{"id":30418,"date":"2021-11-11T08:59:00","date_gmt":"2021-11-11T01:59:00","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=30418"},"modified":"2021-11-23T09:01:38","modified_gmt":"2021-11-23T02:01:38","slug":"enzym-galnt1-han-che-do-lay-nhiem-cua-cac-bien-chung-sars-cov-2","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/enzym-galnt1-han-che-do-lay-nhiem-cua-cac-bien-chung-sars-cov-2\/","title":{"rendered":"Enzym GALNT1 h\u1ea1n ch\u1ebf \u0111\u1ed9 l\u00e2y nhi\u1ec5m c\u1ee7a c\u00e1c bi\u1ebfn ch\u1ee7ng SARS-CoV-2"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>C\u00e1c nh\u00e0 khoa h\u1ecdc t\u1ea1i Vi\u1ec7n Y t\u1ebf Qu\u1ed1c gia M\u1ef9 (NIH) \u0111\u00e3 t\u00ecm ra m\u1ed9t qu\u00e1 tr\u00ecnh trong t\u1ebf b\u00e0o c\u00f3 th\u1ec3 h\u1ea1n ch\u1ebf kh\u1ea3 n\u0103ng l\u00e2y lan c\u1ee7a SARS-CoV-2.<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/khds.1cdn.vn\/2021\/11\/11\/sars-cov-2-virus-particles-1.jpg\" alt=\"sars-cov-2-virus-particles-1.jpg\"\/><\/figure>\n\n\n\n<p>Nghi\u00ean c\u1ee9u ch\u1ee9ng minh r\u1eb1ng c\u00e1c \u0111\u1ed9t bi\u1ebfn \u1edf ch\u1ee7ng Alpha v\u00e0 Delta \u0111\u00e3 gi\u00fap ch\u00fang v\u01b0\u1ee3t qua \u0111\u01b0\u1ee3c tr\u1edf ng\u1ea1i n\u00e0y v\u00e0 gia t\u0103ng kh\u1ea3 n\u0103ng l\u00e2y lan c\u1ee7a virus.<\/p>\n\n\n\n<p>Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 online tr\u00ean trang Proceedings of the National Academy of Sciences. Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c ch\u1ee7 tr\u00ec b\u1edfi TS Kelly Ten Hagen, m\u1ed9t nh\u00e0 nghi\u00ean c\u1ee9u c\u1ea5p cao t\u1ea1i vi\u1ec7n Nghi\u00ean c\u1ee9u R\u0103ng h\u00e0m m\u1eb7t (NIDCR) tr\u1ef1c thu\u1ed9c NIH.<\/p>\n\n\n\n<p>T\u1eeb khi \u0111\u1ea1i d\u1ecbch COVID-19 b\u1eaft \u0111\u1ea7u v\u00e0o \u0111\u1ea7u n\u0103m 2020, SARS-CoV-2 \u0111\u00e3 bi\u1ebfn th\u1ec3 th\u00e0nh nhi\u1ec1u ch\u1ee7ng d\u1ec5 l\u00e2y nhi\u1ec5m h\u01a1n. \u0110a s\u1ed1 c\u00e1c \u0111\u1ed9t bi\u1ebfn \u0111\u1ec1u \u1ea3nh h\u01b0\u1edfng t\u1edbi protein gai.<\/p>\n\n\n\n<p>B\u1ec1 m\u1eb7t b\u00ean ngo\u00e0i c\u1ee7a SARS-CoV-2 \u0111\u01b0\u1ee3c bao ph\u1ee7 b\u1edfi c\u00e1c protein gai, b\u1ed9 ph\u1eadn n\u00e0y \u0111\u01b0\u1ee3c virus s\u1eed d\u1ee5ng \u0111\u1ec3 d\u00ednh v\u00e0o t\u1ebf b\u00e0o v\u00e0 t\u1eeb \u0111\u00f3 x\u00e2m nh\u1eadp v\u00e0o trong n\u00f3. Tuy nhi\u00ean tr\u01b0\u1edbc khi \u0111i\u1ec1u n\u00e0y x\u1ea3y ra, protein gai ph\u1ea3i \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1edfi m\u1ed9t chu\u1ed7i c\u00e1c h\u00e0nh \u0111\u1ed9ng ph\u00e2n t\u00e1ch b\u1edfi protein ch\u1ee7, b\u1eaft \u0111\u1ea7u v\u1edbi enzym furin. \u1ede ch\u1ee7ng Alpha v\u00e0 Delta, c\u00e1c \u0111\u1ed9t bi\u1ebfn \u1edf protein gai \u0111\u00e3 n\u00e2ng c\u1ea5p kh\u1ea3 n\u0103ng ph\u00e2n t\u00e1ch c\u1ee7a furin, l\u00e0m cho virus x\u00e2m nh\u1eadp t\u1ebf b\u00e0o hi\u1ec7u qu\u1ea3 h\u01a1n.<\/p>\n\n\n\n<p>C\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y \u1edf m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p, s\u1ef1 ph\u00e2n t\u00e1ch protein c\u00f3 th\u1ec3 b\u1ecb gi\u1ea3m khi b\u1ed5 sung c\u00e1c ph\u00e2n t\u1eed \u0111\u01b0\u1eddng \u2013 qu\u00e1 tr\u00ecnh n\u00e0y \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh b\u1edfi c\u00e1c enzym t\u00ean l\u00e0 GALNT.<\/p>\n\n\n\n<p>C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 nghi\u00ean c\u1ee9u \u1ea3nh h\u01b0\u1edfng c\u1ee7a GALNT l\u00ean protein gai \u1edf ru\u1ed3i gi\u1ea5m v\u00e0 t\u1ebf b\u00e0o \u1edf \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa. C\u00e1c th\u00ed nghi\u1ec7m cho th\u1ea5y c\u00f3 1 enzym, GALNT1, b\u1ed5 sung \u0111\u01b0\u1eddng v\u00e0o protein gai lo\u1ea1i nguy\u00ean sinh v\u00e0 l\u00e0m gi\u1ea3m s\u1ef1 ph\u00e2n t\u00e1ch c\u1ee7a furin.<\/p>\n\n\n\n<p>Ng\u01b0\u1ee3c l\u1ea1i, c\u00e1c \u0111\u1ed9t bi\u1ebfn \u1edf protein gai, nh\u01b0 \u1edf bi\u1ebfn ch\u1ee7ng Alpha v\u00e0 Delta l\u1ea1i l\u00e0m gi\u1ea3m ho\u1ea1t t\u00ednh c\u1ee7a GALNT1 v\u00e0 gia t\u0103ng s\u1ef1 ph\u00e2n t\u00e1ch furin. \u0110i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a l\u00e0 ho\u1ea1t t\u00ednh c\u1ee7a GALNT1 c\u00f3 th\u1ec3 k\u00ecm h\u00e3m m\u1ed9t ph\u1ea7n s\u1ef1 ph\u00e2n t\u00e1ch furin \u1edf c\u00e1c virus lo\u1ea1i nguy\u00ean sinh, c\u00f2n c\u00e1c \u0111\u1ed9t bi\u1ebfn \u1edf ch\u1ee7ng Alpha v\u00e0 Delta \u0111\u00e3 kh\u1eafc ph\u1ee5c \u0111\u01b0\u1ee3c hi\u1ec7u \u1ee9ng n\u00e0y, cho ph\u00e9p furin ph\u00e2n c\u1eaft m\u00e0 kh\u00f4ng b\u1ecb ki\u1ec3m so\u00e1t.<\/p>\n\n\n\n<p>Khi quan s\u00e1t xu h\u01b0\u1edbng k\u1ebft h\u1ee3p c\u1ee7a t\u1ebf b\u00e0o v\u1edbi t\u1ebf b\u00e0o l\u00e2n c\u1eadn, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 ph\u00e1t hi\u1ec7n ra c\u00e1c t\u1ebf b\u00e0o v\u1edbi protein gai b\u1ecb \u0111\u1ed9t bi\u1ebfn c\u00f3 xu h\u01b0\u1edbng h\u1ee3p nh\u1ea5t v\u1edbi c\u00e1c t\u1ebf b\u00e0o \u201ch\u00e0ng x\u00f3m\u201d nhi\u1ec1u h\u01a1n t\u1ebf b\u00e0o v\u1edbi gai nguy\u00ean sinh. C\u00e1c t\u1ebf b\u00e0o v\u1edbi gai nguy\u00ean sinh k\u1ebft h\u1ee3p k\u00e9m h\u01a1n khi c\u00f3 m\u1eb7t GALNT1, cho th\u1ea5y ho\u1ea1t t\u00ednh c\u1ee7a ch\u1ea5t n\u00e0y \u0111\u00e3 l\u00e0m suy gi\u1ea3m ch\u1ee9c n\u0103ng protein gai.<\/p>\n\n\n\n<p>\u0110\u1ec3 ki\u1ec3m ch\u1ee9ng xem qu\u00e1 tr\u00ecnh n\u00e0y c\u00f3 x\u1ea3y ra \u1edf ng\u01b0\u1eddi kh\u00f4ng, nh\u00f3m \u0111\u00e3 ph\u00e2n t\u00edch bi\u1ec3u hi\u1ec7n RNA \u1edf t\u1ebf b\u00e0o c\u1ee7a c\u00e1c t\u00ecnh nguy\u1ec7n vi\u00ean kh\u1ecfe m\u1ea1nh. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 t\u00ecm th\u1ea5y GALNT1 bi\u1ec3u hi\u1ec7n r\u1ed9ng r\u00e3i t\u1ea1i c\u00e1c t\u1ebf b\u00e0o \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p tr\u00ean v\u00e0 d\u01b0\u1edbi, c\u00e1c v\u1ecb tr\u00ed r\u1ea5t nh\u1ea1y c\u1ea3m v\u1edbi SARS-CoV-2, ch\u1ee9ng t\u1ecf enzym n\u00e0y c\u00f3 \u1ea3nh h\u01b0\u1edfng t\u1edbi s\u1ef1 l\u00e2y nhi\u1ec5m \u1edf con ng\u01b0\u1eddi.<\/p>\n\n\n\n<p>\u201cNghi\u00ean c\u1ee9u n\u00e0y \u0111\u1ec1 xu\u1ea5t r\u1eb1ng ho\u1ea1t t\u00ednh GALNT1 c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh kh\u1ea3 n\u0103ng l\u00e2y nhi\u1ec5m virus v\u00e0 cho ta \u0111\u1ecbnh h\u01b0\u1edbng v\u1ec1 c\u00e1ch bi\u1ebfn ch\u1ee7ng Alpha v\u00e0 Delta s\u1ebd th\u00edch nghi th\u1ebf n\u00e0o\u201d, TS Hagen n\u00f3i. Nh\u1eefng hi\u1ec3u bi\u1ebft n\u00e0y c\u00f3 th\u1ec3 cung c\u1ea5p th\u00f4ng tin \u0111\u1ec3 ph\u00e1t tri\u1ec3n c\u00e1c n\u1ed7 l\u1ef1c can thi\u1ec7p m\u1edbi trong t\u01b0\u01a1ng lai.<\/p>\n\n\n\n<p class=\"has-text-align-right\"><strong>B\u1ea2O NINH<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"https:\/\/khoahocdoisong.vn\/enzym-galnt1-han-che-do-lay-nhiem-cua-cac-bien-chung-sars-cov-2-183600.html\">https:\/\/khoahocdoisong.vn\/enzym-galnt1-han-che-do-lay-nhiem-cua-cac-bien-chung-sars-cov-2-183600.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>C\u00e1c nh\u00e0 khoa h\u1ecdc t\u1ea1i Vi\u1ec7n Y t\u1ebf Qu\u1ed1c gia M\u1ef9 (NIH) \u0111\u00e3 t\u00ecm ra m\u1ed9t qu\u00e1 tr\u00ecnh trong t\u1ebf b\u00e0o c\u00f3 th\u1ec3 h\u1ea1n ch\u1ebf kh\u1ea3 n\u0103ng l\u00e2y lan c\u1ee7a SARS-CoV-2. Nghi\u00ean c\u1ee9u ch\u1ee9ng minh r\u1eb1ng c\u00e1c \u0111\u1ed9t bi\u1ebfn \u1edf ch\u1ee7ng Alpha v\u00e0 Delta \u0111\u00e3 gi\u00fap ch\u00fang v\u01b0\u1ee3t qua \u0111\u01b0\u1ee3c tr\u1edf ng\u1ea1i n\u00e0y v\u00e0 gia [&hellip;]<\/p>\n","protected":false},"author":23,"featured_media":30419,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-30418","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/30418","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=30418"}],"version-history":[{"count":1,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/30418\/revisions"}],"predecessor-version":[{"id":30420,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/30418\/revisions\/30420"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/30419"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=30418"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=30418"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=30418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}