{"id":14678,"date":"2018-11-28T16:16:53","date_gmt":"2018-11-28T09:16:53","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=14678"},"modified":"2018-11-28T16:16:53","modified_gmt":"2018-11-28T09:16:53","slug":"nghien-cuu-xa-tri-ung-thu-se-hieu-qua-hon-neu-ket-hop-mot-loai-thuoc-gian-co-150-nam-tuoi","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/nghien-cuu-xa-tri-ung-thu-se-hieu-qua-hon-neu-ket-hop-mot-loai-thuoc-gian-co-150-nam-tuoi\/","title":{"rendered":"Nghi\u00ean c\u1ee9u: X\u1ea1 tr\u1ecb ung th\u01b0 s\u1ebd hi\u1ec7u qu\u1ea3 h\u01a1n n\u1ebfu k\u1ebft h\u1ee3p m\u1ed9t lo\u1ea1i thu\u1ed1c gi\u00e3n c\u01a1 150 n\u0103m tu\u1ed5i"},"content":{"rendered":"
<\/div>\n

Lo\u1ea1i thu\u1ed1c n\u00e0y c\u1ea7n \u0111\u01b0\u1ee3c tinh ch\u1ec9nh tr\u01b0\u1edbc khi tr\u1edf l\u1ea1i trong vai tr\u00f2 m\u1edbi.<\/h2>\n
M\u1ed9t lo\u1ea1i thu\u1ed1c gi\u00e3n c\u01a1 150 n\u0103m tu\u1ed5i c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111\u01b0a tr\u1edf l\u1ea1i m\u00f4i tr\u01b0\u1eddng y t\u1ebf hi\u1ec7n \u0111\u1ea1i v\u1edbi m\u1ed9t vai tr\u00f2 ho\u00e0n to\u00e0n m\u1edbi: T\u0103ng c\u01b0\u1eddng \u0111i\u1ec1u tr\u1ecb ung th\u01b0 b\u1eb1ng x\u1ea1 tr\u1ecb.<\/div>\n
\n

Ch\u00fang ta bi\u1ebft x\u1ea1 tr\u1ecb gi\u1ebft ch\u1ebft t\u1ebf b\u00e0o ung th\u01b0 b\u1eb1ng c\u00e1ch b\u1eafn ph\u00e1 DNA c\u1ee7a ch\u00fang. Nh\u01b0ng ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u00f3 m\u1ed9t nh\u01b0\u1ee3c \u0111i\u1ec3m l\u1edbn: C\u00e1c tia x\u1ea1 kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng t\u1ed1t tr\u00ean c\u00e1c m\u00f4 b\u1ecb thi\u1ebfu h\u1ee5t oxy.<\/p>\n

Tr\u1edb tr\u00eau thay, c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 l\u1ea1i l\u00e0 n\u01a1i m\u00e0 oxy b\u1ecb thi\u1ebfu h\u1ee5t nhi\u1ec1u nh\u1ea5t, d\u1eabn \u0111\u1ebfn vi\u1ec7c x\u1ea1 tr\u1ecb nhi\u1ec1u khi gi\u1ebft ch\u1ebft t\u1ebf b\u00e0o l\u00e0nh h\u01a1n l\u00e0 t\u1ebf b\u00e0o b\u1ec7nh.<\/p>\n

B\u00e2y gi\u1edd, m\u1ed9t nghi\u00ean c\u1ee9u m\u1edbi \u0111\u0103ng trong K\u1ef7 y\u1ebfu Vi\u1ec7n H\u00e0n l\u00e2m Khoa h\u1ecdc Qu\u1ed1c gia Hoa K\u1ef3 c\u00f3 th\u1ec3 gi\u1ea3i quy\u1ebft v\u1ea5n \u0111\u1ec1 n\u00e0y. C\u00e1c nh\u00e0 khoa h\u1ecdc ph\u00e1t hi\u1ec7n papaverine, lo\u1ea1i thu\u1ed1c gi\u00e3n c\u01a1 kh\u00e1 c\u0169 c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf vi\u1ec7c s\u1eed d\u1ee5ng oxy c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0, t\u0103ng t\u00e1c \u0111\u1ed9ng c\u1ee7a x\u1ea1 tr\u1ecb l\u00ean c\u00e1c v\u00f9ng kh\u00f3 ti\u1ebfp c\u1eadn.<\/p>\n

\n
\"Nghi\u00ean<\/div>\n
\n

M\u1eb7c d\u00f9 \u0111\u01b0\u1ee3c bao quanh b\u1edfi nhi\u1ec1u m\u1ea1ch m\u00e1u, s\u1ef1 ph\u00e1t tri\u1ec3n qu\u00e1 nhanh c\u1ee7a ung th\u01b0 khi\u1ebfn t\u1ebf b\u00e0o kh\u1ed1i u lu\u00f4n thi\u1ebfu h\u1ee5t oxy<\/p>\n<\/div>\n<\/div>\n

“H\u01a1n m\u1ed9t n\u1eeda s\u1ed1 ng\u01b0\u1eddi m\u1ee9c ung th\u01b0 s\u1edbm mu\u1ed9n \u0111\u1ec1u ph\u1ea3i \u0111\u01b0\u1ee3c x\u1ea1 tr\u1ecb<\/i>“, t\u00e1c gi\u1ea3 nghi\u00ean c\u1ee9u Nicholas Denko \u0111\u1ebfn t\u1eeb t\u1ea1i \u0110\u1ea1i h\u1ecdc bang Ohio, Hoa K\u1ef3 n\u00f3i. “Nh\u01b0ng t\u00ecnh tr\u1ea1ng thi\u1ebfu oxy s\u1ebd h\u1ea1n ch\u1ebf hi\u1ec7u qu\u1ea3 c\u1ee7a x\u1ea1 tr\u1ecb, v\u00e0 \u0111\u00f3 l\u00e0 m\u1ed9t v\u1ea5n \u0111\u1ec1 l\u00e2m s\u00e0ng nghi\u00eam tr\u1ecdng<\/i>“.<\/p>\n

Nghi\u00ean c\u1ee9u ch\u1ec9 ra t\u1ebf b\u00e0o ung th\u01b0 ph\u00e1t tri\u1ec3n c\u1ef1c k\u1ef3 nhanh ch\u00f3ng, b\u1edfi v\u1eady, ch\u00fang ti\u00eau th\u1ee5 r\u1ea5t nhi\u1ec1u oxy v\u00e0 th\u01b0\u1eddng r\u01a1i v\u00e0o t\u00ecnh tr\u1ea1ng thi\u1ebfu h\u1ee5t. C\u0169ng v\u00ec l\u00ed do n\u00e0y m\u00e0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p h\u00f3a x\u1ea1 tr\u1ecb b\u1ecb gi\u1ea3m hi\u1ec7u qu\u1ea3.<\/p>\n

“N\u1ebfu t\u1ebf b\u00e0o \u00e1c t\u00ednh trong c\u00e1c khu v\u1ef1c thi\u1ebfu oxy c\u1ee7a m\u1ed9t kh\u1ed1i u s\u1ed1ng s\u00f3t \u0111\u01b0\u1ee3c sau qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1ee9c x\u1ea1, ch\u00fang c\u00f3 th\u1ec3 tr\u1edf th\u00e0nh m\u1ed9t ngu\u1ed3n khi\u1ebfn kh\u1ed1i u t\u00e1i ph\u00e1t<\/i>“, Denko n\u00f3i. “\u0110i\u1ec1u quan tr\u1ecdng l\u00e0 ch\u00fang t\u00f4i \u0111\u00e3 t\u00ecm c\u00e1ch \u0111\u1ec3 v\u01b0\u1ee3t qua h\u00ecnh th\u1ee9c kh\u00e1ng thu\u1ed1c n\u00e0y<\/i>“.<\/p>\n

Su\u1ed1t 6 th\u1eadp k\u1ef7 qua, c\u00e1c nh\u00e0 khoa h\u1ecdc kh\u00e1c \u0111\u00e3 c\u1ed1 g\u1eafng kh\u1eafc ph\u1ee5c nh\u01b0\u1ee3c \u0111i\u1ec3m c\u1ee7a x\u1ea1 tr\u1ecb li\u00ean quan \u0111\u1ebfn oxy trong m\u00f4. M\u1ee5c ti\u00eau c\u1ee7a h\u1ecd l\u00e0 cung c\u1ea5p nhi\u1ec1u oxy h\u01a1n cho kh\u1ed1i u.<\/p>\n

Nh\u01b0ng h\u01b0\u1edbng \u0111i n\u00e0y \u00edt th\u00e0nh c\u00f4ng \u2013 b\u1edfi c\u00e1c kh\u1ed1i u ph\u00e1t tri\u1ec3n qu\u00e1 nhanh v\u00e0 l\u01b0\u1ee3ng m\u1ea1ch m\u00e1u cung c\u1ea5p oxy cho ch\u00fang lu\u00f4n lu\u00f4n kh\u00f4ng \u0111\u1ee7. M\u1eb7t kh\u00e1c, cung c\u1ea5p th\u00eam oxy cho ung th\u01b0 kh\u00e1c n\u00e0o th\u00fac \u0111\u1ea7y ch\u00fang ph\u00e1t tri\u1ec3n.<\/p>\n

“V\u00ec v\u1eady, ch\u00fang t\u00f4i \u0111\u00e3 \u0111i theo h\u01b0\u1edbng ng\u01b0\u1ee3c l\u1ea1i<\/i>\u00a0“, Denko n\u00f3i. “Thay v\u00ec c\u1ed1 g\u1eafng t\u0103ng ngu\u1ed3n cung c\u1ea5p oxy, ch\u00fang t\u00f4i \u0111\u00e3 gi\u1ea3m nhu c\u1ea7u oxy c\u1ee7a ch\u00fang xu\u1ed1ng<\/i>“. V\u00e0 \u00f4ng l\u00e0m \u0111i\u1ec1u \u0111\u00f3 b\u1eb1ng m\u1ed9t lo\u1ea1i thu\u1ed1c gi\u00e3n c\u01a1 \u0111\u00e3 c\u00f3 tu\u1ed5i \u0111\u1eddi 150 n\u0103m.<\/p>\n

\n
\"Nghi\u00ean<\/div>\n
\n

T\u00e1c gi\u1ea3 nghi\u00ean c\u1ee9u Nicholas Denko \u0111\u1ebfn t\u1eeb t\u1ea1i \u0110\u1ea1i h\u1ecdc bang Ohio, Hoa K\u1ef3<\/p>\n<\/div>\n<\/div>\n

Papaverine, t\u00ean c\u1ee7a lo\u1ea1i thu\u1ed1c, ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf s\u1ef1 h\u00f4 h\u1ea5p c\u1ee7a ty l\u1ea1p th\u1ec3 – m\u1ed9t c\u01a1 quan n\u1ed9i b\u00e0o c\u00f3 m\u1eb7t \u1edf c\u1ea3 t\u1ebf b\u00e0o th\u01b0\u1eddng v\u00e0 t\u1ebf b\u00e0o ung th\u01b0 s\u1eed d\u1ee5ng oxy v\u00e0 t\u1ea1o ra n\u0103ng l\u01b0\u1ee3ng.<\/p>\n

B\u1eb1ng c\u00e1ch gi\u1ea3m l\u01b0\u1ee3ng oxy m\u00e0 c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 ti\u00eau th\u1ee5 theo c\u00e1ch n\u00e0y, papaverine \u0111\u00e3 l\u00e0m gi\u1ea3m t\u00ecnh tr\u1ea1ng thi\u1ebfu oxy trong t\u1ebf b\u00e0o ung th\u01b0 v\u00e0 c\u1ea3i thi\u1ec7n hi\u1ec7u qu\u1ea3 x\u1ea1 tr\u1ecb tr\u00ean c\u00e1c kh\u1ed1i u m\u00f4 h\u00ecnh trong th\u00ed nghi\u1ec7m.<\/p>\n

Tuy\u1ec7t v\u1eddi h\u01a1n n\u1eefa, lo\u1ea1i thu\u1ed1c n\u00e0y kh\u00f4ng g\u00e2y t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn c\u00e1c m\u00f4 b\u00ecnh th\u01b0\u1eddng \u0111ang s\u1eed d\u1ee5ng oxy hi\u1ec7u qu\u1ea3- n\u00f3 ch\u1ec9 nh\u1eafm v\u00e0o c\u00e1c m\u00f4 \u0111ang thi\u1ebfu oxy m\u00e0 th\u00f4i.<\/p>\n

“Ch\u00fang t\u00f4i th\u1ea5y r\u1eb1ng m\u1ed9t li\u1ec1u papaverine tr\u01b0\u1edbc khi x\u1ea1 tr\u1ecb l\u00e0m gi\u1ea3m h\u00f4 h\u1ea5p ty th\u1ec3, gi\u1ea3m t\u00ecnh tr\u1ea1ng thi\u1ebfu oxy m\u00e1u, v\u00e0 l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 ph\u1ea3n \u1ee9ng c\u1ee7a c\u00e1c kh\u1ed1i u ung th\u01b0 m\u00f4 h\u00ecnh \u0111\u1ed1i v\u1edbi b\u1ee9c x\u1ea1<\/i>“, Denko cho bi\u1ebft.<\/p>\n

Nh\u00f3m nghi\u00ean c\u1ee9u c\u1ee7a \u00f4ng c\u0169ng n\u00eau ra \u00fd t\u01b0\u1edfng \u0111\u1ec3 tinh ch\u1ec9nh l\u1ea1i ph\u00e2n t\u1eed thu\u1ed1c papaverine nh\u1eb1m c\u1ea3i thi\u1ec7n hi\u1ec7u qu\u1ea3 c\u0169ng nh\u01b0 gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a n\u00f3. D\u00f9 g\u00ec, lo\u1ea1i thu\u1ed1c n\u00e0y c\u0169ng ra \u0111\u1eddi t\u1eeb c\u00e1ch \u0111\u00e2y 150 n\u0103m v\u00e0 c\u1ea7n ph\u1ea3i \u0111\u01b0\u1ee3c l\u00e0m m\u1edbi \u0111\u1ec3 ph\u00f9 h\u1ee3p h\u01a1n v\u1edbi m\u00f4i tr\u01b0\u1eddng l\u00e2m s\u00e0ng hi\u1ec7n t\u1ea1i.<\/p>\n

Tham kh\u1ea3o\u00a0Sciencealert<\/i><\/p>\n

B\u00c1O \u0110I\u1ec6N T\u1eec TR\u00cd TH\u1ee8C TR\u1eba<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Lo\u1ea1i thu\u1ed1c n\u00e0y c\u1ea7n \u0111\u01b0\u1ee3c tinh ch\u1ec9nh tr\u01b0\u1edbc khi tr\u1edf l\u1ea1i trong vai tr\u00f2 m\u1edbi. M\u1ed9t lo\u1ea1i thu\u1ed1c gi\u00e3n c\u01a1 150 n\u0103m tu\u1ed5i c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111\u01b0a tr\u1edf l\u1ea1i m\u00f4i tr\u01b0\u1eddng y t\u1ebf hi\u1ec7n \u0111\u1ea1i v\u1edbi m\u1ed9t vai tr\u00f2 ho\u00e0n to\u00e0n m\u1edbi: T\u0103ng c\u01b0\u1eddng \u0111i\u1ec1u tr\u1ecb ung th\u01b0 b\u1eb1ng x\u1ea1 tr\u1ecb. Ch\u00fang ta bi\u1ebft x\u1ea1 […]<\/p>\n","protected":false},"author":18,"featured_media":14679,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-14678","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/14678","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=14678"}],"version-history":[{"count":1,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/14678\/revisions"}],"predecessor-version":[{"id":14680,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/14678\/revisions\/14680"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/14679"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=14678"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=14678"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=14678"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}