{"id":31186,"date":"2022-01-06T10:35:00","date_gmt":"2022-01-06T03:35:00","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=31186"},"modified":"2022-02-21T10:37:36","modified_gmt":"2022-02-21T03:37:36","slug":"phuong-phap-moi-kham-pha-thuoc-cho-nhung-lieu-phap-dieu-tri-hieu-qua","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/phuong-phap-moi-kham-pha-thuoc-cho-nhung-lieu-phap-dieu-tri-hieu-qua\/","title":{"rendered":"Ph\u01b0\u01a1ng ph\u00e1p m\u1edbi kh\u00e1m ph\u00e1 thu\u1ed1c cho nh\u1eefng li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3"},"content":{"rendered":"\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i \u0110\u1ea1i h\u1ecdc V\u0103n th\u01b0, Ngh\u1ec7 thu\u1eadt v\u00e0 Khoa h\u1ecdc USC Dornsife (M\u1ef9) ph\u00e1t tri\u1ec3n th\u00e0nh c\u00f4ng m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p m\u1edbi cho ph\u00e9p nhanh ch\u00f3ng s\u00e0ng l\u1ecdc hi\u1ec7u qu\u1ea3 h\u00e0ng t\u1ef7 h\u1ee3p ch\u1ea5t h\u00f3a h\u1ecdc \u0111\u1ec3 t\u00ecm ra lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3.<\/strong><\/h2>\n\n\n\n

Qu\u00e1 tr\u00ecnh n\u00e0y tr\u01b0\u1edbc \u0111\u00e2y ch\u1ee7 y\u1ebfu th\u1ef1c hi\u1ec7n th\u1ee7 c\u00f4ng trong ph\u00f2ng th\u00ed nghi\u1ec7m, \u0111\u00f2i h\u1ecfi ngu\u1ed3n l\u1ef1c l\u1edbn v\u00e0 m\u1ea5t nhi\u1ec1u th\u1eddi gian.<\/p>\n\n\n\n

R\u00fat ra t\u1eeb m\u1ed9t nh\u00f3m h\u00e0ng tr\u0103m ngh\u00ecn kh\u1ed1i c\u01a1 b\u1ea3n h\u00f3a h\u1ecdc, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 synthon, c\u00e1c nh\u00e0 h\u00f3a h\u1ecdc \u0111\u1ea7u ti\u00ean s\u1eed d\u1ee5ng c\u00e1c ph\u1ea3n \u1ee9ng \u0111\u01a1n gi\u1ea3n v\u00e0 c\u00f3 \u0111\u1ed9 tin c\u1eady cao, \u0111\u01b0\u1ee3c m\u00f4 ph\u1ecfng h\u00f3a k\u1ebft h\u1ee3p 2 ho\u1eb7c 3 synthon v\u00e0o c\u00f9ng nhau, t\u1ea1o ra nhi\u1ec1u t\u1ef7 ph\u00e2n t\u1eed c\u00f3 h\u00ecnh d\u1ea1ng v\u00e0 \u0111\u1eb7c t\u00ednh h\u00f3a h\u1ecdc b\u1ea5t k\u1ef3.<\/p>\n\n\n\n

B\u1eb1ng c\u00e1ch n\u00e0y, c\u00e1c nh\u00e0 h\u00f3a h\u1ecdc t\u1ea1o ra nh\u1eefng danh m\u1ee5c \u1ea3o c\u00e1c h\u1ee3p ch\u1ea5t “s\u1eb5n c\u00f3 \u0111\u1ec3 t\u1ed5ng h\u1ee3p”, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 “REAL Space” nhi\u1ec1u kh\u1ea3 n\u0103ng c\u00f3 nh\u1eefng ph\u00e2n t\u1eed c\u00f3 \u0111\u1ed9 ph\u00f9 h\u1ee3p ban \u0111\u1ea7u hi\u1ec7u qu\u1ea3 v\u1edbi protein m\u1ee5c ti\u00eau.<\/p>\n\n\n\n

Vi\u1ec7c s\u1eed d\u1ee5ng nh\u1eefng c\u00f4ng c\u1ee5 t\u00ednh to\u00e1n hi\u1ec7n \u0111\u1ea1i r\u00e0 so\u00e1t kh\u1ed1i l\u01b0\u1ee3ng kho\u1ea3ng 20 t\u1ef7 ph\u00e2n t\u1eed \u1ea3o, v\u00e0 ti\u1ebfp t\u1ee5c ph\u00e1t tri\u1ec3n nhanh ch\u00f3ng r\u1ea5t kh\u00f3 kh\u0103n v\u00e0 t\u1ed1n k\u00e9m cho qu\u00e1 tr\u00ecnh kh\u00e1m ph\u00e1 thu\u1ed1c.<\/p>\n\n\n\n

Ph\u01b0\u01a1ng ph\u00e1p m\u1edbi<\/a>, \u0111\u01b0\u1ee3c \u0111\u1eb7t t\u00ean l\u00e0 “V-SYNTHES” ch\u1ec9 c\u1ea7n th\u1eddi gian ng\u1eafn v\u00e0 m\u1ed9t ph\u1ea7n t\u00e0i nguy\u00ean m\u00e1y t\u00ednh so v\u1edbi nh\u1eefng thu\u1eadt to\u00e1n kh\u00e1c, s\u00e0ng l\u1ecdc<\/a> \u1ea3o c\u00e1c th\u01b0 vi\u1ec7n REAL Space.<\/p>\n\n\n\n

V-SYNTHES s\u00e0ng l\u1ecdc qua th\u01b0 vi\u1ec7n t\u1ed5ng h\u1ee3p nh\u1ecf,  t\u00ecm ki\u1ebfm nh\u1eefng ph\u00e2n t\u1eed ph\u00f9 h\u1ee3p v\u1edbi m\u1ed9t ph\u1ea7n nh\u00f3m m\u1ee5c ti\u00eau \u0111\u1eb7t ra \u0111\u1ed1i v\u1edbi protein.<\/p>\n\n\n\n

Nh\u00f3m c\u00e1c ph\u00e2n t\u1eed c\u00f3 k\u1ebft qu\u1ea3 ph\u00f9 h\u1ee3p \u1edf m\u1ed9t ph\u1ea7n m\u1ee5c ti\u00eau sau \u0111\u00f3 \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p v\u1edbi c\u00e1c synthons kh\u00e1c, ph\u00f9 h\u1ee3p v\u1edbi nh\u1eefng ph\u1ea7n c\u00f2n l\u1ea1i c\u1ee7a nh\u00f3m m\u1ee5c ti\u00eau v\u1edbi protein.<\/p>\n\n\n\n

L\u1eb7p l\u1ea1i nhi\u1ec1u l\u1ea7n qu\u00e1 tr\u00ecnh n\u00e0y, c\u1eaft gh\u00e9p c\u00e1c synthons kh\u00e1c cho ph\u00e9p c\u00e1c nh\u00e0 khoa h\u1ecdc x\u00e2y d\u1ef1ng nh\u1eefng ph\u00e2n t\u1eed ho\u00e0n ch\u1ec9nh v\u00e0 t\u1eebng b\u01b0\u1edbc ki\u1ec3m tra \u0111\u1ed9 ph\u00f9 h\u1ee3p v\u1edbi nh\u00f3m m\u1ee5c ti\u00eau. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y khi\u1ebfn quy tr\u00ecnh kh\u00e1m ph\u00e1 c\u00e1c lo\u1ea1i thu\u1ed1c hi\u1ec7u qu\u1ea3, \u0111\u01a1n gi\u1ea3n v\u00e0 d\u1ec5 d\u00e0ng h\u01a1n.<\/p>\n\n\n\n

\u0110\u1ec3 ki\u1ec3m tra V-SYNTHES, nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 th\u1eed nghi\u1ec7m kh\u00e1m ph\u00e1 thu\u1ed1c nh\u1eb1m v\u00e0o c\u00e1c th\u1ee5 th\u1ec3 cannabinoid.<\/p>\n\n\n\n

Th\u1ee5 th\u1ec3 cannabinoid trong c\u01a1 th\u1ec3 c\u00f3 vai tr\u00f2 trung gian cho t\u00e1c \u0111\u1ed9ng c\u1ee7a c\u1ea7n sa, nh\u01b0ng c\u0169ng l\u00e0 m\u1ee5c ti\u00eau ch\u00ednh \u0111\u1ec3 gi\u1ea3m \u0111au v\u00e0 li\u00ean quan \u0111\u1ebfn c\u00e1c b\u1ec7nh ung th\u01b0, \u0111a x\u01a1 c\u1ee9ng, b\u1ec7nh Alzheimer v\u00e0 Parkinson.<\/p>\n\n\n\n

S\u00e0ng l\u1ecdc d\u1eef li\u1ec7u c\u00e1c th\u01b0 vi\u1ec7n t\u1ed5ng h\u1ee3p do c\u00f4ng ty h\u00f3a ch\u1ea5t Enamine ph\u00e1t tri\u1ec3n, V-SYNTHES \u0111\u1ea1t \u0111\u01b0\u1ee3c k\u1ebft qu\u1ea3 nhanh h\u01a1n 5.000 l\u1ea7n so v\u1edbi nh\u1eefng thu\u1eadt to\u00e1n ti\u00eau chu\u1ea9n, s\u1eed d\u1ee5ng trong t\u00ecm ki\u1ebfm c\u00e1c ph\u00e2n t\u1eed t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c, t\u00e1c \u0111\u1ed9ng c\u00f3 ch\u1ecdn l\u1ecdc m\u1ee5c ti\u00eau l\u00ean c\u00e1c th\u1ee5 th\u1ec3 cannabinoid.<\/p>\n\n\n\n

Nh\u1eefng \u1ee9ng vi\u00ean thu\u1ed1c \u0111\u01b0\u1ee3c d\u1ef1 \u0111o\u00e1n, sau khi t\u1ed5ng h\u1ee3p v\u00e0 ki\u1ec3m tra trong ph\u00f2ng th\u00ed nghi\u1ec7m, c\u00f3 kh\u1ea3 n\u0103ng li\u00ean k\u1ebft v\u00e0 \u1ee9c ch\u1ebf hi\u1ec7u qu\u1ea3 c\u00e1c th\u1ee5 th\u1ec3 cannabinoid cao g\u1ea5p \u0111\u00f4i so v\u1edbi c\u00e1c \u1ee9ng vi\u00ean t\u1ed5 h\u1ee3p h\u00f3a h\u1ecdc<\/a>, do c\u00e1c thu\u1eadt to\u00e1n t\u00ecm ki\u1ebfm ti\u00eau chu\u1ea9n \u0111\u1ec1 xu\u1ea5t.<\/p>\n\n\n\n

L\u1eb7p l\u1ea1i s\u00e0ng l\u1ecdc c\u00e1c ph\u00e2n t\u1eed, \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh \u1edf v\u00f2ng \u0111\u00e1nh \u0111\u1ea7u ti\u00ean, ph\u00f2ng th\u00ed nghi\u1ec7m Katritch x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c nh\u1eefng ph\u00e2n t\u1eed m\u1ea1nh nh\u1ea5t, c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng trong m\u00f4i tr\u01b0\u1eddng l\u00e2m s\u00e0ng. Theo PGS Katritch, V-SYNTHES t\u0103ng g\u1ea5p \u0111\u00f4i t\u1ef7 l\u1ec7 th\u00e0nh c\u00f4ng v\u00e0 cho ph\u00e9p l\u1ef1a ch\u1ecdn nh\u1eefng \u1ee9ng vi\u00ean thu\u1ed1c hi\u1ec7u qu\u1ea3 trong l\u00e2m s\u00e0ng.<\/p>\n\n\n\n

Nh\u00f3m nghi\u00ean c\u1ee9u Katritch hi\u1ec7n \u0111ang h\u1ee3p t\u00e1c v\u1edbi Nicos Petasis, GS h\u00f3a h\u1ecdc v\u00e0 d\u01b0\u1ee3c h\u1ecdc t\u1ea1i USC Dornsife \u0111\u1ec3 th\u1eed nghi\u1ec7m V-SYNTHES, s\u1eed d\u1ee5ng m\u1ed9t protein m\u1ee5c ti\u00eau quan tr\u1ecdng, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 ROCK1, t\u00ecm nh\u1eefng \u1ee9ng vi\u00ean thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0.<\/p>\n\n\n\n

Th\u01b0 vi\u1ec7n REAL Space t\u0103ng l\u00ean 21 t\u1ef7 h\u1ee3p ch\u1ea5t ch\u1ec9 v\u1edbi 2 ho\u1eb7c 3 synthon v\u00e0 con s\u1ed1 n\u00e0y ti\u1ebfp t\u1ee5c b\u00f9ng n\u1ed5 khi m\u1edf r\u1ed9ng x\u00e2y d\u1ef1ng c\u00e1c ph\u00e2n t\u1eed b\u1eb1ng 4 ho\u1eb7c 5 synthon, khi\u1ebfn quy tr\u00ecnh kh\u00e1m ph\u00e1 thu\u1ed1c ph\u1ea3i c\u00f3 kh\u1ea3 n\u0103ng thu h\u1eb9p nh\u1eefng l\u1ef1a ch\u1ecdn nhanh ch\u00f3ng v\u00e0 hi\u1ec7u qu\u1ea3 \u0111\u1ec3 t\u00ecm ra nh\u1eefng \u1ee9ng c\u1eed vi\u00ean thu\u1ed1c kh\u1ea3 thi, \u0111\u00e2y c\u0169ng l\u00e0 m\u1ee5c \u0111\u00edch ph\u00e1t tri\u1ec3n V-SYNTHES.<\/p>\n\n\n\n

V-SYNTHES c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u1ee9ng d\u1ee5ng trong ng\u00e0nh c\u00f4ng ngh\u1ec7 sinh h\u1ecdc v\u00e0 d\u01b0\u1ee3c ph\u1ea9m, gi\u00fap t\u00ecm ki\u1ebfm c\u00e1c lo\u1ea1i thu\u1ed1c h\u1ee3p l\u00fd, mang l\u1ea1i hi\u1ec7u qu\u1ea3 cao nh\u1ea5t cho nh\u1eefng b\u1ec7nh nh\u00e2n c\u1ea7n c\u00e1c li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi v\u00e0 t\u1ed1t h\u01a1n.<\/p>\n\n\n\n

TH\u00c1I B\u1eb0NG<\/strong><\/p>\n\n\n\n

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C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i \u0110\u1ea1i h\u1ecdc V\u0103n th\u01b0, Ngh\u1ec7 thu\u1eadt v\u00e0 Khoa h\u1ecdc USC Dornsife (M\u1ef9) ph\u00e1t tri\u1ec3n th\u00e0nh c\u00f4ng m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p m\u1edbi cho ph\u00e9p nhanh ch\u00f3ng s\u00e0ng l\u1ecdc hi\u1ec7u qu\u1ea3 h\u00e0ng t\u1ef7 h\u1ee3p ch\u1ea5t h\u00f3a h\u1ecdc \u0111\u1ec3 t\u00ecm ra lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3. Qu\u00e1 tr\u00ecnh n\u00e0y tr\u01b0\u1edbc \u0111\u00e2y ch\u1ee7 y\u1ebfu […]<\/p>\n","protected":false},"author":23,"featured_media":31187,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-31186","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/31186","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=31186"}],"version-history":[{"count":1,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/31186\/revisions"}],"predecessor-version":[{"id":31188,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/31186\/revisions\/31188"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/31187"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=31186"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=31186"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=31186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}