585"},"modified":"2017-09-27T19:19:51","modified_gmt":"2017-09-27T12:19:51","slug":"sieu-may-tinh-xay-dung-bo-gen-con-nguoi-trong-9-phut","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/sieu-may-tinh-xay-dung-bo-gen-con-nguoi-trong-9-phut\/","title":{"rendered":"Si\u00eau m\u00e1y t\u00ednh x\u00e2y d\u1ef1ng b\u1ed9 gen con ng\u01b0\u1eddi trong 9 ph\u00fat"},"content":{"rendered":"

V\u1edbi s\u1ef1 tr\u1ee3 gi\u00fap c\u1ee7a si\u00eau m\u00e1y t\u00ednh, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 c\u00f3 th\u1ec3 r\u00fat ng\u1eafn th\u1eddi gian x\u00e2y d\u1ef1ng h\u1ec7 gen sinh h\u1ecdc \u0111i r\u1ea5t nhi\u1ec1u.<\/strong><\/p>\n

\"\"<\/p>\n

Si\u00eau m\u00e1y t\u00ednh ng\u00e0y c\u00e0ng \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong nghi\u00ean c\u1ee9u khoa h\u1ecdc<\/p>\n

M\u1ed9t nh\u00f3m th\u00e0nh vi\u00ean t\u1ea1i vi\u1ec7n Joint Genome – tr\u1ef1c thu\u1ed9c ph\u00f2ng th\u00ed nghi\u1ec7m qu\u1ed1c gia Lawrence Barkeley, c\u00f9ng c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u1ee7a tr\u01b0\u1eddng \u0111\u1ea1i h\u1ecdc California Barkeley m\u1edbi \u0111\u00e2y \u0111\u00e3 s\u1eed d\u1ee5ng 15.000 nh\u00e2n c\u1ee7a si\u00eau m\u00e1y t\u00ednh Cray XC30 \u201cEdison\u201d nh\u1eb1m r\u00fat ng\u1eafn vi\u1ec7c x\u00e2y d\u1ef1ng to\u00e0n b\u1ed9 h\u1ec7 gen c\u1ee7a con ng\u01b0\u1eddi. T\u1ed5ng th\u1eddi gian \u0111\u1ec3 c\u00e1c si\u00eau m\u00e1y t\u00ednh Edison th\u1ef1c hi\u1ec7n vi\u1ec7c n\u00e0y l\u00e0 8 ph\u00fat 24 gi\u00e2y.<\/p>\n

C\u00e1c si\u00eau m\u00e1y t\u00ednh hi\u1ec7n nay \u0111\u00f3ng vai tr\u00f2 kh\u00e1 quan tr\u1ecdng trong vi\u1ec7c r\u00fat ng\u1eafn th\u1eddi gian th\u1ef1c hi\u1ec7n nh\u1eefng nghi\u00ean c\u1ee9u khoa h\u1ecdc quy m\u00f4 l\u1edbn. \u0110\u1ed1i v\u1edbi ngh\u00ean c\u1ee9u gen, th\u00e0nh t\u1ef1u tr\u00ean m\u1edf ra nhi\u1ec1u kh\u1ea3 n\u0103ng h\u01a1n so v\u1edbi vi\u1ec7c d\u1ef1ng h\u1ec7 gen b\u1eb1ng c\u00e1c c\u00f4ng c\u1ee5 l\u1eafp r\u00e1p \u201cde novo\u201d nh\u01b0 tr\u01b0\u1edbc \u0111\u00e2y. Ch\u1eb3ng h\u1ea1n nh\u01b0 v\u1edbi c\u00f4ng c\u1ee5 \u201cde novo\u201d, gi\u1ea3i \u0111o\u1ea1n m\u00e3 Meraculous ti\u00eau t\u1ed1n g\u1ea7n 24 gi\u1edd. Vi\u1ec7c d\u1ef1ng h\u1ec7 gen ho\u00e0n ch\u1ec9nh c\u1ee7a c\u00e2y l\u00faa m\u00ec – v\u1ed1n v\u00f4 c\u00f9ng ph\u1ee9c t\u1ea1p \u2013 g\u1ea7n nh\u01b0 n\u1eb1m ngo\u00e0i kh\u1ea3 n\u0103ng c\u1ee7a c\u00f4ng c\u1ee5 n\u00e0y. Nh\u01b0ng v\u1edbi ph\u01b0\u01a1ng ph\u00e1p HipMer, d\u01b0\u1edbi s\u1ef1 tr\u1ee3 gi\u00fap c\u1ee7a si\u00eau m\u00e1y t\u00ednh 15.000 nh\u00e2n, h\u1ec7 gen c\u1ee7a c\u00e2y l\u00faa m\u00ec \u0111\u01b0\u1ee3c d\u1ef1ng n\u00ean ch\u1ec9 trong v\u00f2ng ch\u01b0a \u0111\u1ea7y 40 ph\u00fat.<\/p>\n

Nh\u00f3m nghi\u00ean c\u1ee9u cho bi\u1ebft, tuy ph\u01b0\u01a1ng ph\u00e1p \u201cde novo\u201d c\u00f3 l\u1ee3i th\u1ebf t\u1eeb vi\u1ec7c \u201ct\u00ecm ra nh\u1eefng t\u1ed5 h\u1ee3p gen m\u1edbi c\u00f3 th\u1ec3 \u0111\u00e3 b\u1ecb b\u1ecf s\u00f3t\u201d, nh\u01b0ng th\u1eddi gian m\u00e0 ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u1ea7n \u0111\u1ec3 th\u1ef1c hi\u1ec7n c\u00f4ng vi\u1ec7c l\u1ea1i l\u1edbn h\u01a1n r\u1ea5t nhi\u1ec1u so v\u1edbi c\u00e1c c\u00f4ng c\u1ee5 l\u1eafp r\u00e1p hi\u1ec7n \u0111\u1ea1i.<\/p>\n

Ph\u01b0\u01a1ng ph\u00e1p m\u1edbi \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng mang t\u00ean HipMer (vi\u1ebft t\u1eaft c\u1ee7a High performance Meraculous) c\u00f3 th\u1ec3 gi\u00fap c\u00e1c nh\u00e0 khoa h\u1ecdc gi\u1ea3i quy\u1ebft \u0111\u01b0\u1ee3c v\u1ea5n \u0111\u1ec1 nan gi\u1ea3i tr\u01b0\u1edbc \u0111\u00e2y \u2013 X\u1eed l\u00fd m\u1ed9t l\u01b0\u1ee3ng l\u1edbn d\u1eef li\u1ec7u v\u00e0 gi\u1ea3i quy\u1ebft nh\u1eefng thu\u1eadt to\u00e1n v\u00f4 c\u00f9ng ph\u1ee9c t\u1ea1p.<\/p>\n

\u201cL\u1ea7n \u0111\u1ea7u ti\u00ean trong l\u1ecbch s\u1eed, ch\u00fang t\u00f4i \u0111\u00e3 c\u00f3 th\u1ec3 v\u01b0\u1ee3t qua kh\u1ea3 n\u0103ng c\u1ee7a to\u00e0n b\u1ed9 nh\u1eefng thi\u1ebft b\u1ecb d\u1ef1ng t\u1ed5 h\u1ee3p gen tr\u00ean th\u1ebf gi\u1edbi, v\u00e0 m\u1edf ra m\u1ed9t k\u1ef7 nguy\u00ean m\u1edbi cho ng\u00e0nh nghi\u00ean c\u1ee9u h\u1ec7 gen. Ph\u01b0\u01a1ng ph\u00e1p m\u1edbi k\u1ebft h\u1ee3p gi\u1eefa vi\u1ec7c x\u00e1c \u0111\u1ecbnh tr\u00ecnh t\u1ef1 hi\u1ec7u qu\u1ea3 cao, \u0111\u1ed3ng th\u1eddi c\u0169ng c\u00f3 \u0111\u01b0\u1ee3c t\u00ednh chi ti\u1ebft v\u00e0 \u0111\u1ea7y \u0111\u1ee7 c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p de novo. B\u1eb1ng c\u00e1ch n\u00e0y, ch\u00fang t\u00f4i tin s\u1ebd t\u1ea1o n\u00ean ti\u1ec1n \u0111\u1ec3 cho nh\u1eefng ph\u00e1t tri\u1ec3n c\u1ee7a c\u00f4ng ngh\u1ec7 y sinh trong t\u01b0\u01a1ng lai, bao g\u1ed3m c\u1ea3 vi\u1ec7c \u0111\u1ea3m b\u1ea3o an ninh l\u01b0\u01a1ng th\u1ef1c l\u1eabn vi\u1ec7c \u0111i\u1ec1u ch\u1ebf nh\u1eefng lo\u1ea1i thu\u1ed1c d\u00f9ng cho c\u00e1 nh\u00e2n.\u201d<\/p>\n

Si\u00eau m\u00e1y t\u00ednh Edison \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf t\u1eeb m\u1ed9t n\u0103m tr\u01b0\u1edbc v\u1edbi m\u1ee5c \u0111\u00edch h\u1ed7 tr\u1ee3 c\u00e1c nh\u00e0 khoa h\u1ecdc th\u1ef1c hi\u1ec7n c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 h\u1ec7 gen. B\u1edfi v\u1eady, \u201cEdison\u201d c\u00f3 kh\u1ea3 n\u0103ng c\u00e2n b\u1eb1ng gi\u1eefa vi\u1ec7c x\u1eed l\u00fd m\u1ed9t kh\u1ed1i l\u01b0\u1ee3ng l\u1edbn d\u1eef li\u1ec7u, c\u0169ng nh\u01b0 \u0111\u00e1p \u1ee9ng \u0111\u01b0\u1ee3c nh\u1eefng c\u00f4ng vi\u1ec7c c\u1ea7n \u0111\u1ebfn b\u1ed9 vi x\u1eed l\u00fd nhi\u00eau nh\u00e2n. Khi c\u00e1c th\u00e0nh vi\u00ean NERSC l\u00e0m vi\u1ec7c v\u1edbi Cray \u0111\u1ec3 ph\u00e1t tri\u1ec3n chi\u1ebfc XC30 d\u00f9ng trong nghi\u00ean c\u1ee9u, ngo\u00e0i kh\u1ea3 n\u0103ng li\u00ean k\u1ebft gi\u1eefa s\u1ed1 l\u01b0\u1ee3ng l\u1edbn b\u1ed9 vi x\u1eed l\u00fd, h\u1ecd c\u00f2n mu\u1ed1n c\u00f3 \u0111\u01b0\u1ee3c m\u1ed9t b\u1ed9 nh\u1edb v\u1edbi l\u01b0u l\u01b0\u1ee3ng b\u0103ng th\u00f4ng l\u1edbn. K\u1ebft qu\u1ea3, m\u1ed9t si\u00eau m\u00e1y t\u00ednh v\u1edbi t\u1ed1c \u0111\u1ed9 truy xu\u1ea5t d\u1eef li\u1ec7u kho\u1ea3ng 163 gigabyte tr\u00ean gi\u00e2y v\u00e0 r\u01a1i v\u00e0o kho\u1ea3ng 2,4 petaflop.<\/p>\n

\"\"<\/p>\n

Th\u1eddi gian d\u1ef1ng h\u1ec7 gen b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p HipMer<\/p>\n

\u0110\u1ed1i v\u1edbi si\u00eau m\u00e1y t\u00ednh, b\u1ed9 vi x\u1eed l\u00fd v\u00e0 b\u0103ng th\u00f4ng b\u1ed9 nh\u1edb l\u00e0 hai \u0111i\u1ec3m t\u1ed1i quan tr\u1ecdng. Tuy nhi\u00ean, vi\u1ec7c x\u00e2y d\u1ef1ng b\u1ed9 m\u00e3 \u0111\u1ec3 c\u00f3 th\u1ec3 ph\u00e2n b\u1ed1 hi\u1ec7u qu\u1ea3 c\u00f4ng vi\u1ec7c gi\u1eefa 15.000 b\u1ed9 vi x\u1eed l\u00fd Ivy Bridge 12 nh\u00e2n c\u0169ng quan tr\u1ecdng kh\u00f4ng k\u00e9m. Si\u00eau m\u00e1y t\u00ednh Edison \u0111\u01b0\u1ee3c g\u00e2y d\u1ef1ng tr\u00ean n\u1ec1n t\u1ea3ng t\u1eeb c\u00f4ng c\u1ee5 t\u1ed5 h\u1ee3p gen Meraculous \u2013 hi\u1ec7n \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f4ng c\u1ee5 t\u1ed1i \u01b0u nh\u1ea5t s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p “de novo”.
\nPh\u01b0\u01a1ng ph\u00e1p HipMer c\u00f3 nhi\u1ec1u ti\u1ebfn b\u1ed9 nh\u01b0 s\u1eed d\u1ee5ng nhi\u1ec1u thu\u1eadt to\u00e1n nh\u1eb1m t\u1ed1i \u01b0u h\u00f3a hi\u1ec7u qu\u1ea3 c\u1ee7a UPC, c\u1ea3i thi\u1ec7n t\u1ed1c \u0111\u1ed9 truy xu\u1ea5t, c\u0169ng nh\u01b0 th\u1ef1c hi\u1ec7n song song c\u00e1c c\u00f4ng \u0111o\u1ea1n ph\u1ee9c t\u1ea1p c\u00f9ng m\u1ed9t l\u00fac. \u0110\u1ed3ng th\u1eddi vi\u1ec7c \u0111\u1ecdc v\u00e0 ghi d\u1eef li\u1ec7u t\u1eeb m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng l\u1edbn \u0111\u1ed3ng th\u1eddi t\u1eeb c\u00e1c b\u1ed9 vi x\u1eed l\u00fd c\u0169ng \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n t\u1ed1t h\u01a1n.<\/p>\n

Nh\u00f3m nghi\u00ean c\u1ee9u c\u0169ng \u0111ang ph\u00e1t tri\u1ec3n th\u00eam ph\u01b0\u01a1ng ph\u00e1p ph\u00e2n b\u1ed5 b\u1ed9 nh\u1edb kh\u00e1c cho HipMer, m\u00e0 khi th\u00e0nh c\u00f4ng s\u1ebd r\u00fat ng\u1eafn \u0111\u01b0\u1ee3c b\u1ed9 m\u00e3 gen \u0111\u1ea7y \u0111\u1ee7 c\u1ee7a l\u00faa m\u00ec trong ch\u01b0a \u0111\u1ea7y 11 ph\u00fat. Giai \u0111o\u1ea1n ti\u1ebfp theo nh\u00f3m nghi\u00ean c\u1ee9u h\u01b0\u1edbng \u0111\u1ebfn l\u00e0 \u00e1p d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p n\u00e0y v\u00e0o nghi\u00ean c\u1ee9u h\u1ec7 gen \u1edf quy m\u00f4 l\u1edbn h\u01a1n.
\nTham kh\u1ea3o The Platform<\/p>\n

Ngu\u1ed3n GenK.vn<\/p>\n","protected":false},"excerpt":{"rendered":"

V\u1edbi s\u1ef1 tr\u1ee3 gi\u00fap c\u1ee7a si\u00eau m\u00e1y t\u00ednh, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 c\u00f3 th\u1ec3 r\u00fat ng\u1eafn th\u1eddi gian x\u00e2y d\u1ef1ng h\u1ec7 gen sinh h\u1ecdc \u0111i r\u1ea5t nhi\u1ec1u. Si\u00eau m\u00e1y t\u00ednh ng\u00e0y c\u00e0ng \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong nghi\u00ean c\u1ee9u khoa h\u1ecdc M\u1ed9t nh\u00f3m th\u00e0nh vi\u00ean t\u1ea1i vi\u1ec7n Joint Genome – tr\u1ef1c thu\u1ed9c ph\u00f2ng […]<\/p>\n","protected":false},"author":17,"featured_media":3586,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-3585","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/3585","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=3585"}],"version-history":[{"count":1,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/3585\/revisions"}],"predecessor-version":[{"id":3588,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/3585\/revisions\/3588"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/3586"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=3585"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=3585"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=3585"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}