{"id":27488,"date":"2020-12-04T16:03:00","date_gmt":"2020-12-04T09:03:00","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=27488"},"modified":"2021-11-09T13:28:04","modified_gmt":"2021-11-09T06:28:04","slug":"chinh-sua-gen-quan-trong-trong-te-bao-than-kinh-cua-con-nguoi-co-the-ngan-ngua-benh-alzheimer","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/chinh-sua-gen-quan-trong-trong-te-bao-than-kinh-cua-con-nguoi-co-the-ngan-ngua-benh-alzheimer\/","title":{"rendered":"Ch\u1ec9nh s\u1eeda gen quan tr\u1ecdng trong t\u1ebf b\u00e0o th\u1ea7n kinh c\u1ee7a con ng\u01b0\u1eddi c\u00f3 th\u1ec3 ng\u0103n ng\u1eeba b\u1ec7nh Alzheimer"},"content":{"rendered":"\n

M\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i \u0110\u1ea1i h\u1ecdc Laval \u0111\u00e3 t\u00ecm th\u1ea5y b\u1eb1ng ch\u1ee9ng cho th\u1ea5y c\u00f3 c\u01a1 h\u1ed9i ng\u0103n ch\u1eb7n Alzheimer ph\u00e1t tri\u1ec3n b\u1eb1ng c\u00e1ch ch\u1ec9nh s\u1eeda m\u1ed9t gen c\u00f3 vai tr\u00f2 quan tr\u1ecdng trong c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh. Trong b\u00e0i b\u00e1o \u0111\u01b0\u1ee3c \u0111\u0103ng l\u00ean bioRxiv, nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 m\u00f4 t\u1ea3 c\u00e1c th\u00ed nghi\u1ec7m li\u00ean quan \u0111\u1ebfn ch\u1ec9nh s\u1eeda gen v\u00e0 nh\u1eefng g\u00ec h\u1ecd bi\u1ebft \u0111\u01b0\u1ee3c t\u1eeb ch\u00fang.<\/p>\n\n\n\n

\"\"\/<\/figure><\/div>\n\n\n\n

Ngu\u1ed3n: Pixabay\/CC0 Public Domain<\/em><\/p>\n\n\n\n

Nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y ch\u1ec9 ra r\u1eb1ng m\u1ed9t trong nh\u1eefng y\u1ebfu t\u1ed1 li\u00ean quan \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a b\u1ec7nh Alzheimer l\u00e0 s\u1ef1 t\u00edch t\u1ee5 c\u1ee7a beta-amyloid – m\u1ed9t lo\u1ea1i protein – tr\u00ean c\u00e1c t\u1ebf b\u00e0o n\u00e3o v\u00e0 nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y c\u0169ng cho th\u1ea5y r\u1eb1ng, nh\u1eefng ng\u01b0\u1eddi c\u00f3 bi\u1ec3u hi\u1ec7n m\u1ed9t bi\u1ebfn th\u1ec3 gen c\u00f3 t\u00ean g\u1ecdi l\u00e0 A673T th\u00ec h\u1ecd c\u00f3 nguy c\u01a1 m\u1eafc b\u1ec7nh Alzheimer th\u1ea5p h\u01a1n b\u1ed1n l\u1ea7n so v\u1edbi ng\u01b0\u1eddi kh\u00e1c. Trong n\u1ed7 l\u1ef1c nghi\u00ean c\u1ee9u m\u1edbi n\u00e0y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 xem x\u00e9t \u0111\u1ebfn kh\u1ea3 n\u0103ng ch\u1ec9nh s\u1eeda t\u1ebf b\u00e0o n\u00e3o c\u1ee7a ng\u01b0\u1eddi \u0111\u1ec3 t\u1ea1o ra c\u00e1c bi\u1ebfn th\u1ec3 gen A673T v\u00e0 do \u0111\u00f3 c\u00f3 th\u1ec3 gi\u1ea3m thi\u1ec3u nguy c\u01a1 m\u1eafc b\u1ec7nh Alzheimer cho nhi\u1ec1u ng\u01b0\u1eddi.<\/p>\n\n\n\n

Nh\u00f3m nghi\u00ean c\u1ee9u l\u01b0u \u00fd r\u1eb1ng \u0111\u1ed9t bi\u1ebfn A673T kh\u00e1c v\u1edbi gen c\u00f9ng ngu\u1ed3n g\u1ed1c c\u1ee7a n\u00f3 \u1edf nh\u1eefng ng\u01b0\u1eddi kh\u00f4ng bi\u1ec3u hi\u1ec7n gen n\u00e0y b\u1eb1ng m\u1ed9t k\u00fd t\u1ef1 ADN \u0111\u01a1n l\u1ebb. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y vi\u1ec7c b\u1ed5 sung \u0111\u1ed9t bi\u1ebfn n\u00e0y c\u00f3 th\u1ec3 t\u01b0\u01a1ng \u0111\u1ed1i d\u1ec5 d\u00e0ng. Ti\u1ebfp theo, h\u1ecd \u0111\u00e3 n\u1ed7 l\u1ef1c ch\u1ec9nh s\u1eeda c\u00e1c t\u1ebf b\u00e0o n\u00e3o b\u1eb1ng k\u1ef9 thu\u1eadt CRISPR. V\u00e0 trong khi n\u1ed7 l\u1ef1c n\u00e0y t\u01b0\u01a1ng \u0111\u1ed1i th\u00e0nh c\u00f4ng, nh\u1eefng kh\u00eda c\u1ea1nh kh\u00e1c c\u1ee7a k\u1ef9 thu\u1eadt n\u00e0y \u0111\u00e3 th\u00fac \u0111\u1ea9y c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u1ed1 g\u1eafng th\u1ef1c hi\u1ec7n b\u01b0\u1edbc ch\u1ec9nh s\u1eeda quan tr\u1ecdng nh\u1ea5t. K\u1ef9 thu\u1eadt t\u01b0\u01a1ng \u0111\u1ed1i m\u1edbi n\u00e0y xem x\u00e9t \u0111\u1ebfn vi\u1ec7c chuy\u1ec3n \u0111\u1ed5i tr\u1ef1c ti\u1ebfp m\u1ed9t m\u1eabu t\u1ef1 c\u01a1 s\u1edf sang m\u1eabu t\u1ef1 c\u01a1 s\u1edf kh\u00e1c. V\u1edbi k\u1ef9 thu\u1eadt n\u00e0y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u nh\u1eadn th\u1ea5y r\u1eb1ng h\u1ecd c\u00f3 th\u1ec3 ch\u1ec9nh s\u1eeda kho\u1ea3ng 40% t\u1ebf b\u00e0o n\u00e3o trong \u1ed1ng nghi\u1ec7m.<\/p>\n\n\n\n

H\u1ecd l\u01b0u \u00fd r\u1eb1ng, m\u1eb7c d\u00f9 s\u1ed1 l\u01b0\u1ee3ng nh\u01b0 v\u1eady c\u00f3 kh\u1ea3 n\u0103ng kh\u00f4ng \u0111\u1ee7 l\u1edbn \u0111\u1ec3 ng\u0103n ch\u1eb7n s\u1ef1 t\u00edch t\u1ee5 beta-amyloid, v\u00e0 do \u0111\u00f3 kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 l\u00e0m ch\u1eadm s\u1ef1 kh\u1edfi ph\u00e1t c\u1ee7a b\u1ec7nh Alzheimer nh\u01b0ng nhi\u1ec1u nghi\u00ean c\u1ee9u h\u01a1n s\u1ebd mang l\u1ea1i c\u00e1c k\u1ebft qu\u1ea3 t\u1ed1t h\u01a1n.<\/p>\n\n\n\n

c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u nh\u1eadn th\u1ea5y r\u1eb1ng h\u1ecd c\u00f3 th\u1ec3 ch\u1ec9nh s\u1eeda kho\u1ea3ng 40% t\u1ebf b\u00e0o n\u00e3o trong \u1ed1ng nghi\u1ec7m. H\u1ecd l\u01b0u \u00fd r\u1eb1ng m\u1ed9t l\u01b0\u1ee3ng nh\u01b0 v\u1eady c\u00f3 kh\u1ea3 n\u0103ng kh\u00f4ng \u0111\u1ee7 cao \u0111\u1ec3 ng\u0103n ch\u1eb7n s\u1ef1 t\u00edch t\u1ee5 c\u1ee7a beta-amyloid v\u00e0 do \u0111\u00f3 kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 l\u00e0m ch\u1eadm s\u1ef1 kh\u1edfi ph\u00e1t c\u1ee7a b\u1ec7nh Alzheimer. Nh\u01b0ng nhi\u1ec1u nghi\u00ean c\u1ee9u h\u01a1n c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn k\u1ebft qu\u1ea3 t\u1ed1t h\u01a1n.<\/p>\n\n\n\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u0169ng l\u01b0u \u00fd r\u1eb1ng vi\u1ec7c ch\u1ec9nh s\u1eeda c\u00e1c t\u1ebf b\u00e0o n\u00e3o \u1edf ng\u01b0\u1eddi s\u1ebd c\u1ea7n ph\u1ea3i \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n th\u1ef1c hi\u1ec7n s\u1edbm b\u1edfi v\u00ec khi c\u00e1c tri\u1ec7u ch\u1ee9ng xu\u1ea5t hi\u1ec7n, c\u00f3 th\u1ec3 \u0111\u00e3 qu\u00e1 mu\u1ed9n \u0111\u1ec3 ti\u1ebfn h\u00e0nh ch\u1ec9nh s\u1eeda gen ng\u0103n ch\u1eb7n s\u1ef1 t\u00edch t\u1ee5 beta-amyloid.<\/p>\n\n\n\n

Nh\u00f3m nghi\u00ean c\u1ee9u c\u0169ng cho bi\u1ebft, nh\u1eefng n\u1ed7 l\u1ef1c trong t\u01b0\u01a1ng lai c\u00f3 th\u1ec3 ch\u1ec9 li\u00ean quan \u0111\u1ebfn vi\u1ec7c ch\u1ec9nh s\u1eeda AND \u1edf nh\u1eefng ng\u01b0\u1eddi \u0111\u01b0\u1ee3c coi l\u00e0 c\u00f3 nguy c\u01a1 m\u1eafc b\u1ec7nh khi h\u1ecd v\u1eabn c\u00f2n tr\u1ebb.<\/p>\n\n\n\n

P.T.T (NASATI)<\/em><\/p>\n\n\n\n

theo https:\/\/medicalxpress.com\/news\/2020-11-alzheimer-disease-key-gene-human.html, 30\/11\/2020<\/em><\/p>\n\n\n\n

https:\/\/www.vista.gov.vn\/news\/khoa-hoc-y-duoc\/chinh-sua-gen-quan-trong-trong-te-bao-than-kinh-cua-con-nguoi-co-the-ngan-ngua-benh-alzheimer-3140.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

M\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i \u0110\u1ea1i h\u1ecdc Laval \u0111\u00e3 t\u00ecm th\u1ea5y b\u1eb1ng ch\u1ee9ng cho th\u1ea5y c\u00f3 c\u01a1 h\u1ed9i ng\u0103n ch\u1eb7n Alzheimer ph\u00e1t tri\u1ec3n b\u1eb1ng c\u00e1ch ch\u1ec9nh s\u1eeda m\u1ed9t gen c\u00f3 vai tr\u00f2 quan tr\u1ecdng trong c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh. Trong b\u00e0i b\u00e1o \u0111\u01b0\u1ee3c \u0111\u0103ng l\u00ean bioRxiv, nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 m\u00f4 t\u1ea3 […]<\/p>\n","protected":false},"author":25,"featured_media":29828,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-27488","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/27488","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=27488"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/27488\/revisions"}],"predecessor-version":[{"id":29830,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/27488\/revisions\/29830"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/29828"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=27488"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=27488"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=27488"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}