{"id":25655,"date":"2020-07-12T20:12:07","date_gmt":"2020-07-12T13:12:07","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=25655"},"modified":"2021-11-14T15:20:21","modified_gmt":"2021-11-14T08:20:21","slug":"xay-dung-quy-trinh-chiet-xuat-alkaloid-tu-la-du-du-carica-papaya-l-lam-nguyen-lieu-tao-che-pham-ho-tro-dieu-tri-ung-thu","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/xay-dung-quy-trinh-chiet-xuat-alkaloid-tu-la-du-du-carica-papaya-l-lam-nguyen-lieu-tao-che-pham-ho-tro-dieu-tri-ung-thu\/","title":{"rendered":"X\u00e2y d\u1ef1ng quy tr\u00ecnh chi\u1ebft xu\u1ea5t alkaloid t\u1eeb l\u00e1 \u0111u \u0111\u1ee7 Carica papaya L. l\u00e0m nguy\u00ean li\u1ec7u t\u1ea1o ch\u1ebf ph\u1ea9m h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0"},"content":{"rendered":"\n

B\u00e0i thu\u1ed1c s\u1eed d\u1ee5ng l\u00e1 \u0111u \u0111\u1ee7 trong h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0, \u0111\u00e3 \u0111\u01b0\u1ee3c ng\u01b0\u1eddi d\u00e2n \u1edf m\u1ed9t s\u1ed1 n\u01b0\u1edbc tr\u00ean th\u1ebf gi\u1edbi nh\u01b0 \u00dac, Mehico\u2026 v\u00e0 \u1edf Vi\u1ec7t Nam s\u1eed d\u1ee5ng. N\u0103m 2010, c\u00f4ng b\u1ed1 khoa h\u1ecdc c\u1ee7a t\u00e1c gi\u1ea3 Nam Dang v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p \u1edf Nh\u1eadt B\u1ea3n cho th\u1ea5y d\u1ecbch chi\u1ebft n\u01b0\u1edbc t\u1eeb l\u00e1 \u0111u \u0111\u1ee7 c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf ho\u1eb7c ti\u00eau di\u1ec7t m\u1ed9t s\u1ed1 d\u00f2ng t\u1ebf b\u00e0o ung th\u01b0. Nh\u1eefng nghi\u00ean c\u1ee9u kh\u1ea3o s\u00e1t b\u01b0\u1edbc \u0111\u1ea7u c\u1ee7a ch\u00fang t\u00f4i c\u0169ng cho th\u1ea5y trong s\u1ed1 c\u00e1c nh\u00f3m ch\u1ea5t c\u00f3 trong l\u00e1 \u0111u \u0111\u1ee7 nh\u01b0 flavonoid, saponin, alkaloid th\u00ec nh\u00f3m ch\u1ea5t alkaloid c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf t\u1ebf b\u00e0o ung th\u01b0 trong \u0111\u00f3 c\u00f3 ho\u1ea1t ch\u1ea5t carpaine – l\u00e0 th\u00e0nh ph\u1ea7n ch\u00ednh c\u1ee7a nh\u00f3m ch\u1ea5t alkaloid trong l\u00e1 \u0111u \u0111\u1ee7 c\u00f3 t\u00e1c d\u1ee5ng di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0.<\/p>\n\n\n\n

\"\"\/<\/figure><\/div>\n\n\n\n

V\u1edbi mong mu\u1ed1n g\u00f3p ph\u1ea7n nghi\u00ean c\u1ee9u s\u1ea3n xu\u1ea5t ch\u1ebf ph\u1ea9m t\u1eeb th\u1ef1c v\u1eadt n\u00f3i chung v\u00e0 t\u1eeb l\u00e1 \u0111u \u0111\u1ee7 n\u00f3i ri\u00eang, v\u1edbi \u0111\u1ea7y \u0111\u1ee7 nh\u1eefng minh ch\u1ee9ng khoa h\u1ecdc v\u1ec1 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n ho\u1eb7c c\u00e1c t\u1ebf b\u00e0o ung th\u01b0, nh\u1eb1m t\u1ea1o ra s\u1ef1 ti\u1ec7n l\u1ee3i khi s\u1eed d\u1ee5ng v\u00e0 gi\u00fap cho m\u1ecdi ng\u01b0\u1eddi c\u00f3 c\u01a1 s\u1edf khoa h\u1ecdc \u0111\u1ec3 tin t\u01b0\u1edfng h\u01a1n v\u00e0o c\u00e1c b\u00e0i thu\u1ed1c v\u00e0 v\u1ecb thu\u1ed1c \u0111ang \u0111\u01b0\u1ee3c ph\u1ed5 d\u1ee5ng hi\u1ec7n nay, nh\u00f3m nghi\u00ean c\u1ee9u t\u1ea1i Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc B\u00e1ch Khoa H\u00e0 N\u1ed9i do TS. V\u0169 H\u1ed3ng S\u01a1n<\/em><\/strong> l\u00e0m ch\u1ee7 nhi\u1ec7m, \u0111\u00e3 th\u1ef1c hi\u1ec7n \u0111\u1ec1 t\u00e0i: \u201cX\u00e2y d\u1ef1ng quy tr\u00ecnh chi\u1ebft xu\u1ea5t alkaloid t\u1eeb l\u00e1 \u0111u \u0111\u1ee7 Carica papaya L. l\u00e0m nguy\u00ean li\u1ec7u t\u1ea1o ch\u1ebf ph\u1ea9m h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0<\/em><\/strong>\u201d trong th\u1eddi gian t\u1eeb n\u0103m 2015 \u0111\u1ebfn 2017.<\/p>\n\n\n\n

Nh\u1eefng k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u ch\u00ednh c\u1ee7a \u0111\u1ec1 t\u00e0i \u0111\u01b0\u1ee3c t\u00f3m t\u1eaft nh\u01b0 sau:<\/em><\/p>\n\n\n\n

1. \u0110\u00e3 x\u00e2y d\u1ef1ng \u0111\u01b0\u1ee3c quy tr\u00ecnh chi\u1ebft xu\u1ea5t, tinh s\u1ea1ch v\u00e0 thu nh\u1eadn ch\u1ebf ph\u1ea9m h\u1ed7n h\u1ee3p alkaloid t\u1eeb l\u00e1 \u0111u \u0111\u1ee7 quy m\u00f4 20kg nguy\u00ean li\u1ec7u\/m\u1ebb v\u1edbi c\u00e1c th\u00f4ng s\u1ed1 k\u1ef9 thu\u1eadt th\u00edch h\u1ee3p. H\u00e0m l\u01b0\u1ee3ng alkaloid t\u1ed5ng s\u1ed1 \u0111\u1ea1t 0,2% so v\u1edbi nguy\u00ean li\u1ec7u kh\u00f4.<\/p>\n\n\n\n

2. \u0110\u00e3 ph\u00e2n l\u1eadp, tinh ch\u1ebf v\u00e0 x\u00e1c \u0111\u1ecbnh c\u1ea5u tr\u00fac c\u1ee7a 2 th\u00e0nh ph\u1ea7n alkaloid ch\u00ednh trong l\u00e1 \u0111u \u0111\u1ee7 l\u00e0 carpaine v\u00e0 pseudocarpaine. C\u00f3 \u0111\u1ea7y \u0111\u1ee7 b\u1ed9 ph\u1ed5 v\u00e0 d\u1eef li\u1ec7u ch\u1ee9ng minh c\u1ea5u tr\u00fac c\u1ee7a carpaine v\u00e0 pseudocarpaine.<\/p>\n\n\n\n

3. \u0110\u00e3 ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m 4 ho\u1ea1t t\u00ednh sinh h\u1ecdc c\u1ee7a h\u1ed7n h\u1ee3p alkaloid bao g\u1ed3m: ho\u1ea1t t\u00ednh kh\u00e1ng ung th\u01b0 in vivo, ho\u1ea1t t\u00ednh t\u0103ng c\u01b0\u1eddng kh\u1ea3 n\u0103ng mi\u1ec5n d\u1ecbch, \u0111\u1ed9c t\u00ednh c\u1ea5p v\u00e0 \u0111\u1ed9c t\u00ednh b\u00e1n tr\u01b0\u1eddng di\u1ec5n.<\/p>\n\n\n\n

4. \u0110\u00e3 x\u00e2y d\u1ef1ng \u0111\u01b0\u1ee3c ti\u00eau chu\u1ea9n c\u01a1 s\u1edf c\u1ee7a ch\u1ebf ph\u1ea9m h\u1ed7n h\u1ee3p alkaloid chi\u1ebft xu\u1ea5t t\u1eeb l\u00e1 \u0111u \u0111\u1ee7.<\/p>\n\n\n\n

5. K\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh theo ph\u01b0\u01a1ng ph\u00e1p l\u00e3o h\u00f3a c\u1ea5p t\u1ed1c cho th\u1ea5y ch\u1ebf ph\u1ea9m alkaloid chi\u1ebft xu\u1ea5t t\u1eeb l\u00e1 \u0111u \u0111\u1ee7 c\u00f3 th\u1ec3 \u1ed5n \u0111\u1ecbnh ch\u1ea5t l\u01b0\u1ee3ng trong \u0111i\u1ec1u ki\u1ec7n b\u1ea3o qu\u1ea3n \u1edf nhi\u1ec7t \u0111\u1ed9 th\u01b0\u1eddng trong 24 th\u00e1ng.<\/p>\n\n\n\n

6. \u0110\u00e3 chi\u1ebft xu\u1ea5t 1 kg h\u1ed7n h\u1ee3p alkaloid t\u1eeb l\u00e1 \u0111u \u0111\u1ee7 (d\u00f9ng \u0111\u1ec3 ph\u00e2n t\u00edch, x\u00e2y d\u1ef1ng TCCS; th\u1eed nghi\u1ec7m c\u00e1c ho\u1ea1t t\u00ednh sinh h\u1ecdc, th\u1eed nghi\u1ec7m \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh). H\u00e0m l\u01b0\u1ee3ng carpaine v\u00e0 pseudocarpaine trong h\u1ed7n h\u1ee3p alkaloid \u0111\u1ea1t 63%.<\/p>\n\n\n\n

C\u00f3 th\u1ec3 t\u00ecm \u0111\u1ecdc to\u00e0n v\u0103n B\u00e1o c\u00e1o k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u c\u1ee7a \u0110\u1ec1 t\u00e0i (M\u00e3 s\u1ed1 15431) t\u1ea1i C\u1ee5c Th\u00f4ng tin Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 Qu\u1ed1c gia.<\/em><\/p>\n\n\n\n

N.P.D (NASATI)<\/em> ngu\u1ed3n: vista.gov.vn<\/p>\n\n\n\n

X\u00e2y d\u1ef1ng quy tr\u00ecnh chi\u1ebft xu\u1ea5t alkaloid t\u1eeb l\u00e1 \u0111u \u0111\u1ee7 Carica papaya L. l\u00e0m nguy\u00ean li\u1ec7u t\u1ea1o ch\u1ebf ph\u1ea9m h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 – C\u1ed5ng th\u00f4ng tin Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 (vista.gov.vn)<\/a>
<\/p>\n","protected":false},"excerpt":{"rendered":"

B\u00e0i thu\u1ed1c s\u1eed d\u1ee5ng l\u00e1 \u0111u \u0111\u1ee7 trong h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0, \u0111\u00e3 \u0111\u01b0\u1ee3c ng\u01b0\u1eddi d\u00e2n \u1edf m\u1ed9t s\u1ed1 n\u01b0\u1edbc tr\u00ean th\u1ebf gi\u1edbi nh\u01b0 \u00dac, Mehico\u2026 v\u00e0 \u1edf Vi\u1ec7t Nam s\u1eed d\u1ee5ng. N\u0103m 2010, c\u00f4ng b\u1ed1 khoa h\u1ecdc c\u1ee7a t\u00e1c gi\u1ea3 Nam Dang v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p \u1edf Nh\u1eadt B\u1ea3n cho th\u1ea5y d\u1ecbch […]<\/p>\n","protected":false},"author":25,"featured_media":25656,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-25655","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/25655","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=25655"}],"version-history":[{"count":3,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/25655\/revisions"}],"predecessor-version":[{"id":29926,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/25655\/revisions\/29926"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/25656"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=25655"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=25655"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=25655"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}