{"id":31267,"date":"2022-01-20T09:52:00","date_gmt":"2022-01-20T02:52:00","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=31267"},"modified":"2022-03-09T09:54:01","modified_gmt":"2022-03-09T02:54:01","slug":"phan-tu-moi-kiem-soat-luong-duong-trong-mau-giai-quyet-tinh-trang-khang-insulin","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/phan-tu-moi-kiem-soat-luong-duong-trong-mau-giai-quyet-tinh-trang-khang-insulin\/","title":{"rendered":"Ph\u00e2n t\u1eed m\u1edbi ki\u1ec3m so\u00e1t l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u, gi\u1ea3i quy\u1ebft t\u00ecnh tr\u1ea1ng kh\u00e1ng insulin"},"content":{"rendered":"\n

C\u00e1c nh\u00e0 khoa h\u1ecdc M\u1ef9 trong nghi\u00ean c\u1ee9u m\u1edbi g\u1ea7n \u0111\u00e2y ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c m\u1ed9t lo\u1ea1i hormon, c\u00f3 kh\u1ea3 n\u0103ng \u0111i\u1ec1u ch\u1ec9nh l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u t\u01b0\u01a1ng t\u1ef1 nh\u01b0 insulin, m\u1edf ra m\u1ed9t ph\u01b0\u01a1ng h\u01b0\u1edbng m\u1edbi \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng kh\u00e1ng insulin.<\/strong><\/h2>\n\n\n\n

C\u00e1ch \u0111\u00e2y 100 n\u0103m, ph\u00e1t hi\u1ec7n ra insulin<\/a> mang l\u1ea1i s\u1ef1 s\u1ed1ng v\u00e0 s\u1ef1 \u1ed5n \u0111\u1ecbnh s\u1ee9c kh\u1ecfe cho h\u00e0ng tri\u1ec7u ng\u01b0\u1eddi m\u1eafc b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng. K\u1ec3 t\u1eeb \u0111\u00f3, insulin, hormon t\u1eeb c\u00e1c t\u1ebf b\u00e0o \u0111\u1ea3o t\u1ee5y \u1edf tuy\u1ebfn t\u1ee5y ti\u1ebft ra, tr\u1edf th\u00e0nh ph\u01b0\u01a1ng ti\u1ec7n ch\u00ednh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c t\u00ecnh tr\u1ea1ng b\u1ec7nh l\u00fd do l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u cao (glucose) nh\u01b0 b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng.<\/p>\n\n\n\n

C\u00e1c nh\u00e0 khoa h\u1ecdc thu\u1ed9c Vi\u1ec7n nghi\u00ean c\u1ee9u Salk, M\u1ef9 ph\u00e1t hi\u1ec7n ra m\u1ed9t ph\u00e2n t\u1eed th\u1ee9 hai, \u0111\u01b0\u1ee3c t\u1ea1o ra trong m\u00f4 m\u1ee1, c\u0169ng \u0111i\u1ec1u ch\u1ec9nh l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u m\u1ea1nh v\u00e0 nhanh ch\u00f3ng nh\u01b0 insulin. <\/p>\n\n\n\n

Trong b\u00e1o c\u00e1o khoa h\u1ecdc, \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean T\u1ea1p ch\u00ed Cell Metabolism ng\u00e0y 4\/1\/2022, c\u00e1c nh\u00e0 khoa h\u1ecdc Salk ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c m\u1ed9t lo\u1ea1i hormon, c\u00f3 t\u00ean g\u1ecdi l\u00e0 FGF1<\/a>, c\u00f3 kh\u1ea3 n\u0103ng \u0111i\u1ec1u ch\u1ec9nh l\u01b0\u1ee3ng glucose trong m\u00e1u b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf s\u1ef1 ph\u00e2n h\u1ee7y ch\u1ea5t b\u00e9o.<\/p>\n\n\n\n

T\u01b0\u01a1ng t\u1ef1 nh\u01b0 insulin, FGF1 ki\u1ec3m so\u00e1t l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u b\u1eb1ng \u1ee9c ch\u1ebf s\u1ef1 ph\u00e2n gi\u1ea3i lipid, nh\u01b0ng hai lo\u1ea1i hormon th\u1ef1c hi\u1ec7n theo nh\u1eefng c\u00e1ch kh\u00e1c nhau. \u0110i\u1ec1u quan tr\u1ecdng l\u00e0 s\u1ef1 kh\u00e1c bi\u1ec7t n\u00e0y cho ph\u00e9p s\u1eed d\u1ee5ng FGF1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft th\u00e0nh c\u00f4ng v\u00e0 an to\u00e0n cho nh\u1eefng ng\u01b0\u1eddi b\u1ecb kh\u00e1ng insulin.<\/p>\n\n\n\n

\u0110\u1ed3ng t\u00e1c gi\u1ea3 nghi\u00ean c\u1ee9u, GS Ronald Evans, Ch\u1ee7 t\u1ecbch March of Dimes v\u1ec1 Sinh h\u1ecdc Ph\u00e2n t\u1eed v\u00e0 Ph\u00e1t tri\u1ec3n cho bi\u1ebft, khi th\u1ee9c \u0103n v\u00e0o c\u01a1 th\u1ec3, ch\u1ea5t b\u00e9o gi\u00e0u n\u0103ng l\u01b0\u1ee3ng v\u00e0 glucose \u0111i v\u00e0o m\u00e1u. Insulin th\u01b0\u1eddng v\u1eadn chuy\u1ec3n nh\u1eefng ch\u1ea5t dinh d\u01b0\u1ee1ng n\u00e0y \u0111\u1ebfn c\u00e1c t\u1ebf b\u00e0o trong c\u01a1 v\u00e0 m\u00f4 m\u1ee1, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ngay l\u1eadp t\u1ee9c ho\u1eb7c l\u01b0u tr\u1eef \u0111\u1ec3 s\u1eed d\u1ee5ng khi c\u1ea7n. \u1ede nh\u1eefng ng\u01b0\u1eddi b\u1ecb kh\u00e1ng insulin, glucose kh\u00f4ng \u0111\u01b0\u1ee3c lo\u1ea1i b\u1ecf kh\u1ecfi m\u00e1u hi\u1ec7u qu\u1ea3, d\u1eabn \u0111\u1ebfn s\u1ef1 ph\u00e2n gi\u1ea3i lipid cao, l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 axit b\u00e9o.<\/p>\n\n\n\n

Nh\u1eefng axit b\u00e9o b\u1ed5 sung n\u00e0y \u0111\u1ea9y nhanh qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t glucose t\u1eeb gan, l\u00e0m t\u0103ng g\u1ea5p \u0111\u00f4i l\u01b0\u1ee3ng glucose v\u1ed1n \u0111\u00e3 cao. \u0110\u1ed3ng th\u1eddi c\u00e1c axit b\u00e9o t\u00edch t\u1ee5 trong nh\u1eefng c\u01a1 quan n\u1ed9i t\u1ea1ng, l\u00e0m tr\u1ea7m tr\u1ecdng th\u00eam t\u00ecnh tr\u1ea1ng kh\u00e1ng insulin, \u0111\u1eb7c \u0111i\u1ec3m chung c\u1ee7a b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng v\u00e0 b\u00e9o ph\u00ec.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u Salk tham gia nghi\u00ean c\u1ee9u \u0111i\u1ec1u ch\u1ec9nh l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u.  \u1ea2nh: Vi\u1ec7n Nghi\u00ean c\u1ee9u Salk.<\/em><\/p>\n\n\n\n

Tr\u01b0\u1edbc \u0111\u00f3, nh\u1eefng nghi\u00ean c\u1ee9u ph\u00f2ng th\u00ed nghi\u1ec7m \u0111\u00e3 ch\u1ee9ng minh \u0111\u01b0\u1ee3c, ti\u00eam FGF1 l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u \u1edf chu\u1ed9t, \u0111i\u1ec1u tr\u1ecb FGF1 th\u01b0\u1eddng xuy\u00ean l\u00e0m gi\u1ea3m t\u00ecnh tr\u1ea1ng kh\u00e1ng insulin.<\/p>\n\n\n\n

Nh\u00f3m nghi\u00ean c\u1ee9u x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c, FGF1 ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e2n gi\u1ea3i lipid, \u0111i\u1ec1u ch\u1ec9nh s\u1ea3n xu\u1ea5t glucose trong gan, t\u01b0\u01a1ng t\u1ef1 nh\u01b0 insulin. <\/p>\n\n\n\n

Khoa h\u1ecdc \u0111\u00e3 bi\u1ebft, insulin ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e2n gi\u1ea3i lipid th\u00f4ng qua PDE3B, m\u1ed9t lo\u1ea1i enzym kh\u1edfi \u0111\u1ea7u \u0111\u01b0\u1eddng truy\u1ec1n d\u1eabn t\u00edn hi\u1ec7u. Nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 th\u1eed nghi\u1ec7m m\u1ed9t lo\u1ea1t c\u00e1c enzym t\u01b0\u01a1ng t\u1ef1 v\u1edbi PDE3B h\u00e0ng \u0111\u1ea7u trong danh s\u00e1ch. Nh\u01b0ng c\u00e1c nh\u00e0 khoa h\u1ecdc ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c FGF1 s\u1eed d\u1ee5ng m\u1ed9t \u0111\u01b0\u1eddng d\u1eabn truy\u1ec1n kh\u00e1c, enzym PDE4.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

Theo Gencer Sancar, nghi\u00ean c\u1ee9u sinh sau TS t\u1ea1i ph\u00f2ng th\u00ed nghi\u1ec7m Evans, t\u00e1c gi\u1ea3 nghi\u00ean c\u1ee9u, c\u01a1 ch\u1ebf n\u00e0y v\u1ec1 c\u01a1 b\u1ea3n l\u00e0 v\u00f2ng l\u1eb7p th\u1ee9 hai v\u1edbi t\u1ea5t c\u1ea3 nh\u1eefng \u01b0u \u0111i\u1ec3m c\u1ee7a \u0111\u01b0\u1eddng truy\u1ec1n d\u1eabn t\u00edn hi\u1ec7u song song. Trong tr\u01b0\u1eddng h\u1ee3p ng\u01b0\u1eddi b\u1ecb kh\u00e1ng insulin, t\u00edn hi\u1ec7u insulin suy gi\u1ea3m. Nh\u01b0ng v\u1edbi m\u1ed9t \u0111\u01b0\u1eddng truy\u1ec1n d\u1eabn t\u00edn hi\u1ec7u song song kh\u00e1c, v\u1eabn ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c qu\u00e1 tr\u00ecnh ph\u00e2n gi\u1ea3i lipid v\u00e0 \u0111i\u1ec1u h\u00f2a l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u.<\/p>\n\n\n\n

Ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c \u0111\u01b0\u1eddng truy\u1ec1n d\u1eabn t\u00edn hi\u1ec7u PDE4 m\u1edf ra c\u01a1 h\u1ed9i ph\u00e1t tri\u1ec3n lo\u1ea1i thu\u1ed1c m\u1edbi v\u00e0 nh\u1eefng nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n \u0111i\u1ec1u tr\u1ecb l\u01b0\u1ee3ng \u0111\u01b0\u1eddng huy\u1ebft cao (t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft) v\u00e0 kh\u00e1ng insulin.<\/p>\n\n\n\n

C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111ang nghi\u00ean c\u1ee9u kh\u1ea3 n\u0103ng s\u1eeda \u0111\u1ed5i FGF1 \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a PDE4. M\u1ed9t l\u1ed9 tr\u00ecnh nghi\u00ean c\u1ee9u h\u01b0\u1edbng \u0111\u1ebfn nhi\u1ec1u \u0111i\u1ec3m trong \u0111\u01b0\u1eddng d\u1eabn truy\u1ec1n t\u00edn hi\u1ec7u tr\u01b0\u1edbc khi k\u00edch ho\u1ea1t PDE4.<\/p>\n\n\n\n

Th\u00e1i B\u1eb1ng<\/strong><\/p>\n\n\n\n

L\u1ed9 tr\u00ecnh ph\u00e2n t\u1eed m\u1edbi ki\u1ec3m so\u00e1t l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u, ch\u1ed1ng kh\u00e1ng insulin. – Khoa h\u1ecdc v\u00e0 \u0111\u1eddi s\u1ed1ng (khoahocdoisong.vn)<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

C\u00e1c nh\u00e0 khoa h\u1ecdc M\u1ef9 trong nghi\u00ean c\u1ee9u m\u1edbi g\u1ea7n \u0111\u00e2y ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c m\u1ed9t lo\u1ea1i hormon, c\u00f3 kh\u1ea3 n\u0103ng \u0111i\u1ec1u ch\u1ec9nh l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u t\u01b0\u01a1ng t\u1ef1 nh\u01b0 insulin, m\u1edf ra m\u1ed9t ph\u01b0\u01a1ng h\u01b0\u1edbng m\u1edbi \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng kh\u00e1ng insulin. C\u00e1ch \u0111\u00e2y 100 n\u0103m, ph\u00e1t hi\u1ec7n ra insulin mang l\u1ea1i s\u1ef1 s\u1ed1ng v\u00e0 s\u1ef1 […]<\/p>\n","protected":false},"author":23,"featured_media":31268,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-31267","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/31267","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=31267"}],"version-history":[{"count":1,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/31267\/revisions"}],"predecessor-version":[{"id":31269,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/31267\/revisions\/31269"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/31268"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=31267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=31267"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=31267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}