{"id":14077,"date":"2018-09-21T15:56:28","date_gmt":"2018-09-21T08:56:28","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=14077"},"modified":"2018-10-08T13:45:59","modified_gmt":"2018-10-08T06:45:59","slug":"ky-thuat-chinh-sua-gen-crispr-se-khien-te-bao-ung-thu-khong-con-bat-tu","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/ky-thuat-chinh-sua-gen-crispr-se-khien-te-bao-ung-thu-khong-con-bat-tu\/","title":{"rendered":"K\u1ef9 thu\u1eadt ch\u1ec9nh s\u1eeda gen CRISPR s\u1ebd khi\u1ebfn t\u1ebf b\u00e0o ung th\u01b0 kh\u00f4ng c\u00f2n b\u1ea5t t\u1eed"},"content":{"rendered":"

K\u1ef9 thu\u1eadt ch\u1ec9nh s\u1eeda gen CRISPR c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ng\u0103n ch\u1eb7n s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a ung th\u01b0, theo nghi\u00ean c\u1ee9u m\u1edbi c\u1ee7a c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u1ebfn t\u1eeb \u0110\u1ea1i h\u1ecdc California, Hoa K\u1ef3.<\/p>\n

S\u1eed d\u1ee5ng CRISPR, h\u1ecd ph\u00e1t hi\u1ec7n c\u00f4ng \u1ee5c n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng h\u1ea1n ch\u1ebf m\u1ed9t lo\u1ea1i protein cho ph\u00e9p c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 t\u00e1i t\u1ea1o li\u00ean t\u1ee5c. Lo\u1ea1i protein n\u00e0y c\u00f3 m\u1eb7t trong h\u01a1n 50 lo\u1ea1i ung th\u01b0 v\u00e0 \u0111\u01b0\u1ee3c m\u1ec7nh danh l\u00e0 “chi\u1ebfc\u00a0c\u00f4ng t\u1eafc b\u1ea5t t\u1eed<\/i>” c\u1ee7a ch\u00fang.<\/p>\n

M\u1ed9t khi chi\u1ebfc c\u00f4ng t\u1eafc \u0111\u01b0\u1ee3c b\u1eadt l\u00ean, t\u1ebf b\u00e0o ung th\u01b0 s\u1ebd ph\u00e2n chia v\u00f4 h\u1ea1n \u0111\u1ecbnh, d\u1eabn \u0111\u1ebfn vi\u1ec7c kh\u1ed1i u l\u1edbn l\u00ean nhanh ch\u00f3ng, t\u00e1i ph\u00e1t sau h\u00f3a x\u1ea1 tr\u1ecb ph\u1eabu thu\u1eadt, r\u1ed3i di c\u0103n kh\u1eafp c\u01a1 th\u1ec3 khi\u1ebfn ch\u00fang ta kh\u00f4ng l\u00e0m g\u00ec \u0111\u01b0\u1ee3c n\u1eefa.<\/p>\n

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\"K\u1ef9<\/div>\n
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K\u1ef9 thu\u1eadt ch\u1ec9nh s\u1eeda gen CRISPR s\u1ebd khi\u1ebfn t\u1ebf b\u00e0o ung th\u01b0 kh\u00f4ng c\u00f2n b\u1ea5t t\u1eed<\/p>\n<\/div>\n<\/div>\n

Nghi\u00ean c\u1ee9u m\u1edbi \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1edfi gi\u00e1o s\u01b0 ph\u1eabu thu\u1eadt, \u0111\u1ed3ng th\u1eddi l\u00e0 chuy\u00ean gia ung th\u01b0 th\u1ea7n kinh Joseph Costello t\u1ea1i \u0110\u1ea1i h\u1ecdc California. Trong \u0111\u00f3, \u00f4ng v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p \u0111\u00e3 s\u1eed d\u1ee5ng k\u1ef9 thu\u1eadt ch\u1ec9nh s\u1eeda gen CRISPR \u0111\u1ec3 lo\u1ea1i b\u1ecf protein GABP kh\u1ecfi c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 n\u00e3o Glioblastoma.<\/p>\n

Protein GABP ch\u00ednh l\u00e0 t\u00e1c nh\u00e2n k\u00edch ho\u1ea1t qu\u00e1 tr\u00ecnh ph\u00e2n chia v\u00f4 t\u1eadn c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0. C\u00f2n Glioblastoma, hay c\u00f2n g\u1ecdi l\u00e0 kh\u1ed1i u nguy\u00ean b\u00e0o th\u1ea7n kinh \u0111\u1ec7m, l\u00e0 m\u1ed9t d\u1ea1ng ung th\u01b0 n\u00e3o c\u1ef1c k\u1ef3 nguy hi\u1ec3m v\u00e0 \u00e1c t\u00ednh.<\/p>\n

Tuy nhi\u00ean, sau khi protein GABP b\u1ecb lo\u1ea1i b\u1ecf kh\u1ecfi c\u00e1c t\u1ebf b\u00e0o Glioblastoma, trong m\u00f4i tr\u01b0\u1eddng th\u00ed nghi\u1ec7m v\u00e0 c\u1ea3 trong c\u01a1 th\u1ec3 chu\u1ed9t, ch\u00fang \u0111\u00e3 gi\u1ea3m t\u0103ng tr\u01b0\u1edfng \u0111\u1ed3ng th\u1eddi c\u01b0 x\u1eed nh\u01b0 t\u1ebf b\u00e0o b\u00ecnh th\u01b0\u1eddng. \u0110i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a l\u00e0 s\u1ed1 l\u1ea7n ph\u00e2n chia c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 b\u1ecb gi\u1edbi h\u1ea1n, khi ch\u00fang ph\u00e2n chia \u0111\u1ee7 s\u1ed1 l\u1ea7n, ch\u00fang s\u1ebd t\u1ef1 nhi\u00ean ch\u1ebft.<\/p>\n

“\u0110i\u1ec1u n\u00e0y th\u1ef1c s\u1ef1 h\u1ea5p d\u1eabn ch\u00fang t\u00f4i<\/i>“, Gi\u00e1o s\u01b0 Costello n\u00f3i trong th\u00f4ng c\u00e1o b\u00e1o ch\u00ed. Hai \u00fd t\u01b0\u1edfng \u0111\u01b0\u1ee3c \u00f4ng \u0111\u01b0a ra sau ph\u00e1t hi\u1ec7n n\u00e0y l\u00e0 ph\u00e1t tri\u1ec3n song song m\u1ed9t lo\u1ea1i thu\u1ed1c nh\u1eafm v\u00e0o GABP trong c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 v\u00e0 m\u1ed9t li\u1ec7u ph\u00e1p CRISPR \u0111\u1ec3 ch\u1ec9nh s\u1eeda gen c\u1ee7a con ng\u01b0\u1eddi sao cho ch\u00fang ta kh\u00f4ng s\u1ea3n xu\u1ea5t ra protein nguy hi\u1ec3m n\u00e0y n\u1eefa.<\/p>\n

“B\u1ea1n kh\u00f4ng th\u1ec3 t\u1ea1o ra m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u1ec3 nh\u1eafm v\u00e0o m\u1ed9t gen kh\u1edfi \u0111\u1ed9ng, nh\u01b0ng n\u1ebfu ch\u00fang ta c\u00f3 th\u1ec3 x\u00e1c \u0111\u1ecbnh c\u00e1ch GABP g\u1eafn k\u1ebft v\u1edbi gen kh\u1edfi \u0111\u1ed9ng \u0111\u1ed9t bi\u1ebfn trong nh\u1eefng c\u0103n b\u1ec7nh ung th\u01b0 n\u00e0y, ch\u00fang ta c\u00f3 th\u1ec3 c\u00f3 \u0111\u01b0\u1ee3c m\u1ed9t m\u1ee5c ti\u00eau thu\u1ed1c m\u1edbi cho hi\u1ec7u qu\u1ea3 \u0111\u00e1ng k\u1ec3<\/i>“, gi\u00e1o s\u01b0 Costello n\u00f3i.<\/p>\n

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\"K\u1ef9<\/div>\n
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Ch\u00fang ta c\u00f3 th\u1ec3 ph\u00e1t tri\u1ec3n song song m\u1ed9t lo\u1ea1i thu\u1ed1c nh\u1eafm v\u00e0o GABP trong c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 v\u00e0 m\u1ed9t li\u1ec7u ph\u00e1p CRISPR \u0111\u1ec3 ch\u1ec9nh s\u1eeda gen con ng\u01b0\u1eddi sao cho ch\u00fang ta kh\u00f4ng s\u1ea3n xu\u1ea5t ra protein nguy hi\u1ec3m n\u00e0y n\u1eefa.<\/p>\n<\/div>\n<\/div>\n

M\u1eb7c d\u00f9 s\u1ee9c m\u1ea1nh c\u1ee7a CRISPR c\u00f3 th\u1ec3 khi\u1ebfn nhi\u1ec1u ng\u01b0\u1eddi lo ng\u1ea1i n\u00f3 s\u1ebd b\u1ecb l\u1ea1m d\u1ee5ng, c\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda gen n\u00e0y v\u1eabn \u0111\u01b0\u1ee3c cho l\u00e0 s\u1ebd t\u1ea1o ra nh\u1eefng thay \u0111\u1ed5i c\u00e1ch m\u1ea1ng trong y t\u1ebf v\u00e0 n\u00f4ng nghi\u1ec7p. N\u00f3 \u0111\u01b0\u1ee3c \u0111\u00f3n nh\u1eadn b\u1edfi nh\u1eefng nh\u00e0 \u0111\u1ea7u t\u01b0 nh\u01b0 Bill Gates v\u00e0 Sean Parker, trong khi c\u00e1c c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m c\u0169ng h\u00e1o h\u1ee9c \u0111\u1ed5 h\u00e0ng tri\u1ec7u USD v\u00e0o nghi\u00ean c\u1ee9u.<\/p>\n

Trong m\u1ed9t cu\u1ed9c ph\u1ecfng v\u1ea5n tr\u01b0\u1edbc \u0111\u00e2y v\u1edbi Fast Company, nh\u00e0 b\u00ecnh lu\u1eadn c\u00f4ng ngh\u1ec7 CRISPR Jennifer Doudna \u0111\u00e3 th\u1ea3o lu\u1eadn v\u1ec1 c\u00e1c kh\u1ea3 n\u0103ng – c\u1ea3 t\u1ed1t l\u1eabn x\u1ea5u – m\u00e0 c\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda gen n\u00e0y mang \u0111\u1ebfn cho con ng\u01b0\u1eddi.<\/p>\n

Ch\u1eefa b\u1ec7nh ung th\u01b0 l\u00e0 m\u1ed9t trong nh\u1eefng kh\u1ea3 n\u0103ng \u0111\u00f3, ngo\u00e0i ra CRISPR c\u00f2n c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 lai gen l\u1ee3n v\u1edbi gen ng\u01b0\u1eddi, gi\u00fap\u00a0nu\u00f4i c\u1ea5y \u0111\u01b0\u1ee3c nh\u1eefng n\u1ed9i t\u1ea1ng d\u00f9ng cho c\u1ea5y gh\u00e9p b\u00ean trong c\u01a1 th\u1ec3 ch\u00fang.<\/p>\n

“CRISPR cho ch\u00fang ta s\u1ee9c m\u1ea1nh \u0111\u1ec3 thay \u0111\u1ed5i ho\u00e0n to\u00e0n, m\u1ed9t chi\u1ec1u v\u00e0 v\u0129nh vi\u1ec5n, sinh quy\u1ec3n m\u00e0 ch\u00fang ta \u0111ang s\u1ed1ng b\u1eb1ng c\u00e1ch vi\u1ebft l\u1ea1i c\u00e1c ph\u00e2n t\u1eed t\u1ea1o n\u00ean s\u1ef1 s\u1ed1ng (DNA), theo b\u1ea5t k\u1ef3 c\u00e1ch n\u00e0o ch\u00fang ta mu\u1ed1n<\/i>“, Doudna n\u00f3i.<\/p>\n

“\u0110\u00f3 l\u00e0\u00a0m\u1ed9t kho\u1ea3nh kh\u1eafc \u0111\u00e1ng s\u1ee3 trong khoa h\u1ecdc s\u1ef1 s\u1ed1ng, nh\u01b0ng ch\u00fang ta kh\u00f4ng th\u1ec3 \u0111\u1ec3 m\u00ecnh b\u1ecb cu\u1ed1n v\u00e0o. \u0110i\u1ec1u quan tr\u1ecdng c\u1ea7n nh\u1edb l\u00e0, trong khi CRISPR c\u00f3 ti\u1ec1m n\u0103ng to l\u1edbn v\u00e0 kh\u00f4ng th\u1ec3 ph\u1ee7 nh\u1eadn \u0111\u1ec3 c\u1ea3i thi\u1ec7n th\u1ebf gi\u1edbi c\u1ee7a ch\u00fang ta, th\u00ec vi\u1ec7c m\u00e0y m\u00f2 v\u00e0o n\u1ec1n t\u1ea3ng di truy\u1ec1n c\u1ee7a h\u1ec7 sinh th\u00e1i c\u0169ng c\u00f3 th\u1ec3 \u0111\u1ec3 l\u1ea1i nh\u1eefng h\u1eadu qu\u1ea3 ngo\u00e0i \u00fd mu\u1ed1n<\/i>“.<\/p>\n

Nghi\u00ean c\u1ee9u m\u1edbi v\u1ec1 CRISPR v\u00e0 ung th\u01b0 Glioblastoma \u0111\u01b0\u1ee3c \u0111\u0103ng tr\u00ean t\u1ea1p ch\u00ed Cancer Cell.<\/p>\n

Tham kh\u1ea3o\u00a0Fastcompany<\/i><\/p>\n

B\u00c1O \u0110I\u1ec6N T\u1eec TR\u00cd TH\u1ee8C TR\u1eba<\/p>\n","protected":false},"excerpt":{"rendered":"

K\u1ef9 thu\u1eadt ch\u1ec9nh s\u1eeda gen CRISPR c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ng\u0103n ch\u1eb7n s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a ung th\u01b0, theo nghi\u00ean c\u1ee9u m\u1edbi c\u1ee7a c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u1ebfn t\u1eeb \u0110\u1ea1i h\u1ecdc California, Hoa K\u1ef3. S\u1eed d\u1ee5ng CRISPR, h\u1ecd ph\u00e1t hi\u1ec7n c\u00f4ng \u1ee5c n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng h\u1ea1n ch\u1ebf m\u1ed9t lo\u1ea1i protein cho ph\u00e9p […]<\/p>\n","protected":false},"author":18,"featured_media":14078,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-14077","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/14077","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=14077"}],"version-history":[{"count":1,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/14077\/revisions"}],"predecessor-version":[{"id":14079,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/14077\/revisions\/14079"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/14078"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=14077"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=14077"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=14077"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}