{"id":27470,"date":"2020-11-06T15:54:00","date_gmt":"2020-11-06T08:54:00","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=27470"},"modified":"2021-11-10T08:14:14","modified_gmt":"2021-11-10T01:14:14","slug":"lieu-phap-te-bao-t-car-va-hieu-qua-dieu-tri-benh-nhan-u-lympho-khong-hodgkin","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/lieu-phap-te-bao-t-car-va-hieu-qua-dieu-tri-benh-nhan-u-lympho-khong-hodgkin\/","title":{"rendered":"Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR v\u00e0 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh nh\u00e2n u lympho kh\u00f4ng Hodgkin"},"content":{"rendered":"\n

M\u1ed9t li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 axicabtagene ciloleucel (axi-cel) \u0111\u00e3 \u0111\u1ea9y nh\u1eefng t\u1ebf b\u00e0o ung th\u01b0 \u0111\u1ebfn m\u1ee9c kh\u00f4ng th\u1ec3 ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c \u1edf g\u1ea7n 80% b\u1ec7nh nh\u00e2n b\u1ecb ung th\u01b0 h\u1ea1ch kh\u00f4ng Hodgkin (NHL) trong m\u1ed9t th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n 2, c\u00e1c nh\u00e0 \u0111i\u1ec1u tra c\u1ee7a Vi\u1ec7n Ung th\u01b0 Dana-Farber b\u00e1o c\u00e1o t\u1ea1i H\u1ed9i ngh\u1ecb th\u01b0\u1eddng ni\u00ean l\u1ea7n th\u1ee9 62 c\u1ee7a Hi\u1ec7p h\u1ed9i Huy\u1ebft h\u1ecdc Hoa K\u1ef3 (ASH).<\/p>\n\n\n\n

\"\"\/<\/figure><\/div>\n\n\n\n

Trong khi b\u1ec7nh ung th\u01b0 h\u1ea1ch kh\u00f4ng Hodgkin (NHL) c\u00f3 xu h\u01b0\u1edbng l\u00e0 m\u1ed9t b\u1ec7nh ph\u00e1t tri\u1ec3n ch\u1eadm, b\u1ec7nh nh\u00e2n th\u01b0\u1eddng t\u00e1i ph\u00e1t sau khi \u0111i\u1ec1u tr\u1ecb ti\u00eau chu\u1ea9n, nh\u1ea5n m\u1ea1nh s\u1ef1 c\u1ea7n thi\u1ebft c\u1ee7a c\u00e1c li\u1ec7u ph\u00e1p m\u1edbi. Theo c\u00e1c nh\u00e0 \u0111i\u1ec1u tra, hi\u1ec7u qu\u1ea3 c\u1ee7a Axi-cel \u0111\u1ed1i v\u1edbi nh\u1eefng ng\u01b0\u1eddi tham gia th\u1eed nghi\u1ec7m \u0111\u00e3 t\u00e1i ph\u00e1t ho\u1eb7c kh\u00e1ng l\u1ea1i c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c r\u1ea5t \u0111\u00e1ng kh\u00edch l\u1ec7. Gi\u00e1m \u0111\u1ed1c \u0111i\u1ec1u h\u00e0nh Caron Jacobson – d\u1eabn \u0111\u1ea7u nghi\u00ean c\u1ee9u cho bi\u1ebft: \u201cCh\u00fang t\u00f4i r\u1ea5t \u1ea5n t\u01b0\u1ee3ng v\u1edbi \u0111\u1ed9 m\u1ea1nh c\u1ee7a ph\u1ea3n \u1ee9ng v\u00e0 t\u00ednh b\u1ec1n. Ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0y c\u00f3 \u00fd ngh\u0129a cho nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 cao<\/em>\u201d.<\/p>\n\n\n\n

Axi-cel \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1eb1ng c\u00e1ch thu th\u1eadp m\u1ed9t s\u1ed1 t\u1ebf b\u00e0o T ch\u1ed1ng l\u1ea1i b\u1ec7nh v\u00e0 bi\u1ebfn \u0111\u1ed5i ch\u00fang v\u1ec1 m\u1eb7t di truy\u1ec1n \u0111\u1ec3 tri\u1ec3n khai m\u1ed9t th\u1ee5 th\u1ec3 chuy\u00ean bi\u1ec7t tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a ch\u00fang. Th\u1ee5 th\u1ec3 n\u00e0y cho ph\u00e9p c\u00e1c t\u1ebf b\u00e0o T \u0111\u00e3 bi\u1ebfn \u0111\u1ed5i – \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 th\u1ee5 th\u1ec3 kh\u00e1ng nguy\u00ean chimeric, ho\u1eb7c t\u1ebf b\u00e0o CAR T – b\u00e1m v\u00e0o c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 v\u00e0 ti\u00eau di\u1ec7t ch\u00fang. T\u1ebf b\u00e0o CAR T sau \u0111\u00f3 \u0111\u01b0\u1ee3c truy\u1ec1n v\u00e0o b\u1ec7nh nh\u00e2n. Trong c\u00e1c th\u1eed nghi\u1ec7m tr\u01b0\u1edbc \u0111\u00e2y \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb u lympho t\u1ebf b\u00e0o B l\u1edbn, li\u1ec7u ph\u00e1p n\u00e0y \u0111\u00e3 l\u00e0m gi\u1ea3m c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 xu\u1ed1ng d\u01b0\u1edbi m\u1ee9c c\u00f3 th\u1ec3 ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c, \u0111\u1ea1t \u0111\u01b0\u1ee3c “\u0111\u00e1p \u1ee9ng ho\u00e0n to\u00e0n” \u1edf nhi\u1ec1u b\u1ec7nh nh\u00e2n.<\/p>\n\n\n\n

Trong th\u1eed nghi\u1ec7m hi\u1ec7n t\u1ea1i, \u0111\u01b0\u1ee3c \u0111\u1eb7t t\u00ean l\u00e0 ZUMA-5, c\u00e1c nh\u00e0 \u0111i\u1ec1u tra \u0111\u00e3 s\u1eed d\u1ee5ng axi-cel cho 146 b\u1ec7nh nh\u00e2n b\u1ecb ung th\u01b0 h\u1ea1ch th\u1ec3 nang ho\u1eb7c ung th\u01b0 h\u1ea1ch v\u00f9ng r\u00eca; l\u00e0 hai d\u1ea1ng b\u1ec7nh b\u1ea1ch c\u1ea7u kh\u00f4ng Hodgkin ph\u00e1t tri\u1ec3n ch\u1eadm \u1edf nhi\u1ec1u trung t\u00e2m y t\u1ebf c\u1ee7a Hoa K\u1ef3. T\u1ea5t c\u1ea3 nh\u1eefng ng\u01b0\u1eddi tham gia \u0111\u1ec1u b\u1ecb ung th\u01b0 h\u1ea1ch ho\u1ea1t \u0111\u1ed9ng m\u1eb7c d\u00f9 \u0111\u00e3 tr\u1ea3i qua nhi\u1ec1u \u0111\u1ee3t \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc \u0111\u00f3.<\/p>\n\n\n\n

Trung b\u00ecnh 17,5 th\u00e1ng sau khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng axi-cel, 92% ng\u01b0\u1eddi tham gia th\u1eed nghi\u1ec7m c\u00f3 ph\u1ea3n \u1ee9ng kh\u00e1ch quan; gi\u1ea3m ung th\u01b0 c\u00f3 th\u1ec3 ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c v\u00e0 76% c\u00f3 ph\u1ea3n \u1ee9ng ho\u00e0n to\u00e0n. V\u00e0o ng\u00e0y gi\u1edbi h\u1ea1n thu th\u1eadp d\u1eef li\u1ec7u, 62% b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1eabn ti\u1ebfp t\u1ee5c ph\u1ea3n h\u1ed3i.<\/p>\n\n\n\n

H\u1ea7u h\u1ebft t\u1ea5t c\u1ea3 c\u00e1c b\u1ec7nh nh\u00e2n \u0111\u1ec1u g\u1eb7p ph\u1ea3i nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 b\u1ea5t l\u1ee3i, v\u1edbi 86% g\u1eb7p c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 t\u1eeb \u0111\u1ed9 3 tr\u1edf l\u00ean. 7% tr\u1ea3i qua h\u1ed9i ch\u1ee9ng gi\u1ea3i ph\u00f3ng cytokine c\u1ea5p \u0111\u1ed9 3 tr\u1edf l\u00ean v\u00e0 19% \u0111\u00e3 tr\u1ea3i qua c\u00e1c bi\u1ebfn c\u1ed1 th\u1ea7n kinh c\u1ea5p \u0111\u1ed9 3 tr\u1edf l\u00ean. T\u1ef7 l\u1ec7 \u0111\u00e1p \u1ee9ng cao h\u01a1n m\u1ed9t ch\u00fat v\u00e0 t\u1ef7 l\u1ec7 t\u00e1c d\u1ee5ng ngo\u1ea1i \u00fd th\u1ea5p h\u01a1n m\u1ed9t ch\u00fat \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n ung th\u01b0 h\u1ea1ch d\u1ea1ng nang so v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb ung th\u01b0 h\u1ea1ch v\u00f9ng r\u00eca.<\/p>\n\n\n\n

\u0110.T.V (NASATI)<\/em><\/p>\n\n\n\n

theo https:\/\/medicalxpress.com\/news\/2020-12-car-t-cell-therapy-highly-effective.html, 5\/11\/2020<\/em><\/p>\n\n\n\n

https:\/\/www.vista.gov.vn\/news\/cac-linh-vuc-khoa-hoc-va-cong-nghe\/lieu-phap-te-bao-t-car-hieu-qua-dieu-tri-benh-nhan-u-lympho-khong-hodgkin-3170.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

M\u1ed9t li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 axicabtagene ciloleucel (axi-cel) \u0111\u00e3 \u0111\u1ea9y nh\u1eefng t\u1ebf b\u00e0o ung th\u01b0 \u0111\u1ebfn m\u1ee9c kh\u00f4ng th\u1ec3 ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c \u1edf g\u1ea7n 80% b\u1ec7nh nh\u00e2n b\u1ecb ung th\u01b0 h\u1ea1ch kh\u00f4ng Hodgkin (NHL) trong m\u1ed9t th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n 2, c\u00e1c nh\u00e0 \u0111i\u1ec1u tra c\u1ee7a Vi\u1ec7n Ung […]<\/p>\n","protected":false},"author":25,"featured_media":29893,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-27470","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/27470","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=27470"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/27470\/revisions"}],"predecessor-version":[{"id":29895,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/27470\/revisions\/29895"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/29893"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=27470"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=27470"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=27470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}