{"id":33368,"date":"2023-10-16T16:07:01","date_gmt":"2023-10-16T09:07:01","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=33368"},"modified":"2023-10-16T16:07:12","modified_gmt":"2023-10-16T09:07:12","slug":"dinh-danh-nam-moc-bang-phuong-phap-quan-sat-hinh-thai-va-phuong-phap-khoi-pho-cua-protein-ribosome","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/dinh-danh-nam-moc-bang-phuong-phap-quan-sat-hinh-thai-va-phuong-phap-khoi-pho-cua-protein-ribosome\/","title":{"rendered":"\u0110\u1ecbnh danh n\u1ea5m m\u1ed1c b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p quan s\u00e1t h\u00ecnh th\u00e1i v\u00e0 ph\u01b0\u01a1ng ph\u00e1p kh\u1ed1i ph\u1ed5 c\u1ee7a Protein Ribosome"},"content":{"rendered":"\n

Hi\u1ec7n nay, ng\u00e0y c\u00e0ng c\u00f3 nhi\u1ec1u nh\u00e0 m\u00e1y s\u1ea3n xu\u1ea5t r\u01a1i v\u00e0o t\u00ecnh tr\u1ea1ng nhi\u1ec5m vi sinh trong s\u1ea3n ph\u1ea9m c\u0169ng nh\u01b0 nh\u00e0 x\u01b0\u1edfng, \u0111\u1eb7c bi\u1ec7t l\u00e0 nhi\u1ec5m n\u1ea5m m\u1ed1c. V\u1ea5n \u0111\u1ec1 c\u00e0ng tr\u1edf n\u00ean \u0111\u00e1ng lo ng\u1ea1i v\u1edbi m\u1ed9t qu\u1ed1c gia c\u00f3 kh\u00ed h\u1eadu nhi\u1ec7t \u0111\u1edbi n\u00f3ng \u1ea9m nh\u01b0 Vi\u1ec7t Nam do \u0111\u00e2y l\u00e0 \u0111i\u1ec1u ki\u1ec7n thu\u1eadn l\u1ee3i cho s\u1ef1 ph\u00e1t tri\u1ec3n n\u1ea5m m\u1ed1c.<\/p>\n\n\n\n

N\u1ea5m m\u1ed1c l\u00e0 nh\u00f3m vi sinh v\u1eadt \u0111a d\u1ea1ng v\u1ec1 m\u1eb7t ph\u00e2n lo\u1ea1i, bao g\u1ed3m h\u01a1n 4000 lo\u00e0i c\u00f3 m\u00e0u s\u1eafc, c\u1ea5u tr\u00fac phong ph\u00fa, \u0111\u1ed9c \u0111\u00e1o. Ch\u00fang th\u01b0\u1eddng m\u1ecdc d\u01b0\u1edbi d\u1ea1ng s\u1ee3i nh\u1ecf \u0111a b\u00e0o \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 s\u1ee3i n\u1ea5m (hyphae), sinh s\u1ea3n b\u1eb1ng c\u00e1ch t\u1ef1 ph\u00e2n \u0111\u00f4i t\u1ea1o ra c\u00e1c b\u00e0o t\u1eed. \u0110i\u1ec1u ki\u1ec7n th\u00edch h\u1ee3p cho s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a n\u1ea5m m\u1ed1c l\u00e0 m\u00f4i tr\u01b0\u1eddng \u1ea9m \u01b0\u1edbt, k\u00e9m v\u1ec7 sinh v\u1edbi kho\u1ea3ng nhi\u1ec7t \u0111\u1ed9 t\u1ed1i \u01b0u t\u1eeb (21- 32)oC. Tuy nhi\u00ean, m\u1ed9t s\u1ed1 lo\u00e0i m\u1ed1c c\u00f3 th\u1ec3 sinh tr\u01b0\u1edfng t\u1eeb (0 \u2013 50) oC v\u00e0 c\u0169ng c\u00f3 lo\u00e0i ch\u1ecbu \u0111\u01b0\u1ee3c \u0111i\u1ec1u ki\u1ec7n kh\u00f4 h\u1ea1n (Christensen, 1965).<\/p>\n\n\n\n

N\u1ea5m m\u1ed1c trong m\u00f4i tr\u01b0\u1eddng s\u1ed1ng v\u00e0 th\u1ef1c ph\u1ea9m \u0111\u1ec1u c\u00f3 th\u1ec3 g\u00e2y \u1ea3nh h\u01b0\u1edfng l\u1edbn t\u1edbi s\u1ee9c kh\u1ecfe c\u1ee7a con ng\u01b0\u1eddi. N\u0103m 2004, Vi\u1ec7n Y h\u1ecdc (Institute of Medicine, IOM) \u0111\u00e3 ch\u1ee9ng minh c\u00f3 s\u1ef1 li\u00ean quan vi\u1ec7c ti\u1ebfp x\u00fac trong nh\u00e0 v\u1edbi n\u1ea5m m\u1ed1c v\u1edbi c\u00e1c tri\u1ec7u ch\u1ee9ng \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p tr\u00ean, ho v\u00e0 th\u1edf kh\u00f2 kh\u00e8 ngay c\u1ea3 tr\u00ean nh\u1eefng nh\u1eefng ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh b\u00ecnh th\u01b0\u1eddng.<\/p>\n\n\n\n

C\u00e1c nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y c\u0169ng cho th\u1ea5y m\u1ed1i li\u00ean k\u1ebft ti\u1ec1m t\u00e0ng c\u1ee7a vi\u1ec7c ti\u1ebfp x\u00fac v\u1edbi n\u1ea5m m\u1ed1c trong giai \u0111o\u1ea1n \u0111\u1ea7u v\u1edbi s\u1ef1 ph\u00e1t tri\u1ec3n b\u1ec7nh hen suy\u1ec5n, vi\u00eam ph\u1ed5i \u1edf m\u1ed9t s\u1ed1 tr\u1ebb em. Ngo\u00e0i ra, vi\u1ec7c ti\u00eau th\u1ee5 c\u00e1c lo\u1ea1i th\u1ef1c ph\u1ea9m nhi\u1ec5m m\u1ed1c c\u0169ng g\u00e2y \u1ea3nh h\u01b0\u1edfng tr\u1ef1c ti\u1ebfp \u0111\u1ebfn s\u1ee9c kho\u1ebb con ng\u01b0\u1eddi, \u0111\u1eb7c bi\u1ec7t c\u00e1c lo\u1ea1i m\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng s\u1ea3n sinh ra \u0111\u1ed9c t\u1ed1 h\u1ecd mycotoxin, khi ti\u1ebfp x\u00fac v\u1edbi \u0111\u1ed9c t\u1ed1 n\u00e0y \u1edf n\u1ed3ng \u0111\u1ed9 cao c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 th\u1ea7n kinh, th\u1eadm ch\u00ed c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong.<\/p>\n\n\n\n

Do t\u00e1c h\u1ea1i c\u1ee7a n\u1ea5m m\u1ed1c \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng th\u1ef1c ph\u1ea9m c\u0169ng nh\u01b0 s\u1ee9c kho\u1ebb con ng\u01b0\u1eddi, v\u1eadt nu\u00f4i, v\u1ea5n \u0111\u1ec1 ki\u1ec3m so\u00e1t n\u1ea5m m\u1ed1c ng\u00e0y c\u00e0ng \u0111\u01b0\u1ee3c quan t\u00e2m nhi\u1ec1u h\u01a1n. N\u0103m 2009, T\u1ed5 ch\u1ee9c Y t\u1ebf Th\u1ebf gi\u1edbi \u0111\u00e3 ban h\u00e0nh h\u01b0\u1edbng d\u1eabn b\u1ed5 sung v\u1ec1 ch\u1ea5t l\u01b0\u1ee3ng kh\u00f4ng kh\u00ed trong nh\u00e0 li\u00ean quan \u0111\u1ebfn \u0111\u1ed9 \u1ea9m v\u00e0 n\u1ea5m m\u1ed1c (WHO Guidelines for Indoor Air Quality: Dampness and Mould).<\/p>\n\n\n\n

Ch\u00ednh ph\u1ee7 Vi\u1ec7t Nam c\u0169ng ban h\u00e0nh r\u1ea5t nhi\u1ec1u quy chu\u1ea9n quy \u0111\u1ecbnh v\u1ec1 gi\u1edbi h\u1ea1n \u00f4 nhi\u1ec5m n\u1ea5m m\u1ed1c trong ch\u1ea5t l\u01b0\u1ee3ng kh\u00f4ng kh\u00ed trong nh\u00e0 v\u00e0 nh\u1eefng nh\u00f3m s\u1ea3n ph\u1ea9m nh\u01b0 th\u1ef1c ph\u1ea9m, th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng, ph\u1ee5 gia th\u1ef1c ph\u1ea9m, n\u01b0\u1edbc v\u00e0 ngay c\u1ea3 c\u00e1c s\u1ea3n ph\u1ea9m m\u1ef9 ph\u1ea9m, h\u00e0ng ti\u00eau d\u00f9ng,\u2026 \u0110\u1ec3 \u0111\u00e1p \u1ee9ng nhu c\u1ea7u ki\u1ec3m so\u00e1t tr\u00ean, c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ecbnh l\u01b0\u1ee3ng men m\u1ed1c theo ti\u00eau chu\u1ea9n qu\u1ed1c t\u1ebf (ISO, AOAC, FDA,…) c\u0169ng nh\u01b0 ti\u00eau chu\u1ea9n qu\u1ed1c gia (TCVN, QCVN) \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e2y d\u1ef1ng v\u00e0 \u00e1p d\u1ee5ng r\u1ed9ng r\u00e3i trong h\u1ea7u h\u1ebft c\u00e1c ph\u00f2ng th\u00ed nghi\u1ec7m.<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

H\u00ecnh 1.1. Quan s\u00e1t h\u00ecnh th\u00e1i n\u1ea5m m\u1ed1c tr\u00ean k\u00ednh hi\u1ec3n vi;<\/em><\/p>\n\n\n\n

H\u00ecnh 1.2. \u0110\u1eb7c \u0111i\u1ec3m h\u00ecnh th\u00e1i c\u1ee7a m\u1ed9t s\u1ed1 lo\u1ea1i n\u1ea5m m\u1ed1c tr\u00ean m\u00f4i tr\u01b0\u1eddng ph\u00e2n l\u1eadp v\u00e0 d\u01b0\u1edbi k\u00ednh hi\u1ec3n vi (\u0111\u1ed9 ph\u00f3ng \u0111\u1ea1i 40X). Trong \u0111\u00f3: <\/em><\/p>\n\n\n\n

(1.2a) Khu\u1ea9n l\u1ea1c Aspergillus flavus_oryzae_group tr\u00ean m\u00f4i tr\u01b0\u1eddng DG18: khu\u1ea9n l\u1ea1c m\u00e0u xanh d\u01b0a c\u1ea3i. Tr\u00ean k\u00ednh hi\u1ec3n vi, quan s\u00e1t \u0111\u01b0\u1ee3c n\u1ea5m c\u00f3 b\u1ecdng h\u00ecnh c\u1ea7u, th\u1ec3 b\u00ecnh 1 ho\u1eb7c 2 t\u1ea7ng, b\u00e0o t\u1eed \u0111\u00ednh, h\u00ecnh tr\u00f2n.<\/em><\/p>\n\n\n\n

(1.2b) Khu\u1ea9n l\u1ea1c Fusarium sp. tr\u00ean m\u00f4i tr\u01b0\u1eddng DG18: Khu\u1ea9n l\u1ea1c m\u1eb7t h\u01a1i b\u00f4ng, m\u00e0u tr\u1eafng h\u1ed3ng. Quan s\u00e1t \u0111\u01b0\u1ee3c b\u00e0o t\u1eed to, c\u00f3 h\u00ecnh l\u01b0\u1ee1i li\u1ec1m \u0111\u1eb7c tr\u01b0ng tr\u00ean k\u00ednh hi\u1ec3n vi.<\/em><\/p>\n\n\n\n

(1.2c) Khu\u1ea9n l\u1ea1c Rhizopus sp. tr\u00ean m\u00f4i tr\u01b0\u1eddng DRBC: Khu\u1ea9n l\u1ea1c m\u00e0u tr\u1eafng, m\u1eb7t kh\u00f3m nh\u01b0 len. Quan s\u00e1t \u0111\u01b0\u1ee3c b\u00e0o t\u1eed t\u00fai v\u00e0 r\u1ec5 gi\u1ea3 tr\u00ean k\u00ednh hi\u1ec3n vi.<\/em><\/p>\n\n\n\n

Hi\u1ec7n nay, ng\u00e0y c\u00e0ng c\u00f3 nhi\u1ec1u nh\u00e0 m\u00e1y s\u1ea3n xu\u1ea5t r\u01a1i v\u00e0o t\u00ecnh tr\u1ea1ng nhi\u1ec5m vi sinh trong s\u1ea3n ph\u1ea9m c\u0169ng nh\u01b0 nh\u00e0 x\u01b0\u1edfng, \u0111\u1eb7c bi\u1ec7t l\u00e0 nhi\u1ec5m n\u1ea5m m\u1ed1c. V\u1ea5n \u0111\u1ec1 c\u00e0ng tr\u1edf n\u00ean \u0111\u00e1ng lo ng\u1ea1i v\u1edbi m\u1ed9t qu\u1ed1c gia c\u00f3 kh\u00ed h\u1eadu nhi\u1ec7t \u0111\u1edbi n\u00f3ng \u1ea9m nh\u01b0 Vi\u1ec7t Nam do \u0111\u00e2y l\u00e0 \u0111i\u1ec1u ki\u1ec7n thu\u1eadn l\u1ee3i cho s\u1ef1 ph\u00e1t tri\u1ec3n n\u1ea5m m\u1ed1c.<\/p>\n\n\n\n

Do n\u1ea5m m\u1ed1c r\u1ea5t \u0111a d\u1ea1ng v\u1ec1 \u0111\u1eb7c \u0111i\u1ec3m h\u00ecnh th\u00e1i, sinh l\u00fd, sinh ho\u00e1 n\u00ean vi\u1ec7c lo\u1ea1i b\u1ecf c\u00e1c lo\u00e0i n\u1ea5m m\u1ed1c kh\u00e1c nhau c\u1ea7n c\u00f3 bi\u1ec7n ph\u00e1p x\u1eed l\u00fd kh\u00e1c nhau. \u0110\u1ec3 c\u00f3 th\u1ec3 ch\u1ee7 \u0111\u1ed9ng h\u01a1n trong vi\u1ec7c ki\u1ec3m so\u00e1t m\u00f4i tr\u01b0\u1eddng s\u1ea3n xu\u1ea5t, \u0111i\u1ec1u tra nguy\u00ean nh\u00e2n nhi\u1ec5m m\u1ed1c v\u00e0 c\u00f3 bi\u1ec7n ph\u00e1p x\u1eed l\u00fd ph\u00f9 h\u1ee3p, b\u00ean c\u1ea1nh vi\u1ec7c \u0111\u1ecbnh l\u01b0\u1ee3ng n\u1ea5m m\u1ed1c theo c\u00e1c ti\u00eau chu\u1ea9n hi\u1ec7n h\u00e0nh, ng\u00e0y c\u00e0ng nhi\u1ec1u doanh nghi\u1ec7p quan t\u00e2m, ch\u00fa tr\u1ecdng \u0111\u1ebfn vi\u1ec7c \u0111\u1ecbnh danh \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh \u0111\u1ebfn chi ho\u1eb7c lo\u00e0i n\u1ea5m m\u1ed1c.<\/p>\n\n\n\n

\u0110\u1ec3 gi\u1ea3i quy\u1ebft v\u1ea5n \u0111\u1ec1 tr\u00ean, Ph\u00f2ng Th\u1eed nghi\u1ec7m Vi sinh \u2013 GMO thu\u1ed9c Trung t\u00e2m K\u1ef9 thu\u1eadt Ti\u00eau chu\u1ea9n \u0110o l\u01b0\u1eddng Ch\u1ea5t l\u01b0\u1ee3ng 3 (QUATEST 3) \u0111\u00e3 x\u00e2y d\u1ef1ng v\u00e0 ph\u00e1t tri\u1ec3n ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ecbnh danh n\u1ea5m m\u1ed1c d\u1ef1a tr\u00ean vi\u1ec7c quan s\u00e1t h\u00ecnh th\u00e1i tr\u00ean k\u00ednh hi\u1ec3n vi, qua \u0111\u00f3 c\u00f3 th\u1ec3 quan s\u00e1t r\u00f5 c\u1ea5u tr\u00fac s\u1ee3i, h\u00ecnh th\u00e1i b\u00e0o t\u1eed v\u00e0 c\u00e1c c\u1ea5u tr\u00fac \u0111i\u1ec3n h\u00ecnh kh\u00e1c c\u1ee7a c\u00e1c lo\u1ea1i n\u1ea5m m\u1ed1c kh\u00e1c nhau. Ph\u01b0\u01a1ng ph\u00e1p \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n d\u1ef1a tr\u00ean nh\u1eefng nghi\u00ean c\u1ee9u v\u1ec1 h\u1ec7 n\u1ea5m m\u1ed1c \u1edf Vi\u1ec7t Nam c\u1ee7a TS. \u0110\u1eb7ng Th\u1ecb H\u1ed3ng Mi\u00ean, t\u00e0i li\u1ec7u nghi\u00ean c\u1ee9u n\u1ea5m v\u00e0 n\u1ea5m g\u00e2y h\u01b0 h\u1ecfng th\u1ef1c ph\u1ea9m c\u1ee7a J.I.Pitt v\u00e0 A.D.Hocking.<\/p>\n\n\n\n

Ngo\u00e0i ra, ph\u00f2ng th\u1eed nghi\u1ec7m c\u0169ng s\u1edbm nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ecbnh danh n\u1ea5m m\u1ed1c d\u1ef1a v\u00e0o kh\u1ed1i ph\u1ed5 c\u1ee7a protein ribosome s\u1eed d\u1ee5ng k\u1ef9 thu\u1eadt ion ho\u00e1 laser k\u1ebft h\u1ee3p kh\u1ed1i ph\u1ed5 th\u1eddi gian bay (MALDI TOF MS) tr\u00ean thi\u1ebft b\u1ecb Bruker MALDI Biotyper theo nguy\u00ean t\u1eafc ph\u01b0\u01a1ng ph\u00e1p AOAC 2017.09, AOAC 2017.10 v\u00e0 MBT Filamentous Fungi Module. \u0110\u00e2y l\u00e0 ph\u01b0\u01a1ng ph\u00e1p s\u1eed d\u1ee5ng c\u00f4ng ngh\u1ec7 hi\u1ec7n \u0111\u1ea1i gi\u00fap \u0111\u1ecbnh danh vi sinh v\u1eadt b\u1eb1ng d\u1ea5u \u1ea5n ph\u00e2n t\u1eed d\u1ef1a tr\u00ean s\u1ef1 so s\u00e1nh \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng kh\u1ed1i ph\u1ed5 protein ribosome c\u1ee7a vi sinh v\u1eadt m\u1ee5c ti\u00eau v\u1edbi c\u01a1 s\u1edf d\u1eef li\u1ec7u kh\u1ed1i ph\u1ed5 vi sinh v\u1eadt chu\u1ea9n.<\/p>\n\n\n\n

Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u00f3 nhi\u1ec1u \u01b0u \u0111i\u1ec3m v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi ph\u01b0\u01a1ng ph\u00e1p truy\u1ec1n th\u1ed1ng nh\u01b0: k\u1ebft qu\u1ea3 \u0111\u1ecbnh danh ch\u00ednh x\u00e1c \u0111\u1ebfn lo\u00e0i ho\u1eb7c chi, th\u1eddi gian th\u1eed nghi\u1ec7m nhanh (kho\u1ea3ng 15-30 ph\u00fat) sau khi ph\u00e2n l\u00e2p \u0111\u01b0\u1ee3c khu\u1ea9n l\u1ea1c, k\u0129 thu\u1eadt th\u1ef1c hi\u1ec7n \u0111\u01a1n gi\u1ea3n, k\u1ebft qu\u1ea3 kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi c\u00e1c lo\u1ea1i m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y kh\u00e1c nhau.<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

H\u00ecnh 2.1: Thao t\u00e1c \u0111\u1ecbnh danh n\u1ea5m m\u1ed1c tr\u00ean thi\u1ebft b\u1ecb Bruker MALDI Biotyper H\u00ecnh 2.2 K\u1ebft qu\u1ea3 \u0111\u1ecbnh danh m\u1ed9t s\u1ed1 m\u1eabu n\u1ea5m m\u1ed1c ph\u00e2n l\u1eadp t\u1eeb th\u1ef1c ph\u1ea9m v\u00e0 m\u00f4i tr\u01b0\u1eddng s\u1eed d\u1ee5ng k\u1ef9 thu\u1eadt MALDI TOF MS H\u00ecnh 2.3: Kh\u1ed1i ph\u1ed5 protein \u0111\u1eb7c tr\u01b0ng c\u1ee7a n\u1ea5m m\u1ed1c Penicillium citrinum<\/em><\/p>\n\n\n\n

Hai ph\u01b0\u01a1ng ph\u00e1p tr\u00ean \u0111\u1ec1u c\u00f3 \u0111\u1ed9 tin c\u1eady cao, c\u00e1c th\u00f4ng s\u1ed1 v\u1ec1 \u0111\u1ed9 ch\u1ecdn l\u1ecdc m\u1ee5c ti\u00eau, \u0111\u1ed9 ch\u1ecdn l\u1ecdc lo\u1ea1i tr\u1eeb \u0111\u01b0\u1ee3c \u0111\u1ec1u \u0111\u00e1p \u1ee9ng y\u00eau c\u1ea7u k\u1ef9 thu\u1eadt v\u00e0 tho\u1ea3 m\u00e3n y\u00eau c\u1ea7u v\u1ec1 l\u1ef1a ch\u1ecdn ph\u01b0\u01a1ng ph\u00e1p th\u1eed ph\u00f9 h\u1ee3p m\u1ee5c \u0111\u00edch s\u1eed d\u1ee5ng c\u1ee7a kh\u00e1ch h\u00e0ng. V\u1edbi vi\u1ec7c \u00e1p d\u1ee5ng 2 ph\u01b0\u01a1ng ph\u00e1p tr\u00ean, th\u1eddi gian qua, Trung t\u00e2m K\u1ef9 thu\u1eadt 3 \u0111\u00e3 v\u00e0 \u0111ang ti\u1ebfp t\u1ee5c \u0111\u1ed3ng h\u00e0nh c\u00f9ng r\u1ea5t nhi\u1ec1u doanh nghi\u1ec7p trong qu\u00e1 tr\u00ecnh ki\u1ec3m so\u00e1t m\u00f4i tr\u01b0\u1eddng s\u1ea3n xu\u1ea5t, nghi\u00ean c\u1ee9u s\u1ef1 \u0111a d\u1ea1ng n\u1ea5m m\u1ed1c trong m\u1eabu, x\u00e1c \u0111\u1ecbnh nguy\u00ean nh\u00e2n h\u01b0 h\u1ecfng, bi\u1ebfn t\u00ednh s\u1ea3n ph\u1ea9m, nguy\u00ean nh\u00e2n ng\u1ed9 \u0111\u1ed9c th\u1ef1c ph\u1ea9m,\u2026 nh\u1eb1m \u0111\u01b0a ra c\u00e1c bi\u1ec7n ph\u00e1p x\u1eed l\u00fd h\u1ee3p l\u00fd, k\u1ecbp th\u1eddi.<\/p>\n\n\n\n

Tr\u1ea7n Th\u1ecb \u00c1nh Nguy\u1ec7t – V\u0169 Di\u1ec7u Thu<\/strong><\/p>\n\n\n\n

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Hi\u1ec7n nay, ng\u00e0y c\u00e0ng c\u00f3 nhi\u1ec1u nh\u00e0 m\u00e1y s\u1ea3n xu\u1ea5t r\u01a1i v\u00e0o t\u00ecnh tr\u1ea1ng nhi\u1ec5m vi sinh trong s\u1ea3n ph\u1ea9m c\u0169ng nh\u01b0 nh\u00e0 x\u01b0\u1edfng, \u0111\u1eb7c bi\u1ec7t l\u00e0 nhi\u1ec5m n\u1ea5m m\u1ed1c. V\u1ea5n \u0111\u1ec1 c\u00e0ng tr\u1edf n\u00ean \u0111\u00e1ng lo ng\u1ea1i v\u1edbi m\u1ed9t qu\u1ed1c gia c\u00f3 kh\u00ed h\u1eadu nhi\u1ec7t \u0111\u1edbi n\u00f3ng \u1ea9m nh\u01b0 Vi\u1ec7t Nam do \u0111\u00e2y l\u00e0 […]<\/p>\n","protected":false},"author":26,"featured_media":33369,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-33368","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/33368","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=33368"}],"version-history":[{"count":1,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/33368\/revisions"}],"predecessor-version":[{"id":33370,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/33368\/revisions\/33370"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/33369"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=33368"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=33368"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=33368"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}