{"id":12787,"date":"2018-07-12T14:07:38","date_gmt":"2018-07-12T07:07:38","guid":{"rendered":"https:\/\/ttud.com.vn\/?p=12787"},"modified":"2018-08-07T14:30:39","modified_gmt":"2018-08-07T07:30:39","slug":"them-mot-vac-xin-hiv-nua-tien-den-thu-nghiem-giai-doan-2b-tren-nguoi-dieu-do-nghia-la-gi","status":"publish","type":"post","link":"https:\/\/casta.ttud.com.vn\/index.php\/them-mot-vac-xin-hiv-nua-tien-den-thu-nghiem-giai-doan-2b-tren-nguoi-dieu-do-nghia-la-gi\/","title":{"rendered":"Th\u00eam m\u1ed9t v\u1eafc-xin HIV n\u1eefa ti\u1ebfn \u0111\u1ebfn th\u1eed nghi\u1ec7m giai \u0111o\u1ea1n 2b tr\u00ean ng\u01b0\u1eddi, \u0111i\u1ec1u \u0111\u00f3 ngh\u0129a l\u00e0 g\u00ec?"},"content":{"rendered":"

Giai \u0111o\u1ea1n 2b n\u1eb1m gi\u1eefa giai \u0111o\u1ea1n 2 v\u00e0 3 c\u1ee7a th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng. \u0110\u00f3 l\u00e0 m\u1ed9t c\u1ed9t m\u1ed1c r\u1ea5t quan tr\u1ecdng.<\/p>\n

Theo m\u1ed9t c\u00f4ng b\u1ed1 m\u1edbi \u0111\u1ea7u tu\u1ea7n n\u00e0y tr\u00ean t\u1ea1p ch\u00ed Lancet, m\u1ed9t lo\u1ea1i v\u1eafc-xin HIV v\u1eeba \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng tr\u00ean ng\u01b0\u1eddi \u0111\u1ebfn giai \u0111o\u1ea1n 2b. H\u01a1n 2.600 ph\u1ee5 n\u1eef c\u00f3 nguy c\u01a1 nhi\u1ec5m b\u1ec7nh cao \u1edf Nam Phi \u0111\u00e3 \u0111\u01b0\u1ee3c ti\u00eam v\u1eafc-xin \u0111\u1ec3 xem n\u00f3 c\u00f3 th\u1ef1c s\u1ef1 b\u1ea3o v\u1ec7 h\u1ecd kh\u1ecfi HIV hay kh\u00f4ng.<\/div>\n
\n

Tr\u01b0\u1edbc \u0111\u00f3, th\u1eed nghi\u1ec7m giai \u0111o\u1ea1n 2 tr\u00ean g\u1ea7n 400 ng\u01b0\u1eddi \u0111\u00e3 cho k\u1ebft qu\u1ea3 kh\u1ea3 quan khi v\u1eafc-xin t\u1ea1o ra ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch v\u00e0 dung n\u1ea1p t\u1ed1t. \u1ede kh\u1ec9, v\u1eafc-xin n\u00e0y \u0111\u00e3 cho t\u00e1c d\u1ee5ng ph\u00f2ng b\u1ec7nh t\u1edbi 67%.<\/p>\n

Trong 35 n\u0103m tr\u1edf l\u1ea1i \u0111\u00e2y k\u1ec3 t\u1eeb khi \u0111\u1ea1i d\u1ecbch HIV b\u1eaft \u0111\u1ea7u, c\u00f3 t\u1ea5t c\u1ea3 5 lo\u1ea1i v\u1eafc-xin HIV \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m t\u1edbi giai \u0111o\u1ea1n 2b. \u0110\u00e2y l\u00e0 giai \u0111o\u1ea1n \u1edf ng\u01b0\u1ee1ng 2\/3 con \u0111\u01b0\u1eddng ti\u1ebfn \u0111\u1ebfn k\u1ebft qu\u1ea3 cu\u1ed1i c\u00f9ng. T\u1ef7 l\u1ec7 th\u00e0nh c\u00f4ng c\u1ee7a c\u00e1c lo\u1ea1i v\u1eafc-xin th\u1eed nghi\u1ec7m gi\u1eefa giai \u0111o\u1ea1n 2 v\u00e0 3 l\u00e0 kho\u1ea3ng 30%.<\/p>\n

N\u1ebfu v\u01b0\u1ee3t qua \u0111\u01b0\u1ee3c giai \u0111o\u1ea1n n\u00e0y, v\u1eafc-xin HIV m\u1edbi \u0111\u01b0\u1ee3c coi l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng tr\u00ean ng\u01b0\u1eddi.<\/p>\n

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\"Th\u00eam<\/div>\n
\n

Th\u00eam m\u1ed9t v\u1eafc-xin HIV n\u1eefa ti\u1ebfn \u0111\u1ebfn th\u1eed nghi\u1ec7m giai \u0111o\u1ea1n 2b tr\u00ean ng\u01b0\u1eddi, \u0111i\u1ec1u \u0111\u00f3 ngh\u0129a l\u00e0 g\u00ec?<\/p>\n<\/div>\n<\/div>\n

Ph\u00e1t tri\u1ec3n v\u1eafc-xin ch\u1ed1ng l\u1ea1i \u0111\u01b0\u1ee3c HIV l\u00e0 m\u1ed9t \u0111i\u1ec1u c\u1ef1c k\u1ef3 kh\u00f3. L\u00ed do v\u00ec lo\u1ea1i virus n\u00e0y c\u1ef1c k\u1ef3 tinh qu\u00e1i, khi c\u00e1c nh\u00e0 khoa h\u1ecdc ch\u01b0a ph\u00e1t tri\u1ec3n xong v\u1eafc-xin th\u1eed nghi\u1ec7m, ch\u00fang \u0111\u00e3 \u0111\u1ee7 th\u1eddi gian \u0111\u1ec3 bi\u1ebfn \u0111\u1ed5i v\u00e0 ch\u1ed1ng l\u1ea1i li\u1ec1u thu\u1ed1c c\u1ee7a con ng\u01b0\u1eddi.<\/p>\n

Nh\u1eadn bi\u1ebft \u0111\u01b0\u1ee3c \u0111i\u1ec1u n\u00e0y, c\u00e1c nh\u00e0 khoa h\u1ecdc t\u1ea1i Tr\u01b0\u1eddng Y Harvard \u0111\u00e3 ph\u00e1t tri\u1ec3n m\u1ed9t lo\u1ea1i v\u1eafc-xin \u201ckh\u1ea3m<\/i>\u201d. H\u1ecd k\u1ebft h\u1ee3p v\u00e0o \u0111\u00f3 nhi\u1ec1u th\u00e0nh ph\u1ea7n c\u1ee7a c\u00e1c lo\u1ea1i virus HIV kh\u00e1c nhau, nh\u1eb1m k\u00edch ho\u1ea1t h\u1ec7 mi\u1ec5n d\u1ecbch ch\u1ed1ng l\u1ea1i m\u1ed9t ph\u1ed5 r\u1ed9ng virus k\u1ec3 c\u1ea3 khi ch\u00fang bi\u1ebfn \u0111\u1ed5i.<\/p>\n

C\u00f3 t\u1ea5t c\u1ea3 7 lo\u1ea1i v\u1eafc-xin \u201ckh\u1ea3m<\/i>\u201d \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u1edf Harvard t\u1ea1o ra v\u00e0 \u0111\u01b0a v\u00e0o th\u1eed nghi\u1ec7m giai \u0111o\u1ea1n 2 c\u00f9ng m\u1ed9t l\u00fac. H\u1ecd \u0111\u00e3 tuy\u1ec3n d\u1ee5ng 393 ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh kh\u1ecfe m\u1ea1nh trong \u0111\u1ed9 tu\u1ed5i t\u1eeb 18-50. Nh\u1eefng t\u00ecnh nguy\u1ec7n vi\u00ean n\u00e0y kh\u00f4ng b\u1ecb nhi\u1ec5m HIV v\u00e0 \u0111ang s\u1ed1ng \u1edf \u0110\u00f4ng Phi, Nam Phi , Th\u00e1i Lan v\u00e0 M\u1ef9.<\/p>\n

M\u1ed7i ng\u01b0\u1eddi trong s\u1ed1 h\u1ecd \u0111\u01b0\u1ee3c ti\u00eam 1 trong 7 lo\u1ea1i v\u1eafc-xin kh\u1ea3m. Trong 48 tu\u1ea7n, c\u00f3 t\u1ed5ng c\u1ed9ng 4 m\u0169i ti\u00eam \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n. K\u1ebft qu\u1ea3 c\u00f4ng b\u1ed1 cho th\u1ea5y c\u1ea3 7 lo\u1ea1i v\u1eafc-xin n\u00e0y \u0111\u1ec1u cho ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch ch\u1ed1ng l\u1ea1i HIV v\u00e0 dung n\u1ea1p t\u1ed1t tr\u00ean c\u01a1 th\u1ec3 ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng.<\/p>\n

M\u1eb7c d\u00f9 v\u1eady, t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a thu\u1ed1c \u0111\u01b0\u1ee3c ghi nh\u1eadn, khi c\u00e1c nh\u00f3m t\u00ecnh nguy\u1ec7n vi\u00ean b\u00e1o c\u00e1o c\u1ea3m gi\u00e1c \u0111au \u0111\u1ea7u v\u00e0 m\u1ec7t m\u1ecfi trong ng\u01b0\u1ee1ng nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh. C\u00e1 bi\u1ec7t ch\u1ec9 c\u00f3 5 ng\u01b0\u1eddi g\u1eb7p ph\u1ea3n \u1ee9ng ph\u1ee5 m\u1ea1nh, bao g\u1ed3m ch\u00f3ng m\u1eb7t, ti\u00eau ch\u1ea3y v\u00e0 \u0111au l\u01b0ng.<\/p>\n

\u201cNh\u1eefng k\u1ebft qu\u1ea3 n\u00e0y l\u00e0 m\u1ed9t c\u1ed9t m\u1ed1c quan tr\u1ecdng<\/i>\u201d, ti\u1ebfn s\u0129 Dan Barouch, t\u00e1c gi\u1ea3 d\u1eabn \u0111\u1ea7u nghi\u00ean c\u1ee9u cho bi\u1ebft. B\u00e2y gi\u1edd, c\u00e1c nh\u00e0 khoa h\u1ecdc Harvard \u0111\u00e3 m\u1edf r\u1ed9ng th\u1eed nghi\u1ec7m sang giai \u0111o\u1ea1n 2b, n\u00f3 \u0111\u00e3 \u0111ang \u0111\u01b0\u1ee3c ti\u00eam cho h\u01a1n 2.600 ph\u1ee5 n\u1eef \u1edf Ch\u00e2u Phi c\u00f3 nguy c\u01a1 cao nhi\u1ec5m HIV.<\/p>\n

\u201cCh\u00fang t\u00f4i h\u00e1o h\u1ee9c ch\u1edd \u0111\u1ee3i k\u1ebft qu\u1ea3 th\u1eed nghi\u1ec7m giai \u0111o\u1ea1n 2b<\/i>\u201d, ti\u1ebfn s\u0129 Dan Barouch n\u00f3i. Trong su\u1ed1t 35 n\u0103m qua k\u1ec3 t\u1eeb khi \u0111\u1ea1i d\u1ecbch HIV\/AIDS b\u1eaft \u0111\u1ea7u, ch\u1ec9 c\u00f3 1 lo\u1ea1i v\u1eafc-xin c\u00f3 t\u00ean l\u00e0 RV144 v\u01b0\u1ee3t qua \u0111\u01b0\u1ee3c giai \u0111o\u1ea1n th\u1eed nghi\u1ec7m 2b.<\/p>\n

\u0110\u00e2y l\u00e0 giai \u0111o\u1ea1n ch\u1ee9ng minh hi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7 c\u1ee7a v\u1eafc-xin tr\u00ean ng\u01b0\u1eddi. RV144 ch\u1ec9 cho 31% hi\u1ec7u qu\u1ea3 gi\u1ea3m t\u1ef7 l\u1ec7 nhi\u1ec5m HIV trong nh\u00f3m th\u1eed nghi\u1ec7m. \u0110\u00e1ng ti\u1ebfc l\u00e0 n\u00f3 c\u00f2n qu\u00e1 th\u1ea5p \u0111\u1ec3 \u0111\u01b0\u1ee3c \u0111\u01b0a ra th\u1ecb tr\u01b0\u1eddng.<\/p>\n

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\"Th\u00eam<\/div>\n
\n

C\u00e1c giai \u0111o\u1ea1n c\u1ee7a th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng: Giai \u0111o\u1ea1n 1 th\u1eed nghi\u1ec7m \u0111\u1ed9 an to\u00e0n, t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 li\u1ec1u l\u01b0\u1ee3ng; Giai \u0111o\u1ea1n 2 \u0111\u00e1nh gi\u00e1 t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c, t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 lo\u1ea1i b\u1ecf hi\u1ec7u \u1ee9ng gi\u1ea3 d\u01b0\u1ee3c; Giai \u0111o\u1ea1n 3 ti\u1ebfp t\u1ee5c xem x\u00e9t t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c, trong d\u00e0i h\u1ea1n v\u00e0 trong th\u00e0nh ph\u1ea7n d\u00e2n s\u1ed1 l\u1edbn. T\u1ea5t c\u1ea3 m\u1ea5t trung b\u00ecnh 10-15 n\u0103m, sau \u0111\u00f3 thu\u1ed1c \u0111\u01b0\u1ee3c c\u1ea5p b\u1eb1ng s\u00e1ng ch\u1ebf, ph\u00ea duy\u1ec7t v\u00e0 th\u1eed nghi\u1ec7m giai \u0111o\u1ea1n 4 trong nhi\u1ec1u nh\u00f3m ng\u01b0\u1eddi v\u00e0 nhi\u1ec1u ho\u00e0n c\u1ea3nh kh\u00e1c nhau tr\u01b0\u1edbc khi c\u00f3 th\u1ec3 ho\u00e0n to\u00e0n th\u01b0\u01a1ng m\u1ea1i h\u00f3a.<\/p>\n<\/div>\n<\/div>\n

Trong tr\u01b0\u1eddng h\u1ee3p c\u1ee7a v\u1eafc-xin m\u1edbi, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 Ad26 \/ Ad26 plus gp140. Th\u1eed nghi\u1ec7m tr\u00ean 72 con kh\u1ec9 cho th\u1ea5y n\u00f3 c\u00f3 hi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7 t\u1edbi 67%, \u0111\u1ed1i v\u1edbi virus SHIV (m\u1ed9t ch\u1ee7ng t\u01b0\u01a1ng t\u1ef1 HIV nh\u01b0ng ch\u1ec9 l\u00e2y nhi\u1ec5m tr\u00ean kh\u1ec9).<\/p>\n

M\u1eb7c d\u00f9 v\u1eady, s\u1ef1 th\u1eadt l\u00e0 nhi\u1ec1u lo\u1ea1i v\u1eafc-xin, kh\u00f4ng c\u1ee9 g\u00ec HIV, \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m th\u00e0nh c\u00f4ng trong ph\u00f2ng th\u00ed nghi\u1ec7m v\u00e0 tr\u00ean \u0111\u1ed9ng v\u1eadt, nh\u01b0ng l\u1ea1i kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng tr\u00ean ng\u01b0\u1eddi. \u0110i\u1ec1u n\u00e0y khi\u1ebfn c\u00e1c nh\u00e0 khoa h\u1ecdc t\u1ed1n r\u1ea5t nhi\u1ec1u th\u1eddi gian v\u00e0 ti\u1ec1n b\u1ea1c.<\/p>\n

Nh\u01b0ng ch\u00fang ta kh\u00f4ng h\u1ec1 c\u00f3 c\u00e1ch n\u00e0o kh\u00e1c. Khoa h\u1ecdc l\u00e0 th\u1eed, sai th\u00ec l\u00e0m l\u1ea1i. George Williams Mbogo, nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i Vi\u1ec7n Burnet, Australia cho bi\u1ebft: \u201cCon \u0111\u01b0\u1eddng \u0111\u01b0a v\u1eafc-xin t\u1edbi ph\u00f2ng kh\u00e1m v\u1eabn c\u00f2n ch\u01b0a \u0111\u01b0\u1ee3c khai ph\u00e1, v\u00ec c\u00e1ch v\u1eafc-xin ho\u1ea1t \u0111\u1ed9ng tr\u00ean ng\u01b0\u1eddi l\u00e0 \u0111i\u1ec1u ch\u00fang ta c\u00f2n ch\u01b0a bi\u1ebft\u201d<\/i>.<\/p>\n

\u201cC\u00f3 th\u1ec3 s\u1ef1 b\u1ea3o v\u1ec7 t\u1edbi 67% tr\u00ean kh\u1ec9 kh\u00f4ng th\u1ec3 l\u1eb7p l\u1ea1i tr\u00ean ng\u01b0\u1eddi. Nh\u01b0ng b\u1eb1ng ch\u1ee9ng t\u1eeb th\u1eed nghi\u1ec7m giai \u0111o\u1ea1n tr\u01b0\u1edbc cho th\u1ea5y m\u1ed9t s\u1ef1 l\u1ea1c quan m\u1ea1nh m\u1ebd, \u0111\u1ed3ng th\u1eddi t\u1ea1o ra thang \u0111\u00e1nh gi\u00e1 m\u1edbi \u0111\u1ec3 c\u1ea3i ti\u1ebfn v\u1eafc-xin trong t\u01b0\u01a1ng lai\u201d.<\/i><\/p>\n

Tham kh\u1ea3o\u00a0Sciencealert<\/i><\/p>\n

B\u00c1O \u0110I\u1ec6N T\u1eec TR\u00cd TH\u1ee8C TR\u1eba<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Giai \u0111o\u1ea1n 2b n\u1eb1m gi\u1eefa giai \u0111o\u1ea1n 2 v\u00e0 3 c\u1ee7a th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng. \u0110\u00f3 l\u00e0 m\u1ed9t c\u1ed9t m\u1ed1c r\u1ea5t quan tr\u1ecdng. Theo m\u1ed9t c\u00f4ng b\u1ed1 m\u1edbi \u0111\u1ea7u tu\u1ea7n n\u00e0y tr\u00ean t\u1ea1p ch\u00ed Lancet, m\u1ed9t lo\u1ea1i v\u1eafc-xin HIV v\u1eeba \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng tr\u00ean ng\u01b0\u1eddi \u0111\u1ebfn giai \u0111o\u1ea1n 2b. H\u01a1n 2.600 ph\u1ee5 n\u1eef […]<\/p>\n","protected":false},"author":18,"featured_media":12788,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-12787","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/12787","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=12787"}],"version-history":[{"count":1,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/12787\/revisions"}],"predecessor-version":[{"id":12789,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/12787\/revisions\/12789"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media\/12788"}],"wp:attachment":[{"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=12787"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=12787"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/casta.ttud.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=12787"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}