{"id":25884,"date":"2020-08-16T10:35:48","date_gmt":"2020-08-16T03:35:48","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=25884"},"modified":"2021-11-14T20:01:46","modified_gmt":"2021-11-14T13:01:46","slug":"phat-trien-cac-phan-tu-ngan-chan-kha-nang-lay-nhiem-cua-sars-cov-2","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/phat-trien-cac-phan-tu-ngan-chan-kha-nang-lay-nhiem-cua-sars-cov-2\/","title":{"rendered":"Ph\u00e1t tri\u1ec3n c\u00e1c ph\u00e2n t\u1eed ng\u0103n ch\u1eb7n kh\u1ea3 n\u0103ng l\u00e2y nhi\u1ec5m c\u1ee7a SARS-CoV-2"},"content":{"rendered":"\n

(khoahocdoisong.vn) – SARS-CoV-2, coronavirus g\u00e2y ra \u0111\u1ea1i d\u1ecbch Covid-19 to\u00e0n c\u1ea7u, s\u1eed d\u1ee5ng m\u1ed9t lo\u1ea1i protein, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 polymerase \u0111\u1ec3 sao ch\u00e9p b\u1ed9 gene virus trong t\u1ebf b\u00e0o ng\u01b0\u1eddi b\u1ecb nhi\u1ec5m b\u1ec7nh.<\/strong><\/h2>\n\n\n\n
\"Ph\u00e1t<\/figure><\/div>\n\n\n\n

Ch\u1eb7n ph\u1ea3n \u1ee9ng polymerase s\u1ebd ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a coronavirus<\/a>, h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch c\u1ee7a v\u1eadt ch\u1ee7 (ng\u01b0\u1eddi nhi\u1ec5m b\u1ec7nh) s\u1ebd nhanh ch\u00f3ng di\u1ec7t tr\u1eeb virus.<\/p>\n\n\n\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i Columbia Engineering thu\u1ed9c Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Columbia v\u00e0 \u0110\u1ea1i h\u1ecdc Wisconsin-Madison \u0111\u00e3 thu th\u1eadp m\u1ed9t th\u01b0 vi\u1ec7n nh\u1eefng ph\u00e2n t\u1eed d\u1eadp t\u1eaft \u0111\u01b0\u1ee3c ph\u1ea3n \u1ee9ng polymerase SARS-CoV-2<\/a>. \u0110\u00e2y l\u00e0 m\u1ed9t k\u1ebft qu\u1ea3 then ch\u1ed1t nh\u1eb1m x\u00e1c \u0111\u1ecbnh ti\u1ec1m n\u0103ng c\u1ee7a nh\u1eefng ph\u00e2n t\u1eed n\u00e0y nh\u01b0 c\u00e1c h\u1ee3p ch\u1ea5t tr\u1ecdng t\u00e2m, s\u1ebd \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh th\u00eam \u0111\u1ec3 ph\u00e1t tri\u1ec3n tr\u1ecb li\u1ec7u Covid-19.<\/p>\n\n\n\n

5 trong s\u1ed1 nh\u1eefng ph\u00e2n t\u1eed n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c FDA (C\u01a1 quan Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 Thu\u1ed1c<\/a> M\u1ef9) ph\u00ea chu\u1ea9n s\u1eed d\u1ee5ng \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh nhi\u1ec5m virus kh\u00e1c nh\u01b0 HIV\/AIDS, cytomegalovirus v\u00e0 vi\u00eam gan B. C\u00f4ng tr\u00ecnh Nghi\u00ean c\u1ee9u m\u1edbi \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 ng\u00e0y 18\/6\/2020 tr\u00ean T\u1ea1p ch\u00ed Nghi\u00ean c\u1ee9u ch\u1ed1ng virus (Antiviral Research).<\/p>\n\n\n\n

Theo nh\u00f3m nghi\u00ean c\u1ee9u \u0110\u1ea1i h\u1ecdc Columbia, ho\u1ea1t t\u00ednh triphosphate c\u1ee7a thu\u1ed1c vi\u00eam gan C Sofosbuvir v\u00e0 d\u1eabn xu\u1ea5t c\u1ee7a thu\u1ed1c c\u00f3 th\u1ec3 \u0111\u00f3ng vai tr\u00f2 l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf ti\u1ec1m n\u0103ng \u0111\u1ed1i v\u1edbi SARS-CoV-2 khi ti\u1ebfn h\u00e0nh ph\u00e2n t\u00edch nh\u1eefng \u0111\u1eb7c t\u00ednh ph\u00e2n t\u1eed v\u00e0 \u0111i\u1ec1u ki\u1ec7n sao ch\u00e9p gene c\u1ee7a c\u1ea3 virus vi\u00eam gan C v\u00e0 coronavirus.<\/p>\n\n\n\n

D\u1eabn \u0111\u1ea7u nh\u00f3m nghi\u00ean c\u1ee9u n\u00e0y l\u00e0 nh\u00e0 khoa h\u1ecdc Jingyue Ju, GS Samuel Ruben-Peter G. Viele thu\u1ed9c Columbia Engineering, gi\u00e1o s\u01b0 k\u1ef9 thu\u1eadt h\u00f3a h\u1ecdc v\u00e0 d\u01b0\u1ee3c l\u00fd, Gi\u00e1m \u0111\u1ed1c Trung t\u00e2m C\u00f4ng ngh\u1ec7 gene & K\u1ef9 thu\u1eadt ph\u00e2n t\u1eed sinh h\u1ecdc t\u1ea1i \u0110\u1ea1i h\u1ecdc Columbia. Nh\u00f3m Columbia \u0111\u00e3 h\u1ee3p t\u00e1c v\u1edbi Robert N. Kirchdoerfer, tr\u1ee3 l\u00fd gi\u00e1o s\u01b0 sinh h\u00f3a v\u00e0 l\u00e0 chuy\u00ean gia nghi\u00ean c\u1ee9u v\u1ec1 polymerase coronavirus t\u1ea1i Vi\u1ec7n Virus h\u1ecdc ph\u00e2n t\u1eed v\u00e0 Khoa h\u00f3a sinh thu\u1ed9c \u0110\u1ea1i h\u1ecdc Wisconsin-Madison.<\/p>\n\n\n\n

Trong h\u00e0ng lo\u1ea1t c\u00e1c th\u00ed nghi\u1ec7m tr\u01b0\u1edbc \u0111\u00f3, \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u0111\u1ec3 ki\u1ec3m tra nh\u1eefng thu\u1ed9c t\u00ednh c\u1ee7a polymerase coronavirus g\u00e2y ra d\u1ecbch SARS, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ph\u00e1t hi\u1ec7n ra r\u1eb1ng triphosphate c\u1ee7a thu\u1ed1c sofosbuvir c\u00f3 th\u1ec3 ng\u0103n ch\u1eb7n ph\u1ea3n \u1ee9ng polymerase c\u1ee7a virus.<\/p>\n\n\n\n

Nh\u00f3m c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 ch\u1ee9ng minh \u0111\u01b0\u1ee3c, sofosbuvir v\u00e0 4 ch\u1ea5t nucleotide t\u01b0\u01a1ng t\u1ef1 kh\u00e1c (d\u1ea1ng triphosphate ho\u1ea1t t\u00ednh c\u1ee7a c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf HIV Alovudine, Ziovudine, Tenofovir alafenamide v\u00e0 Emtricitabine) c\u0169ng ng\u0103n ch\u1eb7n polymerase SARS-CoV-2 \u1edf nh\u1eefng m\u1ee9c \u0111\u1ed9 kh\u00e1c nhau.<\/p>\n\n\n\n

S\u1eed d\u1ee5ng nh\u1eefng ph\u00e2n t\u00edch s\u00e2u c\u00e1c ph\u00e2n t\u1eed thu \u0111\u01b0\u1ee3c trong qu\u00e1 tr\u00ecnh nghi\u00ean c\u1ee9u, nh\u00f3m c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u01b0a ra ph\u01b0\u01a1ng ph\u00e1p l\u1ef1a ch\u1ecdn 11 ph\u00e2n t\u1eed nucleotide v\u1edbi nh\u1eefng t\u00ednh n\u0103ng c\u1ea5u tr\u00fac v\u00e0 \u0111\u1eb7c tr\u01b0ng h\u00f3a h\u1ecdc t\u01b0\u01a1ng t\u1ef1 l\u00e0m ch\u1ea5t \u1ee9c ch\u1ebf ti\u1ec1m n\u0103ng \u0111\u1ed1i v\u1edbi c\u00e1c polymerase c\u1ee7a SARS-CoV v\u00e0 SARS-CoV-2.<\/p>\n\n\n\n

Khi th\u1eed nghi\u1ec7m t\u1ea5t c\u1ea3 11 ph\u00e2n t\u1eed, 6 ph\u00e2n t\u1eed ch\u1ea5m d\u1ee9t ngay l\u1eadp t\u1ee9c ph\u1ea3n \u1ee9ng polymerase, 2 ph\u00e2n t\u1eed ch\u1ea5m d\u1ee9t c\u00e1c ph\u1ea3n \u1ee9ng polymerase ch\u1eadm v\u00e0 3 kh\u00f4ng ch\u1ea5m d\u1ee9t \u0111\u01b0\u1ee3c ph\u1ea3n \u1ee9ng polymerase.<\/p>\n\n\n\n

Ti\u1ec1n ch\u1ea5t thu\u1ed1c prodrug c\u1ee7a 5 trong s\u1ed1 c\u00e1c ch\u1ea5t nucleotide t\u01b0\u01a1ng t\u1ef1 n\u00e0y (Cidofovir, Abacavir, Valganciclovir\/Ganciclovir, Stavudine v\u00e0 Entecavir), ng\u0103n ch\u1eb7n ph\u1ea3n \u1ee9ng polymerase SARS-CoV-2 \u0111\u00e3 \u0111\u01b0\u1ee3c FDA ph\u00ea chu\u1ea9n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng kh\u00e1c.<\/p>\n\n\n\n

N\u1ebfu kh\u1ea3 n\u0103ng c\u1ee7a thu\u1ed1c \u1ee9c ch\u1ebf \u0111\u01b0\u1ee3c s\u1ef1 nh\u00e2n b\u1ea3n c\u1ee7a virus trong nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c ch\u1ee9ng minh trong c\u00e1c nghi\u00ean c\u1ee9u t\u01b0\u01a1ng lai, c\u00e1c ph\u00e2n t\u1eed \u1ee9ng vi\u00ean v\u00e0 c\u00e1c bi\u1ebfn th\u1ec3 c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng \u0111\u1ec3 ph\u00e1t tri\u1ec3n nh\u1eefng li\u1ec7u ph\u00e1p ch\u1eefa tr\u1ecb Covid-19 ti\u1ec1m n\u0103ng.<\/p>\n\n\n\n

TH\u00c1I B\u1eb0NG\u00a0<\/strong>ngu\u1ed3n: khoahocdoisong.vn<\/p>\n\n\n\n

Ph\u00e1t tri\u1ec3n c\u00e1c ph\u00e2n t\u1eed ng\u0103n ch\u1eb7n kh\u1ea3 n\u0103ng l\u00e2y nhi\u1ec5m c\u1ee7a SARS-CoV-2 – Khoa h\u1ecdc v\u00e0 \u0111\u1eddi s\u1ed1ng (khoahocdoisong.vn)<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

(khoahocdoisong.vn) – SARS-CoV-2, coronavirus g\u00e2y ra \u0111\u1ea1i d\u1ecbch Covid-19 to\u00e0n c\u1ea7u, s\u1eed d\u1ee5ng m\u1ed9t lo\u1ea1i protein, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 polymerase \u0111\u1ec3 sao ch\u00e9p b\u1ed9 gene virus trong t\u1ebf b\u00e0o ng\u01b0\u1eddi b\u1ecb nhi\u1ec5m b\u1ec7nh. Ch\u1eb7n ph\u1ea3n \u1ee9ng polymerase s\u1ebd ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a coronavirus, h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch c\u1ee7a v\u1eadt ch\u1ee7 (ng\u01b0\u1eddi nhi\u1ec5m b\u1ec7nh) s\u1ebd […]<\/p>\n","protected":false},"author":25,"featured_media":25885,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-25884","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/25884","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=25884"}],"version-history":[{"count":2,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/25884\/revisions"}],"predecessor-version":[{"id":29989,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/25884\/revisions\/29989"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/25885"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=25884"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=25884"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=25884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}