{"id":29448,"date":"2021-10-28T14:45:00","date_gmt":"2021-10-28T07:45:00","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=29448"},"modified":"2022-02-15T09:35:45","modified_gmt":"2022-02-15T02:35:45","slug":"phuong-phap-dieu-tri-ung-thu-moi-tiem-vi-khuan-chet-vao-khoi-u-de-giet-te-bao-ung-thu","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/phuong-phap-dieu-tri-ung-thu-moi-tiem-vi-khuan-chet-vao-khoi-u-de-giet-te-bao-ung-thu\/","title":{"rendered":"Ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0 m\u1edbi: ti\u00eam vi khu\u1ea9n ch\u1ebft v\u00e0o kh\u1ed1i u \u0111\u1ec3 gi\u1ebft t\u1ebf b\u00e0o ung th\u01b0"},"content":{"rendered":"\n
\"Ph\u01b0\u01a1ng<\/figure>\n\n\n\n

C\u00e1c nh\u00e0 khoa h\u1ecdc<\/a> \u0111\u00e3 “kh\u00e1m ph\u00e1 l\u1ea1i” m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0<\/a> \u0111\u00e3 t\u1eebng xu\u1ea5t hi\u1ec7n h\u00e0ng th\u1ebf k\u1ef7 tr\u01b0\u1edbc \u0111\u00e2y, \u0111\u00f3 l\u00e0 ti\u00eam vi khu\u1ea9n<\/a> \u0111\u00e3 ch\u1ebft v\u00e0o c\u00e1c kh\u1ed1i u<\/a> \u0111\u1ec3 gi\u00fap h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch x\u00e1c \u0111\u1ecbnh m\u1ee5c ti\u00eau v\u00e0 ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0o<\/a>ung th\u01b0<\/a> \u0111\u00f3. C\u00e1c x\u00e9t nghi\u1ec7m ti\u1ec1n l\u00e2m s\u00e0ng v\u00e0 th\u1eed nghi\u1ec7m ban \u0111\u1ea7u tr\u00ean ng\u01b0\u1eddi cho th\u1ea5y ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0y r\u1ea5t ti\u1ec1m n\u0103ng, an to\u00e0n v\u00e0 c\u00f3 hi\u1ec7u qu\u1ea3 t\u1ed1t.<\/p>\n\n\n\n

\"dr-william-coley.png\"<\/p>\n\n\n\n

V\u00e0o cu\u1ed1i th\u1ebf k\u1ef7 19, m\u1ed9t nh\u00e0 khoa h\u1ecdc t\u00ean l\u00e0 William Coley \u0111\u00e3 nghi ng\u1edd m\u1ed1i quan h\u1ec7 b\u1ea5t th\u01b0\u1eddng gi\u1eefa s\u1ef1 nhi\u1ec5m khu\u1ea9n v\u00e0 s\u1ef1 thuy\u00ean gi\u1ea3m b\u1ec7nh ung th\u01b0. Coley b\u1eaft \u0111\u1ea7u th\u1eed nghi\u1ec7m c\u00e1c c\u00f4ng th\u1ee9c vi khu\u1ea9n kh\u00e1c nhau \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0. Nh\u1eefng c\u00f4ng th\u1ee9c n\u00e0y \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn v\u1edbi c\u00e1i t\u00ean “Coley\u2019s toxins” v\u00e0 m\u1ed9t c\u00e1ch t\u00ecnh c\u1edd, \u00f4ng tr\u1edf th\u00e0nh ng\u01b0\u1eddi ti\u00ean phong trong li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb mi\u1ec5n d\u1ecbch ung th\u01b0.<\/p>\n\n\n\n

Trong ph\u1ea7n l\u1edbn th\u1eddi gian c\u1ee7a th\u1ebf k\u1ef7 20, nghi\u00ean c\u1ee9u c\u1ee7a Coley \u0111\u00e3 \u0111\u01b0\u1ee3c chuy\u1ec3n th\u00e0nh m\u1ed9t ch\u00fa th\u00edch trong l\u1ecbch s\u1eed khoa h\u1ecdc. C\u00e1c th\u00ed nghi\u1ec7m c\u1ee7a \u00f4ng c\u00f3 ph\u1ea7n th\u1ea5t th\u01b0\u1eddng v\u00e0 thi\u1ebfu ti\u00eau chu\u1ea9n, v\u00ec v\u1eady r\u1ea5t \u00edt nh\u00e0 nghi\u00ean c\u1ee9u c\u00f3 th\u1ec3 l\u1eb7p l\u1ea1i k\u1ebft qu\u1ea3 c\u1ee7a \u00f4ng.<\/p>\n\n\n\n

\"mycobacterium.jpg\"<\/p>\n\n\n\n

M\u00e3i cho \u0111\u1ebfn g\u1ea7n \u0111\u00e2y, m\u1ed9t h\u01b0\u1edbng nghi\u00ean c\u1ee9u m\u1edbi t\u1eadp trung v\u00e0o nh\u1eefng t\u01b0\u01a1ng t\u00e1c ph\u1ee9c t\u1ea1p gi\u1eefa s\u1ee9c kh\u1ecfe c\u1ee7a con ng\u01b0\u1eddi v\u00e0 vi khu\u1ea9n s\u1ed1ng b\u00ean trong ch\u00fang ta, \u0111\u00e3 d\u1eabn \u0111\u1ebfn vi\u1ec7c m\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ng\u01b0\u1eddi \u00dac t\u00ecm hi\u1ec3u l\u1ea1i c\u00e1c \u00fd t\u01b0\u1edfng c\u1ee7a \u00f4ng Coley. Aude Fahrer, tr\u01b0\u1edfng nh\u00f3m nghi\u00ean c\u1ee9u c\u1ee7a d\u1ef1 \u00e1n, \u0111\u00e3 m\u00f4 t\u1ea3 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0 n\u00e0y l\u00e0 kh\u00e1 \u0111\u01a1n gi\u1ea3n v\u00e0 c\u00f3 chi ph\u00ed th\u1ea5p.<\/p>\n\n\n\n

Fahrer gi\u1ea3i th\u00edch: \u201cN\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c ti\u00eam m\u1ed9t dung d\u1ecbch gi\u1ea3i ph\u00f3ng ch\u1eadm vi khu\u1ea9n Mycobacteria \u0111\u00e3 ch\u1ebft tr\u1ef1c ti\u1ebfp v\u00e0o kh\u1ed1i ung th\u01b0. \u00dd t\u01b0\u1edfng l\u00e0 vi\u1ec7c n\u00e0y s\u1ebd \u0111\u01b0a c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch v\u00e0o kh\u1ed1i u \u0111\u1ec3 t\u1ea5n c\u00f4ng c\u00e1c vi khu\u1ea9n, m\u1eb7c d\u00f9 ch\u00fang \u0111\u00e3 ch\u1ebft, v\u00e0 do m\u1ed9t t\u00e1c d\u1ee5ng ph\u1ee5 khi\u1ebfn c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch \u0111\u1ed3ng th\u1eddi c\u0169ng t\u1ea5n c\u00f4ng c\u00e1c t\u1ebf b\u00e0o ung th\u01b0. M\u1ed9t khi c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch \u0111\u01b0\u1ee3c nh\u00e2n l\u00ean, ch\u00fang c\u00f3 th\u1ec3 \u0111i kh\u1eafp n\u01a1i trong c\u01a1 th\u1ec3, v\u00ec v\u1eady n\u00f3 s\u1ebd kh\u00f4ng ch\u1ec9 t\u1ea5n c\u00f4ng t\u1ebf b\u00e0o ung th\u01b0 t\u1ea1i v\u1ecb tr\u00ed ti\u00eam, m\u00e0 c\u00f2n l\u00e0 b\u1ea5t k\u1ef3 ch\u1ed7 di c\u0103n n\u00e0o, n\u01a1i ung th\u01b0 \u0111\u00e3 di c\u0103n sang ph\u1ea7n kh\u00e1c c\u1ee7a c\u01a1 th\u1ec3.”<\/p>\n\n\n\n

\"Freunds-Adjuvant.jpg\"<\/p>\n\n\n\n

Ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0y bao g\u1ed3m ba th\u00e0nh ph\u1ea7n: M\u1ed9t l\u00e0 d\u1ea7u kho\u00e1ng, th\u1ee9 hai l\u00e0 m\u1ed9t ch\u1ea5t ho\u1ea1t \u0111\u1ed9ng b\u1ec1 m\u1eb7t t\u1ea1o n\u00ean ch\u1ea5t b\u1ed5 tr\u1ee3 \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 “Montanide ISA-51”. Ch\u1ea5t b\u1ed5 tr\u1ee3 n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p s\u1eed d\u1ee5ng \u1edf ng\u01b0\u1eddi v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong m\u1ed9t s\u1ed1 lo\u1ea1i v\u1eafc-xin \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch. Th\u00e0nh ph\u1ea7n th\u1ee9 ba ch\u1ec9 \u0111\u01a1n gi\u1ea3n l\u00e0 vi khu\u1ea9n Mycobacteria b\u1ecb gi\u1ebft ch\u1ebft b\u1eb1ng nhi\u1ec7t.<\/p>\n\n\n\n

C\u00f4ng th\u1ee9c t\u1ed5ng th\u1ec3 n\u00e0y \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 “Complete Freund\u2019s Adjuvant” (CFA), v\u00e0 n\u00f3 kh\u00f4ng ph\u1ea3i l\u00e0 m\u1edbi. Tr\u00ean th\u1ef1c t\u1ebf, c\u00f4ng th\u1ee9c n\u00e0y ban \u0111\u1ea7u \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n v\u00e0o nh\u1eefng n\u0103m 1950 b\u1edfi m\u1ed9t nh\u00e0 nghi\u00ean c\u1ee9u t\u00ean l\u00e0 Jules T. Freund. Tuy nhi\u00ean, trong khi c\u00e1c th\u00e0nh ph\u1ea7n ri\u00eang l\u1ebb c\u1ee7a n\u00f3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p d\u00f9ng cho ng\u01b0\u1eddi b\u1ec7nh, CFA v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t cho b\u1ea5t k\u1ef3 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb l\u00e2m s\u00e0ng n\u00e0o.<\/p>\n\n\n\n

\"Complete-Freunds-Adjuvant.jpg\"<\/p>\n\n\n\n

Nghi\u00ean c\u1ee9u m\u1edbi n\u00e0y \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean Journal for Immunotherapy of Cancer, b\u00e1o c\u00e1o t\u00e1c \u0111\u1ed9ng c\u1ee7a CFA tr\u00ean m\u1ed9t s\u1ed1 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ti\u1ec1n l\u00e2m s\u00e0ng v\u00e0 m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng nh\u1ecf b\u1ec7nh nh\u00e2n. Ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m bao g\u1ed3m vi\u1ec7c ti\u00eam tr\u1ef1c ti\u1ebfp m\u1ed9t lo\u1ea1i nh\u0169 t\u01b0\u01a1ng gi\u1ea3i ph\u00f3ng ch\u1eadm c\u1ee7a CFA v\u00e0o kh\u1ed1i u.<\/p>\n\n\n\n

C\u00e1c th\u00ed nghi\u1ec7m ti\u1ec1n l\u00e2m s\u00e0ng cho th\u1ea5y CFA an to\u00e0n tr\u00ean m\u1ed9t s\u1ed1 v\u1eadt m\u1eabu bao g\u1ed3m chu\u1ed9t, ch\u00f3 v\u00e0 ng\u1ef1a. C\u00e1c ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch to\u00e0n th\u00e2n nh\u1eafm v\u00e0o c\u00e1c t\u1ebf b\u00e0o trong kh\u1ed1i u \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong t\u1ea5t c\u1ea3 c\u00e1c x\u00e9t nghi\u1ec7m ti\u1ec1n l\u00e2m s\u00e0ng.<\/p>\n\n\n\n

Nghi\u00ean c\u1ee9u c\u0169ng b\u00e1o c\u00e1o d\u1eef li\u1ec7u ban \u0111\u1ea7u t\u1eeb th\u1eed nghi\u1ec7m tr\u00ean ng\u01b0\u1eddi (giai \u0111o\u1ea1n 1) \u0111ang di\u1ec5n ra \u0111\u1ec3 ki\u1ec3m tra c\u00f4ng th\u1ee9c CFA. K\u1ebft qu\u1ea3 s\u01a1 b\u1ed9 cho th\u1ea5y ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0y l\u00e0 an to\u00e0n \u1edf ng\u01b0\u1eddi. Tuy nhi\u00ean, d\u1eef li\u1ec7u v\u1ec1 hi\u1ec7u qu\u1ea3 t\u1ea1i th\u1eddi \u0111i\u1ec3m n\u00e0y v\u1eabn ch\u01b0a r\u00f5 r\u00e0ng. \u0110i\u1ec1u n\u00e0y ch\u1ee7 y\u1ebfu l\u00e0 do c\u00e1c th\u1eed nghi\u1ec7m n\u00e0y \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n ung th\u01b0 giai \u0111o\u1ea1n r\u1ea5t mu\u1ed9n.<\/p>\n\n\n\n

\"ANU_1.jpg\"<\/p>\n\n\n\n

Fahrer n\u00f3i: \u201cCh\u00fang t\u00f4i \u0111\u00e3 \u0111i\u1ec1u tr\u1ecb 8 b\u1ec7nh nh\u00e2n ung th\u01b0 nh\u01b0 m\u1ed9t ph\u1ea7n c\u1ee7a th\u1eed nghi\u1ec7m n\u00e0y. H\u1ecd \u0111\u1ec1u l\u00e0 b\u1ec7nh nh\u00e2n ung th\u01b0 giai \u0111o\u1ea1n cu\u1ed1i, nh\u01b0ng trong m\u1ed9t tr\u01b0\u1eddng h\u1ee3p c\u1ee5 th\u1ec3, ch\u00fang t\u00f4i c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a b\u1ec7nh nh\u00e2n. Vi\u1ec7c \u0111i\u1ec1u tr\u1ecb l\u00e0m gi\u1ea3m l\u01b0\u1ee3ng ch\u1ea5t l\u1ecfng xung quanh ph\u1ed5i c\u1ee7a h\u1ecd v\u00e0 c\u00f3 th\u1ec3 thu nh\u1ecf m\u1ed9t trong nh\u1eefng kh\u1ed1i u ung th\u01b0 c\u1ee7a h\u1ecd.”<\/p>\n\n\n\n

C\u1ea7n ph\u1ea3i nghi\u00ean c\u1ee9u s\u00e2u h\u01a1n n\u1eefa tr\u01b0\u1edbc khi ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0 n\u00e0y \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p \u0111i\u1ec1u tr\u1ecb r\u1ed9ng r\u00e3i. Nh\u01b0ng c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u cho bi\u1ebft nh\u1eefng d\u1ea5u hi\u1ec7u ban \u0111\u1ea7u n\u00e0y l\u00e0 \u0111\u1ea7y h\u1ee9a h\u1eb9n, c\u1ed9ng v\u1edbi vi\u1ec7c li\u1ec7u ph\u00e1p n\u00e0y c\u00f3 chi ph\u00ed th\u1ea5p v\u00e0 d\u1ec5 th\u1ef1c hi\u1ec7n h\u01a1n so v\u1edbi nh\u1eefng li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb mi\u1ec5n d\u1ecbch hi\u1ec7n t\u1ea1i.<\/p>\n\n\n\n

\"ANU.jpg\"<\/p>\n\n\n\n

Fahrer cho bi\u1ebft th\u00eam: \u201cNh\u1eefng \u0111i\u1ec1u t\u1ed1t nh\u1ea5t v\u1ec1 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi n\u00e0y l\u00e0 n\u00f3 c\u1ea7n \u00edt li\u1ec1u l\u01b0\u1ee3ng, d\u1ec5 s\u1eed d\u1ee5ng v\u00e0 \u00edt t\u00e1c d\u1ee5ng ph\u1ee5. Ch\u00fang t\u00f4i \u0111ang xem x\u00e9t kho\u1ea3ng 20 \u0111\u00f4 la cho m\u1ed9t li\u1ec1u, trong khi chi ph\u00ed c\u1ee7a c\u00e1c li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch kh\u00e1c c\u00f3 th\u1ec3 l\u00ean \u0111\u1ebfn 40.000 \u0111\u00f4 la. \u0110i\u1ec1u n\u00e0y gi\u00fap cho b\u1ec7nh nh\u00e2n \u1edf c\u00e1c n\u01b0\u1edbc \u0111ang ph\u00e1t tri\u1ec3n c\u00f3 th\u1ec3 ti\u1ebfp c\u1eadn \u0111\u01b0\u1ee3c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0 d\u1ec5 d\u00e0ng h\u01a1n.”<\/p>\n\n\n\n

Enzo Le <\/strong><\/p>\n\n\n\n

https:\/\/tinhte.vn\/thread\/phuong-phap-dieu-tri-ung-thu-moi-tiem-vi-khuan-chet-vao-khoi-u-de-giet-te-bao-ung-thu.3418392\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 “kh\u00e1m ph\u00e1 l\u1ea1i” m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u00e3 t\u1eebng xu\u1ea5t hi\u1ec7n h\u00e0ng th\u1ebf k\u1ef7 tr\u01b0\u1edbc \u0111\u00e2y, \u0111\u00f3 l\u00e0 ti\u00eam vi khu\u1ea9n \u0111\u00e3 ch\u1ebft v\u00e0o c\u00e1c kh\u1ed1i u \u0111\u1ec3 gi\u00fap h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch x\u00e1c \u0111\u1ecbnh m\u1ee5c ti\u00eau v\u00e0 ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0oung th\u01b0 \u0111\u00f3. C\u00e1c x\u00e9t nghi\u1ec7m ti\u1ec1n l\u00e2m s\u00e0ng v\u00e0 th\u1eed nghi\u1ec7m ban \u0111\u1ea7u tr\u00ean […]<\/p>\n","protected":false},"author":23,"featured_media":29449,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-29448","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/29448","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=29448"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/29448\/revisions"}],"predecessor-version":[{"id":31090,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/29448\/revisions\/31090"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/29449"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=29448"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=29448"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=29448"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}