{"id":29588,"date":"2020-08-01T09:28:00","date_gmt":"2020-08-01T02:28:00","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=29588"},"modified":"2021-11-07T18:23:59","modified_gmt":"2021-11-07T11:23:59","slug":"tim-thay-peptide-cong-sinh-khang-nam-o-cay-ho-dau","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/tim-thay-peptide-cong-sinh-khang-nam-o-cay-ho-dau\/","title":{"rendered":"T\u00ecm th\u1ea5y peptide c\u1ed9ng sinh kh\u00e1ng n\u1ea5m \u1edf c\u00e2y h\u1ecd \u0111\u1eadu"},"content":{"rendered":"\n<p>N\u1ea5m b\u1ec7nh l\u00e0 m\u1ed9t trong nh\u1eefng t\u00e1c nh\u00e2n g\u00e2y thi\u1ec7t h\u1ea1i \u0111\u00e1ng k\u1ec3 \u0111\u1ed1i v\u1edbi s\u1ea3n xu\u1ea5t n\u00f4ng nghi\u1ec7p h\u00e0ng n\u0103m. Trong \u0111\u00f3, n\u1ea5m&nbsp;<em>Botrytis cinerea<\/em>&nbsp;g\u00e2y b\u1ec7nh m\u1ed1c x\u00e1m l\u00e0 n\u1ed7i lo c\u1ee7a nhi\u1ec1u n\u00f4ng d\u00e2n tr\u1ed3ng d\u00e2u t\u00e2y, nho, c\u00e0 chua&#8230; H\u1ecd th\u01b0\u1eddng s\u1eed d\u1ee5ng thu\u1ed1c h\u00f3a h\u1ecdc \u0111\u1ec3 di\u1ec7t n\u1ea5m, tuy nhi\u00ean hi\u1ec7u qu\u1ea3 gi\u1ea3m d\u1ea7n qua th\u1eddi gian.<\/p>\n\n\n\n<p>M\u1edbi \u0111\u00e2y, c\u00e1c nh\u00e0 khoa h\u1ecdc c\u1ee7a Trung t\u00e2m Danforth (M\u1ef9) g\u1ed3m TS Dilip Shah, Siva Velivelli v\u00e0 Kirk Czymmek c\u00f9ng c\u00e1c c\u1ed9ng t\u00e1c vi\u00ean c\u1ee7a h\u1ecd t\u1ea1i Ph\u00f2ng th\u00ed nghi\u1ec7m qu\u1ed1c gia T\u00e2y B\u1eafc Th\u00e1i B\u00ecnh D\u01b0\u01a1ng \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c m\u1ed9t ph\u00e2n nh\u00f3m peptide trong c\u00e1c n\u1ed1t s\u1ea7n c\u1ee7a c\u00e2y h\u1ecd \u0111\u1eadu&nbsp;<em>Medicago truncatula<\/em>&nbsp;c\u00f3 hi\u1ec7u qu\u1ea3 trong vi\u1ec7c \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a n\u1ea5m g\u00e2y ra b\u1ec7nh n\u1ea5m m\u1ed1c x\u00e1m. K\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean T\u1ea1p ch\u00ed Proceedings of the National Academy of Science cho th\u1ea5y, peptide c\u1ed9ng sinh Antifungal NCR044 c\u00f3 c\u1ea5u tr\u00fac \u0111\u1ed9c \u0111\u00e1o v\u00e0 c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng nhi\u1ec1u m\u1eb7t gi\u00fap b\u1ea3o v\u1ec7 th\u1ef1c v\u1eadt.<\/p>\n\n\n\n<p>Theo TS Dilip Shah, kh\u1ea3 n\u0103ng ph\u00e1t tri\u1ec3n lo\u1ea1i peptide n\u00e0y nh\u01b0 m\u1ed9t lo\u1ea1i thu\u1ed1c di\u1ec7t n\u1ea5m, s\u1ebd cung c\u1ea5p cho n\u00f4ng d\u00e2n m\u1ed9t gi\u1ea3i ph\u00e1p qu\u1ea3n l\u00fd c\u00e1c n\u1ea5m b\u1ec7nh tr\u01b0\u1edbc v\u00e0 sau thu ho\u1ea1ch, th\u00e2n thi\u1ec7n v\u1edbi m\u00f4i tr\u01b0\u1eddng thay th\u1ebf c\u00e1c thu\u1ed1c h\u00f3a h\u1ecdc tr\u1eeb n\u1ea5m. Khi \u00e1p d\u1ee5ng cho c\u00e2y tr\u1ed3ng, c\u00e1c peptide cu\u1ed1i c\u00f9ng s\u1ebd ph\u00e2n h\u1ee7y th\u00e0nh c\u00e1c axit amin trong \u0111\u1ea5t v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng b\u1edfi c\u00e1c vi khu\u1ea9n c\u00f3 l\u1ee3i nh\u01b0 m\u1ed9t ngu\u1ed3n n\u0103ng l\u01b0\u1ee3ng.<\/p>\n\n\n\n<p><em>Medicago truncatula<\/em>&nbsp;l\u00e0 h\u1ecd h\u00e0ng c\u1ee7a c\u1ecf linh l\u0103ng. Shah v\u00e0 nh\u00f3m c\u1ee7a \u00f4ng \u0111\u00e3 t\u1ed5ng h\u1ee3p m\u1ed9t l\u01b0\u1ee3ng l\u1edbn peptide NCR044 t\u00edch \u0111i\u1ec7n cao chi\u1ebft xu\u1ea5t t\u1eeb c\u00e1c n\u1ed1t s\u1ea7n c\u1ee7a c\u00e2y h\u1ecd \u0111\u1eadu n\u00e0y. Sau \u0111\u00f3, h\u1ecd s\u1eed d\u1ee5ng peptide \u1edf n\u1ed3ng \u0111\u1ed9 th\u1ea5p x\u1eed l\u00fd c\u00e2y thu\u1ed1c l\u00e1 v\u00e0 c\u00e0 chua trong ph\u00f2ng th\u00ed nghi\u1ec7m v\u00e0 ch\u1ee7ng c\u00e2y tr\u1ed3ng v\u1edbi n\u1ea5m m\u1ed1c x\u00e1m. C\u00e1c c\u00e2y th\u00ed nghi\u1ec7m cho th\u1ea5y hi\u1ec7u qu\u1ea3 ph\u00f2ng tr\u1eeb \u0111\u00e1ng k\u1ec3 \u0111\u1ed1i v\u1edbi b\u1ec7nh n\u1ea5m n\u00e0y.<br>\u0110\u1ec3 hi\u1ec3u c\u01a1 ch\u1ebf kh\u00e1ng khu\u1ea9n trong t\u1ebf b\u00e0o, c\u00e1c nh\u00e0 khoa h\u1ecdc c\u1ee7a Ph\u00f2ng th\u00ed nghi\u1ec7m qu\u1ed1c gia T\u00e2y B\u1eafc Th\u00e1i B\u00ecnh D\u01b0\u01a1ng \u0111\u00e3 h\u1ee3p t\u00e1c v\u1edbi TS Czymmek (m\u1ed9t nh\u00e0 n\u1ea5m h\u1ecdc c\u00f3 nhi\u1ec1u kinh nghi\u1ec7m trong l\u0129nh v\u1ef1c n\u00e0y). Nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 quan s\u00e1t \u0111\u01b0\u1ee3c c\u00e1ch peptide li\u00ean k\u1ebft v\u1edbi b\u00e0o t\u1eed v\u00e0 ch\u1ed3i m\u1ea7m c\u1ee7a n\u1ea5m, c\u00e1ch n\u00f3 \u0111\u01b0\u1ee3c n\u1ed9i h\u00f3a v\u00e0 n\u01a1i n\u00f3 x\u00e2m nh\u1eadp v\u00e0o b\u00ean trong t\u1ebf b\u00e0o n\u1ea5m. M\u1ed9t ph\u00e1t hi\u1ec7n quan tr\u1ecdng \u1edf \u0111\u00e2y l\u00e0 peptide t\u1eadp trung trong nucleolus, n\u01a1i di\u1ec5n ra qu\u00e1 tr\u00ecnh l\u1eafp r\u00e1p ribosome.<\/p>\n\n\n\n<p>Nh\u00f3m c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u1eb7c bi\u1ec7t c\u00f3 chuy\u00ean m\u00f4n v\u1ec1 sinh h\u1ecdc t\u1ebf b\u00e0o n\u1ea5m v\u00e0 th\u1ef1c v\u1eadt k\u1ebft h\u1ee3p v\u1edbi kh\u1ea3 n\u0103ng h\u00ecnh \u1ea3nh ti\u00ean ti\u1ebfn cho ph\u00e9p h\u1ecd \u0111\u01b0a ra nh\u1eefng gi\u1ea3i th\u00edch quan tr\u1ecdng v\u00e0 x\u00e1c nh\u1eadn gi\u1ea3 thuy\u1ebft c\u1ee7a h\u1ecd. C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 gi\u1ea3i quy\u1ebft c\u1ea5u tr\u00fac ba chi\u1ec1u \u0111\u1ea7u ti\u00ean c\u1ee7a m\u1ed9t peptide \u0111\u1eb7c hi\u1ec7u cho th\u1ea5y c\u1ea5u tr\u00fac peptide b\u1ecb x\u00e1o tr\u1ed9n v\u00e0 thay \u0111\u1ed5i linh ho\u1ea1t, d\u1ea1ng anti-parallel \u03b2-sheet ng\u1eafn, \u03b1-helix nh\u1ecf, v\u00e0 khi b\u1ecb oxy h\u00f3a th\u00ec \u1edf d\u1ea1ng hai li\u00ean k\u1ebft disulfide \u1ed5n \u0111\u1ecbnh.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/vjst.vn\/Images\/editor\/images\/2020\/Thang%207\/Thuong-Tim%20thay%20cong%20sinh%20khang%20nam.jpg\" alt=\"\"\/><figcaption><em>M\u1ed9t ch\u1ea5t peptide ch\u1ed1ng n\u1ea5m (c\u1ea5u tr\u00fac ba chi\u1ec1u \u0111\u01b0\u1ee3c hi\u1ec3n th\u1ecb \u1edf g\u00f3c tr\u00ean b\u00ean ph\u1ea3i), khi nhu\u1ed9m \u0111\u1ecf, chi\u1ebfu hu\u1ef3nh quang v\u00e0 hi\u1ec3n th\u1ecb b\u1eb1ng k\u00ednh hi\u1ec3n vi \u0111\u1ed3ng ti\u00eau, tr\u1edf n\u00ean ph\u00e2n t\u00e1n trong t\u1ebf b\u00e0o ch\u1ea5t v\u00e0 t\u00edch t\u1ee5 trong nh\u00e2n c\u1ee7a m\u1ea7m b\u1ec7nh n\u1ea5m Botrytis cinerea. Canxi tr\u1eafng (l\u1ee5c lam) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 nhu\u1ed9m th\u00e0nh t\u1ebf b\u00e0o v\u00e0 v\u00e1ch ng\u0103n c\u1ee7a t\u1ebf b\u00e0o n\u1ea5m. C\u00e2y c\u00e0 chua phun b\u00e0o t\u1eed n\u1ea5m cho th\u1ea5y c\u00e1c khu v\u1ef1c gi\u1ea3m quang h\u1ee3p (m\u00e0u \u0111\u1ecf nh\u1ea1t) do m\u1ea7m b\u1ec7nh g\u00e2y h\u1ea1i (ph\u00eda d\u01b0\u1edbi b\u00ean tr\u00e1i). C\u00e2y \u0111\u01b0\u1ee3c phun peptide kh\u00e1ng n\u1ea5m NCR044 \u0111\u01b0\u1ee3c b\u1ea3o v\u1ec7 kh\u1ecfi t\u00e1c h\u1ea1i c\u1ee7a n\u1ea5m (ph\u00eda d\u01b0\u1edbi b\u00ean ph\u1ea3i)<\/em><\/figcaption><\/figure><\/div>\n\n\n\n<p><\/p>\n\n\n\n<p><em>Ngu\u1ed3n: L\u00ea Thanh (IASVN)- https:\/\/vjst.vn\/vn\/tin-tuc\/3542\/tim-thay-peptide-cong-sinh-khang-nam-o-cay-ho-dau.aspx<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>N\u1ea5m b\u1ec7nh l\u00e0 m\u1ed9t trong nh\u1eefng t\u00e1c nh\u00e2n g\u00e2y thi\u1ec7t h\u1ea1i \u0111\u00e1ng k\u1ec3 \u0111\u1ed1i v\u1edbi s\u1ea3n xu\u1ea5t n\u00f4ng nghi\u1ec7p h\u00e0ng n\u0103m. Trong \u0111\u00f3, n\u1ea5m&nbsp;Botrytis cinerea&nbsp;g\u00e2y b\u1ec7nh m\u1ed1c x\u00e1m l\u00e0 n\u1ed7i lo c\u1ee7a nhi\u1ec1u n\u00f4ng d\u00e2n tr\u1ed3ng d\u00e2u t\u00e2y, nho, c\u00e0 chua&#8230; H\u1ecd th\u01b0\u1eddng s\u1eed d\u1ee5ng thu\u1ed1c h\u00f3a h\u1ecdc \u0111\u1ec3 di\u1ec7t n\u1ea5m, tuy nhi\u00ean hi\u1ec7u qu\u1ea3 [&hellip;]<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-29588","post","type-post","status-publish","format-standard","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/29588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=29588"}],"version-history":[{"count":1,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/29588\/revisions"}],"predecessor-version":[{"id":29589,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/29588\/revisions\/29589"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=29588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=29588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=29588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}