{"id":27618,"date":"2020-04-30T16:43:00","date_gmt":"2020-04-30T09:43:00","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=27618"},"modified":"2021-11-07T22:13:55","modified_gmt":"2021-11-07T15:13:55","slug":"uc-che-gen-gay-ung-thu-cho-thay-buoc-tien-tot-trong-viec-dieu-tri-u-nguyen-bao-than-kinh","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/uc-che-gen-gay-ung-thu-cho-thay-buoc-tien-tot-trong-viec-dieu-tri-u-nguyen-bao-than-kinh\/","title":{"rendered":"\u1ee8c ch\u1ebf gen g\u00e2y ung th\u01b0 cho th\u1ea5y b\u01b0\u1edbc ti\u1ebfn t\u1ed1t trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb u nguy\u00ean b\u00e0o th\u1ea7n kinh"},"content":{"rendered":"\n

U nguy\u00ean b\u00e0o th\u1ea7n kinh l\u00e0 m\u1ed9t kh\u1ed1i u r\u1eafn \u00e1c t\u00ednh \u1edf tr\u1ebb nh\u0169 nhi v\u00e0 n\u00f3 th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n b\u00ean trong h\u1ec7 th\u1ed1ng th\u1ea7n kinh giao c\u1ea3m \u1edf nhi\u1ec1u tr\u1ebb nh\u1ecf v\u1eabn \u0111ang ch\u1eadp ch\u1eefng bi\u1ebft \u0111i, hi\u1ebfm khi th\u1ea5y \u1edf tr\u1ebb l\u1edbn h\u01a1n 5 tu\u1ed5i. N\u00f3 l\u00e0 m\u1ed9t lo\u1ea1i ung th\u01b0 ph\u00e1t tri\u1ec3n t\u1eeb c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh ch\u01b0a tr\u01b0\u1edfng th\u00e0nh, c\u00f3 th\u1ec3 x\u1ea3y ra \u1edf nhi\u1ec1u v\u1ecb tr\u00ed tr\u00ean kh\u1eafp c\u01a1 th\u1ec3. S\u1ef1 t\u0103ng tr\u01b0\u1edfng kh\u00f4ng \u0111\u01b0\u1ee3c ch\u1ebf ng\u1ef1 n\u00e0y th\u01b0\u1eddng xuy\u00ean x\u1ea3y ra \u1edf b\u00ean trong ho\u1eb7c trong khu v\u1ef1c c\u1ee7a tuy\u1ebfn th\u01b0\u1ee3ng th\u1eadn nh\u1ea5t, n\u1eb1m tr\u00ean \u0111\u1ec9nh c\u1ee7a m\u1ed7i qu\u1ea3 th\u1eadn. Tuy nhi\u00ean, u nguy\u00ean b\u00e0o th\u1ea7n kinh c\u0169ng c\u00f3 th\u1ec3 ph\u00e1t tri\u1ec3n \u1edf c\u00e1c khu v\u1ef1c kh\u00e1c c\u1ee7a b\u1ee5ng, ho\u1eb7c g\u1ea7n c\u1ed9t s\u1ed1ng.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

Gi\u1edd \u0111\u00e2y, c\u00e1c nh\u00e0 khoa h\u1ecdc y h\u1ecdc hi\u1ec7n \u0111ang nghi\u00ean c\u1ee9u v\u1ec1 u nguy\u00ean b\u00e0o th\u1ea7n kinh v\u00e0 c\u00e1ch th\u1ee9c l\u00e0m gi\u1ea3m c\u00e1c d\u1ea1ng ung th\u01b0 nguy hi\u1ec3m nh\u1ea5t t\u1ea1i Trung Qu\u1ed1c cho bi\u1ebft, chi\u1ebfn l\u01b0\u1ee3c m\u1edbi \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n g\u1ea7n \u0111\u00e2y c\u1ee7a h\u1ecd cu\u1ed1i c\u00f9ng \u0111\u00e3 c\u00f3 th\u1ec3 thay \u0111\u1ed5i s\u1ed1 ph\u1eadn nh\u1eefng tr\u1ebb em m\u1eafc c\u0103n b\u1ec7nh u nguy\u00ean b\u00e0o th\u1ea7n kinh.<\/p>\n\n\n\n

Hi\u1ec7n t\u1ea1i, nghi\u00ean c\u1ee9u nh\u1eb1m \u0111\u00e1nh b\u1ea1i m\u1ed9t d\u1ea1ng b\u1ec7nh g\u00e2y ra b\u1edfi v\u00f2ng ph\u1ea3n h\u1ed3i kh\u00e9p k\u00edn d\u1ef1a v\u00e0o gen (gene-driven feedback loop<\/a>) n\u00e0y \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh nghi\u00ean c\u1ee9u tr\u00ean c\u00e1c m\u00f4 h\u00ecnh th\u1eed nghi\u1ec7m xenograft, tuy nhi\u00ean c\u00e1c nh\u00e0 khoa h\u1ecdc \u1edf Trung Qu\u1ed1c cho bi\u1ebft nh\u1eefng ph\u00e1t hi\u1ec7n c\u1ee7a h\u1ecd \u0111\u1ee7 thuy\u1ebft ph\u1ee5c \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o cho c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng.<\/p>\n\n\n\n

U nguy\u00ean b\u00e0o th\u1ea7n kinh l\u00e0 d\u1ea1ng ung th\u01b0 c\u00f3 bi\u1ec3u hi\u1ec7n h\u00e0nh vi l\u00e2m s\u00e0ng \u0111a d\u1ea1ng, t\u1eeb h\u1ed3i quy t\u1ef1 ph\u00e1t \u0111\u1ebfn ung th\u01b0 ti\u1ebfn tri\u1ec3n v\u00e0 di c\u0103n, theo b\u00e1o c\u00e1o c\u1ee7a Ti\u1ebfn s\u0129 Yu-Feng Guo v\u00e0 Shi-Cang Yu – hai nh\u00e0 khoa h\u1ecdc ch\u1ec9 \u0111\u1ea1o nghi\u00ean c\u1ee9u t\u1ea1i Khoa T\u1ebf b\u00e0o g\u1ed1c v\u00e0 Y h\u1ecdc t\u00e1i sinh t\u1ea1i B\u1ec7nh vi\u1ec7n T\u00e2y Nam v\u00e0 H\u1ecdc vi\u1ec7n Qu\u00e2n y th\u1ee9 ba \u1edf Tr\u00f9ng Kh\u00e1nh – th\u00e0nh ph\u1ed1 n\u1eb1m \u1edf khu v\u1ef1c ph\u00eda T\u00e2y Nam Trung Qu\u1ed1c. Guo v\u00e0 Yu \u0111\u00e3 gi\u1ea3i th\u00edch r\u00f5 c\u00e1c chi ti\u1ebft c\u1ee7a nghi\u00ean c\u1ee9u u nguy\u00ean b\u00e0o th\u1ea7n kinh c\u1ee7a h\u1ecd tr\u00ean t\u1ea1p ch\u00ed Science Translational Medicine<\/em>.<\/p>\n\n\n\n

\u0110i\u1ec1u l\u00e0m cho c\u0103n b\u1ec7nh u nguy\u00ean b\u00e0o th\u1ea7n kinh tr\u1edf n\u00ean kh\u00f3 kh\u0103n \u0111\u1ed1i v\u1edbi c\u00e1c gia \u0111\u00ecnh \u0111\u00f3 l\u00e0 n\u00f3 t\u1ea5n c\u00f4ng tr\u1ebb em \u1edf \u0111\u1ed9 tu\u1ed5i \u0111\u1eb7c bi\u1ec7t v\u00e0 d\u1ec5 b\u1ecb t\u1ed5n th\u01b0\u01a1ng. M\u1eb7c d\u00f9 c\u0103n b\u1ec7nh ung th\u01b0 n\u00e0y t\u1ea5n c\u00f4ng tr\u1ebb em kho\u1ea3ng 5 tu\u1ed5i tr\u1edf xu\u1ed1ng, nh\u01b0ng \u0111\u1ed9 tu\u1ed5i trung b\u00ecnh trong ch\u1ea9n \u0111o\u00e1n ch\u1ec9 l\u00e0 18 th\u00e1ng tu\u1ed5i, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u cho bi\u1ebft.<\/p>\n\n\n\n

C\u00e1c kh\u1ed1i u c\u00f3 m\u1ed9t s\u1ed1 sai l\u1ec7ch gen \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u r\u1ed9ng r\u00e3i. Trong s\u1ed1 \u0111\u00f3, m\u1ed1i quan t\u00e2m ch\u00ednh l\u00e0 s\u1ef1 khu\u1ebfch \u0111\u1ea1i c\u1ee7a gen MYCN, \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y \u1edf kho\u1ea3ng 20% b\u1ec7nh nh\u00e2n. Gen n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 m\u1ed9t trong nh\u1eefng y\u1ebfu t\u1ed1 quy\u1ebft \u0111\u1ecbnh m\u1ea1nh nh\u1ea5t c\u1ee7a kh\u1ed1i u, nh\u01b0ng n\u00f3 c\u0169ng c\u00f3 gi\u00e1 tr\u1ecb ti\u00ean l\u01b0\u1ee3ng quan tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n. S\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a n\u00f3 h\u1ed7 tr\u1ee3 trong vi\u1ec7c d\u1ef1 \u0111o\u00e1n c\u00e1c k\u1ebft qu\u1ea3 l\u00e2m s\u00e0ng kh\u00f4ng thu\u1eadn l\u1ee3i v\u00e0 kh\u1ea3 n\u0103ng s\u1ed1ng s\u00f3t th\u1ea5p c\u1ee7a b\u1ec7nh nh\u00e2n u nguy\u00ean b\u00e0o th\u1ea7n kinh nguy c\u01a1 cao.<\/p>\n\n\n\n

MYCN m\u00e3 h\u00f3a N-MYC, m\u1ed9t bi\u1ebfn \u0111\u1ed5i gen v\u00e0 g\u00e2y ung th\u01b0. N-MYC \u0111\u00f3ng nhi\u1ec1u vai tr\u00f2 trong u nguy\u00ean b\u00e0o th\u1ea7n kinh, Guo v\u00e0 Yu gi\u1ea3i th\u00edch, v\u00e0 c\u00e1c ch\u1ee9c n\u0103ng c\u1ee7a n\u00f3 gi\u1ed1ng nh\u01b0 m\u1ed9t b\u1ed9 \u0111i\u1ec1u h\u00f2a phi\u00ean m\u00e3 ch\u00ednh c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t c\u00e1c gen li\u00ean quan \u0111\u1ebfn kh\u1ea3 n\u0103ng t\u1ef1 l\u00e0m m\u1edbi, t\u0103ng sinh, \u0111a n\u0103ng, t\u1ea1o m\u1ea1ch v\u00e0 di c\u0103n. N-MYC c\u0169ng ng\u0103n ch\u1eb7n s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c gen th\u00fac \u0111\u1ea9y s\u1ef1 bi\u1ec7t h\u00f3a, h\u00e3m chu k\u1ef3 t\u1ebf b\u00e0o v\u00e0 gi\u00e1m s\u00e1t mi\u1ec5n d\u1ecbch.<\/p>\n\n\n\n

\u201cCh\u00fang t\u00f4i \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng ph\u00e2n t\u1eed ALDH18A1 trong nh\u00f3m aldehyd dehydrogenase c\u00f3 t\u00e1c \u0111\u1ed9ng m\u1ea1nh \u0111\u1ebfn s\u1ef1 t\u0103ng sinh, kh\u1ea3 n\u0103ng t\u1ef1 l\u00e0m m\u1edbi v\u00e0 \u0111\u1ed9c t\u00ednh kh\u1ed1i u c\u1ee7a c\u00e1c t\u1ebf b\u00e0o u nguy\u00ean b\u00e0o th\u1ea7n kinh v\u00e0 l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 nguy c\u01a1 ti\u1ec1m \u1ea9n \u1edf b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh u nguy\u00ean b\u00e0o th\u1ea7n kinh, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh MYCN khu\u1ebfch \u0111\u1ea1i<\/em>\u201d, Guo v\u00e0 Yu cho bi\u1ebft.<\/p>\n\n\n\n

ALDH18A1 l\u00e0 gen \u0111a ch\u1ee9c n\u0103ng. Guo v\u00e0 Yu \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng ALDH18A1 l\u00e0 m\u1ed9t gen m\u1ea1nh m\u1ebd v\u00ec n\u00f3 \u0111i\u1ec1u ch\u1ec9nh bi\u1ec3u hi\u1ec7n MYCN v\u00e0 MYCN t\u1ea1o th\u00e0nh m\u1ed9t v\u00f2ng ph\u1ea3n h\u1ed3i kh\u00e9p k\u00edn t\u00edch c\u1ef1c. Vi\u1ec7c \u1ee9c ch\u1ebf v\u00f2ng ph\u1ea3n h\u1ed3i kh\u00e9p k\u00edn t\u00edch c\u1ef1c ALDH18A1-MYCN c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m s\u1ef1 t\u0103ng tr\u01b0\u1edfng MYCN khu\u1ebfch \u0111\u1ea1i, v\u00e0 do \u0111\u00f3 gi\u1ea3m nguy c\u01a1 u nguy\u00ean b\u00e0o th\u1ea7n kinh \u00e1c t\u00ednh nh\u1ea5t, nh\u00f3m nghi\u00ean c\u1ee9u nh\u1eadn th\u1ea5y.<\/p>\n\n\n\n

H\u1ecd c\u0169ng ti\u1ebft l\u1ed9 trong nghi\u00ean c\u1ee9u c\u1ee7a m\u00ecnh r\u1eb1ng c\u00f3 m\u1ed9t c\u00e1ch \u0111\u1ec3 ph\u00e1 v\u1ee1 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a v\u00f2ng ph\u1ea3n h\u1ed3i kh\u00e9p k\u00edn n\u00e0y v\u00e0 \u0111\u1ea3o ng\u01b0\u1ee3c ti\u1ebfn tr\u00ecnh g\u00e2y t\u1eed vong theo c\u00e1c xu h\u01b0\u1edbng kh\u00e1c \u0111\u01b0\u1ee3c m\u00e3 h\u00f3a trong t\u1ed5 h\u1ee3p ALDH1A1-MYCN.<\/p>\n\n\n\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u cho bi\u1ebft: \u201cS\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p n\u1ed1i v\u00e0 s\u00e0ng l\u1ecdc ph\u00e2n t\u1eed, ch\u00fang t\u00f4i \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c ch\u1ea5t \u1ee9c ch\u1ebf ALDH18A1 \u0111\u1eb7c hi\u1ec7u, YG1702, v\u00e0 \u0111\u00e3 ch\u1ee9ng minh \u0111\u01b0\u1ee3c r\u1eb1ng vi\u1ec7c \u1ee9c ch\u1ebf d\u01b0\u1ee3c l\u00fd c\u1ee7a ALDH18A1 l\u00e0 \u0111\u1ee7 \u0111\u1ec3 c\u00f3 th\u1ec3 t\u1ea1o ra m\u1ed9t ki\u1ec3u h\u00ecnh \u00edt t\u0103ng sinh v\u00e0 lo\u1ea1i b\u1ecf kh\u1ed1i u<\/em>\u201d. YG1702 l\u00e0 m\u1ed9t protein \u0111\u01b0\u1ee3c nh\u1eafm m\u1ee5c ti\u00eau thay th\u1ebf cho ALDH18A.<\/p>\n\n\n\n

T\u1ea1i Hoa K\u1ef3, theo B\u1ec7nh vi\u1ec7n Qu\u1ed1c gia Tr\u1ebb em \u1edf Washington, D.C \u01b0\u1edbc t\u00ednh, c\u00f3 kho\u1ea3ng 700 tr\u1ebb em \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n m\u1eafc u nguy\u00ean b\u00e0o th\u1ea7n kinh h\u00e0ng n\u0103m. Kh\u1ed1i u c\u00f3 xu h\u01b0\u1edbng hi\u1ec7n di\u1ec7n khi sinh, nh\u01b0ng th\u01b0\u1eddng kh\u00f4ng \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n cho \u0111\u1ebfn khi n\u00f3 b\u1eaft \u0111\u1ea7u ph\u00e1t tri\u1ec3n v\u00e0 g\u00e2y \u00e1p l\u1ef1c l\u00ean c\u00e1c c\u01a1 quan v\u00e0 m\u00f4 xung quanh.<\/p>\n\n\n\n

P.T.T (NASATI), theo https:\/\/medicalxpress.com\/news\/2020-04-cancer-gene-inhibition-neuroblastomas.html, 1\/4\/2020<\/em><\/p>\n\n\n\n

ngu\u1ed3n: https:\/\/www.vista.gov.vn\/news\/khoa-hoc-y-duoc\/uc-che-gen-gay-ung-thu-cho-thay-buoc-tien-tot-trong-viec-dieu-tri-u-nguyen-bao-than-kinh-1736.html<\/p>\n","protected":false},"excerpt":{"rendered":"

U nguy\u00ean b\u00e0o th\u1ea7n kinh l\u00e0 m\u1ed9t kh\u1ed1i u r\u1eafn \u00e1c t\u00ednh \u1edf tr\u1ebb nh\u0169 nhi v\u00e0 n\u00f3 th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n b\u00ean trong h\u1ec7 th\u1ed1ng th\u1ea7n kinh giao c\u1ea3m \u1edf nhi\u1ec1u tr\u1ebb nh\u1ecf v\u1eabn \u0111ang ch\u1eadp ch\u1eefng bi\u1ebft \u0111i, hi\u1ebfm khi th\u1ea5y \u1edf tr\u1ebb l\u1edbn h\u01a1n 5 tu\u1ed5i. N\u00f3 l\u00e0 m\u1ed9t lo\u1ea1i ung th\u01b0 ph\u00e1t […]<\/p>\n","protected":false},"author":25,"featured_media":29700,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-27618","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/27618","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=27618"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/27618\/revisions"}],"predecessor-version":[{"id":29703,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/27618\/revisions\/29703"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/29700"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=27618"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=27618"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=27618"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}