{"id":30831,"date":"2021-01-26T15:00:00","date_gmt":"2021-01-26T08:00:00","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=30831"},"modified":"2022-01-20T15:05:47","modified_gmt":"2022-01-20T08:05:47","slug":"cac-te-bao-lam-hong-he-mien-dich-duoc-kiem-soat-boi-nhip-sinh-hoc-2","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/cac-te-bao-lam-hong-he-mien-dich-duoc-kiem-soat-boi-nhip-sinh-hoc-2\/","title":{"rendered":"C\u00e1c t\u1ebf b\u00e0o l\u00e0m h\u1ecfng h\u1ec7 mi\u1ec5n d\u1ecbch \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t b\u1edfi nh\u1ecbp sinh h\u1ecdc"},"content":{"rendered":"\n<p>Ph\u00e2n t\u00edch t\u1eadp d\u1eef li\u1ec7u \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 c\u00e1c t\u1ebf b\u00e0o c\u1ea7n thi\u1ebft cho h\u1ec7 mi\u1ec5n d\u1ecbch c\u1ee7a \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa cho th\u1ea5y kh\u1ea3 n\u0103ng ch\u1ed1ng l\u1ea1i b\u1ec7nh c\u00f3 th\u1ec3 ph\u1ee5 thu\u1ed9c nhi\u1ec1u h\u01a1n v\u00e0o chu k\u1ef3 sinh h\u1ecdc h\u00e0ng ng\u00e0y so v\u1edbi gi\u1ea3 \u0111\u1ecbnh tr\u01b0\u1edbc \u0111\u00e2y.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.vista.gov.vn\/vn-uploads\/news\/2021_01\/15-1-2021\/6.jpg\" alt=\"\"\/><\/figure><\/div>\n\n\n\n<p>Nh\u1ecbp sinh h\u1ecdc tr\u1ee5c tr\u1eb7c, trong qu\u00e1 tr\u00ecnh gi\u1eef cho c\u01a1 th\u1ec3 ch\u00fang ta b\u1eaft nh\u1ecbp v\u1edbi chu k\u1ef3 ng\u00e0y\/\u0111\u00eam, c\u00f3 li\u00ean quan \u0111\u1ebfn b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng, ung th\u01b0, Alzheimer v\u00e0 nhi\u1ec1u b\u1ec7nh kh\u00e1c. M\u1ed9t \u0111i\u1ec1u tra m\u1edbi \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed Genome Research cho th\u1ea5y ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c \u0111\u1ea1i th\u1ef1c b\u00e0o &#8211; l\u00e0 nh\u1eefng t\u1ebf b\u00e0o trong c\u01a1 th\u1ec3 t\u00ecm ki\u1ebfm v\u00e0 ti\u00eau di\u1ec7t vi khu\u1ea9n x\u00e2m nh\u1eadp &#8211; c\u00f3 th\u1ec3 t\u1ea1o ra thay \u0111\u1ed5i h\u00e0ng ng\u00e0y trong ph\u1ea3n \u1ee9ng c\u1ee7a ch\u00fang v\u1edbi m\u1ea7m b\u1ec7nh v\u00e0 c\u0103ng th\u1eb3ng th\u00f4ng qua vi\u1ec7c ki\u1ec3m so\u00e1t qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ch\u1ea5t theo chu k\u1ef3 sinh h\u1ecdc.<\/p>\n\n\n\n<p>C\u00e1c \u0111\u1ea1i th\u1ef1c b\u00e0o, t\u1ebf b\u00e0o ti\u00eau di\u1ec7t c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch, \u0111\u01b0\u1ee3c \u0111i\u1ec1u khi\u1ec3n b\u1edfi nh\u1ecbp sinh h\u1ecdc.<\/p>\n\n\n\n<p>Gi\u00e1o s\u01b0 Jennifer Hurley c\u00f9ng nh\u00f3m nghi\u00ean c\u1ee9u, \u0111\u1ebfn t\u1eeb H\u1ecdc vi\u1ec7n B\u00e1ch khoa Rensselaer \u0111\u00e3 t\u00ecm hi\u1ec3u m\u1ee9c \u0111\u1ed9 RNA v\u00e0 protein \u1edf \u0111\u1ea1i th\u1ef1c b\u00e0o thay \u0111\u1ed5i nh\u01b0 th\u1ebf n\u00e0o trong hai ng\u00e0y. Hurley cho bi\u1ebft: \u201c<em>Ch\u00fang t\u00f4i \u0111\u00e3 ch\u1ec9 ra th\u1eddi gian sinh l\u00fd h\u1ecdc (xu\u1ea5t hi\u1ec7n kho\u1ea3ng 1 l\u1ea7n m\u1ed9t ng\u00e0y) r\u1ea5t k\u1ef3 l\u1ea1 v\u1ec1 h\u00e0nh vi c\u1ee7a \u0111\u1ea1i th\u1ef1c b\u00e0o, nh\u01b0ng s\u1ef1 t\u00ednh to\u00e1n th\u1eddi gian cho \u0111\u1ea1i th\u1ef1c b\u00e0o th\u00ec l\u1ea1i theo c\u00e1ch b\u1ea5t ng\u1edd<\/em>\u201d.<\/p>\n\n\n\n<p>Nh\u1ecbp sinh h\u1ecdc bao g\u1ed3m m\u1ed9t t\u1eadp h\u1ee3p c\u00e1c protein \u0111\u1ed3ng h\u1ed3 c\u1ed1t l\u00f5i d\u1ef1 \u0111o\u00e1n chu k\u1ef3 ng\u00e0y\/\u0111\u00eam b\u1eb1ng c\u00e1ch g\u00e2y ra nh\u1eefng dao \u0111\u1ed9ng h\u00e0ng ng\u00e0y v\u1ec1 m\u1ee9c \u0111\u1ed9 enzyme v\u00e0 hormone, cu\u1ed1i c\u00f9ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c th\u00f4ng s\u1ed1 sinh l\u00fd nh\u01b0 nhi\u1ec7t \u0111\u1ed9 c\u01a1 th\u1ec3 v\u00e0 ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch. \u0110\u1ed3ng h\u1ed3 ph\u00e2n t\u1eed n\u00e0y \u0111\u00e1nh d\u1ea5u th\u1eddi gian th\u00f4ng qua m\u1ed9t chu k\u1ef3 t\u1ef1 \u0111i\u1ec1u ch\u1ec9nh c\u1ee7a qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t v\u00e0 ph\u00e2n r\u00e3 protein. M\u1ed9t s\u1ed1 protein ph\u1ea7n t\u1eed &#8220;t\u00edch c\u1ef1c&#8221; c\u1ee7a \u0111\u1ed3ng h\u1ed3 k\u00edch ho\u1ea1t s\u1ea3n xu\u1ea5t c\u00e1c protein ph\u1ea7n t\u1eed &#8220;ti\u00eau c\u1ef1c&#8221;, t\u1eeb \u0111\u00f3 ng\u0103n ch\u1eb7n s\u1ea3n xu\u1ea5t protein t\u00edch c\u1ef1c cho \u0111\u1ebfn khi protein ti\u00eau c\u1ef1c ph\u00e2n h\u1ee7y, do \u0111\u00f3 t\u1ea1o ra m\u1ed9t chu k\u1ef3 ph\u1ea3n h\u1ed3i ti\u00eau c\u1ef1c x\u1ea3y ra c\u1ee9 sau 24h\/1 l\u1ea7n.<\/p>\n\n\n\n<p>Nh\u1eefng protein nguy\u00ean t\u1ed1 t\u00edch c\u1ef1c c\u0169ng \u0111i\u1ec1u ch\u1ec9nh s\u1ef1 dao \u0111\u1ed9ng \u0111\u00e1ng k\u1ec3 c\u00e1c s\u1ea3n ph\u1ea9m gen, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 RNA th\u00f4ng tin ho\u1eb7c mRNA. Quy tr\u00ecnh di truy\u1ec1n \u0111\u01b0\u1ee3c phi\u00ean m\u00e3 t\u1eeb ADN sang mRNA, sau \u0111\u00f3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t c\u00f4ng th\u1ee9c \u0111\u1ec3 l\u1eafp r\u00e1p protein, v\u00e0 c\u00e1c kh\u1ed1i c\u1ea5u t\u1ea1o ch\u1ee9c n\u0103ng c\u1ee7a t\u1ebf b\u00e0o. T\u1eeb l\u00e2u, ng\u01b0\u1eddi ta cho r\u1eb1ng nhi\u1ec1u c\u1ea5p \u0111\u1ed9 c\u1ee7a m\u1ed7i b\u01b0\u1edbc ti\u1ebfp theo c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u1ef1 \u0111o\u00e1n t\u1eeb b\u01b0\u1edbc tr\u01b0\u1edbc. N\u1ebfu \u0111\u00fang nh\u01b0 v\u1eady, mRNA dao \u0111\u1ed9ng s\u1ebd t\u01b0\u01a1ng \u1ee9ng v\u1edbi m\u1ee9c \u0111\u1ed9 dao \u0111\u1ed9ng c\u1ee7a protein t\u1ebf b\u00e0o, v\u00e0 do \u0111\u00f3, n\u1ebfu c\u00f3 th\u1ec3 theo d\u00f5i mRNA, h\u1ecd s\u1ebd bi\u1ebft lo\u1ea1i protein n\u00e0o m\u00e0 \u0111\u1ed3ng h\u1ed3 sinh h\u1ecdc \u0111i\u1ec1u khi\u1ec3n trong t\u1ebf b\u00e0o.<\/p>\n\n\n\n<p>Tuy nhi\u00ean, cu\u1ed9c \u0111i\u1ec1u tra n\u00e0y cho th\u1ea5y m\u00f4 h\u00ecnh n\u00e0y c\u00f3 th\u1ec3 kh\u00f4ng ph\u1ea3i l\u00fac n\u00e0o c\u0169ng \u0111\u00fang. Vi\u1ec7c ph\u00e2n t\u00edch t\u1eadp d\u1eef li\u1ec7u \u0111\u1ea1i th\u1ef1c b\u00e0o cho th\u1ea5y c\u00f3 s\u1ef1 kh\u00f4ng ph\u00f9 h\u1ee3p \u0111\u00e1ng k\u1ec3 gi\u1eefa c\u00e1c protein v\u00e0 mRNA \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t b\u1edfi \u0111\u1ed3ng h\u1ed3 sinh h\u1ecdc. D\u1eef li\u1ec7u n\u00e0y c\u0169ng t\u01b0\u01a1ng t\u1ef1 v\u1edbi nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean Cell Systems v\u00e0o n\u0103m 2018 b\u1edfi ph\u00f2ng th\u00ed nghi\u1ec7m Hurley, cho th\u1ea5y kho\u1ea3ng 40% protein dao \u0111\u1ed9ng trong n\u1ea5m v\u00e0 h\u1ec7 th\u1ed1ng m\u00f4 h\u00ecnh sinh h\u1ecdc, Neurospora crassa, kh\u00f4ng c\u00f3 mRNA dao \u0111\u1ed9ng t\u01b0\u01a1ng \u1ee9ng.<\/p>\n\n\n\n<p>Hurley cho bi\u1ebft: \u201c<em>Nh\u01b0ng quy m\u00f4 c\u1ee7a s\u1ef1 kh\u00e1c bi\u1ec7t trong \u0111\u1ea1i th\u1ef1c b\u00e0o th\u1ef1c s\u1ef1 khi\u1ebfn ch\u00fang t\u00f4i ng\u1ea1c nhi\u00ean. 80% protein dao \u0111\u1ed9ng kh\u00f4ng c\u00f3 mRNA dao \u0111\u1ed9ng li\u00ean quan trong \u0111\u1ea1i th\u1ef1c b\u00e0o. \u0110i\u1ec1u \u0111\u00f3 c\u00f3 ngh\u0129a l\u00e0 ch\u00fang t\u00f4i th\u1ef1c s\u1ef1 \u0111\u00e3 b\u1ecf l\u1ee1 c\u00e1ch t\u00ednh to\u00e1n th\u1eddi gian mi\u1ec5n d\u1ecbch<\/em>\u201d.<\/p>\n\n\n\n<p>Nh\u00f3m c\u1ee7a Hurley, c\u1ed9ng t\u00e1c v\u1edbi ph\u00f2ng th\u00ed nghi\u1ec7m c\u1ee7a Annie Curtis t\u1ea1i \u0110\u1ea1i h\u1ecdc B\u00e1c s\u0129 ph\u1eabu thu\u1eadt Ho\u00e0ng gia \u1edf Ireland (RCSI), \u0111\u00e3 c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n v\u00e0 sau \u0111\u00f3 ch\u1ee9ng minh r\u1eb1ng \u0111\u1ed3ng h\u1ed3 \u0111i\u1ec1u ch\u1ec9nh s\u1ef1 trao \u0111\u1ed5i ch\u1ea5t theo th\u1eddi gian c\u00e1c ch\u1ee9c n\u0103ng mi\u1ec5n d\u1ecbch quan tr\u1ecdng trong \u0111\u1ea1i th\u1ef1c b\u00e0o. \u0110\u1ec3 l\u00e0m nh\u01b0 v\u1eady, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1eeb RCSI \u0111\u00e3 theo d\u00f5i nh\u1eefng ty th\u1ec3 t\u1ea1o ra n\u0103ng l\u01b0\u1ee3ng c\u1ee7a c\u00e1c \u0111\u1ea1i th\u1ef1c b\u00e0o, cho th\u1ea5y nh\u1ecbp \u0111i\u1ec7u m\u00e0 m\u1ed9t s\u1ed1 b\u00e0o quan t\u00e1ch ra \u0111\u1ec3 t\u1ea1o ra n\u0103ng l\u01b0\u1ee3ng v\u00e0 t\u00e1i h\u1ee3p nh\u1ea5t trong giai \u0111o\u1ea1n ngh\u1ec9 ng\u01a1i. Sau \u0111\u00f3, ph\u00f2ng th\u00ed nghi\u1ec7m Hurley \u0111\u00e3 c\u00f3 th\u1ec3 ch\u1ec9 ra r\u1eb1ng th\u1eddi gian c\u1ee7a qu\u00e1 tr\u00ecnh mi\u1ec5n d\u1ecbch quan tr\u1ecdng \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t b\u1edfi nh\u1eefng thay \u0111\u1ed5i trong s\u1ea3n xu\u1ea5t n\u0103ng l\u01b0\u1ee3ng do s\u1ef1 ph\u00e2n t\u00e1ch v\u00e0 h\u1ee3p nh\u1ea5t c\u1ee7a ty th\u1ec3.<\/p>\n\n\n\n<p>Gi\u1ea3ng vi\u00ean cao c\u1ea5p Curtis t\u1ea1i RCSI cho bi\u1ebft: D\u1eef li\u1ec7u c\u1ee7a ch\u00fang t\u00f4i ch\u1ec9 ra nhu c\u1ea7u theo d\u00f5i nh\u1ecbp \u0111i\u1ec7u \u1edf m\u1ed9t c\u1ea5p \u0111\u1ed9 ho\u00e0n to\u00e0n m\u1edbi. \u0110i\u1ec1u \u0111\u00f3 c\u0169ng c\u00f3 ngh\u0129a l\u00e0 c\u01a1 th\u1ec3 ch\u00fang ta \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh b\u1edfi \u0111\u1ed3ng h\u1ed3 sinh h\u1ecdc nhi\u1ec1u h\u01a1n ch\u00fang ta t\u01b0\u1edfng. S\u1ef1 t\u00ednh to\u00e1n nh\u1ecbp sinh h\u1ecdc c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch c\u00f3 \u00fd ngh\u0129a \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe con ng\u01b0\u1eddi, \u0111i\u1ec1u tr\u1ecb b\u1ec7nh v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a v\u1eafc-xin.<\/p>\n\n\n\n<p class=\"has-text-align-right\"><em>\u0110.T.V (NASATI), theo https:\/\/medicalxpress.com\/news\/2021-01-immune-killer-cells-circadian-rhythms.htm<\/em><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"https:\/\/www.vista.gov.vn\/news\/khoa-hoc-ky-thuat-va-cong-nghe\/cac-te-bao-lam-hong-he-mien-dich-duoc-kiem-soat-boi-nhip-sinh-hoc-3216.html\">https:\/\/www.vista.gov.vn\/news\/khoa-hoc-ky-thuat-va-cong-nghe\/cac-te-bao-lam-hong-he-mien-dich-duoc-kiem-soat-boi-nhip-sinh-hoc-3216.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ph\u00e2n t\u00edch t\u1eadp d\u1eef li\u1ec7u \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 c\u00e1c t\u1ebf b\u00e0o c\u1ea7n thi\u1ebft cho h\u1ec7 mi\u1ec5n d\u1ecbch c\u1ee7a \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa cho th\u1ea5y kh\u1ea3 n\u0103ng ch\u1ed1ng l\u1ea1i b\u1ec7nh c\u00f3 th\u1ec3 ph\u1ee5 thu\u1ed9c nhi\u1ec1u h\u01a1n v\u00e0o chu k\u1ef3 sinh h\u1ecdc h\u00e0ng ng\u00e0y so v\u1edbi gi\u1ea3 \u0111\u1ecbnh tr\u01b0\u1edbc \u0111\u00e2y. Nh\u1ecbp sinh h\u1ecdc tr\u1ee5c tr\u1eb7c, trong qu\u00e1 [&hellip;]<\/p>\n","protected":false},"author":23,"featured_media":30832,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-30831","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/30831","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=30831"}],"version-history":[{"count":1,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/30831\/revisions"}],"predecessor-version":[{"id":30833,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/30831\/revisions\/30833"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/30832"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=30831"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=30831"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=30831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}