{"id":29029,"date":"2021-09-29T12:57:00","date_gmt":"2021-09-29T05:57:00","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=29029"},"modified":"2022-02-15T10:54:36","modified_gmt":"2022-02-15T03:54:36","slug":"vacxin-hat-nano-co-the-chua-ung-thu-tuyen-tien-liet-di-can","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/vacxin-hat-nano-co-the-chua-ung-thu-tuyen-tien-liet-di-can\/","title":{"rendered":"V\u0103cxin h\u1ea1t nano c\u00f3 th\u1ec3 ch\u1eefa ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t di c\u0103n"},"content":{"rendered":"\n

(khoahocdoisong.vn) – V\u0103cxin \u0111i\u1ec1u tr\u1ecb ho\u1eb7c ng\u0103n ng\u1eeba ung th\u01b0 \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch, nh\u1eb1m k\u00edch ho\u1ea1t h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch c\u1ee7a ch\u00ednh b\u1ec7nh nh\u00e2n ch\u1ed1ng l\u1ea1i c\u00e1c t\u1ebf b\u00e0o ung th\u01b0, ng\u0103n ch\u1eb7n nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 trong qu\u00e1 tr\u00ecnh h\u00f3a tr\u1ecb.<\/strong><\/h2>\n\n\n\n

\u0110\u1eb7c bi\u1ec7t h\u1ee9a h\u1eb9n trong ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t<\/strong><\/p>\n\n\n\n

GS Chad Mirkin, \u0110\u1ea1i h\u1ecdc Northwestern, M\u1ef9 cho bi\u1ebft, v\u0103cxin ung th\u01b0 ho\u1ea1t \u0111\u1ed9ng t\u01b0\u01a1ng t\u1ef1 nh\u01b0 v\u0103cxin ch\u1ed1ng b\u1ec7nh c\u00fam ho\u1eb7c nh\u1eefng b\u1ec7nh truy\u1ec1n nhi\u1ec5m kh\u00e1c l\u00e0 l\u1eadp tr\u00ecnh h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch<\/a> t\u1ef1 nhi\u00ean c\u01a1 th\u1ec3 \u0111\u1ec3 t\u1ea5n c\u00f4ng m\u1ed9t m\u1ee5c ti\u00eau c\u1ee5 th\u1ec3.<\/p>\n\n\n\n

C\u00e1c nh\u00e0 khoa h\u1ecdc cho bi\u1ebft, li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch \u0111\u1eb7c bi\u1ec7t h\u1ee9a h\u1eb9n trong ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t, m\u1ed9t ph\u1ea7n l\u00e0 do m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng l\u1edbn c\u00e1c protein m\u1ee5c ti\u00eau t\u01b0\u01a1ng \u0111\u1ed1i \u00edt \u0111\u1ed9t bi\u1ebfn v\u00e0 kh\u00f4ng c\u00f3 s\u1ef1 hi\u1ec7n di\u1ec7n nh\u1eefng protein m\u1ee5c ti\u00eau n\u00e0y \u1edf c\u00e1c c\u01a1 quan thi\u1ebft y\u1ebfu kh\u00e1c, cho ph\u00e9p gi\u1ea3m c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f4ng mong mu\u1ed1n.<\/p>\n\n\n\n

GS Mirkin v\u00e0 \u0111\u1ed3ng nghi\u1ec7p \u0111\u00e3 s\u1eed d\u1ee5ng v\u0103cxin c\u1ea5u tr\u00fac k\u00edch th\u01b0\u1edbc nano, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 axit nucleic h\u00ecnh c\u1ea7u \u0111\u1ec3 ph\u00e1t tri\u1ec3n m\u1ed9t li\u1ec7u ph\u00e1p t\u1ea5n c\u00f4ng m\u1ee5c ti\u00eau v\u1edbi ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch m\u1ea1nh.<\/p>\n\n\n\n

V\u0103cxin \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n cho nhi\u1ec1u lo\u1ea1i ung th\u01b0 kh\u00e1c nhau, nh\u01b0ng nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p l\u00e2m s\u00e0ng li\u00ean quan \u0111\u1ebfn h\u1ed7n h\u1ee3p mu\u1ed1i \u0111\u01a1n gi\u1ea3n c\u1ee7a c\u00e1c m\u1ee5c ti\u00eau v\u00e0 ch\u1ea5t k\u00edch th\u00edch \u0111\u1ed1i v\u1edbi h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch.<\/p>\n\n\n\n

C\u00e1c h\u1ec7 th\u1ed1ng h\u1ed7n h\u1ee3p \u0111\u01a1n gi\u1ea3n kh\u00f4ng cho ph\u00e9p ki\u1ec3m so\u00e1t vi\u1ec7c h\u1ea5p th\u1ee5 c\u1ee7a t\u1ebf b\u00e0o, ph\u00e2n ph\u1ed1i sinh h\u1ecdc, thanh th\u1ea3i, di chuy\u1ec3n ho\u1eb7c \u0111\u1ed3ng ph\u00e2n ph\u1ed1i c\u00e1c th\u00e0nh ph\u1ea7n v\u00e0o c\u00f9ng m\u1ed9t t\u1ebf b\u00e0o; s\u1ef1 thi\u1ebfu ki\u1ec3m so\u00e1t n\u00e0y l\u00e0 nguy\u00ean nh\u00e2n c\u00e1c lo\u1ea1i v\u0103cxin ung th\u01b0 kh\u00e1c nhau kh\u00f4ng c\u00f3 hi\u1ec7u qu\u1ea3 cao trong trong l\u00e2m s\u00e0ng.<\/p>\n\n\n\n

Ng\u01b0\u1ee3c l\u1ea1i, c\u1ea5u tr\u00fac nano mang l\u1ea1i c\u01a1 h\u1ed9i duy nh\u1ea5t \u0111\u00f3ng g\u00f3i \u0111\u01b0\u1ee3c t\u00e1 d\u01b0\u1ee3c – ch\u1ea5t ph\u1ee5 gia t\u0103ng c\u01b0\u1eddng ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch, kh\u00e1ng nguy\u00ean ho\u1eb7c m\u1ee5c ti\u00eau – v\u00ed d\u1ee5, m\u1ed9t protein t\u00ecm th\u1ea5y tr\u00ean b\u1ec1 m\u1eb7t kh\u1ed1i u h\u1ed7 tr\u1ee3 h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch x\u00e1c \u0111\u1ecbnh v\u00e0 t\u1ea5n c\u00f4ng ung th\u01b0, \u0111\u1ed3ng th\u1eddi c\u0169ng l\u00e0 gi\u1ea3i ph\u00e1p cho ph\u00e9p v\u0103cxin \u0111\u01b0\u1ee3c ph\u00e2n ph\u1ed1i ch\u00ednh x\u00e1c \u0111\u1ebfn nh\u1eefng v\u1ecb tr\u00ed mong mu\u1ed1n trong c\u01a1 th\u1ec3, t\u1ea1o l\u00ean ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch m\u1ea1nh h\u01a1n, hi\u1ec7u qu\u1ea3 h\u01a1n \u1edf b\u1ec7nh nh\u00e2n.<\/p>\n\n\n\n

GS Mirkin cho bi\u1ebft, hi\u1ec7u l\u1ef1c \u0111i\u1ec1u tr\u1ecb c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u0103ng c\u01b0\u1eddng b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p l\u1ea5y c\u00e1c m\u1ee5c ti\u00eau l\u00e2m s\u00e0ng t\u1eeb ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t v\u00e0 \u0111\u00f3ng g\u00f3i l\u1ea1i th\u00e0nh m\u1ed9t lo\u1ea1i v\u0103cxin ung th\u01b0 \u0111\u01b0\u1ee3c t\u1ed1i \u01b0u h\u00f3a c\u00f3 t\u00ednh to\u00e1n \u0111\u1ebfn c\u1ea5u tr\u00fac.<\/p>\n\n\n\n

\ufeffAxit nucleic h\u00ecnh c\u1ea7u<\/strong><\/p>\n\n\n\n

S\u1eed d\u1ee5ng axit nucleic h\u00ecnh c\u1ea7u (SNA), c\u00e1c nh\u00e0 khoa h\u1ecdc kh\u00e1m ph\u00e1 \u0111\u01b0\u1ee3c c\u00e1ch th\u1ee9c ki\u1ec3m so\u00e1t c\u1ea5u tr\u00fac ch\u00ednh x\u00e1c c\u1ee7a c\u00e1c th\u00e0nh ph\u1ea7n v\u0103cxin, c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u1eb7c hi\u1ec7u v\u1edbi kh\u00e1ng nguy\u00ean m\u1ea1nh m\u1ebd so v\u1edbi c\u00e1c c\u00f4ng th\u1ee9c l\u00e2m s\u00e0ng c\u00f3 c\u00f9ng m\u1ee5c ti\u00eau.<\/p>\n\n\n\n

C\u00e1c axit nucleic h\u00ecnh c\u1ea7u (SNA) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong nghi\u00ean c\u1ee9u n\u00e0y bao g\u1ed3m m\u1ed9t l\u00f5i h\u1ea1t nano<\/a> \u0111\u01b0\u1ee3c g\u1eafn v\u1edbi c\u00e1c ph\u00e2n t\u1eed ADN m\u1ea1ch ng\u1eafn t\u1ed5 ch\u1ee9c xuy\u00ean t\u00e2m \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 oligodeoxynucleotide – c\u00f3 t\u00e1c d\u1ee5ng k\u00edch th\u00edch h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch t\u01b0\u01a1ng t\u1ef1 nh\u01b0 ADN c\u1ee7a virus ho\u1eb7c vi khu\u1ea9n.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

C\u1ea5u tr\u00fac h\u1ea1t nano v\u0103cxin \u0111i\u1ec1u tr\u1ecb ung th\u01b0 ti\u1ec1n li\u1ec7t tuy\u1ebfn<\/a>.<\/em><\/p>\n\n\n\n

Nh\u1eefng ph\u00e2n t\u1eed n\u00e0y \u0111\u1eb7c bi\u1ec7t th\u00edch h\u1ee3p \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch do t\u00ednh m\u00f4 \u0111un, kh\u1ea3 n\u0103ng \u0111i\u1ec1u ch\u1ec9nh v\u00e0 t\u1ed5ng h\u1ee3p d\u1ec5 d\u00e0ng, trong th\u00ed nghi\u1ec7m \u0111\u00e3 t\u1ea1o ra ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch m\u1ea1nh m\u1ebd \u1edf chu\u1ed9t.<\/p>\n\n\n\n

SNA \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e0m t\u0103ng s\u1ea3n xu\u1ea5t v\u00e0 b\u00e0i ti\u1ebft c\u00e1c cytokine v\u00e0 t\u0103ng c\u00e1c t\u1ebf b\u00e0o T g\u00e2y \u0111\u1ed9c \u0111a ch\u1ee9c n\u0103ng v\u00e0 b\u1ed9 nh\u1edb hi\u1ec7u \u1ee9ng.<\/p>\n\n\n\n

SNA \u0111\u01b0\u1ee3c t\u1ebf b\u00e0o n\u1ed9i h\u00f3a nhanh h\u01a1n v\u1edbi ph\u1ea1m vi r\u1ed9ng h\u01a1n so v\u1edbi c\u1ea5u tr\u00fac tuy\u1ebfn t\u00ednh, v\u00e0 kh\u00f4ng y\u00eau c\u1ea7u thu\u1ed1c th\u1eed truy\u1ec1n ti\u1ebfp ph\u1ee5 \u0111\u1ed9c h\u1ea1i. B\u1eb1ng gi\u1ea3i ph\u00e1p s\u1ef1 s\u1eafp x\u1ebfp c\u1ee7a ch\u1ea5t k\u00edch th\u00edch mi\u1ec5n d\u1ecbch v\u00e0 kh\u00e1ng nguy\u00ean, c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch \u201cth\u1ea5y \u0111\u01b0\u1ee3c\u201d v\u0103cxin b\u1ecb thay \u0111\u1ed5i, th\u00fac \u0111\u1ea9y ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch m\u1ea1nh h\u01a1n hi\u1ec7n c\u00f3, \u0111\u1ee7 kh\u1ea3 n\u0103ng ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0o kh\u1ed1i u.<\/p>\n\n\n\n

Nh\u1eefng ph\u00e1t hi\u1ec7n n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng cho c\u00e1c b\u1ec7nh ung th\u01b0 v\u00e0 nh\u1eefng lo\u1ea1i b\u1ec7nh kh\u00e1c. Mi\u1ec5n l\u00e0 c\u00f3 proteiin m\u1ee5c ti\u00eau \u0111\u00e3 bi\u1ebft, SNA cung c\u1ea5p kh\u1ea3 n\u0103ng t\u00e1i s\u1eed d\u1ee5ng m\u1ee5c ti\u00eau \u0111\u00f3 v\u00e0 khai th\u00e1c m\u1ee5c ti\u00eau \u0111\u00f3 trong m\u1ed9t ki\u1ebfn tr\u00fac tr\u1ecb li\u1ec7u mi\u1ec5n d\u1ecbch \u0111\u01b0\u1ee3c t\u1ed1i \u01b0u h\u00f3a \u0111\u1ec3 t\u0103ng hi\u1ec7u l\u1ef1c.<\/p>\n\n\n\n

B\u01b0\u1edbc ti\u1ebfp theo l\u00e0 k\u00edch th\u00edch ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch r\u1ed9ng h\u01a1n, nghi\u00ean c\u1ee9u c\u1ea5u tr\u00fac v\u0103cxin SNA mang nhi\u1ec1u m\u1ee5c ti\u00eau cho m\u1ed9t b\u1ec7nh c\u1ee5 th\u1ec3. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y cho ph\u00e9p v\u0103cxin ch\u1ed1ng l\u1ea1i s\u1ef1 kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t trong c\u00e1c b\u1ec7nh ung th\u01b0 c\u1ee7a c\u00e1c b\u1ec7nh nh\u00e2n v\u00e0 cu\u1ed1i c\u00f9ng l\u00e0 x\u00e1c \u0111\u1ecbnh v\u1ecb tr\u00ed ung th\u01b0 \u0111\u1ec3 th\u1ef1c hi\u1ec7n \u0111i\u1ec1u tr\u1ecb.<\/p>\n\n\n\n

TH\u00c1I B\u1eb0NG<\/strong><\/p>\n\n\n\n

https:\/\/khoahocdoisong.vn\/vacxin-hat-nano-co-the-chua-ung-thu-tuyen-tien-liet-di-can-180649.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

(khoahocdoisong.vn) – V\u0103cxin \u0111i\u1ec1u tr\u1ecb ho\u1eb7c ng\u0103n ng\u1eeba ung th\u01b0 \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch, nh\u1eb1m k\u00edch ho\u1ea1t h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch c\u1ee7a ch\u00ednh b\u1ec7nh nh\u00e2n ch\u1ed1ng l\u1ea1i c\u00e1c t\u1ebf b\u00e0o ung th\u01b0, ng\u0103n ch\u1eb7n nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 trong qu\u00e1 tr\u00ecnh h\u00f3a tr\u1ecb. \u0110\u1eb7c bi\u1ec7t h\u1ee9a h\u1eb9n trong ung th\u01b0 tuy\u1ebfn ti\u1ec1n […]<\/p>\n","protected":false},"author":23,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-29029","post","type-post","status-publish","format-standard","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/29029","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=29029"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/29029\/revisions"}],"predecessor-version":[{"id":31128,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/29029\/revisions\/31128"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=29029"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=29029"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=29029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}