{"id":3535,"date":"2015-08-19T18:49:40","date_gmt":"2015-08-19T11:49:40","guid":{"rendered":"http:\/\/ttud.com.vn\/?p=3535"},"modified":"2017-09-27T18:50:35","modified_gmt":"2017-09-27T11:50:35","slug":"chuot-thong-minh-mang-den-hy-vong-ve-cac-phuong-phap-tri-lieu-roi-loan-nhan-thuc-tot-hon","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/chuot-thong-minh-mang-den-hy-vong-ve-cac-phuong-phap-tri-lieu-roi-loan-nhan-thuc-tot-hon\/","title":{"rendered":"CHU\u1ed8T \u201cTH\u00d4NG MINH\u201d MANG \u0110\u1ebeN HY V\u1eccNG V\u1ec0 C\u00c1C PH\u01af\u01a0NG PH\u00c1P TR\u1eca LI\u1ec6U R\u1ed0I LO\u1ea0N NH\u1eacN TH\u1ee8C T\u1ed0T H\u01a0N"},"content":{"rendered":"

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u1ee7a \u0110\u1ea1i h\u1ecdc Leeds – V\u01b0\u01a1ng qu\u1ed1c Anh – \u0111\u00e3 t\u1ea1o ra nh\u1eefng con chu\u1ed9t th\u00f4ng minh b\u1ea5t th\u01b0\u1eddng b\u1eb1ng c\u00e1ch l\u00e0m bi\u1ebfn \u0111\u1ed5i m\u1ed9t gen \u0111\u01a1n. K\u1ebft qu\u1ea3 l\u00e0 nh\u1eefng ch\u00fa chu\u1ed9t n\u00e0y gi\u1ea3m c\u1ea3m gi\u00e1c lo l\u1eafng hay \u00edt nh\u1edb l\u1ea1i nh\u1eefng n\u1ed7i s\u1ee3 \u0111\u00e3 tr\u1ea3i qua. \u0110i\u1ec1u n\u00e0y l\u00e0m r\u00f5 c\u01a1 ch\u1ebf ph\u00e2n t\u1eed c\u1ee7a s\u1ef1 h\u1ecdc h\u1ecfi v\u00e0 ghi nh\u1edb, v\u00e0 c\u00f3 th\u1ec3 tr\u1edf th\u00e0nh c\u01a1 s\u1edf cho vi\u1ec7c nghi\u00ean c\u1ee9u ph\u01b0\u01a1ng ph\u00e1p tr\u1ecb li\u1ec7u m\u1edbi \u0111\u1ed1i v\u1edbi s\u1ef1 suy gi\u1ea3m nh\u1eadn th\u1ee9c do tu\u1ed5i t\u00e1c, c\u00e1c r\u1ed1i lo\u1ea1n nh\u1eadn th\u1ee9c nh\u01b0 b\u1ec7nh Alzheimer, t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t, v\u00e0 c\u00e1c t\u00ecnh tr\u1ea1ng b\u1ec7nh l\u00fd kh\u00e1c<\/strong>.<\/p>\n

\"\"<\/p>\n

Chu\u1ed9t th\u00ed nghi\u1ec7m. Ngu\u1ed3n: \u00a9 mgkuijpers \/ Fotolia<\/p>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 bi\u1ebfn \u0111\u1ed5i m\u1ed9t gen trong chu\u1ed9t \u0111\u1ec3 \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a enzyme phosphodiesterase-4B (PDE4B), l\u00e0 enzyme hi\u1ec7n di\u1ec7n \u1edf nhi\u1ec1u c\u01a1 quan (bao g\u1ed3m c\u1ea3 n\u00e3o) c\u1ee7a \u0111\u1ed9ng v\u1eadt c\u00f3 x\u01b0\u01a1ng s\u1ed1ng.
\nTrong c\u00e1c b\u00e0i ki\u1ec3m tra h\u00e0nh vi, nh\u1eefng con chu\u1ed9t \u0111\u00e3 \u0111\u01b0\u1ee3c \u1ee9c ch\u1ebf enzyme PDE4B t\u1ecf ra \u0111\u01b0\u1ee3c t\u0103ng c\u01b0\u1eddng c\u00e1c kh\u1ea3 n\u0103ng v\u1ec1 m\u1eb7t nh\u1eadn th\u1ee9c. Ch\u00fang c\u00f3 xu h\u01b0\u1edbng h\u1ecdc h\u1ecfi nhanh h\u01a1n, ghi nh\u1edb s\u1ef1 ki\u1ec7n l\u00e2u h\u01a1n v\u00e0 gi\u1ea3i quy\u1ebft c\u00e1c b\u00e0i t\u1eadp ph\u1ee9c t\u1ea1p t\u1ed1t h\u01a1n c\u00e1c con chu\u1ed9t b\u00ecnh th\u01b0\u1eddng. V\u00ed d\u1ee5 , chu\u1ed9t \u201cth\u00f4ng minh\u201d th\u1ec3 hi\u1ec7n t\u1ed1t h\u01a1n chu\u1ed9t b\u00ecnh th\u01b0\u1eddng v\u1ec1 kh\u1ea3 n\u0103ng nh\u1eadn bi\u1ebft con chu\u1ed9t kh\u00e1c \u0111\u00e3 \u0111\u01b0\u1ee3c gi\u1edbi thi\u1ec7u v\u1edbi ch\u00fang v\u00e0o ng\u00e0y tr\u01b0\u1edbc \u0111\u00f3. Trong m\u1ed9t th\u00ed nghi\u1ec7m v\u1edbi m\u00ea cung n\u01b0\u1edbc Morris, ch\u00fang h\u1ecdc \u0111\u01b0\u1ee3c v\u1ecb tr\u00ed c\u1ee7a chi\u1ebfc b\u1ee5c \u1ea9n nhanh h\u01a1n so v\u1edbi chu\u1ed9t b\u00ecnh th\u01b0\u1eddng. Tuy nhi\u00ean, so v\u1edbi c\u00e1c con chu\u1ed9t b\u00ecnh th\u01b0\u1eddng, c\u00e1c con chu\u1ed9t \u0111\u01b0\u1ee3c \u1ee9c ch\u1ebf enzyme PDE4B \u00edt nh\u1edb l\u1ea1i s\u1ef1 ki\u1ec7n \u0111\u00e1ng s\u1ee3 \u0111\u00e3 x\u1ea3y ra v\u00e0o nh\u1eefng ng\u1ea3y tr\u01b0\u1edbc \u0111\u00f3.
\nC\u00e1c ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 ch\u1ec9 gi\u1edbi h\u1ea1n tr\u00ean \u0111\u1ed1i t\u01b0\u1ee3ng chu\u1ed9t v\u00e0 ch\u01b0a \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m tr\u00ean con ng\u01b0\u1eddi, nh\u01b0ng enzyme PDE4B c\u0169ng t\u1ed3n t\u1ea1i trong c\u01a1 th\u1ec3 ng\u01b0\u1eddi. Hi\u1ec7n t\u01b0\u1ee3ng gi\u1ea3m tr\u00ed nh\u1edb v\u1ec1 s\u1ef1 s\u1ee3 h\u00e3i \u1edf nh\u1eefng con chu\u1ed9t b\u1ecb \u1ee9c ch\u1ebf enzyme PDE4B c\u00f3 th\u1ec3 c\u00f3 \u00edch cho c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u trong vi\u1ec7c t\u00ecm ra ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng s\u1ee3 h\u00e3i b\u1ec7nh l\u00fd, ti\u00eau bi\u1ec3u l\u00e0 \u201cR\u1ed1i lo\u1ea1n stress sau sang ch\u1ea5n\u201d(Post-Traumatic Stress Disorder \u2212PTSD).
\nNh\u1eefng con chu\u1ed9t \u0111\u01b0\u1ee3c \u1ee9c ch\u1ebf enzyme PDE4B c\u0169ng t\u1ecf ra \u00edt lo \u00e2u h\u01a1n. Ch\u00fang d\u00e0nh nhi\u1ec1u th\u1eddi gian \u1edf c\u00e1c kh\u00f4ng gian m\u1edf v\u00e0 s\u00e1ng h\u01a1n nh\u1eefng con chu\u1ed9t b\u00ecnh th\u01b0\u1eddng v\u1ed1n th\u00edch c\u00e1c kh\u00f4ng gian t\u1ed1i v\u00e0 kh\u00e9p k\u00edn.
\nTrong t\u1ef1 nhi\u1ec7n, chu\u1ed9t b\u00ecnh th\u01b0\u1eddng r\u1ea5t s\u1ee3 m\u00e8o, nh\u01b0ng c\u00e1c con chu\u1ed9t \u0111\u01b0\u1ee3c \u1ee9c ch\u1ebf enzyme PDE4B gi\u1ea3m ph\u1ea3n \u1ee9ng s\u1ee3 h\u00e3i v\u1edbi n\u01b0\u1edbc ti\u1ec3u c\u1ee7a m\u00e8o, \u0111i\u1ec1u n\u00e0y cho th\u1ea5y m\u1ed9t t\u00e1c d\u1ee5ng c\u1ee7a vi\u1ec7c \u1ee9c ch\u1ebf enzyme PDE4B l\u00e0 c\u00f3 th\u1ec3 gia t\u0103ng h\u00e0nh vi mang t\u00ednh li\u1ec1u l\u0129nh. V\u00ec th\u1ebf, trong khi chu\u1ed9t \u0111\u01b0\u1ee3c \u1ee9c ch\u1ebf enzyme PDE4B r\u1ea5t xu\u1ea5t s\u1eafc trong vi\u1ec7c gi\u1ea3i quy\u1ebft c\u00e1c b\u00e0i t\u1eadp ph\u1ee9c t\u1ea1p th\u00ec s\u1ef1 \u00edt lo l\u1eafng c\u00f3 th\u1ec3 g\u00e2y ph\u1ea3n t\u00e1c d\u1ee5ng \u0111\u1ed1i v\u1edbi m\u1ed9t con chu\u1ed9t s\u1ed1ng hoang d\u00e3.
\nTi\u1ebfn s\u0129 Steven Clapcote \u2212 Gi\u1ea3ng vi\u00ean D\u01b0\u1ee3c v\u1eadt h\u1ecdc \u1edf Khoa Khoa h\u1ecdc Y sinh c\u1ee7a \u0110\u1ea1i h\u1ecdc Leeds, ng\u01b0\u1eddi ch\u1ee7 tr\u00ec nghi\u00ean c\u1ee9u \u2013 cho r\u1eb1ng: \u201cHi\u1ec7n nay, c\u00e1c b\u1ec7nh v\u1ec1 khi\u1ebfm khuy\u1ebft nh\u1eadn th\u1ee9c \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb m\u1ed9t c\u00e1ch k\u00e9m hi\u1ec7u qu\u1ea3, v\u00ec th\u1ebf t\u00f4i r\u1ea5t ph\u1ea5n kh\u1edfi khi c\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u tr\u00ean chu\u1ed9t \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c phosphodiesterase-4B nh\u01b0 m\u1ed9t m\u1ee5c ti\u00eau \u0111\u1ea7y h\u1ee9a h\u1eb9n cho c\u00e1c ph\u01b0\u01a1ng ph\u00e1p tr\u1ecb li\u1ec7u m\u1edbi, c\u00f3 nhi\u1ec1u ti\u1ec1m n\u0103ng.\u201d
\nHi\u1ec7n t\u1ea1i, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111ang nghi\u00ean c\u1ee9u ph\u00e1t tri\u1ec3n c\u00e1c lo\u1ea1i thu\u1ed1c c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf \u0111\u1eb7c hi\u1ec7u enzyme PDE4B. C\u00e1c thu\u1ed1c n\u00e0y s\u1ebd \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m tr\u00ean \u0111\u1ed9ng v\u1eadt \u0111\u1ec3 xem ch\u00fang c\u00f3 th\u00edch h\u1ee3p cho c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng tr\u00ean ng\u01b0\u1eddi hay kh\u00f4ng.
\nTi\u1ebfn s\u0129 Alexander McGirr \u2212 m\u1ed9t b\u00e1c s\u0129 t\u00e2m th\u1ea7n \u0111ang t\u1eadp hu\u1ea5n t\u1ea1i \u0111\u1ea1i h\u1ecdc British Columbia, ng\u01b0\u1eddi \u0111\u1ed3ng ch\u1ee7 tr\u00ec nghi\u00ean c\u1ee9u \u2212 ph\u00e1t bi\u1ec3u: \u201cTrong t\u01b0\u01a1ng lai, c\u00e1c lo\u1ea1i thu\u1ed1c nh\u1eb1m v\u00e0o enzyme PDE4B c\u00f3 ti\u1ec1m n\u0103ng c\u1ea3i thi\u1ec7n cu\u1ed9c s\u1ed1ng c\u1ee7a ng\u01b0\u1eddi m\u1eafc ch\u1ee9ng r\u1ed1i lo\u1ea1n nh\u1eadn th\u1ee9c th\u1ea7n kinh v\u00e0 ch\u1ee9ng lo l\u1eafng, v\u00e0 ch\u00fang c\u00f3 th\u1ec3 \u0111\u00f3ng m\u1ed9t vai tr\u00f2 trong m\u1ed9t kho\u1ea3ng th\u1eddi gian nh\u1ea5t \u0111\u1ecbnh sau khi ch\u1ea5n th\u01b0\u01a1ng\u201d.
\nTi\u1ebfn s\u0129 Laura Phipps c\u1ee7a T\u1ed5 ch\u1ee9c Alzheimer’s Research UK \u2013 ng\u01b0\u1eddi b\u00ean ngo\u00e0i cu\u1ed9c nghi\u00ean c\u1ee9u \u2013 cho r\u1eb1ng: \u201cNghi\u00ean c\u1ee9u n\u00e0y nh\u1ea5n m\u1ea1nh vai tr\u00f2 quan tr\u1ecdng ti\u1ec1m \u1ea9n c\u1ee7a gen PDE4B trong vi\u1ec7c h\u1ecdc h\u1ecfi v\u00e0 tr\u00ed nh\u1edb c\u1ee7a chu\u1ed9t, nh\u01b0ng c\u00e1c nghi\u00ean c\u1ee9u s\u00e2u h\u01a1n c\u1ea7n \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u0111\u1ec3 bi\u1ebft \u0111\u01b0\u1ee3c c\u00e1c ph\u00e1t hi\u1ec7n n\u00e0y c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn c\u0103n b\u1ec7nh Alzheimer ho\u1eb7c c\u00e1c ch\u1ee9ng m\u1ea5t tr\u00ed nh\u1edb kh\u00e1c hay kh\u00f4ng. Ch\u00fang ta c\u1ea7n xem gen n\u00e0y c\u00f3 th\u1ec3 t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn tr\u00ed nh\u1edb v\u00e0 suy ngh\u0129 c\u1ee7a con ng\u01b0\u1eddi nh\u01b0 th\u1ebf n\u00e0o \u0111\u1ec3 c\u00f3 th\u1ec3 \u0111\u01b0a ra \u00fd ki\u1ebfn ch\u00ednh x\u00e1c h\u01a1n v\u1ec1 vi\u1ec7c n\u00f3 c\u00f3 ti\u1ec1m n\u0103ng tr\u1edf th\u00e0nh li\u1ec7u ph\u00e1p ch\u1eefa tr\u1ecb \u0111\u00edch trong vi\u1ec7c ch\u1eefa tr\u1ecb b\u1ec7nh Alzheimer hay kh\u00f4ng?\u201d.
\nCho \u0111\u1ebfn nay, ph\u01b0\u01a1ng ph\u00e1p tr\u1ecb li\u1ec7u hi\u1ec7u qu\u1ea3 cho ch\u1ee9ng m\u1ea5t tr\u00ed v\u1eabn c\u00f2n thi\u1ebfu v\u00e0 vi\u1ec7c hi\u1ec3u r\u00f5 \u1ea3nh h\u01b0\u1edfng c\u1ee7a c\u00e1c gen c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t b\u01b0\u1edbc \u0111\u1ea7u quan tr\u1ecdng tr\u00ean con \u0111\u01b0\u1eddng ph\u00e1t tri\u1ec3n c\u00e1c lo\u1ea1i thu\u1ed1c m\u1edbi. V\u1edbi vi\u1ec7c c\u00f3 r\u1ea5t nhi\u1ec1u ng\u01b0\u1eddi b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi ch\u1ee9ng m\u1ea5t tr\u00ed, vi\u1ec7c nghi\u00ean c\u1ee9u ra nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p ch\u1eefa tr\u1ecb l\u00e0 r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 s\u1edbm t\u00ecm ra c\u01a1 h\u1ed9i ch\u1eefa tr\u1ecb t\u1ed1t nh\u1ea5t cho c\u00e1c b\u1ec7nh nh\u00e2n\u201d.<\/p>\n

Ngu\u1ed3n Sciencedaily<\/p>\n

Ng\u1ecdc Thanh d\u1ecbch
\nhttp:\/\/www.sciencedaily.com<\/p>\n","protected":false},"excerpt":{"rendered":"

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u1ee7a \u0110\u1ea1i h\u1ecdc Leeds – V\u01b0\u01a1ng qu\u1ed1c Anh – \u0111\u00e3 t\u1ea1o ra nh\u1eefng con chu\u1ed9t th\u00f4ng minh b\u1ea5t th\u01b0\u1eddng b\u1eb1ng c\u00e1ch l\u00e0m bi\u1ebfn \u0111\u1ed5i m\u1ed9t gen \u0111\u01a1n. K\u1ebft qu\u1ea3 l\u00e0 nh\u1eefng ch\u00fa chu\u1ed9t n\u00e0y gi\u1ea3m c\u1ea3m gi\u00e1c lo l\u1eafng hay \u00edt nh\u1edb l\u1ea1i nh\u1eefng n\u1ed7i s\u1ee3 \u0111\u00e3 tr\u1ea3i qua. \u0110i\u1ec1u n\u00e0y […]<\/p>\n","protected":false},"author":17,"featured_media":3536,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-3535","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/3535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=3535"}],"version-history":[{"count":1,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/3535\/revisions"}],"predecessor-version":[{"id":3537,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/3535\/revisions\/3537"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/3536"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=3535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=3535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=3535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}