{"id":25948,"date":"2020-08-16T10:38:22","date_gmt":"2020-08-16T03:38:22","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=25948"},"modified":"2021-11-14T16:51:15","modified_gmt":"2021-11-14T09:51:15","slug":"nghien-cuu-moi-xac-dinh-21-loai-thuoc-hien-co-the-dieu-tri-covid-19","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/nghien-cuu-moi-xac-dinh-21-loai-thuoc-hien-co-the-dieu-tri-covid-19\/","title":{"rendered":"Nghi\u00ean c\u1ee9u m\u1edbi x\u00e1c \u0111\u1ecbnh 21 lo\u1ea1i thu\u1ed1c hi\u1ec7n c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb COVID-19"},"content":{"rendered":"\n

Nh\u00f3m nghi\u00ean c\u1ee9u to\u00e0n c\u1ea7u do GS. Sumit Chanda t\u1ea1i Vi\u1ec7n Kh\u00e1m ph\u00e1 thu\u1ed1c Sanford Burnham Prebys d\u1eabn \u0111\u1ea7u, \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c 21 lo\u1ea1i thu\u1ed1c hi\u1ec7n c\u00f3 kh\u1ea3 n\u0103ng ng\u0103n ch\u1eb7n s\u1ef1 nh\u00e2n l\u00ean c\u1ee7a SARS-CoV-2, virus g\u00e2y COVID-19.<\/p>\n\n\n\n

\"\"\/<\/figure><\/div>\n\n\n\n

C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 ph\u00e2n t\u00edch m\u1ed9t trong nh\u1eefng b\u1ed9 s\u01b0u t\u1eadp thu\u1ed1c l\u1edbn nh\u1ea5t th\u1ebf gi\u1edbi c\u00f3 kh\u1ea3 n\u0103ng ng\u0103n ch\u1eb7n s\u1ef1 nh\u00e2n l\u00ean c\u1ee7a SARS-CoV-2 v\u00e0 theo b\u00e1o c\u00e1o 100 ph\u00e2n t\u1eed c\u00f3 ho\u1ea1t t\u00ednh ch\u1ed1ng vi-r\u00fat \u0111\u01b0\u1ee3c x\u00e1c nh\u1eadn trong c\u00e1c th\u1eed nghi\u1ec7m t\u1ea1i lab. Trong \u0111\u00f3, 21 lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh c\u00f3 hi\u1ec7u qu\u1ea3 \u1edf n\u1ed3ng \u0111\u1ed9 v\u1eabn an to\u00e0n cho b\u1ec7nh nh\u00e2n. \u0110\u00e1ng ch\u00fa \u00fd, b\u1ed1n trong s\u1ed1 c\u00e1c h\u1ee3p ch\u1ea5t n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y c\u00f3 t\u00e1c d\u1ee5ng ph\u1ed1i h\u1ee3p c\u00f9ng v\u1edbi remdesivir, li\u1ec7u ph\u00e1p ch\u0103m s\u00f3c ti\u00eau chu\u1ea9n hi\u1ec7n nay cho COVID-19.<\/p>\n\n\n\n

“Remdesivir \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh th\u00e0nh c\u00f4ng trong vi\u1ec7c r\u00fat ng\u1eafn th\u1eddi gian ph\u1ee5c h\u1ed3i cho b\u1ec7nh nh\u00e2n n\u1eb1m vi\u1ec7n, nh\u01b0ng thu\u1ed1c kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng v\u1edbi t\u1ea5t c\u1ea3 m\u1ecdi ng\u01b0\u1eddi. \u0110i\u1ec1u \u0111\u00f3 ch\u01b0a \u0111\u1ee7 t\u1ed1t<\/em>“, GS. Chanda n\u00f3i. “Khi t\u1ef7 l\u1ec7 l\u00e2y nhi\u1ec5m ti\u1ebfp t\u1ee5c gia t\u0103ng \u1edf M\u1ef9 v\u00e0 tr\u00ean th\u1ebf gi\u1edbi, v\u1ea5n \u0111\u1ec1 c\u1ea5p b\u00e1ch l\u00e0 t\u00ecm ra nh\u1eefng lo\u1ea1i thu\u1ed1c gi\u00e1 c\u1ea3 ph\u1ea3i ch\u0103ng, hi\u1ec7u qu\u1ea3 v\u00e0 s\u1eb5n c\u00f3 s\u1eed d\u1ee5ng ph\u1ed1i h\u1ee3p v\u1edbi remdesivir, c\u0169ng nh\u01b0 c\u00e1c lo\u1ea1i thu\u1ed1c ph\u00f2ng ng\u1eeba ho\u1eb7c \u0111\u01b0\u1ee3c cung c\u1ea5p khi c\u00f3 d\u1ea5u hi\u1ec7u \u0111\u1ea7u ti\u00ean c\u1ee7a nhi\u1ec5m tr\u00f9ng tr\u00ean c\u01a1 s\u1edf ngo\u1ea1i tr\u00fa<\/em>“.<\/p>\n\n\n\n

Th\u1ef1c hi\u1ec7n th\u1eed nghi\u1ec7m m\u1edf r\u1ed9ng<\/em><\/p>\n\n\n\n

Trong nghi\u00ean c\u1ee9u, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 th\u1ef1c hi\u1ec7n c\u00e1c nghi\u00ean c\u1ee9u ki\u1ec3m tra v\u00e0 x\u00e1c nh\u1eadn m\u1edf r\u1ed9ng, bao g\u1ed3m \u0111\u00e1nh gi\u00e1 c\u00e1c lo\u1ea1i thu\u1ed1c tr\u00ean m\u1eabu sinh thi\u1ebft ph\u1ed5i ng\u01b0\u1eddi b\u1ecb nhi\u1ec5m virus, sau \u0111\u00f3 \u0111\u00e1nh gi\u00e1 c\u00e1c lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ph\u1ed1i h\u1ee3p c\u00f9ng remdesivir v\u00e0 thi\u1ebft l\u1eadp m\u1ed1i quan h\u1ec7 \u0111\u00e1p \u1ee9ng li\u1ec1u gi\u1eefa thu\u1ed1c v\u00e0 ho\u1ea1t t\u00ednh kh\u00e1ng vi-r\u00fat.<\/p>\n\n\n\n

Trong s\u1ed1 21 lo\u1ea1i thu\u1ed1c c\u00f3 hi\u1ec7u qu\u1ea3 ng\u0103n ch\u1eb7n s\u1ef1 nh\u00e2n l\u00ean c\u1ee7a vi-r\u00fat, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 t\u00ecm th\u1ea5y:<\/em><\/p>\n\n\n\n

\u2022 13 lo\u1ea1i thu\u1ed1c \u0111\u00e3 tr\u1ea3i qua c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1edbi nhi\u1ec1u d\u1ea5u hi\u1ec7u kh\u00e1c v\u00e0 c\u00f3 hi\u1ec7u qu\u1ea3 \u1edf n\u1ed3ng \u0111\u1ed9 ho\u1eb7c li\u1ec1u l\u01b0\u1ee3ng an to\u00e0n cho b\u1ec7nh nh\u00e2n COVID-19.<\/p>\n\n\n\n

\u2022 Hai lo\u1ea1i thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c C\u01a1 quan Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) th\u00f4ng qua: astemizole (d\u1ecb \u1ee9ng), clofazamine (b\u1ec7nh phong) v\u00e0 remdesivir \u0111\u01b0\u1ee3c ph\u00e9p s\u1eed d\u1ee5ng kh\u1ea9n c\u1ea5p t\u1eeb c\u01a1 quan n\u00e0y (COVID-19).<\/p>\n\n\n\n

\u2022 B\u1ed1n lo\u1ea1i thu\u1ed1c ho\u1ea1t \u0111\u1ed9ng ph\u1ed1i h\u1ee3p c\u00f9ng v\u1edbi remdesivir, bao g\u1ed3m c\u1ea3 d\u1eabn xu\u1ea5t chloroquine l\u00e0 hanfangchin A (tetrandrine), lo\u1ea1i thu\u1ed1c ch\u1ed1ng s\u1ed1t r\u00e9t \u0111\u00e3 \u0111\u1ea1t \u0111\u1ebfn th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n 3.<\/p>\n\n\n\n

GS. Chanda cho bi\u1ebft: “Nghi\u00ean c\u1ee9u n\u00e0y m\u1edf r\u1ed9ng \u0111\u00e1ng k\u1ec3 c\u00e1c l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb c\u00f3 th\u1ec3 cho b\u1ec7nh nh\u00e2n COVID-19, \u0111\u1eb7c bi\u1ec7t l\u00e0 v\u00ec nhi\u1ec1u ph\u00e2n t\u1eed \u0111\u00e3 c\u00f3 d\u1eef li\u1ec7u an to\u00e0n v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi. B\u00e1o c\u00e1o n\u00e0y cung c\u1ea5p cho c\u1ed9ng \u0111\u1ed3ng khoa h\u1ecdc m\u1ed9t kho v\u0169 kh\u00ed l\u1edbn ti\u1ec1m n\u0103ng \u0111\u1ec3 \u1ee9ng ph\u00f3 v\u1edbi \u0111\u1ea1i d\u1ecbch to\u00e0n c\u1ea7u \u0111ang di\u1ec5n ra<\/em>“.<\/p>\n\n\n\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u hi\u1ec7n \u0111ang th\u1eed nghi\u1ec7m 21 h\u1ee3p ch\u1ea5t trong c\u00e1c m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt nh\u1ecf v\u00e0 “ph\u1ed5i nh\u1ecf” ho\u1eb7c b\u1ed9 ph\u1eadn ph\u1ed5i m\u00f4 ph\u1ecfng m\u00f4 c\u1ee7a ng\u01b0\u1eddi. N\u1ebfu c\u00e1c nghi\u00ean c\u1ee9u n\u00e0y thu\u1eadn l\u1ee3i, nh\u00f3m nghi\u00ean c\u1ee9u s\u1ebd th\u1ea3o lu\u1eadn v\u1edbi FDA v\u1ec1 vi\u1ec7c tri\u1ec3n khai th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u00e1nh gi\u00e1 vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c l\u00e0m li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb COVID-19.<\/p>\n\n\n\n

GS. Chanda cho r\u1eb1ng: “D\u1ef1a v\u00e0o ph\u00e2n t\u00edch hi\u1ec7n t\u1ea1i c\u1ee7a ch\u00fang t\u00f4i, clofazimine, hanfangchin A, apilimod v\u00e0 ONO 5334 l\u00e0 nh\u1eefng l\u1ef1a ch\u1ecdn tr\u01b0\u1edbc m\u1eaft t\u1ed1t nh\u1ea5t \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb COVID-19 hi\u1ec7u qu\u1ea3. D\u00f9 m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c n\u00e0y hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng cho COVID-19, nh\u01b0ng ch\u00fang t\u00f4i tin r\u1eb1ng vi\u1ec7c ti\u1ebfp t\u1ee5c nghi\u00ean c\u1ee9u c\u00e1c lo\u1ea1i thu\u1ed1c \u1ee9ng vi\u00ean r\u1ea5t quan tr\u1ecdng. Ch\u00fang t\u00f4i s\u1ebd c\u00f3 nhi\u1ec1u l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb n\u1ebfu SARS-CoV-2 tr\u1edf n\u00ean kh\u00e1ng thu\u1ed1c<\/em>“.<\/p>\n\n\n\n

S\u00e0ng l\u1ecdc m\u1ed9t lo\u1ea1i thu\u1ed1c trong th\u01b0 vi\u1ec7n thu\u1ed1c l\u1edbn nh\u1ea5t th\u1ebf gi\u1edbi<\/em><\/p>\n\n\n\n

C\u00e1c lo\u1ea1i thu\u1ed1c n\u00e0y l\u1ea7n \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh b\u1eb1ng c\u00e1ch s\u00e0ng l\u1ecdc th\u00f4ng l\u01b0\u1ee3ng cao t\u1eeb h\u01a1n 12.000 lo\u1ea1i thu\u1ed1c trong ReFRAME – b\u1ed9 s\u01b0u t\u1eadp c\u00e1c h\u1ee3p ch\u1ea5t t\u00e1i ch\u1ebf thu\u1ed1c to\u00e0n di\u1ec7n nh\u1ea5t \u0111\u00e3 \u0111\u01b0\u1ee3c FDA ph\u00ea chu\u1ea9n cho c\u00e1c b\u1ec7nh kh\u00e1c ho\u1eb7c \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m r\u1ed9ng r\u00e3i an to\u00e0n cho con ng\u01b0\u1eddi.<\/p>\n\n\n\n

TS. Arnab Chatterjee, \u0111\u1ed3ng t\u00e1c gi\u1ea3 nghi\u00ean c\u1ee9u cho bi\u1ebft: “Ch\u00fang t\u00f4i s\u1edbm nh\u1eadn ra trong \u0111\u1ea1i d\u1ecbch COVID-19, ReFRAME s\u1ebd ngu\u1ed3n t\u00e0i nguy\u00ean v\u00f4 gi\u00e1 \u0111\u1ec3 s\u00e0ng l\u1ecdc c\u00e1c lo\u1ea1i thu\u1ed1c \u0111\u1ec3 t\u00e1i s\u1eed d\u1ee5ng ch\u1ed1ng virus corona m\u1edbi<\/em>“.<\/p>\n\n\n\n

N.P.D (NASATI), theo https:\/\/medicalxpress.com\/news\/2020-07-drugs-covid-.html<\/em><\/p>\n\n\n\n

ngu\u1ed3n: vista.gov.vn<\/p>\n\n\n\n

Nghi\u00ean c\u1ee9u m\u1edbi x\u00e1c \u0111\u1ecbnh 21 lo\u1ea1i thu\u1ed1c hi\u1ec7n c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb COVID-19 – C\u1ed5ng th\u00f4ng tin Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 (vista.gov.vn)<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Nh\u00f3m nghi\u00ean c\u1ee9u to\u00e0n c\u1ea7u do GS. Sumit Chanda t\u1ea1i Vi\u1ec7n Kh\u00e1m ph\u00e1 thu\u1ed1c Sanford Burnham Prebys d\u1eabn \u0111\u1ea7u, \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c 21 lo\u1ea1i thu\u1ed1c hi\u1ec7n c\u00f3 kh\u1ea3 n\u0103ng ng\u0103n ch\u1eb7n s\u1ef1 nh\u00e2n l\u00ean c\u1ee7a SARS-CoV-2, virus g\u00e2y COVID-19. C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 ph\u00e2n t\u00edch m\u1ed9t trong nh\u1eefng b\u1ed9 s\u01b0u t\u1eadp thu\u1ed1c l\u1edbn […]<\/p>\n","protected":false},"author":25,"featured_media":25949,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-25948","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/25948","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=25948"}],"version-history":[{"count":3,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/25948\/revisions"}],"predecessor-version":[{"id":29984,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/25948\/revisions\/29984"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/25949"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=25948"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=25948"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=25948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}