{"id":29312,"date":"2021-10-20T16:07:00","date_gmt":"2021-10-20T09:07:00","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=29312"},"modified":"2022-02-15T09:48:12","modified_gmt":"2022-02-15T02:48:12","slug":"ung-vien-tiem-nang-dieu-tri-hoi-chung-alzheimer","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/ung-vien-tiem-nang-dieu-tri-hoi-chung-alzheimer\/","title":{"rendered":"\u1ee8ng vi\u00ean ti\u1ec1m n\u0103ng \u0111i\u1ec1u tr\u1ecb h\u1ed9i ch\u1ee9ng Alzheimer"},"content":{"rendered":"\n<p>B\u1ea2O NINH<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Bumetanide, m\u1ed9t lo\u1ea1i thu\u1ed1c l\u1ee3i ti\u1ec3u d\u1ea1ng vi\u00ean u\u1ed1ng c\u00f3 th\u1ec3 l\u00e0 \u1ee9ng c\u1eed vi\u00ean ti\u1ec1m n\u0103ng trong vi\u1ec7c ch\u1eefa tr\u1ecb h\u1ed9i ch\u1ee9ng Alzheimer cho nh\u1eefng ng\u01b0\u1eddi c\u00f3 nguy c\u01a1 m\u1eafc b\u1ec7nh cao do di truy\u1ec1n.<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/khds.1cdn.vn\/2021\/10\/20\/senior-pill-water-glass-777x518.jpg\" alt=\"senior-pill-water-glass-777x518.jpg\"\/><\/figure>\n\n\n\n<p>M\u1ed9t trong c\u00e1c nh\u00e2n t\u1ed1 gene l\u00e0m t\u0103ng kh\u1ea3 n\u0103ng di truy\u1ec1n cho th\u1ebf h\u1ec7 sau c\u1ee7a h\u1ed9i ch\u1ee9ng Alzheimer l\u00e0 m\u1ed9t d\u1ea1ng gene apoplipoprotein E hay c\u00f2n g\u1ecdi l\u00e0 APOE4. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u1ee7a Vi\u1ec7n Gladstone, \u0110\u1ea1i h\u1ecdc California v\u00e0 Tr\u01b0\u1eddng Y h\u1ecdc Icahn t\u1ea1i Mount Sinai, \u0111\u01b0\u1ee3c t\u00e0i tr\u1ee3 b\u1edfi Vi\u1ec7n L\u00e3o h\u00f3a Qu\u1ed1c gia (NIA) \u0111\u00e3 ph\u00e2n t\u00edch d\u1eef li\u1ec7u thu th\u1eadp \u0111\u01b0\u1ee3c t\u1eeb 213 m\u1eabu m\u00f4 n\u00e3o \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh c\u00e1c \u0111\u1eb7c t\u00ednh bi\u1ec3u hi\u1ec7n gene Alzheimer v\u00e0 x\u00e1c \u0111\u1ecbnh m\u1ee9c \u0111\u1ed9 gene n\u00e0o \u0111ang ho\u1ea1t \u0111\u1ed9ng ho\u1eb7c kh\u00f4ng, \u0111\u1eb7c bi\u1ec7t l\u00e0 c\u00e1c gene mang APOE4.<\/p>\n\n\n\n<p>Ti\u1ebfp theo, h\u1ecd \u0111\u00e3 so s\u00e1nh m\u1eabu APOE4 \u0111\u1eb7c tr\u01b0ng c\u1ee7a&nbsp;<a href=\"https:\/\/khoahocdoisong.vn\/benh-Alzheimer-ptag.html\">b\u1ec7nh Alzheimer<\/a>&nbsp;v\u1edbi m\u1eabu \u0111\u00f3 c\u1ee7a h\u01a1n 1300 lo\u1ea1i thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c FDA c\u00f4ng nh\u1eadn. 5 lo\u1ea1i thu\u1ed1c \u0111\u00e3 ti\u1ebfp c\u1eadn \u0111\u01b0\u1ee3c v\u1edbi \u0111\u1eb7c tr\u01b0ng bi\u1ec3u hi\u1ec7n gene m\u00e0 c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u tin l\u00e0 c\u00f3 th\u1ec3 gi\u00fap trung h\u00f2a b\u1ec7nh n\u00e0y. \u1ee8ng c\u1eed vi\u00ean n\u1eb7ng k\u00ed nh\u1ea5t ch\u00ednh l\u00e0 bumetanide, lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u00ed ti\u1ec3u g\u00e2y ra b\u1edfi m\u1ed9t s\u1ed1 b\u1ec7nh li\u00ean quan \u0111\u1ebfn tim, th\u1eadn v\u00e0 gan<\/p>\n\n\n\n<p>C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 th\u1eed bumetanide \u1edf c\u1ea3 m\u1eabu chu\u1ed9t m\u1eafc Alzheimer v\u00e0 t\u1ebf b\u00e0o g\u1ed1c \u0111a n\u0103ng c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb c\u00e1c neuron ng\u01b0\u1eddi. H\u1ecd nh\u1eadn th\u1ea5y nh\u1eefng con chu\u1ed9t c\u00f3 bi\u1ec3u hi\u1ec7n gene APOE4 sau khi \u0111\u01b0\u1ee3c \u0111\u01b0\u1ee3c d\u00f9ng thu\u1ed1c \u0111\u00e3 \u0111\u1ee1 suy gi\u1ea3m v\u1ec1 nh\u1eadn th\u1ee9c v\u00e0 tr\u00ed nh\u1edb. T\u00e1c d\u1ee5ng trung h\u00f2a c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn \u1edf c\u00e1c m\u1eabu t\u1ebf b\u00e0o g\u1ed1c c\u1ee7a con ng\u01b0\u1eddi. \u0110i\u1ec1u n\u00e0y d\u1eabn t\u1edbi gi\u1ea3 thi\u1ebft r\u1eb1ng nh\u1eefng ng\u01b0\u1eddi \u0111\u00e3 s\u1eed d\u1ee5ng bumetanide s\u1ebd ph\u1ea3i c\u00f3 t\u1ec9 l\u1ec7 m\u1eafc Alzheimer th\u1ea5p h\u01a1n.<\/p>\n\n\n\n<p>\u0110\u1ec3 ch\u1ee9ng minh gi\u1ea3 thuy\u1ebft n\u00e0y, nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 chia b\u1ec7nh \u00e1n \u0111i\u1ec7n t\u1eed c\u1ee7a h\u01a1n 5 tri\u1ec7u ng\u01b0\u1eddi th\u00e0nh 2 nh\u00f3m: M\u1ed9t nh\u00f3m g\u1ed3m nh\u1eefng ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh tr\u00ean 65 tu\u1ed5i \u0111\u00e3 s\u1eed d\u1ee5ng bumetanide v\u00e0 m\u1ed9t nh\u00f3m t\u01b0\u01a1ng t\u1ef1 nh\u01b0ng v\u1edbi nh\u1eefng ng\u01b0\u1eddi kh\u00f4ng s\u1eed d\u1ee5ng. Ph\u00e2n t\u00edch cho th\u1ea5y nh\u1eefng ng\u01b0\u1eddi c\u00f3 nguy c\u01a1 m\u1eafc do di truy\u1ec1n v\u00e0 \u0111\u00e3 s\u1eed d\u1ee5ng bumetanide c\u00f3 x\u00e1c su\u1ea5t m\u1eafc h\u1ed9i ch\u1ee9ng Alzheimer th\u1ea5p h\u01a1n 35-75% so v\u1edbi nh\u1eefng ng\u01b0\u1eddi kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y.<\/p>\n\n\n\n<p>\u201cCh\u00fang t\u00f4i bi\u1ebft r\u1eb1ng h\u1ed9i ch\u1ee9ng Alzheimer c\u00f3 th\u1ec3 s\u1ebd \u0111\u00f2i h\u1ecfi nhi\u1ec1u h\u00ecnh th\u1ee9c \u0111i\u1ec1u tr\u1ecb kh\u00e1c nhau. C\u00f3 th\u1ec3 l\u00e0 nhi\u1ec1u li\u1ec7u tr\u00ecnh c\u00f9ng m\u1ed9t l\u00fac, bao g\u1ed3m m\u1ed9t s\u1ed1 c\u00f3 th\u1ec3 nh\u1eafm t\u1edbi \u0111\u1eb7c t\u00ednh di truy\u1ec1n c\u00e1 nh\u00e2n ri\u00eang bi\u1ec7t, t\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0 hi\u1ec7n nay. C\u00e1c k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u n\u00e0y kh\u1eb3ng \u0111\u1ecbnh ta c\u1ea7n ti\u1ebfn h\u00e0nh ki\u1ec3m ch\u1ee9ng th\u1eed nghi\u1ec7m v\u1ec1 bumetanide \u1edf ng\u01b0\u1eddi v\u1edbi nguy c\u01a1 di truy\u1ec1n\u201d, TS.BS Jean Yuan, Gi\u00e1m \u0111\u1ed1c ch\u01b0\u01a1ng tr\u00ecnh Ph\u00e1t tri\u1ec3n thu\u1ed1c v\u00e0 sinh h\u1ecdc ph\u00e2n t\u1eed thu\u1ed9c NIA n\u00f3i.Theo&nbsp;\u0110\u1eddi s\u1ed1ng &#8211; Tri th\u1ee9c cu\u1ed9c s\u1ed1ng<\/p>\n\n\n\n<p class=\"has-text-align-right\"><strong> B\u1ea2O NINH<\/strong> <\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"https:\/\/khoahocdoisong.vn\/ung-vien-tiem-nang-dieu-tri-hoi-chung-alzheimer-182133.html\">https:\/\/khoahocdoisong.vn\/ung-vien-tiem-nang-dieu-tri-hoi-chung-alzheimer-182133.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>B\u1ea2O NINH Bumetanide, m\u1ed9t lo\u1ea1i thu\u1ed1c l\u1ee3i ti\u1ec3u d\u1ea1ng vi\u00ean u\u1ed1ng c\u00f3 th\u1ec3 l\u00e0 \u1ee9ng c\u1eed vi\u00ean ti\u1ec1m n\u0103ng trong vi\u1ec7c ch\u1eefa tr\u1ecb h\u1ed9i ch\u1ee9ng Alzheimer cho nh\u1eefng ng\u01b0\u1eddi c\u00f3 nguy c\u01a1 m\u1eafc b\u1ec7nh cao do di truy\u1ec1n. M\u1ed9t trong c\u00e1c nh\u00e2n t\u1ed1 gene l\u00e0m t\u0103ng kh\u1ea3 n\u0103ng di truy\u1ec1n cho th\u1ebf h\u1ec7 sau c\u1ee7a [&hellip;]<\/p>\n","protected":false},"author":23,"featured_media":29313,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-29312","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/29312","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=29312"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/29312\/revisions"}],"predecessor-version":[{"id":31100,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/29312\/revisions\/31100"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/29313"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=29312"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=29312"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=29312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}