{"id":33985,"date":"2023-11-13T14:07:14","date_gmt":"2023-11-13T07:07:14","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=33985"},"modified":"2023-11-13T14:07:23","modified_gmt":"2023-11-13T07:07:23","slug":"phat-hien-loai-thuoc-uc-che-thanh-cong-gene-gay-ra-nhieu-benh-ung-thu","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/phat-hien-loai-thuoc-uc-che-thanh-cong-gene-gay-ra-nhieu-benh-ung-thu\/","title":{"rendered":"Ph\u00e1t hi\u1ec7n lo\u1ea1i thu\u1ed1c \u1ee9c ch\u1ebf th\u00e0nh c\u00f4ng gene g\u00e2y ra nhi\u1ec1u b\u1ec7nh ung th\u01b0"},"content":{"rendered":"\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i T\u00e2y Ban Nha v\u1eeba ph\u00e1t hi\u1ec7n ra lo\u1ea1i thu\u1ed1c \u1ee9c ch\u1ebf th\u00e0nh c\u00f4ng gene g\u00e2y ra nhi\u1ec1u b\u1ec7nh ung th\u01b0.<\/p>\n\n\n\n

Tr\u00ecnh b\u00e0y k\u1ebft qu\u1ea3 s\u01a1 b\u1ed9 t\u1eeb th\u1eed nghi\u1ec7m t\u1ea1i H\u1ed9i ngh\u1ecb chuy\u00ean \u0111\u1ec1 EORTC-NCI-AACR l\u1ea7n th\u1ee9 34 v\u1ec1 M\u1ee5c ti\u00eau ph\u00e2n t\u1eed v\u00e0 \u0110i\u1ec1u tr\u1ecb ung th\u01b0 \u1edf Barcelona, T\u00e2y Ban Nha, TS. Elena Garralda, Gi\u00e1m \u0111\u1ed1c \u0110\u01a1n v\u1ecb Ph\u00e1t tri\u1ec3n Thu\u1ed1c s\u1edbm t\u1ea1i Vi\u1ec7n Ung th\u01b0 Vall d’Hebron (VHIO) \u1edf Barcelona, th\u00e0nh vi\u00ean \u1ee7y ban khoa h\u1ecdc cho cu\u1ed9c h\u1ecdp, cho bi\u1ebft: \u201cMYC l\u00e0 m\u1ed9t trong nh\u1eefng m\u1ee5c ti\u00eau \u201cmong mu\u1ed1n nh\u1ea5t\u201d trong b\u1ec7nh ung th\u01b0 v\u00ec gene \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c th\u00fac \u0111\u1ea9y v\u00e0 duy tr\u00ec nhi\u1ec1u b\u1ec7nh ung th\u01b0 ph\u1ed5 bi\u1ebfn \u1edf ng\u01b0\u1eddi nh\u01b0 ung th\u01b0 v\u00fa, tuy\u1ebfn ti\u1ec1n li\u1ec7t, ung th\u01b0 ph\u1ed5i, bu\u1ed3ng tr\u1ee9ng. Cho \u0111\u1ebfn nay, kh\u00f4ng c\u00f3 lo\u1ea1i thu\u1ed1c n\u00e0o \u1ee9c ch\u1ebf MYC \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t s\u1eed d\u1ee5ng trong l\u00e2m s\u00e0ng\u201d.<\/p>\n\n\n\n

C\u00e1c nh\u00e0 khoa h\u1ecdc VHIO ph\u00e1t tri\u1ec3n lo\u1ea1i protein nh\u1ecf, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 OMO-103 c\u00f3 kh\u1ea3 n\u0103ng x\u00e2m nh\u1eadp v\u00e0o t\u1ebf b\u00e0o v\u00e0 \u0111\u1ebfn \u0111\u01b0\u1ee3c h\u1ea1t nh\u00e2n. Trong nh\u1eefng th\u00ed nghi\u1ec7m trong ph\u00f2ng th\u00ed nghi\u1ec7m v\u00e0 tr\u00ean chu\u1ed9t, nh\u00f3m nghi\u00ean c\u1ee9u x\u00e1c \u0111\u1ecbnh protein \u1ee9c ch\u1ebf th\u00e0nh c\u00f4ng kh\u1ea3 n\u0103ng c\u1ee7a MYC trong th\u00fac \u0111\u1ea9y s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a kh\u1ed1i u, ng\u0103n ch\u1eb7n ch\u1ee9c n\u0103ng c\u1ee7a MYC, ki\u1ec3m so\u00e1t lu\u1ed3ng th\u00f4ng tin t\u1eeb nhi\u1ec1u \u0111\u1ed9t bi\u1ebfn di truy\u1ec1n ph\u1ed5 bi\u1ebfn, th\u01b0\u1eddng th\u1ea5y trong b\u1ec7nh ung th\u01b0.<\/p>\n\n\n\n

\"\"<\/p>\n\n\n\n

T\u00e2y Ban Nha ph\u00e1t hi\u1ec7n ra lo\u1ea1i thu\u1ed1c c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf nhi\u1ec1u lo\u1ea1i ung th\u01b0. \u1ea2nh minh h\u1ecda.<\/em><\/h2>\n\n\n\n

T\u1eeb th\u00e1ng 4\/2021, TS. Garralda ph\u1ed1i h\u1ee3p v\u1edbi 2 c\u01a1 s\u1edf kh\u00e1c \u1edf T\u00e2y Ban Nha thu nh\u1eadn 22 b\u1ec7nh nh\u00e2n, t\u00ecnh nguy\u1ec7n tham gia th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n I \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 t\u00ednh an to\u00e0n c\u1ee7a OMO-103 v\u00e0 ph\u00e1t hi\u1ec7n d\u1ea5u hi\u1ec7u ban \u0111\u1ea7u x\u00e1c \u0111\u1ecbnh OMO-103 c\u00f3 th\u1ec3 ki\u1ec3m so\u00e1t ung th\u01b0 hay kh\u00f4ng? C\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 m\u1ed9t lo\u1ea1t kh\u1ed1i u r\u1eafn, bao g\u1ed3m ung th\u01b0 tuy\u1ebfn t\u1ee5y, ru\u1ed9t v\u00e0 ung th\u01b0 ph\u1ed5i kh\u00f4ng ph\u1ea3i t\u1ebf b\u00e0o nh\u1ecf. T\u1ea5t c\u1ea3 b\u1ec7nh nh\u00e2n \u0111\u1ec1u \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi c\u00e1c li\u1ec7u ph\u00e1p m\u1ea1nh, nh\u1eadn \u0111\u01b0\u1ee3c t\u1eeb 3 \u0111\u1ebfn 13 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c.<\/p>\n\n\n\n

OMO-103 \u0111\u01b0\u1ee3c ti\u00eam t\u0129nh m\u1ea1ch m\u1ed7i tu\u1ea7n m\u1ed9t l\u1ea7n v\u1edbi 6 m\u1ee9c li\u1ec1u kh\u00e1c nhau, t\u1eeb 0,48 \u0111\u1ebfn 9,72 mg cho m\u1ed7i kg tr\u1ecdng l\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u l\u1ea5y sinh thi\u1ebft t\u1eeb kh\u1ed1i u khi b\u1eaft \u0111\u1ea7u nghi\u00ean c\u1ee9u v\u00e0 sau ba tu\u1ea7n \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 m\u1ee9c \u0111\u1ed9 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a gen MYC v\u00e0 c\u00e1c ch\u1ec9 s\u1ed1 sinh h\u1ecdc kh\u00e1c \u0111\u1ed1i v\u1edbi b\u1ec7nh ung th\u01b0.<\/p>\n\n\n\n

\u0110\u1ebfn ng\u00e0y 10\/10\/2022, 8 trong s\u1ed1 12 b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ch\u1ee5p CT sau 9 tu\u1ea7n b\u1ec7nh \u0111\u00e3 \u1ed5n \u0111\u1ecbnh, qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb \u0111\u00e3 ng\u0103n ch\u1eb7n ung th\u01b0 ph\u00e1t tri\u1ec3n. Trong s\u1ed1 n\u00e0y c\u00f3 2 ng\u01b0\u1eddi b\u1ecb ung th\u01b0 tuy\u1ebfn t\u1ee5y, 3 ng\u01b0\u1eddi b\u1ecb ung th\u01b0 ru\u1ed9t k\u1ebft, 1 ng\u01b0\u1eddi ung th\u01b0 ph\u1ed5i kh\u00f4ng ph\u1ea3i t\u1ebf b\u00e0o nh\u1ecf, 1 ng\u01b0\u1eddi b\u1ecb sarcoma v\u00e0 1 ng\u01b0\u1eddi b\u1ecb ung th\u01b0 tuy\u1ebfn n\u01b0\u1edbc b\u1ecdt.<\/p>\n\n\n\n

TS. Garralda cho bi\u1ebft: \u201cV\u1eabn c\u00f2n qu\u00e1 s\u1edbm \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 ho\u1ea1t t\u00ednh c\u1ee7a thu\u1ed1c nh\u01b0ng ch\u00fang t\u00f4i \u0111ang th\u1ea5y s\u1ef1 \u1ed5n \u0111\u1ecbnh c\u1ee7a b\u1ec7nh \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n. \u0110\u00e1ng ch\u00fa \u00fd, m\u1ed9t b\u1ec7nh nh\u00e2n b\u1ecb ung th\u01b0 tuy\u1ebfn t\u1ee5y \u0111\u00e3 \u1edf l\u1ea1i nghi\u00ean c\u1ee9u h\u01a1n 6 th\u00e1ng, kh\u1ed1i u c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh thu nh\u1ecf 8% v\u00e0 c\u00f3 s\u1ef1 gi\u1ea3m DNA c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb kh\u1ed1i u l\u01b0u th\u00f4ng trong d\u00f2ng m\u00e1u. B\u1ec7nh nh\u00e2n b\u1ecb u tuy\u1ebfn n\u01b0\u1edbc b\u1ecdt, b\u1ec7nh \u1ed5n \u0111\u1ecbnh, sau 15 th\u00e1ng v\u1eabn \u0111ang ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb nghi\u00ean c\u1ee9u.<\/p>\n\n\n\n

\u0110i\u1ec1u th\u00fa v\u1ecb nh\u1ea5t l\u00e0 nh\u1eefng d\u1ea5u hi\u1ec7u sinh h\u1ecdc cho th\u1ea5y ch\u00fang t\u00f4i \u0111\u00e3 th\u00e0nh c\u00f4ng nh\u1eafm v\u00e0o m\u1ee5c ti\u00eau MYC. Nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f4ng mong mu\u1ed1n h\u1ea7u h\u1ebft \u0111\u1ec1u nh\u1eb9, k\u1ebft qu\u1ea3 n\u00e0y r\u1ea5t quan tr\u1ecdng v\u00e0 ch\u00fang ta c\u1ea7n ngh\u0129 \u0111\u1ebfn c\u00e1c b\u01b0\u1edbc ti\u1ebfp theo, k\u1ebft h\u1ee3p OMO-103 v\u1edbi h\u00f3a tr\u1ecb ho\u1eb7c li\u1ec7u ph\u00e1p kh\u00e1c\u201d.<\/p>\n\n\n\n

Nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 li\u00ean quan \u0111\u1ebfn \u0111i\u1ec1u tr\u1ecb th\u01b0\u1eddng g\u1eb7p nh\u1ea5t l\u00e0 ph\u1ea3n \u1ee9ng nh\u1eb9 khi truy\u1ec1n t\u0129nh m\u1ea1ch nh\u01b0 \u1edbn l\u1ea1nh, s\u1ed1t, bu\u1ed3n n\u00f4n, ph\u00e1t ban v\u00e0 huy\u1ebft \u00e1p th\u1ea5p. M\u1ee9c li\u1ec1u cao h\u01a1n xu\u1ea5t hi\u1ec7n nhi\u1ec1u ph\u1ea3n \u1ee9ng h\u01a1n v\u1edbi d\u1ecbch truy\u1ec1n nh\u01b0ng d\u1ec5 d\u00e0ng \u0111i\u1ec1u tr\u1ecb. Vi\u00eam t\u1ee5y l\u00e0 ph\u1ea3n \u1ee9ng gi\u1edbi h\u1ea1n li\u1ec1u duy nh\u1ea5t x\u1ea3y ra \u1edf 1 b\u1ec7nh nh\u00e2n.<\/p>\n\n\n\n

\u201cCh\u00fang t\u00f4i c\u00f3 b\u1eb1ng ch\u1ee9ng th\u1ef1c nghi\u1ec7m cho th\u1ea5y, \u0111\u00e2y c\u00f3 th\u1ec3 l\u00e0 \u0111\u00e1nh gi\u00e1 th\u1ea5p \u0111\u00e1ng k\u1ec3 v\u1ec1 th\u1eddi gian thu\u1ed1c t\u1ed3n t\u1ea1i trong kh\u1ed1i u. B\u1eb1ng ch\u1ee9ng t\u1eeb nghi\u00ean c\u1ee9u c\u1ee7a ch\u00fang t\u00f4i tr\u00ean chu\u1ed9t cho th\u1ea5y, n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong kh\u1ed1i u cao h\u01a1n \u00edt nh\u1ea5t 4 l\u1ea7n so v\u1edbi trong m\u00e1u\u201c, TS. Garralda cho bi\u1ebft.<\/p>\n\n\n\n

\u201cNgo\u00e0i ra, ngay c\u1ea3 sau khi \u0111i\u1ec1u tr\u1ecb l\u00e2u d\u00e0i, ch\u00fang t\u00f4i kh\u00f4ng th\u1ec3 ph\u00e1t hi\u1ec7n ra b\u1ea5t k\u1ef3 kh\u00e1ng th\u1ec3 kh\u00e1ng thu\u1ed1c n\u00e0o, c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m l\u01b0\u1ee3ng thu\u1ed1c c\u00f3 trong c\u01a1 th\u1ec3 v\u00e0 l\u00e0m cho thu\u1ed1c k\u00e9m hi\u1ec7u qu\u1ea3 h\u01a1n\u201d, b\u00e0 cho hay v\u00e0 k\u1ebft lu\u1eadn: \u201cOMO-103 l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf MYC \u0111\u1ea7u ti\u00ean ho\u00e0n th\u00e0nh th\u00e0nh c\u00f4ng th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n I v\u00e0 s\u1eb5n s\u00e0ng cho ti\u1ebfn tr\u00ecnh th\u1eed nghi\u1ec7m giai \u0111o\u1ea1n II. Ch\u00fang t\u00f4i \u0111\u00e3 x\u00e1c \u0111\u1ecbnh li\u1ec1u khuy\u1ebfn c\u00e1o cho giai \u0111o\u1ea1n II l\u00e0 6,48mg\/kg\u201d.<\/p>\n\n\n\n

TS. James L. Gulley, \u0111\u1ed3ng Ch\u1ee7 t\u1ecbch H\u1ed9i ngh\u1ecb chuy\u00ean \u0111\u1ec1 EORTC-NCI-AACR l\u1ea7n th\u1ee9 34 cho NCI, Gi\u00e1m \u0111\u1ed1c D\u1ecbch v\u1ee5 Ung th\u01b0 Y t\u1ebf, Trung t\u00e2m Nghi\u00ean c\u1ee9u Ung th\u01b0, NCI, M\u1ef9, kh\u00f4ng tham gia v\u00e0o nghi\u00ean c\u1ee9u nh\u1eadn x\u00e9t: \u201cMYC \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong nhi\u1ec1u con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u t\u1ebf b\u00e0o th\u00fac \u0111\u1ea9y nhi\u1ec1u lo\u1ea1i b\u1ec7nh ung th\u01b0 kh\u00e1c nhau, t\u1eeb l\u00e2u b\u1ecb coi l\u00e0 m\u1ee5c ti\u00eau \u201ckh\u00f4ng th\u1ec3 \u0111i\u1ec1u tr\u1ecb\u201d. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 d\u00e0nh nhi\u1ec1u th\u1eddi gian v\u00e0 c\u00f4ng s\u1ee9c t\u00ecm ki\u1ebfm c\u00e1c lo\u1ea1i thu\u1ed1c, c\u00f3 th\u1ec3 nh\u1eafm v\u00e0o MYC th\u00e0nh c\u00f4ng nh\u01b0ng r\u1ea5t kh\u00f3 \u0111\u1ec3 ph\u00e1t tri\u1ec3n c\u00e1c li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3 nh\u01b0ng kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5 qu\u00e1 nghi\u00eam tr\u1ecdng khi\u1ebfn b\u1ec7nh nh\u00e2n kh\u00f4ng th\u1ec3 ch\u1ecbu \u0111\u1ef1ng \u0111\u01b0\u1ee3c.<\/p>\n\n\n\n

Nh\u1eefng k\u1ebft qu\u1ea3 n\u00e0y cho th\u1ea5y, b\u1ec7nh nh\u00e2n th\u01b0\u1eddng g\u1eb7p c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nh\u1eb9 v\u1edbi OMO-103 c\u00f3 \u00fd ngh\u0129a quan tr\u1ecdng khi xem x\u00e9t nh\u1eefng b\u01b0\u1edbc ti\u1ebfp theo v\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb k\u1ebft h\u1ee3p v\u1edbi h\u00f3a tr\u1ecb li\u1ec7u. Ch\u00fang t\u00f4i v\u1edbi s\u1ef1 quan t\u00e2m l\u1edbn mong \u0111\u1ee3i k\u1ebft qu\u1ea3 t\u1eeb th\u1eed nghi\u1ec7m giai \u0111o\u1ea1n II\u201d.<\/p>\n\n\n\n

Tr\u01b0\u1edbc \u0111\u00f3, c\u00e1c nh\u00e0 khoa h\u1ecdc t\u1ecf ra ph\u1ea5n kh\u00edch tr\u01b0\u1edbc th\u00f4ng tin v\u1ec1 lo\u1ea1i thu\u1ed1c \u0111\u1ea7u ti\u00ean ch\u1eefa kh\u1ecfi ho\u00e0n to\u00e0n ung th\u01b0 tr\u1ef1c tr\u00e0ng. Thu\u1ed1c t\u00ean dostarlimab \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 sau m\u1ed9t th\u1eed nghi\u1ec7m nh\u1ecf \u1edf M\u1ef9, trong \u0111\u00f3 12 b\u1ec7nh nh\u00e2n ung th\u01b0 tr\u1ef1c tr\u00e0ng \u0111\u1ec1u thuy\u00ean gi\u1ea3m 100% sau khi s\u1eed d\u1ee5ng thu\u1ed1c trong kho\u1ea3ng 6 th\u00e1ng.<\/p>\n\n\n\n

T\u1ef7 l\u1ec7 thuy\u00ean gi\u1ea3m n\u00e0y l\u00e0 \u0111i\u1ec1u ch\u01b0a t\u1eebng c\u00f3 ti\u1ec1n l\u1ec7, c\u0169ng l\u00e0 nguy\u00ean nh\u00e2n khi\u1ebfn m\u1ed9t s\u1ed1 chuy\u00ean gia l\u1ea1c quan \u0111\u1ebfn v\u1eady. Tuy nhi\u00ean, c\u00e1c chuy\u00ean gia kh\u00e1c l\u01b0u \u00fd \u0111\u00e2y ch\u1ec9 l\u00e0 th\u1eed nghi\u1ec7m nh\u1ecf, c\u1ea7n nghi\u00ean c\u1ee9u s\u00e2u r\u1ed9ng h\u01a1n.<\/p>\n\n\n\n

Dostarlimab \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn \u1edf M\u1ef9 v\u00e0 ch\u00e2u \u00c2u v\u00e0o th\u00e1ng 4\/2021. \u0110\u00e2y l\u00e0 lo\u1ea1i thu\u1ed1c mi\u1ec5n d\u1ecbch s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 n\u1ed9i m\u1ea1c t\u1eed cung, t\u00e1c \u0111\u1ed9ng v\u00e0o ni\u00eam m\u1ea1c t\u1eed cung, c\u00f3 hi\u1ec7u qu\u1ea3 r\u1ea5t cao. N\u0103m 2022, c\u00e1c nh\u00e0 khoa h\u1ecdc l\u1ea7n \u0111\u1ea7u ti\u00ean th\u1eed nghi\u1ec7m thu\u1ed1c tr\u00ean kh\u1ed1i u tr\u1ef1c tr\u00e0ng.<\/p>\n\n\n\n

An D\u01b0\u01a1ng<\/strong><\/p>\n\n\n\n

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C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i T\u00e2y Ban Nha v\u1eeba ph\u00e1t hi\u1ec7n ra lo\u1ea1i thu\u1ed1c \u1ee9c ch\u1ebf th\u00e0nh c\u00f4ng gene g\u00e2y ra nhi\u1ec1u b\u1ec7nh ung th\u01b0. Tr\u00ecnh b\u00e0y k\u1ebft qu\u1ea3 s\u01a1 b\u1ed9 t\u1eeb th\u1eed nghi\u1ec7m t\u1ea1i H\u1ed9i ngh\u1ecb chuy\u00ean \u0111\u1ec1 EORTC-NCI-AACR l\u1ea7n th\u1ee9 34 v\u1ec1 M\u1ee5c ti\u00eau ph\u00e2n t\u1eed v\u00e0 \u0110i\u1ec1u tr\u1ecb ung th\u01b0 \u1edf Barcelona, […]<\/p>\n","protected":false},"author":26,"featured_media":33986,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-33985","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/33985","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=33985"}],"version-history":[{"count":1,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/33985\/revisions"}],"predecessor-version":[{"id":33987,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/33985\/revisions\/33987"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/33986"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=33985"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=33985"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=33985"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}