{"id":26638,"date":"2021-02-03T16:44:50","date_gmt":"2021-02-03T09:44:50","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=26638"},"modified":"2022-02-08T11:01:36","modified_gmt":"2022-02-08T04:01:36","slug":"khang-sinh-mien-dich-tac-dung-kep-chong-khang-thuoc","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/khang-sinh-mien-dich-tac-dung-kep-chong-khang-thuoc\/","title":{"rendered":"Kh\u00e1ng sinh mi\u1ec5n d\u1ecbch t\u00e1c d\u1ee5ng k\u00e9p ch\u1ed1ng kh\u00e1ng thu\u1ed1c"},"content":{"rendered":"\n

C\u00e1c nh\u00e0 khoa h\u1ecdc c\u1ee7a Vi\u1ec7n Wistar t\u00ecm \u0111\u01b0\u1ee3c m\u1ed9t nh\u00f3m h\u1ee3p ch\u1ea5t m\u1edbi c\u00f3 k\u1ebft h\u1ee3p \u0111\u1ed9c \u0111\u00e1o, m\u1ed9t kh\u00e1ng sinh tr\u1ef1c ti\u1ebfp ti\u00eau di\u1ec7t c\u00e1c vi khu\u1ea9n kh\u00e1ng thu\u1ed1c, t\u1ea1o ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch nhanh ch\u00f3ng, \u0111\u1ed3ng th\u1eddi ch\u1ed1ng l\u1ea1i s\u1ef1 kh\u00e1ng thu\u1ed1c (AMR). Ph\u00e1t hi\u1ec7n n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 h\u00f4m nay tr\u00ean t\u1ea1p ch\u00ed Nature.<\/strong><\/h2>\n\n\n\n

Th\u1ebf h\u1ec7 kh\u00e1ng sinh m\u1edbi<\/strong><\/p>\n\n\n\n

T\u1ed5 ch\u1ee9c Y t\u1ebf Th\u1ebf gi\u1edbi (WHO) tuy\u00ean b\u1ed1, AMR l\u00e0 m\u1ed9t trong 10 m\u1ed1i \u0111e d\u1ecda s\u1ee9c kh\u1ecfe c\u1ed9ng \u0111\u1ed3ng<\/a> to\u00e0n c\u1ea7u. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u01b0\u1edbc t\u00ednh, \u0111\u1ebfn n\u0103m 2050, nh\u1eefng b\u1ec7nh nhi\u1ec5m tr\u00f9ng kh\u00e1ng thu\u1ed1c kh\u00e1ng sinh c\u00f3 th\u1ec3 khi\u1ebfn 10 tri\u1ec7u ng\u01b0\u1eddi thi\u1ec7t m\u1ea1ng m\u1ed7i n\u0103m, t\u1ea1o ra g\u00e1nh n\u1eb7ng t\u00edch l\u0169y 100 ngh\u00ecn t\u1ef7 USD cho n\u1ec1n kinh t\u1ebf to\u00e0n c\u1ea7u.<\/p>\n\n\n\n

Danh s\u00e1ch c\u00e1c vi khu\u1ea9n kh\u00e1ng t\u1ea5t c\u1ea3 c\u00e1c lo\u1ea1i kh\u00e1ng sinh hi\u1ec7n c\u00f3 ng\u00e0y c\u00e0ng gia t\u0103ng, g\u00e2y n\u00ean nhu c\u1ea7u b\u1ee9c thi\u1ebft v\u1ec1 nh\u1eefng lo\u1ea1i kh\u00e1ng sinh m\u1edbi, ng\u0103n ch\u1eb7n kh\u1ee7ng ho\u1ea3ng s\u1ee9c kh\u1ecfe c\u1ed9ng \u0111\u1ed3ng.<\/p>\n\n\n\n

\"\"<\/td><\/tr>
Vi khu\u1ea9n kh\u00e1ng thu\u1ed1c, nguy c\u01a1 l\u1edbn cho s\u1ee9c kh\u1ecfe c\u1ed9ng \u0111\u1ed3ng trong t\u01b0\u01a1ng lai g\u1ea7n.<\/em><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Farokh Dotiwala, b\u00e1c s\u0129, ph\u00f3 gi\u00e1o s\u01b0 v\u1ec1 Vaccine & Immunotherapy cho bi\u1ebft: \u201cCh\u00fang t\u00f4i th\u1ef1c hi\u1ec7n m\u1ed9t chi\u1ebfn l\u01b0\u1ee3c k\u00e9p, ph\u00e1t tri\u1ec3n nh\u1eefng ph\u00e2n t\u1eed m\u1edbi c\u00f3 th\u1ec3 ti\u00eau di\u1ec7t c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng kh\u00f3 \u0111i\u1ec1u tr\u1ecb \u0111\u1ed3ng th\u1eddi t\u0103ng c\u01b0\u1eddng ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch t\u1ef1 nhi\u00ean c\u1ee7a b\u1ec7nh nh\u00e2n. \u0110\u00e2y l\u00e0 m\u1ed9t th\u1ebf h\u1ec7 kh\u00e1ng sinh m\u1edbi v\u00e0 \u0111\u1eb7t t\u00ean l\u00e0 kh\u00e1ng sinh mi\u1ec5n d\u1ecbch t\u00e1c d\u1ee5ng k\u00e9p (DAIA).<\/p>\n\n\n\n

C\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1ng sinh hi\u1ec7n c\u00f3 t\u1ea5n c\u00f4ng v\u00e0o c\u00e1c ho\u1ea1t \u0111\u1ed9ng ch\u1ee9c n\u0103ng c\u1ea7n thi\u1ebft c\u1ee7a vi khu\u1ea9n nh\u01b0 t\u1ed5ng h\u1ee3p axit nucleic v\u00e0 protein, x\u00e2y d\u1ef1ng m\u00e0ng t\u1ebf b\u00e0o v\u00e0 c\u00e1c \u0111\u01b0\u1eddng trao \u0111\u1ed5i ch\u1ea5t. Nh\u01b0ng vi khu\u1ea9n c\u00f3 th\u1ec3 kh\u00e1ng thu\u1ed1c b\u1eb1ng c\u00e1ch l\u00e0m bi\u1ebfn \u0111\u1ed5i m\u1ee5c ti\u00eau m\u00e0 kh\u00e1ng sinh h\u01b0\u1edbng t\u1edbi, g\u00e2y b\u1ea5t ho\u1ea1t thu\u1ed1c ho\u1eb7c \u0111\u1ea9y thu\u1ed1c ra ngo\u00e0i.<\/p>\n\n\n\n

V\u00ec v\u1eady, c\u1ea7n khai th\u00e1c h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch \u0111\u1ec3 t\u1ea5n c\u00f4ng \u0111\u1ed3ng th\u1eddi vi khu\u1ea9n tr\u00ean hai m\u1eb7t tr\u1eadn kh\u00e1c nhau khi\u1ebfn ch\u00fang kh\u00f3 ph\u00e1t tri\u1ec3n kh\u1ea3 n\u0103ng \u0111\u1ec1 kh\u00e1ng.<\/p>\n\n\n\n

\u00d4ng v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p t\u1eadp trung v\u00e0o m\u1ed9t \u0111\u01b0\u1eddng trao \u0111\u1ed5i ch\u1ea5t c\u1ea7n thi\u1ebft cho h\u1ea7u h\u1ebft c\u00e1c vi khu\u1ea9n nh\u01b0ng kh\u00f4ng c\u00f3 \u1edf ng\u01b0\u1eddi, khi\u1ebfn \u0111\u01b0\u1eddng trao \u0111\u1ed5i ch\u1ea5t tr\u1edf th\u00e0nh m\u1ee5c ti\u00eau l\u00fd t\u01b0\u1edfng \u0111\u1ec3 ph\u00e1t tri\u1ec3n kh\u00e1ng sinh b\u00f3p ngh\u1eb9t vi khu\u1ea9n.<\/p>\n\n\n\n

\u0110\u01b0\u1eddng trao \u0111\u1ed5i ch\u1ea5t n\u00e0y, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 methyl-D-erythritol phosphate (MEP) ho\u1eb7c \u0111\u01b0\u1eddng kh\u00f4ng mevalonate, c\u00f3 ch\u1ee9c n\u0103ng sinh t\u1ed5ng h\u1ee3p isoprenoids, nh\u1eefng ph\u00e2n t\u1eed c\u1ea7n thi\u1ebft cho s\u1ef1 t\u1ed3n t\u1ea1i c\u1ee7a t\u1ebf b\u00e0o \u1edf h\u1ea7u h\u1ebft c\u00e1c vi khu\u1ea9n g\u00e2y b\u1ec7nh.<\/p>\n\n\n\n

K\u00edch ho\u1ea1t mi\u1ec5n d\u1ecbch<\/strong><\/p>\n\n\n\n

Trong ph\u00f2ng th\u00ed nghi\u1ec7m, c\u00e1c nh\u00e0 khoa h\u1ecdc nh\u1eafm \u0111\u1ebfn m\u1ee5c ti\u00eau enzym IspH, m\u1ed9t enzym thi\u1ebft y\u1ebfu trong qu\u00e1 tr\u00ecnh sinh t\u1ed5ng h\u1ee3p isoprenoid, t\u1ea5n c\u00f4ng ng\u0103n ch\u1eb7n \u0111\u01b0\u1eddng trao \u0111\u1ed5i ch\u1ea5t n\u00e0y v\u00e0 ti\u00eau di\u1ec7t vi khu\u1ea9n. Do s\u1ef1 hi\u1ec7n di\u1ec7n r\u1ed9ng r\u00e3i c\u1ee7a IspH trong th\u1ebf gi\u1edbi vi khu\u1ea9n, ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn n\u00e0y c\u00f3 th\u1ec3 ti\u00eau di\u1ec7t nhi\u1ec1u lo\u1ea1i vi khu\u1ea9n kh\u00e1c nhau.<\/p>\n\n\n\n

Nh\u00f3m nh\u00e0 nghi\u00ean c\u1ee9u s\u1eed d\u1ee5ng m\u00f4 h\u00ecnh m\u00e1y t\u00ednh s\u00e0ng l\u1ecdc h\u00e0ng tri\u1ec7u h\u1ee3p ch\u1ea5t c\u00f3 s\u1eb5n tr\u00ean th\u1ecb tr\u01b0\u1eddng v\u1ec1 kh\u1ea3 n\u0103ng li\u00ean k\u1ebft v\u1edbi enzym, ch\u1ecdn nh\u1eefng h\u1ee3p ch\u1ea5t m\u1ea1nh nh\u1ea5t \u1ee9c ch\u1ebf ch\u1ee9c n\u0103ng IspH l\u00e0m \u0111i\u1ec3m kh\u1edfi \u0111\u1ea7u cho vi\u1ec7c kh\u00e1m ph\u00e1 thu\u1ed1c kh\u00e1ng sinh m\u1edbi.<\/p>\n\n\n\n

Do nh\u1eefng ch\u1ea5t \u1ee9c ch\u1ebf IspH c\u00f3 s\u1eb5n tr\u01b0\u1edbc \u0111\u00e2y kh\u00f4ng th\u1ec3 x\u00e2m nh\u1eadp v\u00e0o th\u00e0nh t\u1ebf b\u00e0o vi khu\u1ea9n, Dotiwala ph\u1ed1i h\u1ee3p v\u1edbi nh\u00e0 h\u00f3a d\u01b0\u1ee3c h\u1ecdc Joseph Salvino thu\u1ed9c Wistar, gi\u00e1o s\u01b0 t\u1ea1i Trung t\u00e2m Ung th\u01b0 Vi\u1ec7n Wistar v\u00e0 l\u00e0 \u0111\u1ed3ng t\u00e1c gi\u1ea3 c\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u, \u0111\u1ec3 ph\u00e2n t\u00edch v\u00e0 t\u1ed5ng h\u1ee3p c\u00e1c ph\u00e2n t\u1eed \u1ee9c ch\u1ebf IspH m\u1edbi, c\u00f3 th\u1ec3 x\u00e2m nh\u1eadp v\u00e0o b\u00ean trong vi khu\u1ea9n.<\/p>\n\n\n\n

Nh\u00f3m nghi\u00ean c\u1ee9u ch\u1ee9ng minh \u0111\u01b0\u1ee3c, c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf IspH k\u00edch th\u00edch h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch v\u1edbi ho\u1ea1t t\u00ednh ti\u00eau di\u1ec7t vi khu\u1ea9n m\u1ea1nh h\u01a1n v\u00e0 \u0111\u1eb7c hi\u1ec7u h\u01a1n so v\u1edbi nh\u1eefng kh\u00e1ng sinh t\u1ed1t nh\u1ea5t hi\u1ec7n nay khi th\u1eed nghi\u1ec7m in vitro (trong \u1ed1ng nghi\u1ec7m) tr\u00ean c\u00e1c ch\u1ee7ng vi khu\u1ea9n kh\u00e1ng kh\u00e1ng sinh ph\u00e2n l\u1eadp l\u00e2m s\u00e0ng.<\/p>\n\n\n\n

Trong c\u00e1c m\u00f4 h\u00ecnh ti\u1ec1n l\u00e2m s\u00e0ng v\u1ec1 nhi\u1ec5m vi khu\u1ea9n gram \u00e2m, t\u00e1c d\u1ee5ng di\u1ec7t khu\u1ea9n c\u1ee7a nh\u1eefng ch\u1ea5t \u1ee9c ch\u1ebf IspH v\u01b0\u1ee3t tr\u1ed9i h\u01a1n so v\u1edbi c\u00e1c kh\u00e1ng sinh truy\u1ec1n th\u1ed1ng.<\/p>\n\n\n\n

\u0110\u1ed3ng th\u1eddi, t\u1ea5t c\u1ea3 c\u00e1c h\u1ee3p ch\u1ea5t th\u1eed nghi\u1ec7m \u0111\u00e3 ch\u1ee9ng minh l\u00e0 kh\u00f4ng \u0111\u1ed9c h\u1ea1i \u0111\u1ed1i v\u1edbi t\u1ebf b\u00e0o c\u1ee7a con ng\u01b0\u1eddi \u0111\u1ed3ng th\u1eddi l\u1ea1i k\u00edch th\u00edch kh\u1ea3 n\u0103ng mi\u1ec5n d\u1ecbch c\u1ee7a t\u1ebf b\u00e0o c\u01a1 th\u1ec3.<\/p>\n\n\n\n

“K\u00edch ho\u1ea1t mi\u1ec5n d\u1ecbch \u0111\u1ea1i di\u1ec7n cho \u0111\u1ee3t t\u1ea5n c\u00f4ng th\u1ee9 hai c\u1ee7a chi\u1ebfn l\u01b0\u1ee3c DAIA”, TS Kumar Singh, nghi\u00ean c\u1ee9u sinh sau ti\u1ebfn s\u0129 t\u1ea1i ph\u00f2ng th\u00ed nghi\u1ec7m Dotiwala v\u00e0 l\u00e0 t\u00e1c gi\u1ea3 ch\u00ednh c\u1ee7a nghi\u00ean c\u1ee9u cho bi\u1ebft.<\/p>\n\n\n\n

PGS Dotiwala nh\u1ea5n m\u1ea1nh: \u201cCh\u00fang t\u00f4i tin r\u1eb1ng chi\u1ebfn l\u01b0\u1ee3c s\u00e1ng t\u1ea1o DAIA c\u00f3 th\u1ec3 \u0111\u1ea1i di\u1ec7n cho b\u01b0\u1edbc ngo\u1eb7t ti\u1ec1m n\u0103ng trong cu\u1ed9c chi\u1ebfn ch\u1ed1ng l\u1ea1i AMR tr\u00ean to\u00e0n th\u1ebf gi\u1edbi, t\u1ea1o ra s\u1ee9c m\u1ea1nh t\u1ed5ng h\u1ee3p gi\u1eefa kh\u1ea3 n\u0103ng ti\u00eau di\u1ec7t vi khu\u1ea9n tr\u1ef1c ti\u1ebfp c\u1ee7a kh\u00e1ng sinh v\u00e0 s\u1ee9c m\u1ea1nh t\u1ef1 nhi\u00ean c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch.<\/p>\n\n\n\n

TH\u00c1I B\u1eb0NG<\/strong><\/p>\n\n\n\n

https:\/\/khoahocdoisong.vn\/khang-sinh-mien-dich-tac-dung-kep-chong-khang-thuoc-161972.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

C\u00e1c nh\u00e0 khoa h\u1ecdc c\u1ee7a Vi\u1ec7n Wistar t\u00ecm \u0111\u01b0\u1ee3c m\u1ed9t nh\u00f3m h\u1ee3p ch\u1ea5t m\u1edbi c\u00f3 k\u1ebft h\u1ee3p \u0111\u1ed9c \u0111\u00e1o, m\u1ed9t kh\u00e1ng sinh tr\u1ef1c ti\u1ebfp ti\u00eau di\u1ec7t c\u00e1c vi khu\u1ea9n kh\u00e1ng thu\u1ed1c, t\u1ea1o ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch nhanh ch\u00f3ng, \u0111\u1ed3ng th\u1eddi ch\u1ed1ng l\u1ea1i s\u1ef1 kh\u00e1ng thu\u1ed1c (AMR). Ph\u00e1t hi\u1ec7n n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 h\u00f4m nay […]<\/p>\n","protected":false},"author":23,"featured_media":26639,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-26638","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/26638","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=26638"}],"version-history":[{"count":4,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/26638\/revisions"}],"predecessor-version":[{"id":30912,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/26638\/revisions\/30912"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/26639"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=26638"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=26638"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=26638"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}