{"id":27554,"date":"2020-04-27T16:24:00","date_gmt":"2020-04-27T09:24:00","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=27554"},"modified":"2021-11-09T10:28:03","modified_gmt":"2021-11-09T03:28:03","slug":"hat-nano-cai-thien-dieu-tri-khuyet-tat-xuong","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/hat-nano-cai-thien-dieu-tri-khuyet-tat-xuong\/","title":{"rendered":"H\u1ea0T NANO C\u1ea2I THI\u1ec6N \u0110I\u1ec0U TR\u1eca KHUY\u1ebeT T\u1eacT X\u01af\u01a0NG"},"content":{"rendered":"\n

M\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 khoa h\u1ecdc v\u1eadt li\u1ec7u sinh h\u1ecdc v\u00e0 nha s\u0129 t\u1ea1i Tr\u01b0\u1eddng Nha khoa thu\u1ed9c \u0110\u1ea1i h\u1ecdc California, Los Angeles \u0111\u00e3 t\u1ea1o ra c\u00e1c h\u1ea1t nano c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n vi\u1ec7c \u0111i\u1ec1u tr\u1ecb c\u00e1c khuy\u1ebft t\u1eadt x\u01b0\u01a1ng trong c\u00e1c th\u00ed nghi\u1ec7m ban \u0111\u1ea7u tr\u00ean \u0111\u1ed9ng v\u1eadt. Nghi\u00ean c\u1ee9u \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed Science Advances<\/em>.<\/p>\n\n\n\n

\"\"\/<\/figure><\/div>\n\n\n\n

C\u00e1c khuy\u1ebft t\u1eadt x\u01b0\u01a1ng c\u00f3 th\u1ec3 do ch\u1ea5n th\u01b0\u01a1ng, nhi\u1ec5m tr\u00f9ng, lo\u00e3ng x\u01b0\u01a1ng ho\u1eb7c lo\u1ea1i b\u1ecf c\u00e1c kh\u1ed1i u g\u00e2y ra, r\u1ea5t kh\u00f3 \u0111\u1ec3 c\u00e1c b\u00e1c s\u0129 ph\u1eabu thu\u1eadt ch\u1ec9nh h\u00ecnh x\u1eed l\u00fd. Nhu c\u1ea7u gh\u00e9p x\u01b0\u01a1ng \u0111ang tr\u1edf n\u00ean ph\u1ed5 bi\u1ebfn h\u01a1n m\u1ed9t ph\u1ea7n do d\u00e2n s\u1ed1 gi\u00e0 h\u00f3a: Ch\u1ea5n th\u01b0\u01a1ng x\u01b0\u01a1ng \u0111\u1eb7c bi\u1ec7t ph\u1ed5 bi\u1ebfn \u1edf ng\u01b0\u1eddi cao tu\u1ed5i.<\/p>\n\n\n\n

Ph\u01b0\u01a1ng ph\u00e1p th\u00f4ng th\u01b0\u1eddng hi\u1ec7n nay trong \u0111i\u1ec1u tr\u1ecb khuy\u1ebft t\u1eadt x\u01b0\u01a1ng l\u00e0 gh\u00e9p x\u01b0\u01a1ng, bao g\u1ed3m gh\u00e9p x\u01b0\u01a1ng kh\u1ecfe m\u1ea1nh t\u1eeb m\u1ed9t b\u1ed9 ph\u1eadn kh\u00e1c c\u1ee7a c\u01a1 th\u1ec3 \u0111\u1ec3 s\u1eeda ch\u1eefa khu v\u1ef1c b\u1ecb t\u1ed5n th\u01b0\u01a1ng. Tuy nhi\u00ean, th\u1ee7 t\u1ee5c n\u00e0y c\u00f3 th\u1ec3 g\u00e2y bi\u1ebfn ch\u1ee9ng nh\u01b0 nhi\u1ec5m tr\u00f9ng v\u1ecb tr\u00ed l\u1ea5y x\u01b0\u01a1ng, ch\u1ea3y m\u00e1u v\u00e0 t\u1ed5n th\u01b0\u01a1ng th\u1ea7n kinh.<\/p>\n\n\n\n

V\u00ec v\u1eady, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 chuy\u1ec3n sang s\u1eed d\u1ee5ng liposome, t\u00fai h\u00ecnh c\u1ea7u nh\u1ecf c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb lipit t\u1ef1 nhi\u00ean. Liposome \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng t\u1eeb nh\u1eefng n\u0103m 1990 \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00e0 c\u00e1c b\u1ec7nh truy\u1ec1n nhi\u1ec5m. G\u1ea7n \u0111\u00e2y, ch\u00fang \u0111ang \u0111\u01b0\u1ee3c khai th\u00e1c \u0111\u1ec3 s\u1eed d\u1ee5ng trong k\u1ef9 thu\u1eadt m\u00f4 x\u01b0\u01a1ng. Liposome c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 cung c\u1ea5p c\u00e1c ch\u1ea5t dinh d\u01b0\u1ee1ng v\u00e0 d\u01b0\u1ee3c ph\u1ea9m trong c\u01a1 th\u1ec3 v\u00e0 d\u1ec5 d\u00e0ng x\u00e2m nh\u1eadp v\u00e0o c\u00e1c t\u1ebf b\u00e0o, nh\u01b0ng ch\u00fang c\u00f3 m\u1ed9t s\u1ed1 nh\u01b0\u1ee3c \u0111i\u1ec3m: kh\u00f4ng \u1ed5n \u0111\u1ecbnh v\u00e0 kh\u00f3 ki\u1ec3m so\u00e1t c\u00e1ch th\u1ee9c v\u00e0 th\u1eddi \u0111i\u1ec3m gi\u1ea3i ph\u00f3ng thu\u1ed1c. \u0110\u1ec3 t\u0103ng c\u01b0\u1eddng m\u1ee9c \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 kh\u1ea3 n\u0103ng t\u1ea1o x\u01b0\u01a1ng trong c\u01a1 th\u1ec3, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 t\u1ea1o ra lo\u1ea1i liposome m\u1edbi \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 sterosome (do ch\u00fang c\u00f3 ch\u1ee9a n\u1ed3ng \u0111\u1ed9 steroid cao). C\u1ee5 th\u1ec3, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 thay th\u1ebf cholesterol, m\u1ed9t th\u00e0nh ph\u1ea7n quan tr\u1ecdng c\u1ee7a liposome b\u1eb1ng oxapseol, m\u1ed9t lo\u1ea1i cholesterol c\u00f3 vai tr\u00f2 ch\u00ednh \u0111\u1ed1i v\u1edbi s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a x\u01b0\u01a1ng v\u00e0 h\u00e0n g\u1eafn x\u01b0\u01a1ng. Trong c\u00e1c th\u1eed nghi\u1ec7m s\u1eed d\u1ee5ng chu\u1ed9t b\u1ecb khuy\u1ebft t\u1eadt x\u01b0\u01a1ng, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ph\u00e1t hi\u1ec7n ra r\u1eb1ng c\u00e1c sterosome \u0111\u00e3 t\u1ef1 k\u00edch ho\u1ea1t th\u00e0nh c\u00f4ng qu\u00e1 tr\u00ecnh t\u00e1i t\u1ea1o x\u01b0\u01a1ng m\u00e0 kh\u00f4ng c\u1ea7n thu\u1ed1c \u0111i\u1ec1u tr\u1ecb.<\/p>\n\n\n\n

Trong giai \u0111o\u1ea1n th\u1ee9 hai, c\u00e1c nh\u00e0 khoa h\u1ecdc mu\u1ed1n nghi\u00ean c\u00e1ch c\u00e1ch \u0111\u1ec3 sterosome ho\u1ea1t \u0111\u1ed9ng hi\u1ec7u qu\u1ea3 h\u01a1n. H\u1ecd \u0111\u00e3 b\u1ed5 sung h\u1ea1t nano sterosome v\u00e0o gi\u00e0n khung k\u1ef9 thu\u1eadt m\u00f4, m\u1ed9t c\u1ea5u tr\u00fac th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 di chuy\u1ec3n v\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c t\u1ebf b\u00e0o g\u1ed1c t\u1ef1 nhi\u00ean, ph\u00f9 h\u1ee3p v\u1edbi v\u1ecb tr\u00ed khuy\u1ebft t\u1eadt v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong qu\u00e1 tr\u00ecnh gh\u00e9p x\u01b0\u01a1ng. C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 n\u1ea1p c\u00e1c sterosome b\u1eb1ng m\u1ed9t lo\u1ea1i thu\u1ed1c t\u1ea1o x\u01b0\u01a1ng g\u1ecdi l\u00e0 purmorphamine. Ti\u1ebfp theo, h\u1ecd b\u1ea5t \u0111\u1ed9ng c\u00e1c sterosome \u0111\u01b0\u1ee3c n\u1ea1p thu\u1ed1c v\u00e0o c\u1ea5u tr\u00fac khung \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o r\u1eb1ng c\u00e1c sterosome t\u1eadp trung t\u1ea1i c\u00e1c v\u1ecb tr\u00ed b\u1ecb khuy\u1ebft t\u1eadt x\u01b0\u01a1ng v\u00e0 gi\u1ea3i ph\u00f3ng c\u00e1c lo\u1ea1i thu\u1ed1c trong th\u1eddi gian l\u00e2u nh\u1ea5t c\u00f3 th\u1ec3.<\/p>\n\n\n\n

Trong m\u1ed9t nghi\u00ean c\u1ee9u k\u00e9o d\u00e0i 6 tu\u1ea7n s\u1eed d\u1ee5ng nh\u1eefng con chu\u1ed9t b\u1ecb khuy\u1ebft t\u1eadt x\u01b0\u01a1ng trong h\u1ed9p s\u1ecd, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 quan s\u00e1t t\u00ecnh tr\u1ea1ng gi\u1ea3m trung b\u00ecnh kho\u1ea3ng 50% k\u00edch th\u01b0\u1edbc c\u1ee7a c\u00e1c khuy\u1ebft t\u1eadt sau khi c\u1ea5y gi\u00e0n khung ch\u1ee9a thu\u1ed1c.<\/p>\n\n\n\n

“B\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng h\u1ea1t nano c\u00f3 kh\u1ea3 n\u0103ng t\u1ea1o x\u01b0\u01a1ng n\u1ed9i t\u1ea1i, c\u00f9ng v\u1edbi vi\u1ec7c b\u1ed5 sung c\u00e1c lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb, ch\u00fang t\u00f4i \u0111\u00e3 \u0111\u1ea9y nhanh qu\u00e1 tr\u00ecnh t\u00e1i t\u1ea1o x\u01b0\u01a1ng<\/em>“, PGS. Lee n\u00f3i. “C\u00e1c lo\u1ea1i thu\u1ed1c ch\u1ee9a h\u1ea1t nano s\u1ebd h\u1eefu \u00edch trong nhi\u1ec1u t\u00ecnh hu\u1ed1ng l\u00e2m s\u00e0ng, trong \u0111\u00f3 vi\u1ec7c gh\u00e9p x\u01b0\u01a1ng l\u00e0 c\u1ea7n thi\u1ebft \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c khuy\u1ebft t\u1eadt x\u01b0\u01a1ng kh\u00f4ng l\u00e0nh v\u00e0 c\u00e1c b\u1ec7nh l\u00fd x\u01b0\u01a1ng li\u00ean quan<\/em>“.<\/p>\n\n\n\n

N.P.D (NASATI)<\/em><\/p>\n\n\n\n

theo https:\/\/phys.org\/news\/2020-04-scientists-nanoparticle-treatment-bone-defects.html, 22\/4\/2020<\/em><\/p>\n\n\n\n

https:\/\/www.vista.gov.vn\/news\/khoa-hoc-y-duoc\/hat-nano-cai-thien-dieu-tri-khuyet-tat-xuong-2353.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

M\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 khoa h\u1ecdc v\u1eadt li\u1ec7u sinh h\u1ecdc v\u00e0 nha s\u0129 t\u1ea1i Tr\u01b0\u1eddng Nha khoa thu\u1ed9c \u0110\u1ea1i h\u1ecdc California, Los Angeles \u0111\u00e3 t\u1ea1o ra c\u00e1c h\u1ea1t nano c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n vi\u1ec7c \u0111i\u1ec1u tr\u1ecb c\u00e1c khuy\u1ebft t\u1eadt x\u01b0\u01a1ng trong c\u00e1c th\u00ed nghi\u1ec7m ban \u0111\u1ea7u tr\u00ean \u0111\u1ed9ng v\u1eadt. Nghi\u00ean c\u1ee9u \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 […]<\/p>\n","protected":false},"author":25,"featured_media":29788,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-27554","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/27554","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=27554"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/27554\/revisions"}],"predecessor-version":[{"id":29789,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/27554\/revisions\/29789"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/29788"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=27554"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=27554"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=27554"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}