{"id":26795,"date":"2021-03-29T09:55:21","date_gmt":"2021-03-29T02:55:21","guid":{"rendered":"http:\/\/ttud.com.vn\/?p=26795"},"modified":"2022-02-08T14:18:24","modified_gmt":"2022-02-08T07:18:24","slug":"viet-nam-lam-chu-cong-nghe-chinh-sua-gene-tren-dau-tuong","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/viet-nam-lam-chu-cong-nghe-chinh-sua-gene-tren-dau-tuong\/","title":{"rendered":"Vi\u1ec7t Nam l\u00e0m ch\u1ee7 c\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda gene tr\u00ean \u0111\u1eadu t\u01b0\u01a1ng"},"content":{"rendered":"\n

C\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda gene CRISPR\/Cas 9 l\u1ea7n \u0111\u1ea7u \u0111\u01b0\u1ee3c nh\u00e0 khoa h\u1ecdc Vi\u1ec7t \u00e1p d\u1ee5ng t\u1ea1o ra gi\u1ed1ng \u0111\u1eadu t\u01b0\u01a1ng m\u1edbi c\u00f3 l\u01b0\u1ee3ng \u0111\u01b0\u1eddng kh\u00f3 ti\u00eau th\u1ea5p h\u01a1n 25%.<\/p>\n\n\n\n

C\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda gene CRISPR\/Cas 9 hay c\u00f2n g\u1ecdi l\u1ea1i “chi\u1ebfc k\u00e9o ph\u00e2n t\u1eed” cho ph\u00e9p c\u00e1c nh\u00e0 khoa h\u1ecdc l\u1ef1a ch\u1ecdn gene t\u1ed1t \u0111\u1ec3 ph\u00e1t tri\u1ec3n. T\u1eeb n\u0103m 2019, PGS.TS Ph\u1ea1m B\u00edch Ng\u1ecdc v\u00e0 c\u1ed9ng s\u1ef1 t\u1ea1i Vi\u1ec7n C\u00f4ng ngh\u1ec7 Sinh h\u1ecdc, Vi\u1ec7n H\u00e0n l\u00e2m Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 Vi\u1ec7t Nam b\u1eaft \u0111\u1ea7u ti\u1ebfp c\u1eadn v\u00e0 s\u1eed d\u1ee5ng ch\u1ec9nh s\u1eeda gene tr\u00ean c\u00e2y \u0111\u1eadu t\u01b0\u01a1ng.<\/p>\n\n\n\n

\"Sau
Sau khi t\u1ea1o \u0111\u1ed9t bi\u1ebfn, c\u00e2y \u0111\u1eadu t\u01b0\u01a1ng \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n v\u00e0 nu\u00f4i d\u01b0\u1ee1ng trong ph\u00f2ng th\u00ed nghi\u1ec7m. \u1ea2nh: NX<\/em>.<\/figcaption><\/figure><\/div>\n\n\n\n

PGS Ng\u1ecdc v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u1eb7t m\u1ee5c ti\u00eau t\u1ea1o \u0111\u1ed9t bi\u1ebfn c\u00e1c gene m\u00e3 h\u00f3a cho enzyme Galactinol Synthase trong \u0111\u1eadu t\u01b0\u01a1ng \u0111\u1ec3 c\u00f3 th\u1ec3 gi\u1ea3m l\u01b0\u1ee3ng \u0111\u01b0\u1eddng kh\u00f3 ti\u00eau. Nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 t\u00ecm c\u00e1ch \u0111\u01b0a vi khu\u1ea9n v\u00e0o trong t\u1ebf b\u00e0o ch\u1ee7 \u0111\u1ec3 “k\u00e9o ph\u00e2n t\u1eed” c\u00f3 th\u1ec3 nh\u1eadn bi\u1ebft v\u00e0 t\u00ecm \u0111\u1ebfn \u0111\u00fang \u0111o\u1ea1n gene c\u1ea7n c\u1eaft. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y gi\u00fap h\u1ea1n ch\u1ebf t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o, b\u1ea3n l\u1eb7p c\u1ee7a gene chuy\u1ec3n so v\u1edbi ph\u01b0\u01a1ng ph\u00e1p c\u1eaft th\u00f4ng th\u01b0\u1eddng. C\u00e2y \u0111\u1eadu t\u01b0\u01a1ng mang \u0111\u1ed9t bi\u1ebfn ti\u1ebfp t\u1ee5c \u0111\u01b0\u1ee3c s\u00e0ng l\u1ecdc, \u0111\u00e1nh gi\u00e1 t\u00e1c \u0111\u1ed9ng \u0111\u1ed9t bi\u1ebfn, \u0111\u1eb7c \u0111i\u1ec3m sinh tr\u01b0\u1edfng, ph\u00e1t tri\u1ec3n v\u00e0 kh\u1ea3 n\u0103ng gi\u1ea3m l\u01b0\u1ee3ng \u0111\u01b0\u1eddng kh\u00f3 ti\u00eau.<\/p>\n\n\n\n

K\u1ebft qu\u1ea3 ph\u00e2n t\u00edch c\u1ee7a Vi\u1ec7n nghi\u00ean c\u1ee9u di truy\u1ec1n th\u1ef1c v\u1eadt v\u00e0 c\u00e2y tr\u1ed3ng \u0110\u1ee9c v\u1ec1 h\u00f3a sinh, nh\u00f3m ghi nh\u1eadn 4 d\u00f2ng \u0111\u1eadu t\u01b0\u01a1ng \u0111\u1ed9t bi\u1ebfn c\u00f3 t\u1ed5ng h\u00e0m l\u01b0\u1ee3ng \u0111\u01b0\u1eddng kh\u00f3 ti\u00eau th\u1ea5p h\u01a1n so v\u1edbi h\u1ea1t c\u1ee7a c\u00e2y kh\u00f4ng mang \u0111\u1ed9t bi\u1ebfn \u00edt nh\u1ea5t 25%. \u0110\u1ed9t bi\u1ebfn c\u00f3 l\u1ee3i n\u00e0y \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh c\u00f3 kh\u1ea3 n\u0103ng duy tr\u00ec trong c\u00e1c th\u1ebf h\u1ec7 ti\u1ebfp theo. K\u1ebft qu\u1ea3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed Frontiers in Plant Science.<\/p>\n\n\n\n

PGS Ng\u1ecdc cho bi\u1ebft, c\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda gen CRISPR\/Cas9 cho ph\u00e9p thay \u0111\u1ed5i ADN c\u1ee7a sinh v\u1eadt, l\u00e0 ph\u01b0\u01a1ng ph\u00e1p hi\u1ec7u qu\u1ea3 v\u00e0 ch\u00ednh x\u00e1c trong t\u1ea1o \u0111\u1ed9t bi\u1ebfn ph\u1ee5c v\u1ee5 ch\u1ecdn t\u1ea1o gi\u1ed1ng c\u00e2y tr\u1ed3ng. H\u1ec7 th\u1ed1ng n\u00e0y gi\u00fap c\u1eaft ch\u00ednh x\u00e1c c\u00e1c ph\u00e2n \u0111o\u1ea1n DNA t\u1ea1i v\u1ecb tr\u00ed nh\u1ea5t \u0111\u1ecbnh trong h\u1ec7 gene v\u00e0 t\u1ea1o hi\u1ec7n t\u01b0\u1ee3ng m\u1ea5t, ch\u00e8n \u0111o\u1ea1n ho\u1eb7c thay th\u1ebf v\u00e0o \u0111\u00f3 nh\u1eefng tr\u00ecnh t\u1ef1 ADN m\u1edbi.<\/p>\n\n\n\n

Sau khi ch\u1ecdn \u0111\u01b0\u1ee3c v\u1ecb tr\u00ed c\u1ea7n ch\u1ec9nh s\u1eeda trong h\u1ec7 gene c\u1ee7a t\u1ebf b\u00e0o ch\u1ee7, c\u1ea5u tr\u00fac CRISPR\/Cas9 \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf v\u00e0 chuy\u1ec3n v\u00e0o t\u1ebf b\u00e0o c\u1eaft s\u1eeda gene \u0111\u1ec3 t\u1ea1o c\u00e1c d\u00f2ng t\u1ebf b\u00e0o, c\u00e2y \u0111\u1ed9t bi\u1ebfn.<\/p>\n\n\n\n

“\u0110i\u1ec1u quan tr\u1ecdng nh\u1ea5t trong nghi\u00ean c\u1ee9u n\u00e0y \u0111\u1ec3 l\u00e0m ch\u1ee7 \u0111\u01b0\u1ee3c c\u00f4ng ngh\u1ec7 l\u00e0 thi\u1ebft k\u1ebf “k\u00e9o ph\u00e2n t\u1eed” ch\u1ee9a c\u00e1c tr\u00ecnh t\u1ef1 \u0111\u1ecbnh h\u01b0\u1edbng v\u00e0 chuy\u1ec3n \u0111\u01b0\u1ee3c c\u00e1c c\u1ea5u tr\u00fac n\u00e0y v\u00e0o gi\u1ed1ng \u0111\u1eadu t\u01b0\u01a1ng \u0110T26 trong n\u01b0\u1edbc, t\u1ea1o \u0111\u1ed9t bi\u1ebfn”, TS \u0110\u1ed7 Ti\u1ebfn Ph\u00e1t, th\u00e0nh vi\u00ean nh\u00f3m nghi\u00ean c\u1ee9u n\u00f3i. \u00d4ng cho bi\u1ebft, m\u1ed7i gi\u1ed1ng \u0111\u1eadu t\u01b0\u01a1ng c\u00f3 ph\u1ea3n \u1ee9ng kh\u00e1c nhau v\u1edbi quy tr\u00ecnh chuy\u1ec3n gene, ngo\u00e0i ra tr\u00ecnh t\u1ef1 c\u00e1c gene tr\u00ean c\u00e1c gi\u1ed1ng c\u0169ng c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n nh\u1eefng thay \u0111\u1ed5i nh\u1ea5t \u0111\u1ecbnh, v\u00ec v\u1eady c\u1ea7n ph\u00e2n t\u00edch k\u1ef9 tr\u00ecnh t\u1ef1 gene c\u0169ng nh\u01b0 t\u1ed1i \u01b0u quy tr\u00ecnh cho ph\u00f9 h\u1ee3p v\u1edbi m\u1ed7i \u0111\u1ed1i t\u01b0\u1ee3ng.<\/p>\n\n\n\n

M\u1ed7i n\u0103m Vi\u1ec7t Nam nh\u1eadp kh\u1ea9u h\u01a1n 90% \u0111\u1eadu t\u01b0\u01a1ng ch\u1ee7 y\u1ebfu ph\u1ee5c v\u1ee5 ch\u1ebf bi\u1ebfn th\u1ee9c \u0103n ch\u0103n nu\u00f4i. L\u00e0m ch\u1ee7 c\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda gene CRISPR\/Cas9 v\u00e0 b\u01b0\u1edbc \u0111\u1ea7u \u00e1p d\u1ee5ng th\u00e0nh c\u00f4ng tr\u00ean \u0111\u1eadu t\u01b0\u01a1ng, nh\u00f3m nghi\u00ean c\u1ee9u mong mu\u1ed1n \u0111\u01b0a c\u00f4ng ngh\u1ec7 \u0111\u1ec3 t\u1ea1o ra nh\u1eefng gi\u1ed1ng c\u00e2y kh\u00e1ng b\u1ec7nh cao v\u00e0 ch\u1ed1ng ch\u1ecbu \u0111i\u1ec1u ki\u1ec7n m\u00f4i tr\u01b0\u1eddng b\u1ea5t l\u1ee3i. Ngo\u00e0i h\u1ec7 th\u1ed1ng ch\u1ec9nh s\u1eeda gen CRISPR\/Cas9 tr\u00ean th\u1ef1c v\u1eadt, nh\u00f3m c\u0169ng \u0111ang nghi\u00ean c\u1ee9u ch\u1ec9nh s\u1eeda gene tr\u00ean vi sinh v\u1eadt \u1ee9ng d\u1ee5ng trong n\u00f4ng nghi\u1ec7p v\u00e0 y d\u01b0\u1ee3c.<\/p>\n\n\n\n

Nguy\u1ec5n Xu\u00e2n<\/strong><\/p>\n\n\n\n

https:\/\/vnexpress.net\/viet-nam-lam-chu-cong-nghe-chinh-sua-gene-tren-dau-tuong-4253370.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

C\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda gene CRISPR\/Cas 9 l\u1ea7n \u0111\u1ea7u \u0111\u01b0\u1ee3c nh\u00e0 khoa h\u1ecdc Vi\u1ec7t \u00e1p d\u1ee5ng t\u1ea1o ra gi\u1ed1ng \u0111\u1eadu t\u01b0\u01a1ng m\u1edbi c\u00f3 l\u01b0\u1ee3ng \u0111\u01b0\u1eddng kh\u00f3 ti\u00eau th\u1ea5p h\u01a1n 25%. C\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda gene CRISPR\/Cas 9 hay c\u00f2n g\u1ecdi l\u1ea1i “chi\u1ebfc k\u00e9o ph\u00e2n t\u1eed” cho ph\u00e9p c\u00e1c nh\u00e0 khoa h\u1ecdc l\u1ef1a ch\u1ecdn gene t\u1ed1t […]<\/p>\n","protected":false},"author":20,"featured_media":26796,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-26795","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/26795","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=26795"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/26795\/revisions"}],"predecessor-version":[{"id":30917,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/26795\/revisions\/30917"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/26796"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=26795"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=26795"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=26795"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}