{"id":3503,"date":"2015-08-10T18:09:15","date_gmt":"2015-08-10T11:09:15","guid":{"rendered":"http:\/\/ttud.com.vn\/?p=3503"},"modified":"2017-09-27T18:42:53","modified_gmt":"2017-09-27T11:42:53","slug":"xet-nghiem-nuoc-tieu-giup-phat-hien-ung-thu","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/xet-nghiem-nuoc-tieu-giup-phat-hien-ung-thu\/","title":{"rendered":"X\u00e9t nghi\u1ec7m n\u01b0\u1edbc ti\u1ec3u gi\u00fap ph\u00e1t hi\u1ec7n ung th\u01b0"},"content":{"rendered":"

M\u1ed9t k\u1ef9 thu\u1eadt m\u1edbi \u0111ang \u0111\u01b0\u1ee3c c\u00e1c nh\u00e0 khoa h\u1ecdc th\u1eed nghi\u1ec7m, cho ph\u00e9p ph\u00e1t hi\u1ec7n b\u1ec7nh l\u00fd (nh\u01b0 ung th\u01b0) trong th\u1eddi gian ch\u1ec9 m\u1ed9t ng\u00e0y.<\/strong><\/p>\n

\"\"<\/p>\n

Hai nghi\u00ean c\u1ee9u kh\u00e1c nhau \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n, nh\u01b0ng l\u1ea1i c\u00f3 \u0111i\u1ec3m chung l\u00e0 \u0111\u1ec1u s\u1eed d\u1ee5ng vi khu\u1ea9n bi\u1ebfn \u0111\u1ed5i gen \u0111\u1ec3 ph\u00e1t hi\u1ec7n c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a b\u1ec7nh trong c\u01a1 th\u1ec3. V\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p hi\u1ec7n nay, vi\u1ec7c ch\u1ea9n \u0111o\u00e1n m\u1ed9t s\u1ed1 c\u0103n b\u1ec7nh c\u00f3 th\u1ec3 t\u1ed1n nhi\u1ec1u th\u1eddi gian v\u00e0 r\u1ea5t kh\u00f3 kh\u0103n.<\/p>\n

Ch\u1eb3ng h\u1ea1n, m\u1ed9t s\u1ed1 b\u1ec7nh ung th\u01b0 hi\u1ec7n ch\u1ec9 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n b\u1eb1ng sinh thi\u1ebft x\u00e2m l\u1ea5n, v\u00e0 ch\u1ee5p CT ch\u1ec9 c\u00f3 th\u1ec3 nh\u00ecn th\u1ea5y c\u00e1c kh\u1ed1i u khi n\u00f3 ph\u00e1t tri\u1ec3n t\u01b0\u01a1ng \u0111\u1ed1i l\u1edbn (v\u00e0o kho\u1ea3ng n\u1eeda inch). Nh\u1eefng r\u1ed1i lo\u1ea1n kh\u00e1c r\u1ea5t kh\u00f3 bi\u1ebft \u0111\u01b0\u1ee3c do c\u00e1c d\u1ea5u t\u00edch \u0111\u1ec3 l\u1ea1i trong m\u00e1u v\u00e0 n\u01b0\u1edbc ti\u1ec3u \u1edf n\u1ed3ng \u0111\u1ed9 c\u1ef1c th\u1ea5p.<\/p>\n

Gi\u1edd \u0111\u00e2y, khai th\u00e1c \u1ee9ng d\u1ee5ng c\u1ee7a vi khu\u1ea9n, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u cho bi\u1ebft h\u1ecd \u0111\u00e3 t\u00ecm th\u1ea5y c\u00e1ch ph\u00e1t hi\u1ec7n ung th\u01b0 s\u1edbm h\u01a1n. \u0110\u1ed3ng th\u1eddi t\u00ecm ki\u1ebfm c\u00e1c h\u00f3a ch\u1ea5t c\u1ee5 th\u1ec3 trong d\u1ecbch c\u01a1 th\u1ec3, l\u00e0m cho x\u00e9t nghi\u1ec7m tr\u1edf n\u00ean d\u1ec5 d\u00e0ng h\u01a1n v\u00e0 \u0111\u01b0a ra k\u1ebft qu\u1ea3 ch\u00ednh x\u00e1c.<\/p>\n

Nghi\u00ean c\u1ee9u c\u1ee7a MIT v\u00e0 \u0110\u1ea1i h\u1ecdc California, San Diego<\/strong><\/p>\n

\u1ede m\u1ed9t trong hai nghi\u00ean c\u1ee9u m\u1edbi, c\u00e1c nh\u00e0 khoa h\u1ecdc t\u1ea1i H\u1ecdc vi\u1ec7n C\u00f4ng ngh\u1ec7 Massachusetts (MIT) v\u00e0 \u0110\u1ea1i h\u1ecdc California, San Diego s\u1eed d\u1ee5ng vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t Escherichia coli \u0111\u1ec3 x\u00e2m nh\u1eadp v\u00e0o kh\u1ed1i u \u00e1c t\u00ednh \u1edf chu\u1ed9t. \u0110\u01b0\u1ee3c bi\u1ebft vi khu\u1ea9n E. coli m\u00e0 h\u1ecd s\u1eed d\u1ee5ng l\u00e0 m\u1ed9t trong nh\u1eefng lo\u1ea1i v\u00f4 h\u1ea1i, th\u01b0\u1eddng \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng s\u1ee9c kh\u1ecfe \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n

\"\"
\nC\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 s\u1eeda \u0111\u1ed5i c\u1ea5u tr\u00fac c\u00e1c m\u1ea1ch di truy\u1ec1n c\u1ee7a vi khu\u1ea9n E.coli, gi\u00fap ph\u00e1t hi\u1ec7n b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng v\u00e0 ung th\u01b0 qua n\u01b0\u1edbc ti\u1ec3u. \u200b<\/p>\n

Khi v\u00e0o trong c\u00f3 th\u1ec3 chu\u1ed9t, vi khu\u1ea9n \u0103n ho\u00e1 ch\u1ea5t t\u1ea1o ra b\u1edfi “l\u00f5i ho\u1ea1i t\u1eed” c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0, v\u1ed1n t\u1ed3n t\u1ea1i \u1edf trung t\u00e2m c\u00e1c kh\u1ed1i u. “Trong l\u00f5i ho\u1ea1i t\u1eed c\u1ee7a kh\u1ed1i u, vi khu\u1ea9n l\u1ea5y \u0111i n\u0103ng l\u01b0\u1ee3ng t\u1eeb c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 s\u1eafp ch\u1ebft”, Tal Danino – ti\u1ebfn s\u0129 t\u1ea1i MIT, t\u00e1c gi\u1ea3 ch\u00ednh c\u1ee7a c\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u chia s\u1ebb v\u1edbi Live Science.<\/p>\n

\u0110\u1ed3ng th\u1eddi, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ti\u00eam v\u00e0o nh\u1eefng con chu\u1ed9t m\u1ed9t h\u1ed7n h\u1ee3p \u0111\u01b0\u1eddng galactose li\u00ean k\u1ebft v\u1edbi protein luciferin. Th\u00e0nh ph\u1ea7n n\u00e0y c\u00f3 c\u01a1 ch\u1ebf t\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c ph\u00e2n t\u1eed gi\u00fap \u0111om \u0111\u00f3m ph\u00e1t s\u00e1ng.<\/p>\n

V\u1edbi c\u1ea5u tr\u00fac nh\u01b0 v\u1eady, khi E. coli \u0103n c\u00e1c t\u1ebf b\u00e0o kh\u1ed1i u, ch\u00fang s\u1ebd s\u1ea3n xu\u1ea5t m\u1ed9t lo\u1ea1i enzyme c\u00f3 kh\u1ea3 n\u0103ng t\u00e1ch galactose ra kh\u1ecfi luciferin. Luciferin sau \u0111\u00f3 \u0111\u01b0\u1ee3c th\u1eadn l\u1ecdc ra kh\u1ecfi m\u00e1u, qua \u0111\u01b0\u1eddng ti\u1ec3u. L\u00fac n\u00e0y, n\u01b0\u1edbc ti\u1ec3u chu\u1ed9t s\u1ebd ch\u1ee9a di c\u0103n kh\u1ed1i u v\u00e0 c\u00e1c nh\u00e0 khoa h\u1ecdc c\u00f3 th\u1ec3 d\u1ec5 d\u00e0ng nh\u1eadn bi\u1ebft \u0111\u01b0\u1ee3c.<\/p>\n

\u201cHi\u1ec7n nghi\u00ean c\u1ee9u v\u1eabn \u1edf giai \u0111o\u1ea1n \u0111\u1ea7u v\u00e0 ch\u01b0a c\u00f3 g\u00ec b\u1ea3o \u0111\u1ea3m n\u00f3 s\u1ebd l\u00e0m vi\u1ec7c tr\u00ean c\u01a1 th\u1ec3 con ng\u01b0\u1eddi. Tuy nhi\u00ean v\u1edbi ph\u01b0\u01a1ng ph\u00e1p n\u00e0y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u00f3 th\u1ec3 ph\u00e1t hi\u1ec7n h\u1ea7u h\u1ebft c\u00e1c thay \u0111\u1ed5i sinh h\u1ecdc trong c\u01a1 th\u1ec3, m\u1eb7c d\u00f9 kh\u1ea3 n\u0103ng ph\u00e1t hi\u1ec7n ung th\u01b0 l\u00e0 m\u1ee5c ti\u00eau \u0111\u1ea7u ti\u00ean c\u1ee7a c\u00f4ng tr\u00ecnh.\u201d, Danino n\u00f3i.<\/p>\n

Nghi\u00ean c\u1ee9u c\u1ee7a Vi\u1ec7n Nghi\u00ean c\u1ee9u Y khoa Ph\u00e1p (INSERM)<\/strong><\/p>\n

\u1ede m\u1ed9t nghi\u00ean c\u1ee9u kh\u00e1c c\u1ee7a c\u00e1c chuy\u00ean gia \u0111\u1ebfn t\u1eeb Vi\u1ec7n Nghi\u00ean c\u1ee9u Y khoa Ph\u00e1p, vi khu\u1ea9n E. coli bi\u1ebfn \u0111\u1ed5i gen gi\u00fap h\u1ecd ph\u00e1t hi\u1ec7n glucose v\u00e0 c\u00e1c d\u1ea5u hi\u1ec7u kh\u00e1c trong n\u01b0\u1edbc ti\u1ec3u, t\u1eeb \u0111\u00f3 k\u1ebft lu\u1eadn b\u1ec7nh nh\u00e2n c\u00f3 m\u1eafc b\u1ec7nh \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng hay kh\u00f4ng.<\/p>\n

\"\"<\/p>\n

C\u00e1c nh\u00e0 khoa h\u1ecdc c\u1ea5y v\u00e0o E. coli m\u1ed9t gen, gi\u00fap thay \u0111\u1ed5i m\u00e0u s\u1eafc n\u01b0\u1edbc ti\u1ec3u n\u1ebfu vi khu\u1ea9n nh\u1eadn ra c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng. H\u1ecd \u0111\u00e3 th\u1eed nghi\u1ec7m v\u1edbi c\u00e1c m\u1eabu n\u01b0\u1edbc ti\u1ec3u c\u1ee7a con ng\u01b0\u1eddi, t\u1eeb nh\u1eefng ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh \u0111\u1ebfn ng\u01b0\u1eddi b\u1ec7nh.<\/p>\n

K\u1ebft<\/strong><\/p>\n

Kh\u1ea3 n\u0103ng ph\u00e1t hi\u1ec7n m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf c\u00e1c ch\u1ea5t h\u00f3a h\u1ecdc c\u1ee7a vi khu\u1ea9n l\u00e0 y\u1ebfu t\u1ed1 m\u00e0 c\u00e1c nh\u00e0 khoa h\u1ecdc khai th\u00e1c, \u1edf c\u1ea3 hai nghi\u00ean c\u1ee9u. Theo Danino, v\u1ea5n \u0111\u1ec1 l\u1edbn \u0111\u1ed1i v\u1edbi b\u1ec7nh ung th\u01b0 l\u00e0 r\u1ea5t kh\u00f3 \u0111\u1ec3 nh\u00ecn th\u1ea5y c\u00e1c kh\u1ed1i u, cho \u0111\u1ebfn khi k\u00edch th\u01b0\u1edbc c\u1ee7a ch\u00fang l\u1edbn d\u1ea7n. L\u00fac b\u1ea5y gi\u1edd, vi\u1ec7c \u0111i\u1ec1u tr\u1ecb h\u1ebft s\u1ee9c kh\u00f3 kh\u0103n. .<\/p>\n

Ph\u00e1t hi\u1ec7n m\u1edbi cho th\u1ea5y vi khu\u1ea9n c\u00f3 th\u1ec3 x\u00e2m nh\u1eadp v\u00e0o c\u01a1 th\u1ec3 v\u00e0 x\u00e2m chi\u1ebfm c\u00e1c kh\u1ed1i u nh\u1ecf, t\u1eeb \u0111\u00f3 cung c\u1ea5p c\u01a1 h\u1ed9i \u0111\u1ec3 ph\u00e1t hi\u1ec7n b\u1ec7nh ung th\u01b0 s\u1edbm h\u01a1n nhi\u1ec1u.<\/p>\n

J\u00e9r\u00f4me Bonnet – ng\u01b0\u1eddi \u0111\u1ee9ng \u0111\u1ea7u nghi\u00ean c\u1ee9u c\u1ee7a INSERM cho bi\u1ebft, vi\u1ec7c d\u00f9ng vi khu\u1ea9n \u0111\u1ec3 ch\u1ea9n \u0111o\u00e1n b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng kh\u00f4ng th\u1ec3 thay th\u1ebf c\u00e1ch l\u00e0m hi\u1ec7n t\u1ea1i. Tuy nhi\u00ean, c\u00f3 nh\u1eefng d\u1ea5u hi\u1ec7u kh\u00e1c m\u00e0 c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u00f3 th\u1ec3 mu\u1ed1n t\u00ecm ki\u1ebfm, v\u00e0 vi khu\u1ea9n l\u00e0m \u0111i\u1ec1u \u0111\u00f3 t\u1ed1t h\u01a1n so v\u1edbi ph\u01b0\u01a1ng ph\u00e1p th\u00f4ng th\u01b0\u1eddng. “Ch\u00fang t\u00f4i \u0111ang ph\u00e1t tri\u1ec3n c\u00f4ng c\u1ee5 ch\u1ea9n \u0111o\u00e1n d\u1ef1a v\u00e0o c\u00e1c y\u1ebfu t\u1ed1 t\u1ef1 nhi\u00ean”, \u00f4ng n\u00f3i.<\/p>\n

Th\u1eddi gian t\u1edbi, nh\u00f3m chuy\u00ean gia MIT s\u1ebd \u00e1p d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p m\u1edbi \u0111\u1ec3 ph\u00e1t hi\u1ec7n c\u00e1c lo\u1ea1i ung th\u01b0 kh\u00e1c. H\u1ecd s\u1ebd c\u1ed1 ch\u1ee9ng minh vi khu\u1ea9n an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 \u0111\u1ec3 c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng tr\u00ean c\u01a1 th\u1ec3 ng\u01b0\u1eddi. B\u00ean c\u1ea1nh \u0111\u00f3, c\u00e1c nh\u00e0 khoa h\u1ecdc Ph\u00e1p \u0111ang c\u00f3 k\u1ebf ho\u1ea1ch t\u00ecm ki\u1ebfm d\u1ea5u hi\u1ec7u sinh h\u1ecdc kh\u00e1c c\u1ee7a b\u1ec7nh, c\u0169ng nh\u01b0 c\u00e1c bi\u1ec7n ph\u00e1p h\u1eefu \u00edch trong ch\u1ea9n \u0111o\u00e1n l\u00e2m s\u00e0ng.<\/p>\n

Theo: Live Science<\/p>\n

Ngu\u1ed3n tinhte.vn<\/p>\n","protected":false},"excerpt":{"rendered":"

M\u1ed9t k\u1ef9 thu\u1eadt m\u1edbi \u0111ang \u0111\u01b0\u1ee3c c\u00e1c nh\u00e0 khoa h\u1ecdc th\u1eed nghi\u1ec7m, cho ph\u00e9p ph\u00e1t hi\u1ec7n b\u1ec7nh l\u00fd (nh\u01b0 ung th\u01b0) trong th\u1eddi gian ch\u1ec9 m\u1ed9t ng\u00e0y. Hai nghi\u00ean c\u1ee9u kh\u00e1c nhau \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n, nh\u01b0ng l\u1ea1i c\u00f3 \u0111i\u1ec3m chung l\u00e0 \u0111\u1ec1u s\u1eed d\u1ee5ng vi khu\u1ea9n bi\u1ebfn \u0111\u1ed5i gen \u0111\u1ec3 ph\u00e1t hi\u1ec7n c\u00e1c d\u1ea5u hi\u1ec7u […]<\/p>\n","protected":false},"author":17,"featured_media":3523,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-3503","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/3503","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=3503"}],"version-history":[{"count":1,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/3503\/revisions"}],"predecessor-version":[{"id":3525,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/3503\/revisions\/3525"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/3523"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=3503"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=3503"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=3503"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}