{"id":27605,"date":"2020-04-16T16:40:00","date_gmt":"2020-04-16T09:40:00","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=27605"},"modified":"2021-11-07T22:20:51","modified_gmt":"2021-11-07T15:20:51","slug":"cac-nha-than-kinh-hoc-cung-cap-cai-nhin-sau-sac-moi-ve-nguy-co-di-truyen-cua-benh-tam-than-phan-liet","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/cac-nha-than-kinh-hoc-cung-cap-cai-nhin-sau-sac-moi-ve-nguy-co-di-truyen-cua-benh-tam-than-phan-liet\/","title":{"rendered":"C\u00c1C NH\u00c0 TH\u1ea6N KINH H\u1eccC CUNG C\u1ea4P C\u00c1I NH\u00ccN S\u00c2U S\u1eaeC M\u1edaI V\u1ec0 NGUY C\u01a0 DI TRUY\u1ec0N C\u1ee6A B\u1ec6NH T\u00c2M TH\u1ea6N PH\u00c2N LI\u1ec6T"},"content":{"rendered":"\n

Nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y trong l\u0129nh v\u1ef1c khoa h\u1ecdc th\u1ea7n kinh cho th\u1ea5y c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o ri\u00eang bi\u1ec7t c\u00f3 th\u1ec3 g\u00f3p ph\u1ea7n v\u00e0o s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n, bao g\u1ed3m c\u1ea3 t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t. Tuy nhi\u00ean, vi\u1ec7c x\u00e1c \u0111\u1ecbnh c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o \u0111\u00f3ng vai tr\u00f2 trong b\u1ec7nh t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t \u0111\u1eb7c bi\u1ec7t kh\u00e1 kh\u00f3 kh\u0103n khi s\u1eed d\u1ee5ng m\u1ed9t s\u1ed1 k\u1ef9 thu\u1eadt th\u00f4ng th\u01b0\u1eddng nh\u1ea5t \u0111\u1ec3 ph\u00e2n t\u00edch m\u00f4 ng\u01b0\u1eddi.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i Vi\u1ec7n ph\u00e1t tri\u1ec3n n\u00e3o Lieber v\u00e0 Vi\u1ec7n nghi\u00ean c\u1ee9u Astellas c\u1ee7a M\u1ef9 g\u1ea7n \u0111\u00e2y \u0111\u00e3 th\u1ef1c hi\u1ec7n m\u1ed9t nghi\u00ean c\u1ee9u m\u1edbi nh\u1eb1m nghi\u00ean c\u1ee9u bi\u1ec3u hi\u1ec7n gen b\u00ean trong m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o th\u1ea7n kinh quan tr\u1ecdng c\u00f3 kh\u1ea3 n\u0103ng li\u00ean quan \u0111\u1ebfn b\u1ec7nh t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t. Trong b\u00e0i b\u00e1o c\u1ee7a h\u1ecd, \u0111\u01b0\u1ee3c \u0111\u0103ng tr\u00ean t\u1ea1p ch\u00ed Nature Neuroscience<\/em>, h\u1ecd \u0111\u00e3 m\u00f4 t\u1ea3 bi\u1ec3u hi\u1ec7n gen \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y n\u1eb1m trong v\u00f9ng n\u00e3o b\u1ed9 c\u00f3 li\u00ean quan \u0111\u1ebfn t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t, c\u1ee5 th\u1ec3 l\u00e0 v\u00f9ng h\u1ed3i r\u0103ng (dentate gyrus) trong v\u00f9ng h\u1ea3i m\u00e3.<\/p>\n\n\n\n

Trong v\u00e0i n\u0103m qua, nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 ti\u1ebfn h\u00e0nh m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u v\u1edbi m\u1ee5c ti\u00eau c\u00f3 th\u1ec3 hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 s\u1ef1 t\u01b0\u01a1ng quan ph\u00e2n t\u1eed c\u1ee7a b\u1ec7nh t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t b\u1eb1ng c\u00e1ch ph\u00e2n t\u00edch c\u00e1c m\u00f4 n\u00e3o \u0111\u01b0\u1ee3c l\u1ea5y t\u1eeb c\u00e1c b\u1ec7nh nh\u00e2n \u0111\u00e3 ch\u1ebft. Nh\u1eefng th\u00ed nghi\u1ec7m n\u00e0y \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u00ean m\u00f4 n\u00e3o \u0111\u1ed3ng nh\u1ea5t ch\u1ee9a h\u1ed7n h\u1ee3p ph\u1ee9c t\u1ea1p c\u1ee7a nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o. Tuy nhi\u00ean, vi\u1ec7c s\u1eed d\u1ee5ng m\u00f4 n\u00e3o \u0111\u1ed3ng nh\u1ea5t d\u01b0\u1eddng nh\u01b0 xa v\u1eddi v\u1edbi \u00fd t\u01b0\u1edfng v\u1edbi nh\u00f3m nghi\u00ean c\u1ee9u b\u1edfi v\u00ec n\u00f3 khi\u1ebfn vi\u1ec7c \u0111i\u1ec1u tra c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o c\u1ee5 th\u1ec3 li\u00ean quan \u0111\u1ebfn t\u00edn hi\u1ec7u bi\u1ec3u hi\u1ec7n gen trong b\u1ec7nh t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t tr\u1edf n\u00ean kh\u00f3 kh\u0103n h\u01a1n.<\/p>\n\n\n\n

Tr\u00ean Medical Xpress, Daniel Hoeppner, th\u00e0nh vi\u00ean trong nh\u00f3m th\u1ef1c hi\u1ec7n nghi\u00ean c\u1ee9u, cho bi\u1ebft: \u201cNghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y c\u0169ng li\u00ean quan \u0111\u1ebfn v\u00f9ng h\u1ed3i r\u0103ng trong b\u1ec7nh t\u00e2m th\u1ea7n v\u00e0 ti\u1ec3u v\u00f9ng c\u1ee7a v\u00f9ng h\u1ea3i m\u00e3 n\u00e0y \u0111\u00f3ng m\u1ed9t vai tr\u00f2 r\u1ea5t quan tr\u1ecdng trong vi\u1ec7c nh\u1edb. Trong nghi\u00ean c\u1ee9u c\u1ee7a ch\u00fang t\u00f4i, ch\u00fang t\u00f4i \u0111\u00e3 t\u1eadn d\u1ee5ng s\u1ef1 xu\u1ea5t hi\u1ec7n c\u00e1c h\u00ecnh th\u00e1i kh\u00e1c bi\u1ec7t c\u1ee7a l\u1edbp t\u1ebf b\u00e0o h\u1ea1t, s\u1eed d\u1ee5ng c\u00f4ng ngh\u1ec7 microdissection \u0111\u1ec3 c\u1eaft l\u1edbp n\u00e0y ra kh\u1ecfi m\u00f4 quanh v\u00f9ng h\u1ea3i m\u00e3<\/em>\u201d.<\/p>\n\n\n\n

Thi\u1ebft k\u1ebf th\u1eed nghi\u1ec7m m\u00e0 c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u s\u1eed d\u1ee5ng trong nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y c\u1ee7a h\u1ecd c\u00f3 m\u1ed9t s\u1ed1 l\u1ee3i th\u1ebf quan tr\u1ecdng. M\u1ed9t trong nh\u1eefng th\u1ebf m\u1ea1nh ch\u00ednh c\u1ee7a n\u00f3 l\u00e0 n\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c s\u1eed d\u1ee5ng d\u1eef li\u1ec7u gi\u1ea3i tr\u00ecnh t\u1ef1 RNA (RNA-seq) t\u1eeb c\u1ea3 hai b\u00ean b\u00e1n c\u1ea7u c\u1ee7a n\u00e3o; v\u00f9ng h\u1ea3i m\u00e3 kh\u1ed1i l\u1edbn xu\u1ea5t ph\u00e1t t\u1eeb m\u1ed9t b\u00e1n c\u1ea7u n\u00e3o v\u00e0 l\u1edbp t\u1ebf b\u00e0o h\u1ea1t v\u00f9ng h\u1ed3i r\u0103ng xu\u1ea5t ph\u00e1t t\u1eeb v\u00f9ng kh\u00e1c.<\/p>\n\n\n\n

B\u1eb1ng c\u00e1ch ph\u00e2n t\u00edch d\u1eef li\u1ec7u n\u00e0y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u00f3 th\u1ec3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c gen bi\u1ec3u hi\u00ean d\u1ea5u hi\u1ec7u \u0111\u1eb7c bi\u1ec7t \u0111\u1ed1i v\u1edbi l\u1edbp t\u1ebf b\u00e0o h\u1ea1t c\u1ee7a v\u00f9ng h\u1ed3i r\u0103ng (DG-GCL) v\u00e0 nh\u1eefng gen kh\u00e1c d\u01b0\u1eddng nh\u01b0 \u0111\u01b0\u1ee3c ph\u00e2n chia v\u1edbi c\u00e1c ph\u1ea7n kh\u00e1c c\u1ee7a v\u00f9ng h\u1ea3i m\u00e3. Nh\u1eefng tr\u00e1i ng\u01b0\u1ee3c x\u1ea3y ra b\u00ean trong c\u00e1c t\u1ebf b\u00e0o ri\u00eang bi\u1ec7t trong c\u00e1c v\u00f9ng h\u1ea3i m\u00e3 kh\u00e1c nhau l\u00e0 tr\u1ecdng t\u00e2m ch\u00ednh c\u1ee7a c\u00e1c ph\u00e2n t\u00edch nghi\u00ean c\u1ee9u.<\/p>\n\n\n\n

\u201cT\u1eeb quan \u0111i\u1ec3m ph\u01b0\u01a1ng ph\u00e1p lu\u1eadn, nhi\u1ec1u nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 chuy\u1ec3n t\u1eeb nghi\u00ean c\u1ee9u m\u00f4 n\u00e3o \u0111\u1ed3ng nh\u1ea5t tr\u1ef1c ti\u1ebfp sang nghi\u00ean c\u1ee9u c\u00e1c h\u1ea1t nh\u00e2n t\u1ebf b\u00e0o ri\u00eang l\u1ebb b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c c\u00f4ng c\u1ee5 gi\u1ea3i tr\u00ecnh t\u1ef1 RNA nh\u00e2n \u0111\u01a1n (snRNA-seq). Tuy nhi\u00ean, c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfn b\u1ed9 n\u00e0y ch\u1ec9 m\u00f4 t\u1ea3 \u0111\u01b0\u1ee3c s\u01a1 l\u01b0\u1ee3c c\u00e1c bi\u1ec3u hi\u1ec7n gen, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u0111\u1ed1i v\u1edbi c\u00e1c qu\u1ea7n th\u1ec3 t\u1ebf b\u00e0o \u00edt phong ph\u00fa. Vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c thi\u1ebft b\u1ecb vi ph\u1eabu laser (laser capture microdissection – LCM) cho ph\u00e9p nh\u00f3m nghi\u00ean c\u1ee9u t\u1eadp trung v\u00e0o c\u00e1c qu\u1ea7n th\u1ec3 t\u1ebf b\u00e0o c\u00f3 h\u00ecnh th\u00e1i h\u1ecdc ho\u1eb7c kh\u00f4ng gian \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh v\u00e0 s\u1eed d\u1ee5ng c\u00e1c c\u00f4ng ngh\u1ec7 gi\u1ea3i tr\u00ecnh t\u1ef1 ti\u00ean ti\u1ebfn hi\u1ec7n nay \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh c\u00e1c h\u1ec7 phi\u00ean m\u00e3 c\u1ee7a ch\u00fang<\/em>\u201d, Thomas Hyde, m\u1ed9t nh\u00e0 nghi\u00ean c\u1ee9u kh\u00e1c tham gia nghi\u00ean c\u1ee9u, cho bi\u1ebft.<\/p>\n\n\n\n

S\u1eed d\u1ee5ng thi\u1ebft b\u1ecb LCM k\u1ebft h\u1ee3p v\u1edbi k\u1ef9 thu\u1eadt gi\u1ea3i tr\u00ecnh t\u1ef1 RNA, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u00f3 th\u1ec3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o v\u00e0 hi\u1ec7u \u1ee9ng di truy\u1ec1n trong v\u00f9ng n\u00e3o DG-GCL c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn nguy c\u01a1 ph\u00e1t tri\u1ec3n t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t. Nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 x\u00e1c \u0111\u1ecbnh kho\u1ea3ng 9 tri\u1ec7u \u0111\u1eb7c \u0111i\u1ec3m bi\u1ec3u hi\u1ec7n gen trong v\u00f9ng DG-GCL, 15% trong s\u1ed1 \u0111\u00f3 c\u00f3 s\u1ef1 kh\u00e1c l\u1ea1 h\u1eb3n v\u1edbi v\u00f9ng n\u00e3o n\u00e0y v\u00e0 kh\u00f4ng bi\u1ec3u hi\u1ec7n \u1edf c\u00e1c v\u00f9ng kh\u00e1c trong kh\u1ed1i v\u00f9ng h\u1ea3i m\u00e3. 15% n\u00e0y bao g\u1ed3m 15 v\u1ecb tr\u00ed bi\u1ec3u hi\u1ec7n \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u00e1nh d\u1ea5u tr\u01b0\u1edbc \u0111\u00e2y \u0111\u01b0\u1ee3c xem nh\u01b0 l\u00e0 c\u00e1c bi\u1ebfn th\u1ec3 c\u00f3 nguy c\u01a1 g\u00e2y b\u1ec7nh t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t.<\/p>\n\n\n\n

Ti\u1ebfn h\u00e0nh ph\u00e2n t\u00edch nh\u1eefng ph\u00e1t hi\u1ec7n n\u00e0y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ph\u00e1t hi\u1ec7n th\u1ea5y c\u00e1c t\u00edn hi\u1ec7u di truy\u1ec1n li\u00ean quan \u0111\u1ebfn t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t ch\u01b0a t\u1eebng \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh tr\u01b0\u1edbc \u0111\u00e2y, bao g\u1ed3m s\u1ef1 gi\u1ea3m bi\u1ec3u hi\u1ec7n gen GRM3 v\u00e0 CACNA1C.<\/p>\n\n\n\n

\u201cVi\u1ec7c x\u00e1c \u0111\u1ecbnh c\u00e1c li\u00ean k\u1ebft gen r\u1ee7i ro m\u1edbi v\u00e0 \u0111\u1eb7c bi\u1ec7t trong v\u00f9ng h\u1ed3i r\u0103ng \u0111\u00e3 th\u00fac \u0111\u1ea9y nh\u00f3m nghi\u00ean c\u1ee9u th\u1ef1c hi\u1ec7n c\u00e1c th\u00ed nghi\u1ec7m ch\u1ee9c n\u0103ng \u0111\u1ec3 t\u1ea1o ra c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh h\u1ea1t v\u00f9ng h\u1ea3i m\u00e3 t\u1eeb c\u00e1c t\u1ebf b\u00e0o g\u1ed1c \u0111a n\u0103ng c\u1ea3m \u1ee9ng (iPSCs) v\u00e0 thay \u0111\u1ed5i c\u00e1c bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c gen nguy c\u01a1 \u0111\u00f3 \u0111\u1ec3 c\u00f3 th\u1ec3 hi\u1ec3u r\u00f5 h\u01a1n m\u1ee9c \u0111\u1ed9 r\u1ee7i ro c\u00e1c c\u01a1 ch\u1ebf sinh h\u1ecdc<\/em>\u201d,  Mitsuyuki Matsumoto, thu\u1ed9c nh\u00f3m nghi\u00ean c\u1ee9u, cho bi\u1ebft.<\/p>\n\n\n\n

B\u00e1o c\u00e1o g\u1ea7n \u0111\u00e2y \u0111\u00e3 l\u00e0m n\u1ed5i b\u1eadt ti\u1ec1m n\u0103ng to l\u1edbn c\u1ee7a vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c chi\u1ebfn l\u01b0\u1ee3c ch\u1ecdn m\u1eabu nh\u1eafm m\u1ee5c ti\u00eau, ch\u1eb3ng h\u1ea1n nh\u01b0 microdissection, \u0111\u1ec3 nghi\u00ean c\u1ee9u c\u00e1c m\u1eabu t\u1ebf b\u00e0o c\u1ee5 th\u1ec3 trong n\u00e3o ng\u01b0\u1eddi. Nh\u1eefng ph\u00e1t hi\u1ec7n trong nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 cung c\u1ea5p c\u00e1i nh\u00ecn s\u00e2u s\u1eafc c\u00f3 gi\u00e1 tr\u1ecb m\u1edbi v\u1ec1 c\u00e1c m\u1eabu bi\u1ec3u hi\u1ec7n gen c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn nguy c\u01a1 ph\u00e1t tri\u1ec3n t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t.<\/p>\n\n\n\n

P.T.T (NASATI0, theo https:\/\/medicalxpress.com\/news\/2020-03-neuroscientists-insight-genetic-schizophrenia.html, 31\/3\/2020<\/em><\/p>\n\n\n\n

ngu\u1ed3n: https:\/\/vista.gov.vn\/news\/khoa-hoc-y-duoc\/cac-nha-than-kinh-hoc-cung-cap-cai-nhin-sau-sac-moi-ve-nguy-co-di-truyen-cua-benh-tam-than-phan-liet-1798.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y trong l\u0129nh v\u1ef1c khoa h\u1ecdc th\u1ea7n kinh cho th\u1ea5y c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o ri\u00eang bi\u1ec7t c\u00f3 th\u1ec3 g\u00f3p ph\u1ea7n v\u00e0o s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n, bao g\u1ed3m c\u1ea3 t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t. Tuy nhi\u00ean, vi\u1ec7c x\u00e1c \u0111\u1ecbnh c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o \u0111\u00f3ng vai tr\u00f2 trong b\u1ec7nh t\u00e2m […]<\/p>\n","protected":false},"author":25,"featured_media":29710,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-27605","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/27605","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=27605"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/27605\/revisions"}],"predecessor-version":[{"id":29711,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/27605\/revisions\/29711"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/29710"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=27605"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=27605"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=27605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}